Lead With a Poisonous Electron Shield
...he different behavior of lead in these two enzymes demonstrates that it can enter into complexes in which the metal–ligand bonds can either point in all directions, or into only one hemisphere, while the other hemisphere is filled by the free electron pair. This observation may help in the design of future lead-s...Probing the Effect of Endurance Exercise on Athletes' Hearts
...ith VA. Prof Heidbüchel said: "Our study clearly demonstrates RV functional abnormalities in high-level endurance athletes with VA. The observed RV dysfunction is more subtle than in familial or overt ARVC. ARVC was only present in a minority of the athletes, based on conventional, internationally accepted crit...Tamoxifen Discontinuation Rates Surprisingly High
... were more likely to stop tamoxifen. "This study demonstrates that persistence with tamoxifen cannot be assumed and raises concerns about persistence with other oral hormonal therapies for breast cancer and oral anti-neoplastics in general," the authors write. "This is of particular importance," they conclude, ...Europeans Developing First-Ever Dengue Fever Vaccine
...ment of certain cancers, however, and new evidence demonstrates that higher than normal concentrations can lead to haemorrhaging. The research team was able to identify a direct relationship between cells infected by the Dengue virus and increased production of metalloproteinase. They crosschecked their finding...Estrogen Linked to Immune Surveillance in Breast Cancer
... are associated with poor prognoses. This study demonstrates how basic research can have important and unanticipated implications for understanding diseases such as breast cancer, Shapiro said. The finding that estrogens stimulate PI-9 production could eventually help drug designers develop new tests – and tar...A Novel Technique Nudges Genes Into Activity
...outhwestern research, coupled with that from 2005, demonstrates a shift away from conventional thinking about how gene expression is naturally controlled, as well as how scientists might be able to exploit the process to develop new drug targets, Dr. Corey said. For example, current methods to block gene expres...Scientists Identify Pancreatic Cancer Stem Cells
...f those concepts, the researchers said. “Our study demonstrates that the very small subset of cells in a human pancreatic tumor that cause the cancer to grow and propagate have stem cell-like features,” Simeone said. To look for cancer stem cells in pancreatic cancer, the research team implanted cancerous tiss...Growth Factors Given With Chemotherapy may Increase Risk of Blood Diseases
... not treated with the growth factors. "Our study demonstrates that the elevated risk of AML or MDS associated with adjuvant chemotherapy may be further increased by the concurrent use of growth factors," the authors write. "It is unclear if the growth factors cause an increased risk or if the requirements for t...Marked Increase of Cancer Cases Among Aging Population
...estimated to have risen by 300,000 to 3.2 million, demonstrates the impact of the ageing of the European population and underlines the need for active and effective tobacco control measures and screening programmes in Europe." Source-Eurekalert......ofessor of gerontology and geriatric medicine. "It demonstrates that up until age 80, both older men and women gained fat but lost lean mass each year. These age-related changes were compounded by the obesity epidemic." In addition to measuring the effects of aging on body composition, the researchers also look...Early Switch to an Aromatase Inhibitor Increases Survival
... in follow-up after two years of tamoxifen therapy demonstrates clear and, in some cases, improved reduction of recurrence risk. However, there is conflicting evidence about mortality benefits. Led by Professor Francesco Boccardo, M.D. of the National Cancer Research Institute and the University of Genoa in It...Liver an Excellent Target For Cancer Gene Therapy
A study demonstrates that cancer cells in the liver are excellent targe..., hidden from the blood vessels. The research also demonstrates that in cancerous cells the receptor for adenovirus, called the coxsackie-adenoviral receptor or CAR...DNA-based Detection of Heavy Metals
... laboratory instruments. "This latest success demonstrates that our methodology can be used to make cost-effective sensors for other hazardous metals, as well, with extremely high sensitivity and selectivity," Lu said. "We can also construct sensor arrays that detect and quantify many metal ions simultaneous...Modified Ligament Surgery Improves Outcomes Players, Athletes
...hat this particular operation in throwing athletes demonstrates better results than the classic operation,” said David W. Altchek, M.D., senior author of the study and co-chief of the Sports Medicine and Shoulder Service at Hospital for Special Surgery (HSS) in New York. The study was presented at a special sessi...Family Planning Method is as Effective as the Contraceptive Pill
...re difficult due to methodological problems. “This demonstrates a fairly good acceptability for this particular FAB method,” said Prof Frank-Herrmann. The authors were surprised by the relatively low rate of unintended pregnancies (7.5%) among women who had unprotected sex during their fertile period. “If peopl...Treatment Extends Survival in Mouse Model of Spinal Muscular Atrophy
...-concept experiment," says Dr. Sumner. "It clearly demonstrates that this treatment can ameliorate the disease in mice." While the results are exciting, there are still no studies that have proven the effectiveness of HDAC inhibitors in humans, she cautions. The investigators are now testing whether treatment w...DVT Treatment Vacuums Away Blood Clots – Prevents Disabilit
A study presented today demonstrates that a new technique safely and effectively removes blood clots in the body faster, reducing// patient risk for pulmonary embolism and disability. The interventional radiology treatment was also shown to have a positive impact on patients’ quality...Targeting SOCS-3 can Control Obesity
A new research demonstrates how obesity causes the breakdown of a brain system...ot develop these health problems. "This research demonstrates how a portion of the hypothalamus of the brain, called the arcuate nucleus, is negatively impacted b...Doctors Not Drowsy When Treating Women's Sleep Issues
...at the sleep patterns of adult women. "This poll demonstrates that chest specialists take sleep problems seriously. ACCP members are asking about sleep problems and taking action when problems are identified," said Barbara A. Phillips, MD, FCCP, Chairman of the NSF Board of Directors and ACCP member. "The NSF t......at the sleep patterns of adult women. "This poll demonstrates that chest specialists take sleep problems seriously. ACCP members are asking about sleep problems and taking action when problems are identified," said Barbara A. Phillips, MD, FCCP, Chairman of the NSF Board of Directors and ACCP member. "The NSF t...