UCLA scientists transform HIV into cancer-seeking missile
...DS virus. They injected the camouflaged HIV into a vein in the mouse's tail and used a special optical camera to watch the carrier's movement. "The virus traveled through the animal's bloodstream and homed straight to the cancer cells in the lungs, where the melanoma had migrated," said Chen. When the r...Pulsating ultrasound enhances gene therapy for tumors
...jected an easily measurable reporter gene into the vein in their tails. The reporter gene in this study--a fluorescent-green protein found in deep-sea invertebrates--was visible in all sections of the tumors exposed to pulsed-HIFU. Tumors not targeted with pulsed-HIFU showed negligible signs of the gene. ...Sugar beet virus mutation requires Texas touch
... in 2002 when a new strain of beet necrotic yellow vein virus emerged. The new strain threatened sugar be...ion in the world, Rush said. Beet necrotic yellow vein virus, which causes the disease known as rhizomania, was found near Hereford in 1986 by a California...Columbia study shows widely used artery clearing device does not help patients during heart attack
...mmonly and successfully used during angioplasty in vein grafts and stenting in carotid arteries. The study, published in the March 2 issue of the Journal of the American Medical Association, found that the devices were successful in removing debris from the arteries in angioplasties during heart attacks, ......ollaborators shows that the events leading to deep vein thrombosis are reduced. P-selectin inhibitors have also been shown to be anti-thrombotic in early human trials" Measurement of P-selectin levels in the blood stream may provide a new diagnostic tool to identify people at risk of heart disease and st...Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon Allelic Discrimination Kits
...t carriers have a 7-fold higher risk for deep vein thrombosis 11 MTHFR (Methylene-tetrahydrofolate reductase) A key enzyme in homocysteine metabolism C to T substitution at nucleotide position 677 that results in an Ala to V...High-Efficiency Transfections Achieved with New Low-Toxicity Reagent
...ial endothelial cells (HUAEC), and human umbilical vein endothelial cells (HUVEC)in 24-well plates. For optimization, we used four different concentrations ofGeneJammer reagent (3, 6, 9, and 12 l per 1 g of DNA) and threeconcentrations of the competitive reagents within the ranges recommended by eachmanuf...... (PromoCell) forthe cultivation of human umbilical vein endothelial cell(HUVEC) in comparison with the sta...n comparativestudies on cultivated human umbilical vein endothelialcells. In this case, the serum-free medium fromPromoCell was clearly advantageous for pro......cells weretransfected and analyzed: humanumbilical vein endothelial cells(HUVEC) and normal human dermalfibroblasts (NHDF). Theadvantages of using the compact2100 bioanalyzer for monitoringtransfection efficiency in primarycells include low cell consumption,high reproducibility ofresults, fast on-chip sta...Efficient Delivery of siRNAs to Human Primary Cells: Electroporation vs. Chemical Transfection
...cted into normal human umbilical vein endothelial cells (HUVEC) and normal human epidermal keratinocytes (NHEK) using a panel of chemical transfection reagents. Cells were harvested 48 hours post transfection and analyzed for GAPDH ex...How to diagnose heart failure?
... pressure - by observing pulsations in the jugular vein in the neck. Increased pressure may indicate that the patient with heart failure is retaining excess fluid. These new findings should direct physicians' attention towards simple measures that can detect those patients most at risk. In this study, t...Blood clots likely in long travel
...ncreased with the duration of air travel.Like deep vein thrombosis (DVT), pulmonary embolisms are blood clots that are believed to be associated with long-distance travel. Frederic Lapostolle and colleagues, from Avicenne Hospital in Bobigny near Paris, studied all cases of pulmonary embolism needing ca......k of blood clotting in the veins of the legs (deep vein thrombosis, or DVT). If the clot breaks off, it may travel to the lungs, forming a pulmonary embolism (PE) which is a potentially life-threatening condition. Researchers in France and the US have monitored all passengers arriving at Charles de Gaul......ble. Varicose veins arise when the valves// in the vein stop functioning properly. Varicose veins may look unsightly but are not usually a medical threat. If you have symptoms, like throbbing, cramping or swelling arising from your varicose veins, then do seek medical advice. Similarly, see your doctor ...Prothrombin Time Comes in Small (CLIA-Waived) Packages
...rgery, who is being anticoagulated to prevent deep vein thrombosis, may have a target INR of between two and three. To prevent arterial thrombosis in a patient with an artificial heart valve, the INR therapeutic goal may be in the 2.5- to 3.5-range. Several medical manufacturers have gained CLIA-waived ......primarily due tothe incidence of asymptomatic deep vein thrombosis (DVT) detectedby protocol required venography at the end of therapy. Major VTEoccurred at similar rates across all treatment groups (3.0% and3.4% for 150 mg and 220 mg dabigatran etexilate respectively,versus 2.2% enoxaparin). Although maj...New Information on the Potential of Plasmin Shared at ISTH Congress
...orders, such as peripheralarterial occlusion, deep vein thrombosis, and ischemic stroke. Plasmin, which is...ns in other acutebleeding disorders including deep vein thrombosis and ischemicstroke. The plasmin molecule contains fibrin-binding domains notpresent in ot......an0.001) in the composite primary endpoint of deep vein thrombosis(DVT), non-fatal pulmonary embolism (PE) and all-cause mortalitycompared to those treated with enoxaparin. A 62% reduction of risk(p=0.01) for developing major VTE (the composite of proximal DVT,non-fatal PE and VTE-related death) - the sec......I) study reported increased risk of stroke anddeep vein thrombosis in postmenopausal women (50 to 79 years..., invasivebreast cancer, pulmonary emboli and deep vein thrombosis inpostmenopausal women (50 to 79 years of age) during five years ofdaily treatment with 0...