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Tag: "biochemical" at medical news

Computational Model Reveals Working of AZT in Body

...ional model that allows scientists to simulate the biochemical reactions that take place when AZT is metabolized in cells, including their mitochondria, under different metabolic conditions. Drugs like AZT may interfere with DNA replication in the mitochondria, the energy factories of our cells, and can lead to ...

Protein's Role in Triggering Cancer Identified

...otein called p53. In some of the body's cells, the biochemical ratio between MDM2 and p53 can become unbalanced c... interested in understanding how this happens at a biochemical level.' 'In the current study, funded by Cancer Research UK, we have identified protein fragments ...

A New Approach towards Anti-Cancer Drugs

...e. //MDM2 is a protein which destroys p53 due to a biochemical imbalance inside the cell. p53 is the guardian protein and is the tumor suppressor protein. Hence the lead researcher Dr. Kathryn Ball said that anti cancer drugs should be targeted against the MDM2 protein. The study has also pointed out a number...

eGFR Diagnostic Test -A reliable and understandable measure of kidney impairment

...Department of Health has advised that all clinical biochemical laboratories should incorporate this test as part of the routine tests for blood urea and creatinine. Interpreting the eGFR test is pretty easy, as any figure over 100 signifies normal functioning of the kidneys. An eGFR between 90 and 60 is also o...

Gene Responsible For Mammary Gland Function, When Mutated Results in Leukemias

... is one of two such cellular signaling cascades of biochemical reactions that enable SRF to activate specific genes, according to Morris. The other pathway uses a group of three proteins collectively called TCF. These proteins help SRF bind to SRE DNA sequences and activate the expression of other genes. 'The MK...

Scientist Recognized for Drug Addiction Research

...nd the MERIT Award in 1996 for his research on the biochemical mechanisms of the action of cocaine. Carroll also earned the Distinguished Lecturer Award from the North Carolina Section of the American Chemical Society in 1993, the Southern Chemist Award in 2000, the Herty Award and the RTI Margaret E. Knox Excel...

Atherosclerosis and its Mechanics

...irst to link mechanical forces with structural and biochemical changes in blood vessel cells that could explain w...d vessels, but we've not been able to identify the biochemical events that trigger formation of the lesions," said Shu Chien, director of the Whitaker Institute of...

Researchers Beginning to Identify Genetic Culprits of Arthritis

...his study, Cook uses specific MRI, arthroscopy and biochemical techniques to identity problems associated with arthritis, such as bone and cartilage damage. Then he identifies the genetic changes that correlate with the damage. "The specific injury that we are studying leads to articular cartilage degradation,...

Researchers Find Molecular "Brake" to Cell Death

...ATP. However, through a series of biological and biochemical experiments, Tang and his research team found that adding ATP to a cancer cell could potentially impede apoptosis. They discovered that these nucleotide pools, in fact, act not to promote apoptosis through production of ATP, but to hinder it. They ar...

Scientist Optimistic In Breakthrough For Causes Of Neurodegenerative Diseases

...gests that many neurodegenerative diseases leave a biochemical calling card, or biomarker, that could be used to predict the earliest stages of brain impairment. Many biomedical researchers believe that detecting disease states before symptoms occur is the key to reversing many as-yet-incurable diseases. The b...

Link between Obesity and Post-Radiotherapy Outcome in Prostate Cancer Patients

...a higher risk for developing failures in clinical, biochemical and radiation therapy – a new study published in a...ree consecutive increases in blood PSA, indicating biochemical failure. Meanwhile, 127 of the men had clinical failure (local recurrence and/or distant metastasis)...

Restriction of Carbohydrates to Prevent Alzheimer's Disease

...mechanistic pathways in the brain and scrutinizing biochemical functions. We hope these findings further unlock t...tly, as mechanistic pathways are defined and their biochemical functions scrutinized, the evidence supporting a direct link between nutrition and AD neuropathology...

Folic Acid Supplements to Prevent Cancer

...in dietary supplements and fortified foods. At the biochemical level, folate is incorporated into coenzymes that are essential in facilitating a variety of reactions in nucleic acid and amino acids metabolism. Some of which are critical to healthy life, such as DNA synthesis, DNA repair, and converting homocyste...

New Role of COX Enzymes Discovered

...aled that the COX enzymes interact physically in a biochemical partnership as well as function in the development of blood vessels. // The study was conducted by researchers at the University of Pennsylvania School of Medicine and Queen's University, Ontario, Canada and reported in the online edition of Nature...

Oxygen-Induced Damage A Leading Cause For Parkinson’s Diseas

...s a first real step in understanding at a detailed biochemical level what the challenge is.’ Bennett said he now plans to model the observation by extracting mitochondrial DNA from the cells of donated PD brains, put the DNA into a cell and express it to see if the phenomenon can be eproduced....

Nanotechnology Could Revolutionize Cardiac Treatment

...ofessor of biomedical engineering and chemical and biochemical engineering at Rutgers, said that vascular plaque and inflammation develop when certain forms of LDL are attacked by white blood cells that scavenge cellular debris and disease agents. ‘While these scavengers, called macrophages, perform an essential...

Mice Aids in Shedding Light on Origin of Autism

...hat gets into at least the right cell or the right biochemical pathway is very important.’ ...

Novel Metal Detector To Measure Zinc Level In Humans

A biochemical metal detector to measure the physiological levels of zinc has been developed by US scientists. This could eventually pave way// for new approach to study human diseases at a cellular level. Zinc, a familiar dietary supplement to millions of health...

Study Would Pave Way for the Development of New Drugs That Targets TB Proteasome

...t the Lab’s National Synchrotron Light Source. The biochemical studies were conducted at Weill Medical College of Cornell University by Gang Lin in a group led by Carl Nathan. Other collaborating institutions included the Max Planck Institute of Biochemistry, Cold Spring Harbor Laboratory, and Millennium Pharmac...

'Winter Blues' Treated by Breakthrough Lighting Technology

... indicates that the absence of sunlight triggers a biochemical reaction that may cause symptoms such as loss of energy, fatigue, lethargy, decreased activity, sadness, excessive eating, carbohydrate cravings and sleepiness. Individuals affected by "winter depression" who go untreated can lose their jobs, destroy...

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