JCI table of contents: March 23, 2009
... cause of leukemia is thought to be that the viral vectors
used to carry the therapeutic gene into cells ... The authors therefore conclude that SIN viral vectors
should be the preferred choice in future gene ...
TITLE: The genotoxic potential of retroviral vectors
is strongly modulated by vector design and ...
ALS TDI and Asklepios to Develop New Therapeutic Delivery Options for Treating Lou Gehrig's Disease
... Collaboration to evaluate gene delivery vectors
CAMBRIDGE, Mass. and CHAPEL HILL, ... aimed at developing a panel of viral vectors
that could be used to deliver therapeutics based ... custom constructed Biological Nano Particle (BNP) vectors
are designed using proprietary technology ...
In blood vessel stents, innovative materials allow better control, delivery of gene therapy
... that can bind to a variety of gene therapy vectors
and can be custom-designed for controlled local ... allows us to increase the dosage of gene therapy vectors
delivered, and we can tune the materials for ... one molecule thick, containing adenovirus vectors
that delivered genes that successfully inhibited ...
Freeze-dried tendon implants prove effective in early studies
... drugs, growth factors or gene therapy vectors
to drive healing and reduce swelling. ... into the graft site, a solution of gene therapy vectors
that directed the recipients cells to accept the ... human cells and insert their own DNA. Viral vectors
retain this ability, but have been harnessed to ...
Converting adult somatic cells to pluripotent stem cells using a single virus
... Stem Cells .
Prior research studies have required multiple retroviral vectors
for reprogramming -- steps that depended on four different viruses to ... Medicine in the Gastroenterology Section, achieved was combining the four vectors
into a single "stem cell cassette" containing all four genes. The ...
Vaccine and drug research aimed at ticks and mosquitoes to prevent disease transmission
... only be able to stop disease transmission, but also prematurely kill the vectors
carrying these diseases; such vectors
include ticks, sand flies and mosquitoes the insects responsible for most ...
Vectors in Medical Technology
In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy
... that can bind to a variety of gene
and can be custom-designed for controlled local ... allows us to
increase the dosage of gene therapy vectors
delivered, and we can tune the
materials for ... components into a complex that
tethers viral vectors
to stent surfaces. One of the three components is ...
Celladon Provides MYDICAR(R) Program Update of First-In-Human Trial for Advanced Heart Failure at American Society of Gene Therapy Annual Meeting
... has been demonstrated in clinical studies of more than 500 patients. AAV vectors
are the product of decades of research focused on the safety of gene ... of a non-replicating, non-pathogenic, commonly occurring human virus. AAV vectors
do not integrate into the chromosome and are considered non-mutagenic. In ...
Celladon Announces Presentation of Clinical Data From First-in-Human MYDICAR(R) Trial for Advanced Heart Failure at American Heart Association Scientific Sessions
... has been demonstrated in clinical studies of more than 500 patients.
are the product of decades of research focused on the safety of
gene ... of a non-replicating,
non-pathogenic, commonly occurring human virus. AAV vectors
integrate into the chromosome and are considered non-mutagenic. ...
VIRxSYS to Host a Web Conference to Announce Clinical Trial Update
... minimizing the likelihood of new infections.
Conference on Lentiviral vectors
(Evry, France) July 2008
VIRxSYS was invited to present its patient ... vector derived from HIV-1 itself. Unlike other
viral vectors, lentiviral vectors
appear to sustain expression of the
delivered genes of interest for a ...
Epeius Biotechnologies Applauds the Belated Scholarship of Their Academic Contemporaries in 2007, As Targeted Gene Therapy Comes of Age in Clinical Medicine
... Reviews, Genetics, 2007,
8:573-587) entitled "Engineering Targeted Viral vectors
for Gene Therapy."
Among the flotsam and jetsam of adenoviral shipwrecks, ... facility and
national resource was ostensibly to provide clinical grade vectors
clinical gene transfer protocols -- has closed its doors and announced ...
Glybera(TM) Shows Long-Term Health Benefits
... platform that circumvents the obstacles that
have hindered development of gene therapy technologies into drugs. Using
adeno-associated viral vectors
as the delivery vehicle of choice for
therapeutic genes, the company has designed and validated a stable, scalable,
commercially attractive and ...
Vectors in Medical Products
Description:... quality, comprehensive portable and bedside monitoring. The large 8.4-inch TFT color display allows you to see up to four waveforms, including two vectors
of ECG. The touch screen allows easy navigation through menus and is not impaired by gloves or temperature.
Standard features include two ...
Company:Welch Allyn Medical Products
Vectors in Biological News
Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols
... COLD SPRING HARBOR, N.Y. (Wed., Aug. 5, 2009) vectors
derived from retroviruses are useful tools for ... and propagation into daughter cells. Lentiviral vectors
are preferred because they can transduce non-proliferating cellular targets. These vectors
can be engineered to target specific tissues. In ...
UF researchers develop improved gene therapy agent
... about 30 times more efficiently in mice than vectors
scientists currently rely on.
The discovery ...
In tissue samples and in mice, all the new vectors
worked better than a commonly used version of ...
The researchers are creating additional new vectors
based on this concept, with the goal of creating ...
Selfish DNA and the Genetic Control of Vector-Borne Diseases
... medicine have had limited success. The insect vectors
responsible for spread of these diseases are ... reducing the spread of disease by these insect vectors
is genetically modifying the mosquitoes. ... populations of mosquitoes can be changed from vectors
of deadly pathogens to merely annoying pests.
'Jumping genes' could make for safer gene delivery system
... lot with it, and it is safer. Problems with viral vectors
are extremely rare, but the consequences can be ... risk."
Techniques for targeting transposon vectors
to regions of the genome devoid of cancer genes ... to be worked out in the development of transposon vectors
before they could be tried in human therapy. But ...
Protein analysis methods, viral vectors featured in Cold Spring Harbor Protocols
... complexes. An additional featured article details the generation of viral vectors
for gene transfer.
"Systematic Monitoring of Protein Complex ... can infect post-mitotic cells, which makes them particularly useful as vectors
for gene delivery into cells like neurons. In the May issue of Cold ...
Moving gene therapy forward with mobile DNA
... ultimately depends on these gene delivery vehicles or vectors. Most vectors
have been derived from virusses that can be tailor-made to deliver therapeutic genes into the patients' cells. However, some of these viral vectors
can induce side-effects, including cancer and inflammation.
Vectors in Biological Technology
Vectors in Biological Products
Vectors in Biological Definition
2.1 Ex vivo
2.2 In vivo
in gene therapy
3.2 ... from the patients body and incubated with vectors
that inserted copies of the genes. Most gene-therapy vectors
are viruses , although there are techniques for ...
... another. It can also be applied geometrically to vectors
In many important cases, operators ... function domain , which may itself consist of vectors
or functions , rather than just numbers. The ... an example of a linear transformation between vectors
in R 2 is reflection, given a vector x =(x 1 ...
... as tools for genetic engineering
Geneticists regularly use viruses as vectors
to introduce DNA into cells that they are studying. Attempts to treat ... ways. Deaths have occurred through virus infections caused by virus vectors
used in gene therapy , so their application to human subjects is still ...
... and clothing; however, there is no evidence that the virus can survive in well cooked meat.
Cats are also thought to be possible infection vectors
for H5N1 strains of avian flu (Kuiken et al, 2004).
The incubation period is 3 to 5 days. Symptoms in animals vary, but virulent strains can ...
... surrounding a conductor or travelling through a waveguide may be calculated by integrating the cross product of the magnetic and electric field vectors
throughout the volume. (And the reason that Power equals Volts times Current is directly related to the fact that electromagnetic energy flow equals ...
... strain, which is turned into Vibrio cholerae by a phage, causing cholera .
Phages play an important role in molecular biology as cloning vectors
to insert DNA into bacteria. Phage therapy has been used since the 1940s in the former Soviet Union as an alternative to antibiotics for ...
Vectors in Biological Dictionary
... This article is about the vectors
mainly used in physics and engineering to ... ... on real numbers have close analogues for vectors
. ... A vector space is a mathematical structure formed by a collection of vectors
: objects that may be added together and ...
... cell types. The main advantage of these vectors
is they can be manipulated in E. coli and then ... origin, the RecA gene ... The shuttle vectors
do not integrate into the genome and do not ... pRN1 as starting point to construct shuttle vectors
for Sulfolobus. ... IUPAC > Gold Book > ...
... restriction mapping Creation of exo ... ... vectors
" Cloning vectors
" Viral Cloning vectors
" Phagemid ...
... into another cell. The four major types of vectors
are plasmids, bacteriophages and other ... ... Protocol: pCI and pSI Mammalian Expression vectors
, TB206. GenBank® Acc.#: U47119 ... BRIEF ... Expression Vector Subcloning ... The Flexi® vectors
are available for expression of N- and ...
... the processes ... DNA Cloning with Plasmid vectors
The ... Human Molecular Genetics 2 conveys the ... on Religious Tolerance. ... ... into vectors
of your choice, DNA Cloning Service is based ... of the genes we do not purify the DNA and the vectors
on an ... Home > Research > Research ...
... DNA with the ... Modern cloning vectors
include selectable markers (most frequently ... ... and cancer research tools: multigenic vectors
, plasmid vectors
, cytokines genes, chemokines genes, ...