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Tag: "bind" at medical news

Genetic Link To High Blood Pressure

...that is essentially an on/off switch for genes) to bind and turn on the kinase gene. "The result is more copies of the gene, more of the kinase in the cell, and, ultimately, more contraction and proliferation of smooth muscle cells," she said. The transcription factor that binds the mutated gene more e...

"Dynamic Energy Landscape" of enzyme in Catalysis

... by aiding the movement of ligands (molecules that bind to one chemical entity to form a larger complex) on and off the enzyme. "These findings contrast with the traditional 'induced fit' hypothesis," Wright said. "One of the tenets of that hypothesis is that the binding of ligands induces a structural ...

Study Suggests Vitamin K Deficiency as an Osteoporosis Risk Factor

...e protein that changes its shape making it easy to bind to calcium) in the presence of sufficient vitamin K. With adequate vitamin K, this protein can bind to calcium in the bone environment---sort of like glue, Lukacs said. The study involved volunteer ...

Using Multiphoton Microscopy to See Chromosomes in Action

...he researchers also discovered that HSF activators bind to hsp70 genes much longer than previously thought before being replaced with new HSFs, which raises new questions about the mechanisms of gene transcription. The technique also may offer a new tool for researchers across the biological sciences. W...

New Path from Estrogen to Survival in Breast Cancer Cells Described

... had no known function.* NEDD8, a protein that can bind to other proteins and alter their function. * SENP8, a protease (enzyme) that can break bonds between other molecules.* SIRT1* NFkB (Nuclear Factor kappa B), a family of proteins that turn on genes involved in cell death (apoptosis) and cell prolifer...

Bacterial Protein Shows Promise in Treating Intestinal Parasites

...atodes and insects. However, since the toxin can’t bind to the cells of mammals or other vertebrates, Cry proteins can’t hurt humans. “Crystal proteins had been used for decades to kill insects by organic farmers who sprayed their crops with Bt,” said Aroian. “Until now, however, no one has used a purif...

New Malaria Treatment

...eins that project from the surface of the cell and bind with receptors on other blood cells and on the vessel wall, and thus act like a glue. The challenge facing scientists has been to break these bonds so that the infected blood cells can be transported by the blood stream into the spleen and destroyed....

Computer Tool Predicts Effectiveness Of Microbicides

...layer, and the microbicide's documented ability to bind to and disable the viral particles. The researchers demonstrated their new tool by applying it to the promising microbicide Cyanovirin-N, a protein with anti-HIV activity that has been well documented by other scientists. "Our results suggest HIV...

Hotel Guests Often Leave Their Cold Behind

... rhinovirus is surrounded by proteins that help it bind to other cells. Without a host cell, the virus cannot replicate, making it even more surprising that it survived overnight to be detected and transferred. “While transmission of rhinovirus through dried nasal mucus on surfaces is not efficient, peo...

New Tool for Understanding Estrogen-Fueled Breast Cancer

...wn of only a handful of the portions of genes that bind to the ER -- the so-called control regions that activate or deactivate the genes," says Dana-Farber's Myles Brown, MD, the senior author of the new study. "With this project we’ve located all of them, and found there are thousands more than were prev...

Researchers Uncover Critical Player in Cell Communication

...it” to fish for candidate proteins that physically bind to TFII-I. The fishing expedition returned one protein known to control when and how much calcium a cell takes in. “The partner we found in the fishing experiment and the abundance of TFII-I outside the cell nucleus led us to suspect that this prot...

Carcinogens found in Grilled chicken

... toxic forms, arylnitrenium ions, which ultimately bind to DNA, leading to HCA-induced DNA adducts. PhIP and other HCAs are more toxic than commonly known carcinogens such as benzo-(a)-pyrene. Studies have already found that among others, intake of PhIP and other HCAs may increase risk of colon, breast a...

Inhibition of Colorectal tumor growth by Grape seed extract

...ased the level of Cip1/p21 protein, allowing it to bind to and shut down the CDKs driving the cell cycle. The investigators also found that the extract can do that even if a cancer cell is missing p53 function (which also helps controls the cell cycle). "That is good news, because most cancers are missing...

Commonplace Sugar Compound Silences Seizures

...generates a lot of NADH, so CTBP is more likely to bind with the sugar byproduct than NRSF. But without CTBP, NRSF most likely derails the normal function of certain neuronal genes - including those connected to epilepsy. Scientists believe that NSRF also controls genes that potentially play a role in c...

Listening to the Sound of Skin Cancer

...could be attached to the cells using proteins that bind to special receptors on the cells' membranes. With their own photoacoustic signature, the gold particles would then signal the presence of cancer cells. Source-Newswise...

Potential New Therapeutic Target for Asthma, Allergies and Cancer

...ed by some cells into the circulation where it can bind to specific S1P receptors. Until now, researchers have not known the mechanism by which S1P is transported out of cells. “Our study shows that mast cells can use a special kind of transporter that has long been known to be used by cancer cells to p...

Cell Wall of Pneumonia Bacteria Can Cause Brain and Heart Damage

...emonstrated that pieces of the bacterial cell wall bind to the vascular endothelium (inner surface of the ...all, resembles PAF and exploits this similarity to bind to PAFr. The researchers demonstrated the role of PAFr by injecting fragments of S. pneumoniae cel...

More Stress, More Cancer

... hormones – epinephrine and norepinephrine – would bind to places on the surface of ovarian cancer cells, called adrenergic receptors, and stimulate the release of MMP-2, MMP-9 and VEGF which might then foster cancer growth. The Ohio State team wanted to see if the same occurred with other cancer cell...

Genes determine the capacity to fight HIV in early stages

...they focused on 173 HIV protein fragments known to bind to those HLA types to see if particular peptides were more powerful in activating the HIV-specific CD8 response. The researchers found that, for many varieties of HLA, only a few HIV protein fragments were responsible for the activation of CD8 T cel...

Memories Linked To Their Packaging In The Brain

...curred. When this brain region wasn't activated to bind together the details, only some aspects of an event were recalled. The findings appear in the current issue of Neuron. 'This study provides a neurological basis for what psychologists have been telling us for years,' said Michael Rugg, director of U...

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