Tag: "antimalarial" at medical news
Malarial gene ascertained
...lasmodium falciparum, to develop imperviousness to antimalarial
drugs.Plasmodium,is a single-celled organism which...rasitic cell to thrive in higher concentrations of antimalarial
drugs by stopping the drugs from accruing within the cell. The mutation helps confer resistance to ...
Old is gold– proved yet another tim
Chloroquine, an antimalarial
drug was highly successful in combating the disease when launched in the 1950s.// It soon became useless because of resistance being developed by the malarial parasite. Scientists have found a way to breathe new life into the drug. It has been found...
Infants Malarial Risk Lowered by Preventive Measures
...evention that relied on frequent administration of antimalarial
drugs were unaffordable in the long run and might ...in explored the intermittent administration of the antimalarial
sulfadoxine-pyrimethamine (SP) to infants in their first year. Infants given SP at 3, 4, and 9 month...
Antihistamine Could also be used as a Potential Antimalarial Drug
...till needs to be evaluated for effectiveness as an antimalarial
in humans.” For the study, Sullivan and colleagues Curtis Chong and Jun Liu of the Johns Hopkins School of Medicine’s Department of Pharmacology first assembled the Johns Hopkins Clinical Compound Library, which is a collection of 2,687 drugs. Seve...
Malaria Truths Discovered By Einstein Researchers
...squito to humans and how it develops resistance to antimalarial
drugs.” The research effort was conducted primarily by Louis Nkrumah, an MD/PhD student at Einstein. Central to this effort was a bacterial phage (virus) that Dr. Jacobs isolated from soil in his backyard in the Bronx and dubbed the “Bronx Bomber.” ...
Risk of Malaria treatment failure in some HIV-positive patients
...patients could lead to the emergence and spread of antimalarial
drug resistance. "This is a major concern, as antimalarial
drug resistance is now generally acknowledged to be one of the greatest threats to our ability to ro...
Malaria: The Invincible Might of a Parasite, Nestled in a 'Mite'
...tated to complex forms, developing a resistance to antimalarial
drugs, especially chloroquine. Therefore elaborate, expensive and evolved treatment is required in such cases to kill the parasite. It is estimated that nearly 300 million people worldwide are affected by malaria and between 1 and 1.5 million deat...
Safer Method for Large-Scale Malaria Screening Developed
...at using blood samples. “Programs for monitoring antimalarial
drug and vaccine efficacy could therefore adopt such a bloodless method, while maintaining high sensitivity for clinically significant infections,” said Sungano Mharakurwa, PhD, lead author of the study and a researcher with the Malaria Research Inst...
New Compound for Anti-Malarial Prophylaxis
...malaria parasite. This unique specificity in an antimalarial
drug makes the development of drug resistance much less likely, and suggests that this compound is a promising new candidate for anti-malarial prophylaxis. Source-Eurekalert SRI...
Scientists Boost Production of Cheap Malaria Drugs
...communities who cannot access or afford to pay for antimalarial
products developed by the pharmaceutical industry. A separate study explored new technologies to make extracting artemisinin cheaper and more environmentally friendly.The current process uses the solvent hexane, which is both highly toxic and expl...
Researchers Discover Breakthrough in Malaria Treatment
... herbal extract (artemisinin) with a longer acting antimalarial
drug. The researchers found that both treatments provided initial cure from disease. However those receiving a treatment which stayed in the blood stream for longer were three times less likely to have another episode of malaria within 42 days and ...
Single Drug Dose Cures Malaria in Mice
...uable in several ways, from their brisk and potent antimalarial
activity to their lack of resistance and cross-resistance with other antimalarial
agents," Shapiro said. The Johns Hopkins trioxanes mimic artemisinin, the active agent in a Chine...
Diagnostic Tests for Malaria Underused in Zambia
...lities with artemether-lumefantrine in stock, this antimalarial
was prescribed to a large proportion of patients with fever with a positive diagnostic test result, but also to some with a negative diagnostic test result (blood smear, 30.4 percent; RDT, 26.7 percent). "RDTs have been proposed as a cost-effective...
Antifolate Drugs may Be Effective in Treating P Vivax Malaria
...stant to treatment with antifolates, an affordable antimalarial
class. The study included 767 patients (315 from Pakistan and 452 from Afghanistan) with P vivax malaria. The researchers found that although chloroquine remains the drug of choice, all three therapies effectively cleared parasites by day 14 and w...
Antibody-based Therapies Effective at Controlling Malaria
...of suitable animal models, according to this study antimalarial
efficacy of human antibodies can be determined using rodent malaria parasites transgenic for P. falciparum antigens in mice and humans. An in vivo mouse model has significant advantage over the use of new world primates, the only other model for huma...
Effective Treatment for Malaria Control
...mine is currently the only single-dose long-acting antimalarial
drug that has ideal properties (low cost, document...pulation, mostly with artemisinin-based [a type of antimalarial
drug] combinations. Reserving the use of sulfadoxine-pyrimethamine for IPT during pregnancy and fo...