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Tag: "systemic" at medical news

Therapeutic Cancer Vaccine Trials

...they are less capable of measuring the more subtle systemic effects of immune response, Schlom said. While there is no conclusive evidence to explain why a vaccine may lead to better patient sur-vival, Schlom believes the evidence suggests that vaccines are, in fact, priming the immune sys-tem. Vaccines are...

BioCryst Receives Special Protocol Assessment for Fodosine

...rent during or after treatment with at least three systemic therapies. The study's primary endpoint is to determine the objective response rate, defined as either complete response or partial cutaneous response, achieved with a once-daily oral regimen of Fodosine(TM). Secondary endpoints include assessing the...

C -reactive Protein is the Marker for Cardiovascular Disease

...because the condition is now viewed as a low-grade systemic inflammatory disorder, and is associated with incr...r, the current findings reinforce the concept that systemic inflammation is a constitutive component and consequence of OSA and that the presence of increased s...

Steroids may Reduce Recurrence of Asthma

...Our systematic review strongly supports the use of systemic corticosteroids for treatment of outpatients who leave hospital after an asthma attack, says colleague Carol Spooner. The review, however, was not able to identify enough data to show whether there was any difference between oral or intramuscular ro...

Steroids may Reduce Chances of Asthma Relapse

...Our systematic review strongly supports the use of systemic corticosteroids for treatment of outpatients who leave hospital after an asthma attack, Spooner said....

Replidyne Announces Positive Phase I Results for Topical Antibiotic REP8839

...pears safe, well-tolerated and associated with low systemic exposure, or drug absorption into the bloodstream,...tion to safety, tolerability and dermal irritancy, systemic exposure was examined following repeated daily application of REP8839 on a larger surface area of in...

Reduced Lung Capacity Linked to Cardiovascular Disease by Inflammation

...ignificant atherosclerosis. Establishing whether systemic inflammation leads to reduced lung function or whether lower lung function leads to inflammation is difficult, but this research suggests that the association between poor lung function and cardiovascular disease may be mediated by an inflammatory me...

Novel Investigational Drug May Help American Women Suffering from Breast Pain

...wever, this medication typically produces unwanted systemic side effects, which often causes women to stop their necessary treatment. In many cases, women are sent home and told to ice their breasts or purchase a tighter fitting brassiere leaving them feeling hopeless....

Infertility is Seen in Men With SLE

The prognosis for systemic lupus erythematosus (SLE), an autoimmune disease that mainly affects women in their reproductive years , has improved recently, prompting a shift toward improving quality of life. For men with SLE, concerns have been raised about their future ferti...

Pain and Intensity Of Post-stroke Spasticity Decreased by Botox Treatment

...al anti-spasticity medications are associated with systemic side effects such as sedation, mental confusion, dizziness and muscle weakness, all of which can seriously hinder rehabilitation after a stroke....

WHO's Guidelines Lack Evidence, Lancet Says

... journals editor. This study shows that there is a systemic problem within the organization, that it refuses to put science first. WHO Director-General Dr. Margaret Chan, who took over the position this year, will be under pressure to respond to the studys criticism. We need a strong WHO, which in recent ...

Impact of Periodontal Health High With Smoking and Sleeping

... as the body of evidence linking oral disease with systemic diseases continues to grow because ultimately these lifestyle factors might impact a patient's overall health," he added....

A Non-profit Drug Firms Injection to Fight Kala Azar Included in WHOs Model List

...deadly parasitic disease after malaria. It is a systemic infection caused by various species of Leishmania parasites. The infection is transmitted by sandflies and causes chronic fever, weight loss, anemia and spleen and liver and anemia. With approximately 500,000 new cases occurring annually worldwide, v...

High Pretreatment PSA Velocity Predicts Worse Outcome

...h aggressive prostate cancer and in whom effective systemic treatment in addition to mono-therapy with RP or RT is needed to decrease PCSM rates."...

New Insights into Chronic Inflammation and Atherosclerosis

...e remain unclear. Does atherosclerosis result from systemic inflammation, a hallmark of these rheumatic diseases, or from local inflammation of vessels? To shed light on the link between chronic inflammation and atherosclerosis, a team of researchers in Norway and the United States, affiliated with the Clev...

Scientists Identify the Most Significant Single Predictor of Aggressive Prostate Cancer

...h aggressive prostate cancer and in whom effective systemic treatment in addition to mono-therapy with RP or RT is needed to decrease PCSM rates," conclude the authors....

Aerobic Exercise Helps Maintain Muscle in Elderly: Research

...tion in which either a complete lack of insulin or systemic resistance to the hormone's activity (as in type 2 diabetes) causes blood sugar levels to soar out of control. Recent studies have shown, however, that insulin also provides crucial assistance in building muscle, and that its ability to do so drops o...

Nexavar Significantly Extends Survival of Liver Cancer Patients

...aluated 602 liver cancer patients who had no prior systemic therapy at sites in the Americas, Europe, and Australia/New Zealand. The primary objective of the study was to compare overall survival in patients administered Nexavar versus those administered placebo. Median overall survival was 10.7 months in N...

Recurrent Gliomas: Vorinostat Shows Anti-cancer Activity

...l lymphoma in patients who have failed two or more systemic therapies. An additional group of patients in this study was treated with vorinostat prior to surgery, and a gene and protein analysis of their resected tumors was performed. This analysis confirmed increase in histone acetylation and showed gene c...

Pazopanib Shows Positive in Advanced Renal Carcinoma, Ovarian Cancer and Soft Tissue Sarcoma

...nced or metastatic RCC who have not received prior systemic therapy or have failed one prior therapy (cytokine or bevacizumab-containing regimen). All patients received 800 mg of pazopanib taken orally, once-daily during a 12 week lead-in period. Based on data available on 60 patients at the time of a planned...

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