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Tag: "bind" at medical news

Understanding Autoimmune Disease

...ene regulator called Foxp3. Master gene regulators bind to specific genes and control their level of activity, which in turn affects the behavior of cells. In fact, when Foxp3 stops functioning, the body can no longer produce working regulatory T cells. When this happens, the frontline T cells damage mult...

A Protein in Brain Cells Controls Obesity: Research

... beneath the cell membrane and the nucleus, it can bind to many different molecules and facilitate signaling. Specifically, it can bind to a variety of molecules called tyrosine kinases, including ones that serve as receptors for insuli...

A Novel Technique Nudges Genes Into Activity

...erence, rely on using RNA strands to intercept and bind with messenger RNA. While RNA interference is an effective tool for studying gene expression, Dr. Janowski said, it’s more efficient to use RNA to control both activation and de-activation at the level of the chromosome. "It goes right to the sour...

Potentially Pathogenic Virus Found in Mad Cow Cells

...ticles. They also found that the particles did not bind antibodies for the prion protein, indicating they were not composed of prion protein. The development of the particles was independent of pathological changes or neuronal specialization, and preparations with an abundance of these particles correlate...

Environmental Toxicants Target Stem Cells

...mical reactions – normally set off when substances bind to receptors on the cell's surface. Noble and his colleagues found that these compounds turned off specific sets of receptors and set into motion a molecular chain reaction that causes the cells to shut down and stop dividing. "These toxicants are ...

Man-Made Proteins Could Be More Useful Than Real Ones

...ll. Schepartz and colleagues now want to try to bind metal ions to the Zwit1-F structure. Metal ion binding would enable the researchers to begin designing enzymes based on the a-peptide, she explained. “We're also interested in generating versions that can assemble in membranes, as a first step toward...

Sea Creature's Toxin Could Lead to Promising Cancer Treatment

...zonamide A blocked cell division, it seemed not to bind directly to tubulin. Instead, Dr. Xiaodong Wang, professor of biochemistry, and Dr. Gelin Wang, instructor of biochemistry, found that the toxin interacted with an enzyme called OAT, which was known to be involved in cellular metabolism but had no pr...

UC Davis Creates New Nanoparticles

...Kennedy said. Antibodies, which can be tailored to bind to specific molecules, can be attached to the nanoparticles to find certain chemicals or objects. Checking food supplies for bioterrorism agents, the environment for toxins and human DNA for mutations are among the uses of the new nanoparticle, he ...

New Drug Promises Prolonged Survival in Prostate Cancer Patients

... Pertuzumab is a single-agent antibody designed to bind to the HER2 receptor and inhibit the ability of HER2 to pair with other HER family members (HER1, HER2, HER3 and HER4). If the pairing process (called dimerization) is not interrupted, the binding of these growth factors activates an intracellular si...

Primitive Yeast Yields Secrets Of Human Cholesterol And Drug Metabolism

...s team tested the ability of human Dap1 protein to bind to four of the 57 known human P450 enzymes, essentially challenging Dap1 to bind to P450s that perform totally different functions in different cells as a way to see how far-reachin...

New Drugs Shows Promise in Slowing the Progression of Prostate Cancer

... Pertuzumab is a single-agent antibody designed to bind to the HER2 receptor and inhibit the ability of HER2 to pair with other HER family members (HER1, HER2, HER3 and HER4). If the pairing process (called dimerization) is not interrupted, the binding of these growth factors activates an intracellular si...

Research Offers Hope to Control Meningococci

... that produce the human receptor that the bacteria bind to. Marking the bacteria to emit light, the scientists used cameras to monitor their activities in the living mice during the course of the disease. “The bacteria are almost knocked out by the immune defense system, but then they resurge, this time...

Cancer Cells Forming Blood Vessels Send Their Copper to the Edge

... copper, with the proteins and macromolecules that bind them in the cell must have very fluid dynamics themselves. Sorce-Newswise SRM...

Researchers Develop Resin Beads That Capture Mad Cow Disease Agent From Blood

... small resin beads with molecules that are able to bind to harmful prion proteins. The beads serve as an adsorption filter, capturing the bad proteins and allowing other blood components to be effectively cleansed of the prion-disease-causing agents. A paper describing the research was published in the ...

Antibiotic Vancomycin May Trigger Dangerously Low Platelet Count

...d out how the drugs cause this type of antibody to bind to blood cells and cause their destruction. A longer-term goal is to develop ways to identify environmental and genetic factors that predispose individuals to experience this type of drug hypersensitivity reaction,” says Dr. Aster. Source-Nwswise ...

Insights into Osteosarcoma in Cats and Dogs may Improve Palliative Care

...ounter-regulates RANK-L by blocking its ability to bind to RANK. Eventual therapeutic interventions may make use of OPG or other RANK-L inhibitors to slow the process of bone destruction in skeletal tumors in cats and dogs, Barger said. Although not a cure, this could reduce the pain and other complica...

PET Imaging Identifies Aggressive Kidney Cancers That Require Surgery

... at MSKCC. G250 has since been shown to target and bind to clear cell renal carcinoma and to react against an enzyme that is present in 94 percent of these cancers. Studies have also demonstrated that renal carcinoma has the highest recorded tumor uptake for G250 of any solid tumor, making the antibody id...

A New Inexpensive Technology for Multiplexed Detection

...ample, target molecules (DNA, proteins, etc.) will bind to the region of the particles containing the corresponding probe. This interaction can be detected by fluorescence, which is brighter when more of the target is present. To rapidly "read" the particles, the researchers designed a custom "flow cyto...

Inhibiting Blood to Save the Brain

...ressing a mutant form of fibrinogen that failed to bind Mac-1 had fewer inflammatory lesions and less severe MS symptoms. Blocking the interaction between Mac-1 and fibrinogen after the first episode of paralysis using the fibrin peptide prevented subsequent relapses. It also prevented further microglia a...

Tumors Targeted Naturally

...ny alpha-Gal molecules are present for anti-Gal to bind with. Armed with this knowledge, Kiessling's group modified an agent known to bind tightly to integrin and tethered it to alpha-Gal. When they mixed this molecule with cells displayin...

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