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Tag: "cultured" at medical news

Scientists Develop a Harmless Multi-Tasking Reovirus

...ad cleared the patient's system. These cells, when cultured in the laboratory, also appeared to be vulnerable to re-infection with reovirus. Moreover, Dr. Fraser noted that dendritic cells, which prime the immune system against cancer, were activated by exposure to the reovirus. "We understand how the reovi...

Sea Creature's Toxin Could Lead to Promising Cancer Treatment

...l how the toxin blocks uninhibited reproduction of cultured human cancer cells while leaving healthy cells unaffected. An accompanying study in PNAS shows that, in pre-clinical trials, a synthetic form of the toxin reduced human tumors implanted in mice without the harmful side effects seen using other canc...

Salk Scientists - Links Between Cancer and Aging

... microscope. Then they artificially supplied the cultured cells with one of two genes-either a functional copy of the WRN gene, which is mutant or nonfunctional in Werner Syndrome, or a gene encoding the protein telomerase, which elongates short or missing telomeres. After cells divided several times, their...

Human Skin Harbors Many More Types of Bacteria

...risk contamination. Traditionally, bacteria are cultured in the lab in petri dishes, which contain a medium to grow bacteria. But the method leads to inaccuracies, she explains, because only a fraction of bacteria in a sample grow in that medium. So the team used a powerful molecular method that involved e...

A Novel Technique Nudges Genes Into Activity

...agues describe how they activated certain genes in cultured cells using strands of RNA to perturb the delicately balanced mixture of proteins that surround chromosomal DNA, proteins that control whether genes are turned on or off. Dr. David Corey, professor of pharmacology and the paper’s senior author, sa...

A Breakthrough in the Study of Hepatitis C

...irus replication in transfected and serum-infected cultured human fetal hepatocytes,’ appears in the February ...due to the host's natural defenses. Interestingly, cultured hepatocytes responded to viral replication by displaying signs of distress and cell death and by exp...

New Test Predicts CLL’s Sensitivity to Experimental Drug

... Abbott's investigational compound ABT-737 against cultured CLL cells with striking results. "We've treated CLL samples from several dozen patients, and each has responded to a very low concentration of the drug," said Letai. "We find it particularly interesting that the cells died within four hours." Cells...

Genetically Altered Cells Prevent Lethal Infections in Substituted Skin

...eloped modified skin cells which on being added to cultured skin substitutes, may help fight off potentially l...rn wound care and infection control. Using them in cultured skin substitutes, she adds, could also decrease a patient's risk for infection, improve skin graft s...

Underground Air - Associated With - DNA Damages

...red how particles from a variety of sources affect cultured lung cells. The results, which are presented in her thesis Particularly harmful particles show that particles from the Stockholm underground are much more damaging to cellular DNA than the other sources tested (e.g. wood smoke and cars). The airbor...

Link Between Huntington’s and Abnormal Cholesterol Levels in Brain Establishe

...served the abnormal accumulation of cholesterol in cultured neuronal cells in the laboratory and in the brains of animal models. They found that this happens only when the mutant Huntington’s protein is expressed together with the molecule, caveolin-1. Caveolin-1 is the major structural protein of small vesic...

Altered Sodium Channel Function Linked to Heart Failure

...ion, it was shown that overexpression of CaMKII in cultured heart muscle cells from rabbits and as a transgene in mice altered Na+ channel function. CaMKII mediated these effects by binding Na+ channel components and phosphorylating them. Importantly, mice overexpressing CaMKII were more susceptible to VTs th...

Parkinson's Mutation Stunts Neurons

... neural circuitry. The researchers also found that cultured neurons with mutant LRRK2 enzymes showed reduced survival. The researchers analyzed the function of the mutant proteins, establishing that it was the "triggering" kinase segment of the protein that was central to the enzyme's defective function. ...

Brain’s natural Antioxidant Defense Syste

...searchers have found that high levels of PGC-1a in cultured cells offers protection against nerve toxins. This study is to be published in the Oct. 20 issue of the journal Cell. They are at present working on compounds that would stimulate the expression of PGC-1a in brain cells. <BR...

Eating Strawberries may boost memory

...ons that fisetin protects and promotes survival of cultured neurons and boosts memory in healthy mice make it a promising candidate for further studies. Notes Maher, "This is the first time that the function of a defined natural product has been characterized at the molecular level in the central nervous syst...

First Major Study of Mammalian “Disorderly” Proteis

...ied quantities from extracts of a standard type of cultured mouse cells called NIH3T3 fibroblasts. The IUPs were resistant to the heat, unlike more structured proteins, which fell apart. Based on these studies, the investigators were able to classify all proteins into one of three categories: IUPs; intrinsica...

Grant Encourages Drug Testing Sans Animals

...at the University, have developed techniques using cultured human cells to more effectively weed out cancer-ca... scientists establish new genotoxicity tests using cultured human liver cells.It is hoped the new test will not only reduce the number of compounds that are tes...

Genetic Map Reveals How Drugs Fight Diseases: Study

...esearchers collected gene-expression profiles from cultured human cells treated with 164 bioactive small molecules, including the anti-cancer drug gedunin, estrogen and certain antipsychotics. They also collected genetic signatures from cells affected by conditions such as diet-induced obesity, Alzheimer's ...

Cell transplantation - Potential treatment for blindness

...n this study, Retinal pigment epithelium (RPE) was cultured from human embryonic stem cell lines. RPE are the ...at support the light sensing cells in the eye. The cultured RPE was then transplanted into the eyes of a special breed of rat that had an RPE defect, resulting ...

Study Finds Parkinson’s Cell Death Blocked by Stopping Inflammatory Facto

...ced by about half. The same effect was found on cultured dopamine neurons exposed to either toxin. The researchers are now looking into why TNF inhibition did not fully protect against cell death. For example, the drug may not have been able to fully diffuse throughout the tissue, it might take longer t...

Carbon Monoxide May Prevent Pre-Eclampsia

...rian section from nonsmoking, low-risk women. When cultured tissues were exposed to oxidative stress (hypoxia and re-oxygenation), syncytiotrophoblast cell death occurred. However, when tissues were treated with carbon monoxide, at levels similar to those found in blood of smoking mothers, cell death was sign...

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