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Tag: "apolipoprotein" at medical news

New heart disease marker

...eyed extensive medical literature to conclude that apolipoprotein B levels are a more accurate indicator of who is m...se than cholesterol levels. They also say that the apolipoprotein B to apolipoprotein A-1 level is important. This is all especially true for patients on statin thera...

Could Midlife Alcohol Drinking Lead To Dementia ?

...gene known to increase the risk of dementia -- the apolipoprotein e4 allele -- appeared more likely to actually develop serious mental problems with increased drinking. Researchers say since this is the first population-based study that prospectively evaluated the effects of midlife alcohol drinking on the develop...

Strong possibility of delaying the progress of Alzheimer’s exist

...iagnosed with mild cognitive impairment (MCI) with apolipoprotein E-4 (APOE-?4) were benefited from delayed onset of Alzheimer’s. apolipoprotein E-4 is the only known genetic factor that makes people in the high risk category for Alzheimer’s. T...

Testing genes for disease does not cause harm to children of people with Alzheimers

... for the biomarker ApoE4, which is the part of the apolipoprotein E (APOE) gene of adult children of patients with Alzheimers. ApoE4 is linked with incidence of Alzheimer's disease. The data was a comparison between two sets of participants, one who were told that they are either positive or negative in the test, a...

The Link Between Oxidized Phospholipids And Coronary Artery Disease

...re bound to it. Lp(a) lipoprotein is composed of apolipoprotein (apo) B-100, to which apo(a) is covalently bound. Believing that oxidized phospholipids on lipoproteins containing apo B-100 may explain some of the atherogenic properties of Lp(a) lipoprotein, Sotirios Tsimikas (University of California, San Diego...

Blood Test May help Heart Prediction

...e protein part of HDL, the good cholesterol, while apolipoprotein B, or apoB is the protein in LDL, the bad choleste...e done on whether treatments aimed at changing the apolipoprotein levels will work better at preventing the progression of heart disease than our current drugs....

Gene Activity connected to Schizophrenia

...enia had nearly three times the gene expression of apolipoprotein L1, a protein that is manufactured by a family of genes called the apo L family. These genes play an important role in cholesterol transport. Cholesterol is important in the adult brain as well as during its early development. The findings led the r...

Cholesterol provides immunity against infection by certain parasites

...exposed to it. To identify the proteins known as apolipoprotein L-1 (apo L-1) and haptoglobin-related protein (Hpr), the researchers tested different permutations of the proteins on Trypanosoma brucei brucei specimens, which is dependent on HDL cholesterol for its survival. HDL proteins would be the ideal antimic...

Protein Fragments Blocking Cures Alzheimer's Disease

...f Neurological Disease have found that the protein apolipoprotein E (apoE) is responsible for causing Alzheimer's disease //that acts by inactivating the conversion of glucose into energy in Mitochondirial cells due to the protein fragments released from apoE. The apoE protein is found to be responsible for causi...

Scientists Closer To Identifying Gene Connected To Alzheimer's

...problems. An example is APOE4, a common SNP in the apolipoprotein E gene that increases the risk for Alzheimer's disease. "The region of DNA implicated in our study contains six genes. We don't know which of those genes is most likely to harbor this particular risk factor for Alzheimer's disease, but we're getti...

Three dimensional structure of apolipoprotein revealed

...st time created the three dimensional structure of apolipoprotein E using X-ray crystallography. X-ray crystallograp...hanism of action and ways to inhibit the action of apolipoprotein E which is found to be associated with cardiovascular and Alzheimer’s disease. Apolipoprotein E4 (...

Link between Epsilon4 allele heterozygotes and Alzheimer’s diseas

...al VA Hospital have reported that individuals with apolipoprotein E epsilon4 allele has been linked // to a reduced ... researchers studied the inherited linkage between apolipoprotein E epsilon4 alleles heterozygote by detecting the brain activity by functional magnetic resonance ima...

Alzheimer's-linked apolipoprotein E produced by neurons, Gladstone study

...alized mouse model that the controversial protein, apolipoprotein E, is indeed produced by neurons.// The results of this study have for the first time established a definitive association between the two. Also known as apoE, this cholesterol-carrying protein has three common forms, one of which, apoE4, is the ma...

MRIs Show Drug Treatment Slows Brain Deterioration on Road to Alzheimer's Disease

...c resonance imaging (MRI). Among carriers of the apolipoprotein E4 (APOE 4) allele, serial brain imaging studies of patients treated with donepezil showed less shrinkage of the hippocampus, a structure located at the base of the brain that is key for memory function, than for study patients who received placebo (...

The interplay of genes, diet and heart disease

...s University. The study involved examination of apolipoprotein A5 (APOA5) gene. This gene codes for a protein that has a vital role in fat metabolism in the blood. A specific variant of APOA5 may cause increase in risk for heart disease, which can be altered by consumption of high amounts of omega-6 fatty acids....

Carriers With Alzheimer's High Risk Gene Type Age Normally Until the Disease Strikes

...to transport cholesterol through the production of apolipoprotein E. People carry two copies of APOE, each being one of four APOE alleles. APOE4 raises Alzheimer's risk. In this study, researchers at the University of Melbourne and Australian National University assessed whether the small percentage (varying by eth...

New Therapy to Treat Patients With Severely Elevated Cholesterol Levels

...erol levels by 58%, triglyceride levels by 65% and apolipoprotein B levels by 56% from baseline. In contrast to statin drugs, which have relatively little effect on cholesterol levels in homozygous FH patients, the MTP inhibitor was shown to reduce the liver’s ability to produce LDL. The most notable adverse events...

Study Finds Dietary Fat Interacts With Genes

...population with a specific gene variant within the apolipoprotein A5 gene (APOA5), higher dietary fat was not relate...n as single nucleotide polymorphisms (SNPs) of the apolipoprotein A5 gene (APOA5), which produces a protein (APOA5) involved in the metabolism of fats in the body. Fo...

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