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Xeroderma in Medical News

How defects in 1 gene cause 3 distinct and devastating human diseases

... at neighboring sitescan spell the difference between cancer-prone xeroderma pigmentosa, the aging disorder known as Cockayne syndrome and another ... site or the site of DNA damage. Defects in XPD are known to underlie xeroderma pigmentosa (XP), Cockayne syndrome (CS) and trichothiodystrophy (TTD). ...

Enhanced skin cancer risk linked to defects in cellular aging controls

... and pigmentation. Researchers from Spain investigated the molecular mechanisms underlying skin cell telomere dysfunction using a mouse model of xeroderma Pigmentosum (XP), a disease in which patients have increased sensitivity to ultraviolet (UV) radiation. Their studies revealed that these mice have ...

New year brings new hope to children born with cleft lip, palate

... Non-profit organizations that have received grants for first quarter missions include: Children of the Americas, Healing the Children Northeast, xeroderma Pigmentosa Foundation, and Nicaplast. ASPS Member Surgeons participating in these medical missions will do so in coordination with one of the ...

New Year Brings New Hope to Children Born With Cleft Lip, Palate

... Non-profit organizations that have received grants for first quarter missions include: Children of the Americas, Healing the Children Northeast, xeroderma Pigmentosa Foundation, and Nicaplast. ASPS Member Surgeons participating in these medical missions will do so in coordination with one of the ...

Skin Cancer Risk Increases With Ultraviolet-B Radiation Exposure

... is the commonest cause of skin cancer and is responsible for breaking DNA strands in exposed skin cells. Patients who have a condition called xeroderma pigmentosum are unable to repair these broken strands and hence are at increased risk of developing skin cancer. Li-E Wang, M.D., and Qingyi Wei, ....
Xeroderma in Medical Technology

Dimericine(R) Receives FDA Fast Track Designation for Treatment Of Photosensitivity in XP Patients

... for treatment of solar and ultraviolet photosensitivity in patients with xeroderma Pigmentosum (XP). Dimericine, also known as T4N5 Liposome Lotion, is a ... the thousands of people who suffer from the life-threatening disease XP." xeroderma pigmentosum, or XP, is a rare genetic disorder that blocks the body's ...
Xeroderma in Medical Dictionary

Xeroderma Pigmentosum

... xeroderma pigmentosum : A genetic disease characterized ... of skin cancer at a very early age. xeroderma pigmentosum A genetic condition characterized ... make the skin sensitive to the sun, such as xeroderma pigmentosum , albinism , and basal cell nevus ...

Albinism

... body pigmentation at birth , a condition that can occur in all races. albino ... Disease s that make the skin sensitive to the sun, such as xeroderma pigmentosum , albinism , and basal cell nevus syndrome Radiation therapy Medical conditions or drugs that suppress the immune system ...

Enzyme

... diagnose patients. An ELISA test for HIV works by attaching HIV antigen s to a plastic well or beads. Enzyme lotion used in treating xeroderma pigmentosum . T900607 A substance that is being studied as a treatment for cancer . It belongs to the family of drugs called tubulin-binding ...

Neoplasm

... glands . Proposed indication: topical agent for the prevention of cutaneous neoplasm s and other skin abnormalities in patients with xeroderma pigmentosum (XP); product received orphan drug designation for this indication in 1989. Antineoplastic: Acting to prevent, inhibit or halt the ...

Ulcers

... reaction to medications ... Chronic skin inflammation or skin ulcers Disease s that make the skin sensitive to the sun, such as xeroderma pigmentosum , albinism , and basal cell nevus syndrome Radiation therapy Medical conditions or drugs that suppress the immune system ... ...

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Xeroderma in Biological News

Researchers probe a DNA repair enzyme

... repair such damage. Mutations in the human members of this helicase family impede DNA repair and may contribute to breast cancer, Fanconi Anemia and xeroderma pigmentosum. The researchers studied the archaeal version of Rad3. Archaea are microbes whose DNA repair systems are closely related to those of ...

Buildup of damaged DNA in cells drives aging

... in one DNA repair mechanism, nucleotide excision repair (NER), causes xeroderma pigmentosum, a rare disease in which people have a 2,000-fold increased ... had a mutation in XPF, because mutations in this gene typically cause xeroderma pigmentosum, which is a disease characterized primarily by skin and other ...

Discovering the first steps in transcription-coupled repair

... of cells from patients with Cockayne Syndrome (CS) versus those with xeroderma pigmentosum (XP), two different hereditary diseases with a common feature: ... significant because XPB and XPD, the other two proteins associated with xeroderma pigmentosum that can cause Cockayne Syndrome when defective (in addition ...

Heal thyself: Systems biology model reveals how cells avoid becoming cancerous

... be used to develop drugs to boost DNA repair in response to environmental toxins and possibly treat inherited degenerative diseases such as xeroderma pigmentosum, a disease in which the body's ability to repair DNA damage caused by ultraviolet light is disabled, ataxia telangiectasia, a ...

Enzyme crystal structure reveals 'unexpected' genome repair functions

... and nucleotide excision repair (NER), as well as other cell processes. "XPB was initially identified as the gene responsible for NER defects in xeroderma pigmentosum patients, who are hypersensitive to light and have a dramatically increased risk of skin cancer," says John A. Tainer, a professor at ...
Xeroderma in Biological Technology

AGI Dermatics President to be Keynote Speaker at the 11th Annual Sunscreen Symposium

... & Drug Administration recently granted Fast Track designation for Dimericine for treatment of solar and ultraviolet photosensitivity in patients with xeroderma Pigmentosum (XP), a rare genetic disorder that blocks the body's natural ability to repair DNA damage caused by ultraviolet light. AGI Dermatics is ...
Xeroderma in Biological Dictionary

Xeroderma pigmentosum

... xeroderma pigmentosa, or XP, is an autosomal recessive ... This disorder leads to multiple basal ... xeroderma pigmentosa, or XP, is an autosomal recessive ... disorder leads to multiple basaliomas ... xeroderma pigmentosum is a rare ... ...
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