bind 1 8

Tag: "bind" at medical news

Penn Scientists Engineer Small Molecules to Probe Proteins Deep Inside Cell Membrane

...f Medicine have designed peptides that are able to bind to specific regions of transmembrane proteins, usi... to design small proteins called peptides that can bind to only one of a number of closely related membrane proteins." The researchers targeted two transm...

Anticancer Effects of Curcumin Revealed

...bit the synthesis of MDM2, an oncoprotein known to bind p53 and modulate p21 expression. In the issue of Cancer Research, Li and colleagues from the Comprehensive Cancer Center of the University of Alabama report on a study designed to elucidate the molecular anticancer effect of curcumin in a preclinic...

Scientists Identify Genes Activated During Learning and Memory

...st 20,000 genes to find those that CREB and zif268 bind to. This work, conducted by Carnegie Mellon underg... program found hundreds of instances of genes that bind with either CREB or zif268 — and sometimes both — in human and mouse genomes. A huge proportion of t...

Scientists Identify Critical Gene Factor in Heart Development

...lthough only 20-22 nucleotides long, the microRNAs bind to the much longer messenger RNAs and prevent their blueprint for building a protein from being used. They typically prevent many messenger RNAs from making proteins and therefore can affect myriad events. The Gladstone team looked at one particul...

New Mechanism Identified for Resistance to Targeted Lung Cancer Drugs

...lled irreversible EGFR inhibitors that permanently bind to the protein are currently being tested in clinical trials. But what leads to other cases of resistance has been unknown, and the current study was designed to discover additional mechanisms. To do so, the investigators modeled in a laboratory se...

Lead Removing Drug Improves Muscle Function in Lead-Exposed Children

...,” in which a drug is administered to seek out and bind to poisonous heavy metals, such as lead or mercury, in the bloodstream. The compound resulting from this binding is then excreted in the urine, essentially cleaning out the dangerous metals. Succimer (Chermet) is an oral chelating drug approved by ...

New Agent to Fight Genetic Disorders Found

..., Sweden, describe how they developed Zorro-LNA to bind with both strands of a gene’s DNA simultaneously, effectively disabling that gene. This development has clinical implications for virtually every human condition caused by or worsened by dominant defective genes. Examples include: Huntington’s dis...

Cytokine Resistance Contributes to Pathology of Type 2 Diabetes

...sed on a number of cytokines, protein signals that bind to specific receptors on cells and set off a cascade of biochemical reactions within the cell. Interleukins, interferons, tumour necrosis factors, and some growth factors are among the cytokines that direct many aspects of the immune response say t...

Give Up Sugar to Keep Yourself Young

...ds to glycation process that makes sugar molecules bind to your protein fibres, which are flexible collage...g food this way creates AGEs which, once consumed, bind to the collagen and elastin fibres. AGEs form when any food thats made up of sugar, protein and/or f...

New Insights into Antimalarial Drug Resistance

...quine enter the parasite, and how efficiently they bind to pre crystalline heme. If these drugs cant enter blood cells as efficiently, and if the efficiency of heme binding is pushed in the wrong direction, they cant prevent heme from crystallizing. We know these mutant proteins are controlling pH ac...

Study Finds Lymphoma Drug Effective Over Long Term

...s like a guided missile through the bloodstream to bind to a protein found on the surface of the cancerous cells. The radiation zaps these malignant cells with minimal exposure to normal tissues. With the Bexxar therapeutic regimen, a patient receives an injected test dose of radioactive Bexxar, followe...

Global Heartbeat Control Suggests Therapy for Beating Heart Failure

...s to identify the gene promoters to which ERR and bind in the adult mouse heart and to investigate changes in gene and protein expression when levels of ERR are manipulated. That investigation provided evidence that ERR and control most aspects of the integrated processes that fuel the heart by regulati...

Scientists Identify New Breast Cancer Gene

...at cancer-causing mutations in the protein fail to bind to the Rap80 protein, disabling BRCA1 to identify DNA damage sites in the genome. As a result of this, cancer-causing mutations accumulate, spawning the development of breast and ovarian malignancies. "With this current discovery, we have made sign...

Scientists Create Synthetic Proteins

...ube derived protein was not only stable, but could bind its target molecule ATP twice as tight as naturally evolved ones. The researchers say that they now have a technology potential with which they can improve the stability and function of any of the natures proteins. "We have the distinct advanta...

Ways to Stop Organ Damage When Blood Flow Is Cut Off

...et in, like after a heart attack. The antibodies bind and identify the damaged tissue for removal by the...g to isolate B cells that make the antibodies that bind and identify the damaged tissue. When too many antibodies are bound, proteins in the blood called co...

Now Fingerprints can Be Used to Detect Drugs and Diseases Instead of Blood Samples

... cotinine-specific antibodies were attached. These bind to the cotinine. Subsequently, a second antibody, which was tagged with a fluorescent dye and binds specifically to cotinine antibodies, was applied to the fingerprint. Because there are many cotinine antibodies attached to each nanosphere, there is ...

Now a Green Agenda for Mental Health

... (SSRIs) block the ability of the nerve endings to bind and break down serotonin so that more serotonin is available to help the brain process nerves messages more efficiently and correctly. But unlike drugs, ecotherapy is low-cost, has no negative side effects and is available on most people's doorste...

Targeting Sugar on Blood Vessels may Inhibit Cancer Growth

...olecules critical to tumor endothelial growth also bind to heparan sulfate," Fuster said. "Altering this binding would allow for suppression of a broader array of the tumor fuels for angiogenesis, without a major effect on normal vascular function." The researchers hope to develop novel therapies by inh...

Vaginal Lubricants can Reduce Cervical Cancer Risk

...ital tract lining were HPV resistant and would not bind to the virus. "The crucial step for infection seems to be the virus binding to the basement membrane that underlies these cells," Schiller said....

Male Pheromones Build Brain Cells in Female Mice

...he adds. The researchers believe the pheromones bind to specialized receptor proteins, which then signal to another brain region called the hypothalamus, triggering the release of hormones that cause the birth of new neurons. "This mechanism is likely to be just one piece of the puzzle," says Barry K...

1 2 3 4 5 6 7 8 9