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Tag: "chromosome" at medical news

A new century of Alzheimer's disease research

...yloid-beta precursor protein, or APP) was found on chromosome 21. This made sense, because patients with Down syndrome, all of whom inherit an extra chromosome 21, typically develop early brain plaques and tangles. Then scientists linked mutations in two othe...

New Asthma Gene Identified

...'s risk for asthma. These markers are located on chromosome 17, and children with this marker had higher levels of a new gene called ORMDL3 in their blood, which occurs in higher amounts in children with asthma. The presence of the disease-associated version of ORMDL3 increases the risk of asthma by 60-70 per...

Chromosone Disorders - Unrevealed Facts

...n the scientific journal Nature Genetics shows how chromosome disorders can arise when sex cells are formed. S...tribution mechanism in female sex cells that cause chromosome disorders. Aberrant chromosomes orientate themselves like normal chromosomes, and this ability to ad...

Genetic Marker That Increases Colon Cancer Risk Discovered

...ween genetic variation in a single region of human chromosome 8 and the risk of colorectal cancer. People who carry the specific genetic variation, the C allele of rs10505477, were found to be 23 percent more likely to have colon cancer than individuals without the marker. The genetic link between the mar...

Genetic Risk Factor for Prostate Cancer

...egion of the human genome devoid of known genes on chromosome 8. The studys complete findings will be published in the July 8 online edition of Nature Genetics. This is an important finding because, for the first time, a common genetic risk factor for multiple cancers has been identified, says lead author Chri...

Scientists Identify New Genetic Mutation Behind Common Dementia

...The researchers say that the mutation in a gene on chromosome 17 halves the production of progranulin, a protein growth factor that helps brain cells survive. For the study, the researchers conducted DNA tests on 70 family members, including 13 people with the disease. They found the new mutation in nine of t...

Advancement in Gene Associated With Colon Cancer

...een genetic variation in a single region of human chromosome 8 and the risk of colorectal cancer. A 10-year s...aneously found their way to the same small area of chromosome 8, called 8q24, in the search for colon cancer genetic links. The fact that these studies were perfo...

Non-invasive Screening in Early Pregnancy Halves Down's Syndrome Births

...orate or exclude the diagnosis of Down syndrome by chromosome analysis. "We found that making non-invasive screening available to all pregnant women meant that the numbers of invasive procedures decreased by 40% between 2004 and 2006", says Professor Brndum-Nielsen. "Although we have not yet studied the who...

Genome Annotation by Mutation

...posts. In the new method, loxP is inserted in a chromosome on one mouse, and in a different position on the same chromosome in a second mouse, which also has a gene named Cre in its cells. When the mice are bred, an offsprin...

Early Pregnancy Test Reduces Down Syndrome in Children

...nfirm or exclude the diagnosis of Down syndrome by chromosome analysis. We found that making non-invasive screening available to all pregnant women meant that the numbers of invasive procedures decreased by 40% between 2004 and 2006, says Professor Brondum-Nielsen. Although we have not yet studied the whole o...

Non-invasive Screening in Early Pregnancy Halves Down's Syndrome Births

...orate or exclude the diagnosis of Down syndrome by chromosome analysis. "We found that making non-invasive screening available to all pregnant women meant that the numbers of invasive procedures decreased by 40% between 2004 and 2006", says Professor Brndum-Nielsen. "Although we have not yet studied the who...

Genetic Variations Leads to Fever After Smallpox Vaccination

... found that variations in the IL-1 gene complex on chromosome 2 were most closely linked to an increased risk of...itionally, several variations in the IL-18 gene on chromosome 11 increased fever risk, while one decreased the likelihood of fever. That gene is involved in revvi...

New Transgenic Mushrooms Raise Hope for Mass Production of Human Drugs

... cell, and integrated the introduced gene into the chromosome of the mushroom. The researchers then exposed the mushroom cells to hygromycin. The antibiotic killed all the normal cells, separating out those that had been genetically altered for resistance. The study demonstrated that if a second gene, insul...

Researchers Reverse Mental Retardation Symptoms in Mice

...se of autism. The condition, tied to a mutated X chromosome gene called fragile X mental retardation 1 (FMR1) gene, causes mild learning disabilities to severe autism. Researchers identified a key enzyme, a chemical reaction-inducing protein as a possible target for an FXS drug. The enzyme, called p21-activ...

First Bacterial Genome Transplantation Changing One Species to Another

...ctable marker gene was added to the M. mycoides LC chromosome to allow for selection of living cells containing ...ed chromosome. Then the team purified the DNA or chromosome from M. mycoides LC so that it was free from proteins (called naked DNA). This M. mycoides LC chromo...

Benoits Son Suffered from Fragile X Syndrome, a Rare Mental Disability

...e road.' Fragile X Syndrome is a defect of the X chromosome which causes mild mental retardation. The disorder occurs more frequently and severely among males than females. This condition is the leading known familial cause of mental retardation in the United States. Language delays, behavioral problems, au...

RNA Play a Vital Role in Gene Activity

...ing one ncRNA dubbed HOTAIR, in the HOXC region on chromosome 12 of a skin cell, significantly increased the expression of HOXD genes on chromosome 2. The finding marks the first time that ncRNA has been shown to affect gene expression on a chromos...

Genetic Variation is Linked to Substantial Risk in Heart Attack

A common genetic variation on chromosome 9p21 is linked to a substantial increase in risk f...genetic variation (one from each parent), found on chromosome 9p21. The research project was led by the Icelandic genomics company deCODE Genetics, along with ...

Genetic Marker Linked to Aggressive Prostate Cancer

... over the past year are located on the long arm of chromosome 8....

Chemotherapy Drug Shrinks Brain Tumors

...an added benefit is the discovery that the loss of chromosome 1p/19q predicts how well a person is going to respond to the treatment," said study author Khe Hoang-Xuan, MD, PhD, with the Pitie-Salpetriere Hospital in Paris, France. However, Hoang-Xuan says comparing temozolomide to radiotherapy, which is the...

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