Lean Protein Could Be Key to Obesity Drugs
A protein that lets mice eat more but weigh less could prove the magic ingr...echam and the University of Cambridge have created mice with a human protein known as Uncoupling Protein 3 (UCP3) that increases their metabolism.In what is......uses cause no disease in their host or, so far, in mice or men. But cause for concern comes from their clo...f pig-organ transplantation. Indeed, PERV-infected mice remain as healthy as immunosuppressed animals can be. Needles to say that the jury is still out on u...Vaccine for Alzheimer’s diseas
...zheimer’s disease have shown that it seems to stop mice with the condition losing their memory. The result...ts and killing the nerve cells. When Alzheimer’s mice are vaccinated with beta-amyloid peptide they develop antibodies against the protein, which sweep th...Experimental treatment for Ebola Virus Shows promising results in mice
...h Gupta took antibodies from the immune systems of mice that had survived infection with the deadly Ebola ...cted them into other Ebola-free mice. Later, these mice were then infected with Ebola virus. Nearly all the mice were protected against infection from the ......mans and grown in the laboratory. In their study, mice that had human glioma cells transplanted to them, ...nety days after being treated, the majority of the mice treated with live reovirus were still alive, but all of the animals injected with the dead virus had......environmental organisms is supported by studies of mice specially bred to be germ-free, said Dr. Fergus Shanahan, of the National University of Ireland, Cork. Their gut movements are slower and the blood supply to that area differs from that seen in normal mice. A recent study of 50 people who had underg......sles vaccine virus caused remission of lymphoma in mice injected with human cells containing the cancer.//...ssion of the human B- cell lymphoma in labaoratory mice with the cancer. Intravenous administration of the same resulted in considerable slowing of tumor pr...In an experiment once thought impossible, lab mice with full blown versions of of Type 1 Diabetes are...at the Massachusetts General Hospital have rid the mice of the immune cells that attack the pancreas and the islets in the first place.// Once the m......actor (NGF) which underlies this neuronal loss. In mice with experimental forms of these diseases, transport of NGF to these areas was impaired as the mice aged. What's more, infusing NGF into areas close to the vulnerable cells reversed the damage. A ge......med the mushroom's toxicity by feeding extracts to mice and measuring creatine kinase, an enzyme produced during muscle breakdown, in the blood.// The study "raises as many questions as answers, at least in my mind," said Dr. Denis Benjamin, chair of the North American Mycological Association's toxicolo...Drugs disrupt formation of blood vessels
...e drugs have beneficial effects when used to treat mice developing organ-specific cancer ". The work on mice is significant because scientists believe it closely mirrors the conditions found in human tumours. ...Gene therapy - Aim to improve blood flow
...alifornia in San Francisco, found a way to produce mice whose skin cells had high levels of activity of a gene called HIF-1. Researchers have managed to produce a genetically-altered mouse which has grown large numbers of new blood capillaries in its skin. This gene is known to send commands to several ......traviolet (UV) rays. The results showed that young mice went on to develop melanoma - the most serious form of skin cancer - in adulthood. A single dose of UV radiation was enough to induce melanoma in the young mice. In adults, 30 times more UV was needed to achieve the same effect. Glenn Merlino, chie...Omega-3 fatty acids impair immunity
...ting infection. // The Missouri team studied how mice responded to bacterial infection when given diets containing either fish oil or no fish oil. Those on fish oil were slower to respond to the infection and more likely to die. This doesn't mean you should throw away your supplements, but be aware that......mice, the researchers discovered that the sperm of mice without the CatSper gene were unable to penetrate the outer covering of the egg, called the zona pellucida. But when the researchers mixed the sperm with eggs that had the covering removed, they fertilised normally. "It might be that this channel is......mice, the researchers discovered that the sperm of mice without the CatSper gene were unable to penetrate the outer covering of the egg, the zona pellucida. But when the researchers mixed the sperm with eggs that had the covering removed, they fertilised normally. A contraceptive designed to prevent fert...Antioxidants used for longevity
...nzyme called superoxide dismutase (SOD) lacking in mice paves the way towards new treatment for brain dege...xidant enzyme called superoxide dismutase (SOD) in mice normally swipe off the free radicals produced by mitochondria, the 'power house' of the cell. Within...A need for new stem cell lines
...lls and serum" creating the fear that pathogens in mice or cows could be transmitted to humans if the stem cells are used for therapeutic applications. Another problem is that patient's immune system may attack the newly introduced stem cells. One way of sidestepping the problem is through a process know......ges that usually occur with aging were absent from mice that were given 44 per cent fewer calories, the te...prise, cutting calories for only four weeks in old mice mimicked most of the genetic effects of a lifetime of calorific abstinence.Even old people may be ab......ing into account differences in metabolism between mice and humans. The researchers found Ritalin increased the activity of a gene called c-fos in the striatum, a part of the brain involved in movement and motivation. "These data do suggest that there are effects of Ritalin on cell function that outlast ...