Tag: "engineered" at medical news
Pediatric Cancer Stem Cell Identified
...pathways to induce ERMS in a strain of genetically engineered
zebrafish. Some transgenic zebrafish developed visible tumors by 10 days of age. Through their model, Dr. Zon and colleagues were able to identify both an ERMS tumor-cell-of-origin and a novel genetic signature that underlies ERMS progression in z...
New Strategy Identified for Preventing Acute and Chronic Brain Disease
...ate that when tau is removed from mice genetically engineered
to simulate Alzheimer's disease, their memory function is retained and they live a normal lifespan. Reducing tau levels also made mice more resistant to epileptic seizures. "This is the most striking therapeutic effect I have ever seen in our disea...
Study Revises Dynamin's Role in Nerve Cell Function
...n had worked hard to develop a unique, genetically engineered
mouse without dynamin 1. If the enzyme was essential to all synaptic activity, these mice would die very soon after birth. But the pups were born, and initially appeared healthy. 'That was the really big surprise here,' Dr. Ryan says. 'Pups lacking...
Scientists Equip Bacteria With Custom Chemo-Navigational System
...atly enhance the impressive arsenal of natural and engineered
cell behaviors,' says Dr. Gallivan....
Insulin Therapy Shown to Treat Early Experimental Diabetic Retinopathy
...e retina for prolonged periods. The hydrogels were engineered
to be thermoresponsive and hydrolytically degradable, and their pharmacokinetic and pharmacodynamic properties were studied in vitro and in vivo using R28 cells in culture and SD rats respectively. Lead researcher Ravi S.J. Singh, MD, of the Pennsy...
Cancer Cells Reprogram Energy Needs To Grow And Spread
...tain no VHL protein and in the same cells with VHL engineered
back in. Restoring VHL caused the cells to make two to three times more mitochondria and use two to three times more oxygen. VHL normally blocks the action of HIF-1, a protein that the Hopkins group discovered in 1992. Cells normally make HIF-1 on...
Proteins Behind Mad Cow Disease may Protect Against Alzheimer's
... been confirmed by experiments on mice genetically engineered
to lack the prion proteins, suggest that the prions may have a preventive effect on the development of Alzheimer's. The researchers are now planning to study whether ageing has an effect on the ability of the prion proteins to protect against Alzh...
New Engineered Drug Shows Promise in Treating Lymphocytic Leukaemia
A recent research has found that a new type of engineered
drug may have the potential to treat chronic lymph...nal Blood. The research has established that an engineered
drug candidate is promising in treating lymphocytic leukemia in both test tube and early animal test...
Potential Cure for HIV Discovered
..., a study released Thursday said. The scientists engineered
an enzyme which attacks the DNA of the HIV virus a... three months in the laboratory. The researchers engineered
an enzyme called Tre which removes the virus from the genome of infected cells by recognizing and th...
Research Shows Way for Drug Therapy for Autism
...erns of behaviour. A strain of mice, genetically engineered
by the Nobel laureate Susumu Tonegawa and colleagues at MIT, were manipulated to model "fragile X syndrome (FXS)", the leading inherited cause of mental retardation and the most common genetic cause of autism. "The condition, tied to a mutated gene...
Adenoviruses Could Help Kick Drinking
...ss for more than a month after being injected with engineered
adenoviruses. Many people in East Asia react bad.... To provide a longer-lasting effect, scientists engineered
adenoviruses to carry an "antisense" version of the aldehyde dehydrogenase gene that blocks the prod...
Diet Could Be Life or Death for Prostate Cancer Patients
...on to the condition. Working with mice genetically engineered
to develop prostate tumors, scientists fed some of...acid found in vegetable oils. In normal mice not engineered
for prostate cancer, all survived regardless of diet, according to the study funded by the National ...
Weizmann Researchers Developed Control Switch for Protein Activity
...ical drug, which affects the activity level of the engineered
protein by increasing or reducing it. When the dru... method consists of preparing a set of genetically engineered
proteins (called a library in scientific language) with the amino acid segment inserted in different...
Animal Research Uncovers Another Mechanism of Cholesterol Lowering Drug
...s dual action by studying mice that were specially engineered
to produce NPC1L1 in the liver. When there were high levels of the protein in the liver, which enhanced cholesterol absorption by the cells, there was a drastic reduction in cholesterol levels in the bile. But when the mice were treated with Zetia,...
US FDA may Be Asked to Monitor Toxic Levels of Cigarettes
...xpose and ultimately limit the ways cigarettes are engineered
to the detriment of the public's health. But some have a different take. "It would still be a deadly product. They are not going to make it a safe product by taking out particular smoke constituents. The problem is the public is going to perceive t...
First Drug for Post-traumatic Stress Disorder
...eir extinction. In the current work, genetically engineered
mice received mild foot shocks in a certain environment and were re-exposed to the same environment without the foot shock. Mice with increased levels of Cdk5 activity had more trouble letting go--or extinguishing--the memory of the foot shock and...
Key Mechanism to Emergence of Strep Bacteria
... said Walker. The research team used genetically engineered
mice expressing human plasminogen and infected them with M1T1 strep clone, discovering that the bacteria routinely mutated to the invasive form, then spread throughout the body to produce a fatal infection. When the researchers eliminated the singl...
Modified Herpes Virus Keeps Arteries Free-flowing Following Procedures
A genetically engineered
herpes simplex virus, primarily known for causing ...of Chicago noted that in recent years, genetically engineered
herpes simplex virus studied for its efficacy against malignant tumors of the central nervous system...
Scientists Identify "master Switch" for Brown Fat in Mice
... "You might not have to implant a large amount of engineered
precursors in people who are at risk for being obese. In theory, you would only have to reduce the accumulation of white fat by 1 percent or so to have an effect," said Dr. Spiegelman....
Scientists Identified Obesity Control Switch
... "You might not have to implant a large amount of engineered
precursors in people who are at risk for being obese," said Spiegelman, who is also a professor of cell biology at Harvard Medical School. "In theory, you would only have to reduce the accumulation of white fat by 1 percent or so to have an effect."...
1 2 3 4 5 6 7 8 9 10