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Virulence in Medical News

Genes key to staph disease severity, drug resistance found hitchhiking together

... that genetic factors that affect Staphylococcus virulence and drug resistance can be transferred from one ... to another. Staph bacteria also can exchange virulence genes using the same mechanism, but this was ... "The discovery that bundled genes determine virulence and antimicrobial resistance suggests a new ...

MRSA study suggests strategy shift needed to develop effective therapeutics

... of certain proteins such as toxins affects its virulence in humans. NIAID scientist Michael Otto, ... identical in virulence, as is their level of virulence gene production. This suggests that the ... long believed to play key roles in USA300 virulence have no significant impact, because while USA300 ...

Space Research May Help Explain Salmonella Illness

... causes a short-term alteration in Salmonella virulence -- the bacteria cultured in space were more ... helped researchers identify ways to counter the virulence effect. A research team led by Cheryl Nickerson ... bacteria's environment can turn off the rise in virulence caused by spaceflight. The space experiments ...

Key to virulence protein entry into host cells discovered

... have identified the region of a large family of virulence proteins in oomycete plant pathogens that enables ... RXLR and dEER and has the ability to carry the virulence proteins across the membrane surrounding plant ... to progress. The work, which focused on the virulence protein Avr1b from the soybean plant pathogen ...

Salmonella: Trickier than we imagined

... than we imagined." Sun's team found that a virulence protein known as AvrA dampens the inflammatory ... cultured human cells. AvrA is one of several virulence proteins that Salmonella has at its disposal, ... like the gut and bears close resemblance to a virulence protein known as YopJ that is active in Yersinia ...

Microscopic 'astronauts' to go back in orbit

... new experiment, called Microbial Drug Resistance virulence is part of the STS-123 space shuttle Endeavor ... us the opportunity to independently replicate the virulence studies of Salmonella typhimurium from our last ... effect of spaceflight on the gene expression and virulence potential of other model microorganisms, ...

JCI online early table of contents: Feb. 7, 2008

... EDITOR'S PICK: The key to survival and virulence for a fungal pathogen is autophagy Autophagy ... Atg8 expression was knocked down showed reduced virulence in mice. The authors therefore suggested that more detailed understanding of this virulence pathway might lead to new drugs for treating ...

Key Anthrax Virulence Factor Discovered

... could be met, they may have knocked out the virulence of the organism, as they showed in the mouse ... "We expected some effect." But with a decrease in virulence of almost 1,000-fold, he explained, "This implies bNOS is an essential virulence factor in anthrax." The results present an ...

Winemaking waste proves effective against disease-causing bacteria in early studies

... stents, by forming biofilms. GTFs are a main virulence factor responsible for S. mutans biofilm ... to interfere with many. A second linked set of virulence factors for S. mutans are its abilities to ... "Overall, the phenolic extracts disrupt essential virulence traits for a widespread, destructive oral ...

Bacteria 'See' the Light

... on its ability to sense light to maximize its virulence once it's out of a host. "It wasn't expected ... fact, activate with light, and it increases the virulence when activated by light." The finding is ... by which detection of light turns on its virulence response," Kennis explained. Kennis said this ...

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Virulence in Medical Technology

Promising Data from Paratek Pharmaceuticals' MAR Inhibitor Program Presented in 'Late Breaker' Session at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy

... serve as the "master switch" controlling virulence and antibiotic resistance. Paratek has shown that shutting down this switch disables bacterial virulence and prevents bacteria from causing infection. ... aeruginosa significantly reduced bacterial virulence and were protective in an animal model from ...

USAID Provides $5M in Emergency Support as Swine Flu Spreads

... the U.S. Centers for Disease Control and Prevention, to work with authorities in Mexico. The team will further investigate and characterize the virulence and transmission dynamics of the disease. USAID is responding to the international outbreak in coordination with the Centers for Disease Control ...

Paratek Reports Positive Phase 2 Clinical Data on its New Antibiotic PTK 0796 in Late Breaker Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy

... small molecules that inhibit bacteria-specific transcription factors for Multiple Adaptational Response (MAR) genes which control bacterial virulence and resistance development. Based upon a growing body of clinical research and as part of its effort to exploit its novel tetracycline derivatives ...

Paratek to Present Clinical Data in Late Breaker Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy

... small molecules that inhibit bacteria-specific transcription factors for Multiple Adaptational Response (MAR) genes which control bacterial virulence and resistance development. Based upon a growing body of clinical research and as part of its effort to exploit its novel tetracycline derivatives ...

Isis Announces $1.2 Million Award to Its Ibis Subsidiary to Expand Influenza Detection Capabilities and Enable Large-Scale Influenza Transmission Studies

... agents. The Ibis T5000 is capable of identifying virtually all bacteria, viruses and fungi, and can provide information about drug resistance, virulence and strain type of these pathogens. Commercial applications for the Ibis T5000 Biosensor System include epidemiologic surveillance, monitoring of ...

Study Confirms Limited Human-To-Human Spread of Avian-Flu Virus in Indonesia in 2006

... vaccine supply could be made available. That's why it's so important to ascertain whether human-to-human transmission is happening as well as the virulence of the strain." The researchers estimated the secondary-attack rate of the virus in Indonesia -- the risk of one infected person passing it to ...

Replikins LLC Finds West Nile Virus Replikin Count Has Reached Its Highest Recorded Value

... of replikins (p less than 0.001), also has been isolated in silico. Analysis of RPG permits a more accurate forecast, and comparison of the virulence of the current and past versions of the organism. (See http://www.replikins.com for quantitative data in Figures and press releases.) Earlier work ...
Virulence in Medical Dictionary

Vaccine

... your legs. Clots can break off and lodge in your lungs . bacterial virulence gene expression and whether they also have any effect in epithelial ... of this regulatory system will lead to the identification of additional virulence factors and provide novel targets for vaccine and ... ...

Genes

... two novel genes , Pini and Pin2, involved in mitotic regulation. Research Interest: The main focus of my research is quorum sensing regulation of virulence genes in entero hemorrhagic Escherichia coli (EHEC) O157:H7. People with sickle cell anemia have inherited genes for a type of ...

Labor

... protein , ... Our labor atory is interested in trying to identify and understand the regulatory cascade involved in quorum sensing regulation of virulence genes in EHEC. "Many labor under the mistaken idea that if they have taken cold , they must carefully exclude the outside air, and increase ...

Lead

... designed for those who lead busy ... between the bacterial autoinducer and the host signals, and how these compounds regulate bacterial virulence gene expression and whether they also have any effect in epithelial cells. Further understanding of this regulatory system will lead to the ... ...

Pathogen

... Pathogen icity of Vibrio chlerae and entero pathogenic E. coli Research Interest: The main focus of my research is quorum sensing regulation of virulence genes in entero hemorrhagic Escherichia coli (EHEC) O157:H7. Inactine pathogen inactivation Investigational product intended to prevent ...

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Virulence in Biological News

New insights into a leading poultry disease and its risks to human health

... tools that contribute in fully understanding the virulence of APEC, and provide new avenues of research," ... material. Plasmids are able to acquire more virulence genes or turn benign bacteria into harmful ... "The problem right now is understanding the virulence of APEC as well as Salmonella to find a way that ...

UT Public Health researchers find link to severe Staph infections

... of Public Health and colleagues also tested the virulence of PVL in CA MRSA by using clinical strains of ... of infections reinforcing the importance of this virulence factor in the disease process. LukS-PV given ... compared to antibody responses to other USA300 virulence factors. The study found patients who had Staph ...

The medium is the message: Manipulating salmonella in spaceflight curtails infectiousness

... Although the study of a broad range of microbial virulence factors is now well advanced, many pieces of the ... have shown that Salmonella gene expression and virulence are profoundly altered by microgravity, with the ... microbial growth medium to gene expression and virulence during spaceflight. "Pathogenic cells are smart," ...

Scripps research scientists identify blood component that turns bacteria virulent

... the signal for Bacillus anthracis to unleash virulence factors. Without the presence of the bicarbonate ... B. anthracis and thus are likely to have similar virulence triggering mechanisms. Gram-positive bacteria ... an essential component for the induction of virulence gene expression in response to host bicarbonate ...

Brucella abortus S19 genome sequenced; points toward virulence genes

... discovered a group of 24 genes that are linked to virulence by making comparisons of the newly available S19 ... S19 compared to virulent strains yields candidate virulence genes" was published recently in PLoS One (May ... genomics narrowed down the search for Brucella virulence factors to a small group of genes. Of particular ...

Pathogen virulence proteins suppress plant immunity

... identified a key function of a large family of virulence proteins that play an important role in the ... in The Netherlands, examined the function of the virulence (or effector) protein Avr1b in P. sojae and ... are also present in many other members of a huge virulence gene superfamily that Tylers group found recently ...

New drug targets may fight tuberculosis and other bacterial infections in novel way

... proof of principle for the inhibition of this virulence factor in bacteria cultured in the lab. Our next ... Stirrett, focused on particular small-molecule virulence factors called phenolic glycolipids (PGLs). ... he adds. "I believe that drugs targeting virulence factors are just one component of the paradigm ...

Developing kryptonite for Superbug

... profile of staph that will quickly reveal the virulence of infections. To accomplish that goal, ... available to quickly and accurately judge the virulence of staph bacteria, Bohach noted. Finding ... toxin profile and insights into the virulence of specific staph infections. Finding an RNA ...

Spaceflight shown to alter ability of bacteria to cause disease

... the genetic changes that show an increase in the virulence of Salmonella as a result of spaceflight. The ... media to keep the bacteria growing to perform the virulence studies. As a synchronous control experiment ... in on the key molecular players necessary for virulence from among thousands of potential candidates. ...

K-State researcher, collaborators study virulence of pandemic H1N1 virus

... Richt said. His work with outside collaborators is testing the virulence of pandemic H1N1 in animal models. In pigs, Richt and his fellow ... to validate our testing systems." The researchers also studied the virulence of two strains of the pandemic H1N1 virus in a nonhuman primate model as a ...

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Virulence in Biological Technology

Quick microchip test for dangerous antibiotic resistant bacteria

... a test chip which can accurately identify 56 virulence genes in the diarrhoea-causing Escherichia coli ... surveillance studies to monitor the way genes for virulence and antimicrobial resistance are spread in the ... unique and previously unknown combinations of virulence genes, whose significance still needs to be ...

The Plasmodium vivax genome provides new routes and challenges in the global fight against malaria

... from this centre have contributed their experience in studying the virulence of the parasite in order to validate and analyse the data obtained in the ... field when they discovered the largest family of genes controlling the virulence of this parasite in a study also published in Nature in 2001. The ...

Scientists develop strategy to rapidly describe outbreak strains with next-generation DNA sequencing

... attack, rapid identification of the genetic changes responsible for virulence or drug resistance is essential to mounting an effective response. ... to identify immediately the genetic determinants responsible for modified virulence or transmission, explains La Scola. The aim of this work was to evaluate ...

Isis Announces Equity Investment in Ibis Biosciences Subsidiary by Abbott; Option Acquired to Purchase Remaining Ibis Equity

... viruses and fungi, and can provide information about drug resistance, virulence and strain type of these pathogens within a few hours. Under the terms ... viruses and fungi, and can provide information about drug resistance, virulence and strain type of these pathogens. Commercial applications for the Ibis ...

CEL-SCI Corporation Releases Letter to Shareholders

... anticipate its evolution and prepare for mutant strains to appear from remote regions of the globe. Those mutant strains of the virus could possess virulence and other properties that far exceed those of the current strains. We believe the therapeutic and longer-term preventative vaccine approaches we are ...

Abbott Exercises Its Option to Acquire Ibis Biosciences, a Subsidiary of Isis

... in diagnostic procedures. It is capable of identifying virtually all bacteria, viruses and fungi, and can provide information about drug resistance, virulence and strain type of these pathogens. Commercial applications for the Ibis T5000 Biosensor System include epidemiologic surveillance, monitoring of ...

STC.UNM Signs License Option Agreement With GeneThera for E. coli O157:H7 Vaccine

... but now Chief of Environmental Microbiology in the Maryland Department of Health. These bacteria are harmless to humans and animals because the key virulence genes of the bugs are mutated by molecular approaches. According to the CDC, " ... there may be about 70,000 infections with E. coli O157 each year ...

Isis' Ibis Biosciences Subsidiary Highlights the Power of the Ibis T5000 Pathogen Identification and Characterization System at the ICAAC/IDSA Meeting

... in diagnostic procedures. It is capable of identifying virtually all bacteria, viruses and fungi, and can provide information about drug resistance, virulence and strain type of these pathogens. Commercial applications for the Ibis T5000 Biosensor System include epidemiologic surveillance, monitoring of ...

Isis Announces Award of Up to $8.4 Million in New Government Grants and Contracts to Its Ibis Biosciences Subsidiary for Pathogen Detection and Human Forensics

... in diagnostic procedures. It is capable of identifying virtually all bacteria, viruses and fungi, and can provide information about drug resistance, virulence and strain type of these pathogens. Commercial applications for the Ibis T5000 Biosensor System include epidemiologic surveillance, monitoring of ...

U.S. Genomics Inc. Receives $4.5 Million Investment from BD

... molecular diagnostic test. A diagnostic platform based on DLA has the potential to provide information to physicians concerning pathogen identity, virulence and drug resistance within hours, as opposed to the multi-day techniques such as culturing, plating, and staining that are done today. U.S. ...

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Virulence in Biological Definition

Avian influenza

... influenza in humans 3 Prevention and treatment 4 Increasing virulence 5 Symptoms 6 References 7 External links ... months to produce and must be prepared for each subtype. Increasing virulence In July 2004 researchers, headed by H. Deng of the Harbin Veterinary ...

Plasmid

... that can kill other bacteria. Degrative plasmids , which enable the digestion of unusual substances, e.g., toluole or salicylic acid . virulence plasmids , which turn the bacterium into a pathogen . Plasmids can belong to more than one of these functional groups. Plasmids that exist ...

Virus

... in horses, could be responsible for psychiatric illness in humans. The relative ability of viruses to cause disease is described in terms of virulence . The ability of viruses to cause devastating epidemics in human societies has led to concern that viruses will be weaponized for biological ...
Virulence in Biological Dictionary

Virulence

... virulence is the degree of pathogenicity of an organism: ... of a pathogen to cause disease. The noun virulence derives from the adjective virulent. In ... effect severity, and in ... virulence ( ′virələns ) ( microbiology ) The ...

Mating type

... ... Before 1984, A2 mating type had only been detected in Mexico, the possible ... Impact of Mating Type , Serotype, and Ploidy on the virulence of Cryptococcus neoformans. ... Identification of Mating Type Genes in the Bipolar Basidiomycetous Yeast ... ( mating type ) amongst a ...

Kilobase

... of the polymerase ... One limitation of conventional PCR is that it requires primers complementary to ... ... Analysis of the 50- Kilobase virulence Plasmid of Salmonella ... of 50 kilobase -plasmid, pKDSC50, of Salmonella choleraesuis RF-1 strain on pig septicemia. ... A 1.6- kilobase -pair ...

Glycoprotein

... life. ... Lifestyle, fitness & health information about Glycoprotein . ... Human metapneumovirus glycoprotein G is an important virulence factor ... P Glycoprotein , the product of the MDR1 gene, is expressed in distinct non ... Elevated levels of P Glycoprotein have also been ...

Antigenic variation

... This genetic mechanism, employed by certain bacteria and protozoa, poses a challenge in the development of ... of antigenic variation and virulence ... Antigenic variation is the primary cause of the persistence and lethality of ... This process is called Antigenic Variation , and ...

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