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Tag: "inhibitory" at medical news

Gene Therapy for Parkinsons Disease

...on overdrive in the disease process and GABA is an inhibitory transmitter and is important in trying to calm thi...novel strategy included packing genes that make an inhibitory chemical called GABA into pieces of viruses that have been rendered non-infectious. They began study...

Immune Substance in Semen may Help Determine Male Fertility

...ays that the substance called macrophage migration inhibitory factor (MIF) is the key to helping sperm mature, which is necessary for its union with an egg. The findings, published in Molecular Medicine, attain significance as they may lead to a diagnostic test to determine fertility status. During the st...

Immune System Protein Could Be the Key Infertility

... level of a substance called macrophage migration inhibitory factor (MIF) in semen could be the key. The finding, detailed in the latest issue of the journal Molecular Medicine, could lead to fertility tests for males or new types of male contraception, Yousef Al-Abed and his colleagues say. They first is...

Nanomedicine Gives the Way for Nerve Cell Regeneration

...ity for rapid regeneration, and CNS glia create an inhibitory environment for growth after injury. Can these cha...th may provide a possible method for bypassing the inhibitory interface and the tissue beyond a CNS related injury. Using optic nerve and spinal cord tissues as i...

Yoga Helps to Combat Depression, Anxiety

...ma-aminobutyric (GABA) levels, the brain's primary inhibitory neurotransmitter. Using magnetic resonance spectroscopic imaging, the researchers compared the GABA levels of 8 volunteers prior to and after one hour of yoga, with 11 volunteers who did no yoga but instead read for one hour. The researchers foun...

Vegetarian Diet Could Reduce Risk of Colon Cancer

... lean and obese subjects and whether this possible inhibitory effect would be related to changes in gastric functions. For the study, investigators recruited 12 lean and 12 obese healthy subjects and invited each group to the lab for two sessions (eating both fatty soup and protein soup with the same number ...

Drink, Binge and the Genetic Link

...e increases risk to alcoholism. GABA is a common inhibitory neurotransmitter in the mammalian nervous system. Research is underway to find out the underlying mechanism. It has been observed that there is a loss of inhibition in those with the variant genes, and this has lead to some of them externalizing ...

Brain Cells Activity: New Treatment Target for Psychiatric Diseases

...receptor, ErbB4, promote inhibition at the site of inhibitory synapses in the brain by increasing release of GABA, a major inhibitory neurotransmitter. In 2000, a research team led by Dr. Mei showed that neuregulin-1 and ErbB4 also ...

A New Target for Cancer Therapy-Integrin Alpha7 Molecule

...naturally mutated in cells, those cells lost their inhibitory signals for both cell migration and proliferation. This suggests that the loss of integrin alpha7 activity may lead to unchecked tumor cell proliferation and a significantly increased risk of tumor metastasis. More importantly, it suggests that if...

Scientists Spotted Out Tumor Vessel by Molecular Markers

... particularly attractive target because a suitable inhibitory molecule might be able to deliver a double blow: one to the tumor cells themselves and the other to the blood vessels that feed it. 'These studies reveal that tumor vessels contain a unique molecular fingerprint that can be used to distinguish th...

Green Tea Compound may Be a Therapy for Rheumatoid Arthritis

...gradation. The laboratory now is focused on the inhibitory role of EGCG in gene expression. The scientists plan to test EGCG in animal models of rheumatoid arthritis to see if it provides similar therapeutic or preventive effects. Ahmed believes that the outcome of these studies will form a strong foundation...

How Morphine Affects Memory

...ine to impede the brain’s capacity to energize the inhibitory synapse connections. During trials conducted on ra...he study showed that the synapses occurred between inhibitory neurons and dopamine neurons. The inhibitory cells in a healthy brain were able to contain the rel...

Addictive Drugs Harms the Brain

...at Brown said that “What we have found is that the inhibitory synapses can no longer be strengthened 24 hours after treatment with morphine, which suggests that a natural brake has been removed,” “By shutting off the natural ability to strengthen connections that inhibit pleasure, the brain may be learning to c...

Genes That Spread Breast Cancer Fast Identified

...nter said: "We found that the combination of these inhibitory drugs was effective even though the drugs individually were not very effective. "This really nailed the case that if we can inactivate these genes in concert, it will affect metastasis." "These genes are used together to attract blood vessels a...

$1.5 Million Grant to Yale for Narcolepsy-Neurotransmitter Study

...continuing presence of both neurotransmitters, the inhibitory MCH cell response to dynorphin rapidly declined, w...sed nerve cell activity by reducing the release of inhibitory neurotransmitters onto the NPY cells. In this case, the transmitters act synergistically to excite t...

Bladder Pacemaker For Incontinence

...successful by making it more selective, delivering inhibitory pulses only in response to bladder contractions ra... with bladder contraction to deliver a conditional inhibitory stimulus," Grill said. "It's a fully bioelectric and practical way to improve urinary continence." ...

Genes for Nicotine Dependence Identified

...t increase communication between nerve cells — and inhibitory mechanisms — those that slow firing between nerve cells. "An imbalance between excitatory and inhibitory activity in the brain may predispose people to addiction, such as alcoholism, drug dependence or nic...

Anti-Aging Powers of Enzyme Sirtuins

...uins. Any such drug would, in essence, inhibit the inhibitory effect of nicotinamide. As in mathematics, the two negatives would create a positive result – activation of sirtuins. "Our findings suggest a new avenue for designing sirtuin-activating drugs," says Marmorstein. "The jury is still out as to whether...

Suppression of Enzyme Delays a Type of Breast Cancer

... of this disease. Clinical trials of a drug with inhibitory reaction to this protein are underway. There is already a research finding which claims that diabetes 2 and obesity can be treated by this enzyme suppression. In addition to this, PTP1B inhibitors have been developed by drug companies too. Testing ...

New Treatment Offers Hope for Systemic Sclerosis

...imulated with TGF? and PDGF and incubated with the inhibitory molecule, imatinib mesylate. Then, applying real-t...e. These results were achieved by induction of the inhibitory molecule at strengths between 50 and 150 mg/kg. "The present study provides the molecular backgrou...

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