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Tag: "bind" at medical news

Ancient Ancestors Might Have Had a Clue to HIV

...the human version of the TRIM5-alpha protein could bind to the virus, labeling it for the cell to destroy. Tinkering with the protein, the scientists found that a single mutation made it better at recognizing HIV but worse at attaching to the ancient virus. This antiviral protein appears to be able ...

Researchers Link Bacteria Destroying Proteins to Alzheimer's Treatment

...e, the scientists showed that the antibodies first bind to the surface of the cells and connect to a protein called amyloid precursor protein (APP), which is already present on the cell surface. Then both proteins are internalized inside the cell. Once inside the cell, APP is broken down into pieces, so...

Ex-IITian-designed Alzheimer's Drug's Human Clinical Trials Begin

...osh had built an inhibitor that had the ability to bind to and inactivate the beta-secretase enzyme, which is significant to the progression of Alzheimer's. Since then he has been leading the structure-based design of these inhibitors for therapeutic intervention of the disease. His most recent work, wh...

Scientists Trace New Pathway That may Stem Antibiotic Resistance

...producing drugs that will efficiently enter cells, bind to the RNA polymerase, and destroy bacteria without inhibiting the growth of human cells. Irina Artsimovitch of Ohio State University and Robert Laudick of the University of Wisconsin collaborated with Vassylyev for carrying out the study, funded by...

Anticoagulants is Better for Atrial Fibrillation

...s aspirin that make blood platelets less likely to bind together and trigger a clot. In standard medical practice, anticoagulants are often given to people with AF who are at high risk of strokes, while anti-platelet treatments are offered to people at lower risk. A team of Cochrane Researchers set out ...

Protein Structure of Pathogens Associated With CF and TB Solved

...st. To do this, they make complex molecules that bind tightly to the iron. We have determined the structure of a protein that is essential to produce normal amounts of one of these complex molecules in Pseudomonas. What is interesting is that other bacteria use a very similar protein and we assume the p...

WBC Selective About Sugar

...ure. She identified several proteins in serum that bind to beta-1,6-glucan, but not beta-1,3-glucan, and then pinpointed a molecule on the surface of the neutrophil that recognizes these proteins. To link her experiments back to real fungi, Rubin-Bejerano worked with the pathogen Candida albicans, which...

Insights into Acute Promyelocytic Leukemia

...lay a role in the ability of the fusion protein to bind to DNA and regulate gene expression. Dr. Chi Wai Eric So from The Institute of Cancer Research in London and Dr. Shuo Dong from Baylor College of Medicine in Houston and their colleagues characterized the transformation mechanisms involved in APL b...

Genzyme Announces First Phase III Study of Tolevamer in Diarrhea Patients

...ard antibiotic therapy. Tolevamer is designed to bind and neutralize the toxins released by C. difficile that damage the intestine. A non-antibiotic approach has the potential to treat CDAD and reduce the number of disease recurrences, resulting in improved quality of life for the patient and significan...

Prions Capacity can Be Aggrevated by Solid Particles

...otein agents of a family of fatal brain disorders, bind tightly to a common soil mineral and significantly...sin researchers looked at the ability of prions to bind to different types of common soil materials. One, known as montmorillonite, is a type of clay and pr...

Scientists Identify Antibodies That Block Human and Animal SARS Viruses

...e researchers identified two human antibodies that bind to a region on the SARS virus' spike glycoprotein that is called the receptor binding domain (RBD). One of the antibodies, called S230.15, was found in the blood of a patient who had been infected with SARS and later recovered, while the second antib...

A new century of Alzheimer's disease research

... off the microtubules they had once supported, and bind together into paired and twisted filaments. “The hypothesis is that AB stresses neurons, releasing cascades of signals that affect the phosphorylated state of tau bound to microtubules, causing them to be released,” says Dr. Hutton. This process prov...

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