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Vectors in Medical News

JCI table of contents: March 23, 2009

... cause of leukemia is thought to be that the viral vectors used to carry the therapeutic gene into cells ... The authors therefore conclude that SIN viral vectors should be the preferred choice in future gene ... TITLE: The genotoxic potential of retroviral vectors is strongly modulated by vector design and ...

ALS TDI and Asklepios to Develop New Therapeutic Delivery Options for Treating Lou Gehrig's Disease

... Collaboration to evaluate gene delivery vectors for ALS CAMBRIDGE, Mass. and CHAPEL HILL, ... aimed at developing a panel of viral vectors that could be used to deliver therapeutics based ... custom constructed Biological Nano Particle (BNP) vectors are designed using proprietary technology ...

In blood vessel stents, innovative materials allow better control, delivery of gene therapy

... that can bind to a variety of gene therapy vectors and can be custom-designed for controlled local ... allows us to increase the dosage of gene therapy vectors delivered, and we can tune the materials for ... one molecule thick, containing adenovirus vectors that delivered genes that successfully inhibited ...

Freeze-dried tendon implants prove effective in early studies

... drugs, growth factors or gene therapy vectors to drive healing and reduce swelling. ... into the graft site, a solution of gene therapy vectors that directed the recipients cells to accept the ... human cells and insert their own DNA. Viral vectors retain this ability, but have been harnessed to ...

Converting adult somatic cells to pluripotent stem cells using a single virus

... Stem Cells . Prior research studies have required multiple retroviral vectors for reprogramming -- steps that depended on four different viruses to ... Medicine in the Gastroenterology Section, achieved was combining the four vectors into a single "stem cell cassette" containing all four genes. The ...

Vaccine and drug research aimed at ticks and mosquitoes to prevent disease transmission

... only be able to stop disease transmission, but also prematurely kill the vectors carrying these diseases; such vectors include ticks, sand flies and mosquitoes the insects responsible for most ...

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Vectors in Medical Technology

In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy

... that can bind to a variety of gene therapy vectors and can be custom-designed for controlled local ... allows us to increase the dosage of gene therapy vectors delivered, and we can tune the materials for ... components into a complex that tethers viral vectors to stent surfaces. One of the three components is ...

Celladon Provides MYDICAR(R) Program Update of First-In-Human Trial for Advanced Heart Failure at American Society of Gene Therapy Annual Meeting

... has been demonstrated in clinical studies of more than 500 patients. AAV vectors are the product of decades of research focused on the safety of gene ... of a non-replicating, non-pathogenic, commonly occurring human virus. AAV vectors do not integrate into the chromosome and are considered non-mutagenic. In ...

Celladon Announces Presentation of Clinical Data From First-in-Human MYDICAR(R) Trial for Advanced Heart Failure at American Heart Association Scientific Sessions

... has been demonstrated in clinical studies of more than 500 patients. AAV vectors are the product of decades of research focused on the safety of gene ... of a non-replicating, non-pathogenic, commonly occurring human virus. AAV vectors do not integrate into the chromosome and are considered non-mutagenic. ...

VIRxSYS to Host a Web Conference to Announce Clinical Trial Update

... minimizing the likelihood of new infections. Conference on Lentiviral vectors (Evry, France) July 2008 VIRxSYS was invited to present its patient ... vector derived from HIV-1 itself. Unlike other viral vectors, lentiviral vectors appear to sustain expression of the delivered genes of interest for a ...

Epeius Biotechnologies Applauds the Belated Scholarship of Their Academic Contemporaries in 2007, As Targeted Gene Therapy Comes of Age in Clinical Medicine

... Reviews, Genetics, 2007, 8:573-587) entitled "Engineering Targeted Viral vectors for Gene Therapy." Among the flotsam and jetsam of adenoviral shipwrecks, ... facility and national resource was ostensibly to provide clinical grade vectors for clinical gene transfer protocols -- has closed its doors and announced ...

Glybera(TM) Shows Long-Term Health Benefits

... platform that circumvents the obstacles that have hindered development of gene therapy technologies into drugs. Using adeno-associated viral vectors as the delivery vehicle of choice for therapeutic genes, the company has designed and validated a stable, scalable, commercially attractive and ...
Vectors in Medical Products

Propaq CS

Description:... quality, comprehensive portable and bedside monitoring. The large 8.4-inch TFT color display allows you to see up to four waveforms, including two vectors of ECG. The touch screen allows easy navigation through menus and is not impaired by gloves or temperature. Standard features include two ...
Company:Welch Allyn Medical Products
Vectors in Biological News

Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols

... COLD SPRING HARBOR, N.Y. (Wed., Aug. 5, 2009) vectors derived from retroviruses are useful tools for ... and propagation into daughter cells. Lentiviral vectors are preferred because they can transduce non-proliferating cellular targets. These vectors can be engineered to target specific tissues. In ...

UF researchers develop improved gene therapy agent

... about 30 times more efficiently in mice than vectors scientists currently rely on. The discovery ... In tissue samples and in mice, all the new vectors worked better than a commonly used version of ... The researchers are creating additional new vectors based on this concept, with the goal of creating ...

Selfish DNA and the Genetic Control of Vector-Borne Diseases

... medicine have had limited success. The insect vectors responsible for spread of these diseases are ... reducing the spread of disease by these insect vectors is genetically modifying the mosquitoes. ... populations of mosquitoes can be changed from vectors of deadly pathogens to merely annoying pests. ...

'Jumping genes' could make for safer gene delivery system

... lot with it, and it is safer. Problems with viral vectors are extremely rare, but the consequences can be ... risk." Techniques for targeting transposon vectors to regions of the genome devoid of cancer genes ... to be worked out in the development of transposon vectors before they could be tried in human therapy. But ...

Protein analysis methods, viral vectors featured in Cold Spring Harbor Protocols

... complexes. An additional featured article details the generation of viral vectors for gene transfer. "Systematic Monitoring of Protein Complex ... can infect post-mitotic cells, which makes them particularly useful as vectors for gene delivery into cells like neurons. In the May issue of Cold ...

Moving gene therapy forward with mobile DNA

... ultimately depends on these gene delivery vehicles or vectors. Most vectors have been derived from virusses that can be tailor-made to deliver therapeutic genes into the patients' cells. However, some of these viral vectors can induce side-effects, including cancer and inflammation. Marinee ...

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Vectors in Biological Technology

DNA2.0 Introduces Freedom of Expression With a New Family of Bacterial Expression Vect:ors

... A significant challenge utilizing pET vectors for bacterial expression has been the cost and uncertainty associated with vectors that have been patented. In order to tackle this problem, DNA2.0 has developed a new family of vectors called pJexpress that are free of IP constraints. ...

Lentigen Corporation Receives Four Research Grants From the National Institutes of Health

... these diseases. For melanoma, HCV, and EBV, the vectors will transduce T cells, which play a central role ... to attack the targeted disease. For CLL, the vectors will carry weakened cells of this cancer combined ... in biotechnology and medicine. Lentiviral vectors are the most efficient vehicles for the delivery ...

Lentigen Licenses Fundamental Lentiviral Vector Technology Patent From the University of Cambridge

... fundamental compositions of HIV-based lentiviral vectors that are currently widely used in research and ... About Lentiviral Vectors Lentiviral vectors (LV) are the most efficient vehicles for ... in biotechnology and medicine. Lentiviral vectors are the most efficient vehicles for the delivery ...

Lentigen Corporation Announces Exclusive Licensing Agreement With Case Western Reserve University to Develop Novel Stem-Cell Therapy for Brain Cancer

... About Lentiviral Vectors Lentiviral vectors (LV) are vehicles that can deliver genes or ... non-viral, adenoviral and adeno-associated viral vectors have not been shown to achieve both high and ... in biotechnology and medicine. Lentiviral vectors are the most efficient vehicles for the delivery ...

Cell Genesys Announces Sale of Lentiviral Gene Delivery Technology for $12 Million

... therapy." About Lentiviral Vectors Lentiviral vectors are modified viruses that are used to transfer ... or in vivo. In preclinical studies, lentivirus vectors developed by Cell Genesys, have demonstrated ... capacity than certain other gene delivery vectors and therefore hold the potential to be used ...

Lentigen Corporation Announces Relocation to New Facility

... growth needs as the leading developer and manufacturer of lentiviral vectors (LVs) and proteins for a wide range of clinical and research applications. ... and research applications in biotechnology and medicine. Lentiviral vectors are the most efficient vehicles for the delivery of genes or gene ...

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Vectors in Biological Products

Kilo Sequencing Deletion Kit from Takara Mirus Bio

Description:... DNA fragments cloned into the multiple cloning sites (MCS) of M13 phage vectors (mp18/19) or pUC-related plasmid or phagemid vectors (pUC18/19). The kit is used to create nested unidirectional deletions in ...
Company:Takara Mirus Bio

Zero Blunt TOPO Kit for Sequencing with One Shot Mach1 T1 Phage-Resistant Chemically Competent E. coli from Invitrogen

Description:... and subsequent sequencing of PCR products. The kits contain TOPO Cloning vectors with primer sites located as close as 33 base pairs from the PCR product ... enabling 5-minute bench-top ligation yielding recombinants (1). Both vectors ...
Company:Invitrogen

pCITE-2a(+) DNA from Novagen

Description:... The pCITE-2a-c(+) vectors are designed for enhanced translation of cloned sequences in vitro using ... 5 bp from all sites beyond Msc I at 522. The f1 origin in pCITE-2a-c(+) vectors is oriented so that infection with helper phage wil produce virions ...
Company:Novagen

HRV 3C Protease from Novagen

Description:... an ideal choice for rapid removal of fusion tags. The pET expression vectors pET-47b(+) through pET-50b(+) incorporate the HRV 3C protease cleavage ... sequences. The combination of pET-47b(+) to pET-50b(+) vectors for expression, HRV 3C protease for fusion tag cleavage, and Ni-NTA ...
Company:Novagen

RTS AviTag E. coli Biotinylation Kit, Plasmid; Cloning vector and in vitro protein mono-biotinylation system for use with RTS 100 and RTS 500 E. coli HY Kits from Roche Applied Science

Description:... kits. (Cat. No. 3 186 148, 3 186 156, 3 335 461). This kit provides vectors for the easy introduction of a C- or N-terminal AviTag peptide sequence. ... by E. coli biotin protein ligase (BirA, E.C. 6.3.4.15). The vectors contain all regulatory elements necessary for expression in RTS reactions ...
Company:Roche Applied Science

pTriEx™-4 DNA from Novagen

Description:... The pTriEx™ vectors combine the proven features of the pET, BacVector ® and mammalian ... versatility of each expression system in one vector backbone. The pTriEx vectors have been extensively tested for performance with various target genes in ...
Company:Novagen

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Vectors in Biological Definition

Gene therapy

... 2.1 Ex vivo 2.2 In vivo 3 vectors in gene therapy 3.1 Retroviruses 3.2 ... from the patients body and incubated with vectors that inserted copies of the genes. Most gene-therapy vectors are viruses , although there are techniques for ...

Operator

... another. It can also be applied geometrically to vectors as operands. In many important cases, operators ... function domain , which may itself consist of vectors or functions , rather than just numbers. The ... an example of a linear transformation between vectors in R 2 is reflection, given a vector x =(x 1 ...

Virus

... as tools for genetic engineering Geneticists regularly use viruses as vectors to introduce DNA into cells that they are studying. Attempts to treat ... ways. Deaths have occurred through virus infections caused by virus vectors used in gene therapy , so their application to human subjects is still ...

Avian influenza

... and clothing; however, there is no evidence that the virus can survive in well cooked meat. Cats are also thought to be possible infection vectors for H5N1 strains of avian flu (Kuiken et al, 2004). The incubation period is 3 to 5 days. Symptoms in animals vary, but virulent strains can ...

Electrical energy

... surrounding a conductor or travelling through a waveguide may be calculated by integrating the cross product of the magnetic and electric field vectors throughout the volume. (And the reason that Power equals Volts times Current is directly related to the fact that electromagnetic energy flow equals ...

Phage

... strain, which is turned into Vibrio cholerae by a phage, causing cholera . Phages play an important role in molecular biology as cloning vectors to insert DNA into bacteria. Phage therapy has been used since the 1940s in the former Soviet Union as an alternative to antibiotics for ...

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Vectors in Biological Dictionary

Vectors

... This article is about the vectors mainly used in physics and engineering to ... ... on real numbers have close analogues for vectors . ... A vector space is a mathematical structure formed by a collection of vectors : objects that may be added together and ...

Shuttle vector

... cell types. The main advantage of these vectors is they can be manipulated in E. coli and then ... origin, the RecA gene ... The shuttle vectors do not integrate into the genome and do not ... pRN1 as starting point to construct shuttle vectors for Sulfolobus. ... IUPAC > Gold Book > ...

Phagemid

... restriction mapping Creation of exo ... ... vectors " Cloning vectors " Viral Cloning vectors " Phagemid ...

Expression Vector

... into another cell. The four major types of vectors are plasmids, bacteriophages and other ... ... Protocol: pCI and pSI Mammalian Expression vectors , TB206. GenBank® Acc.#: U47119 ... BRIEF ... Expression Vector Subcloning ... The Flexi® vectors are available for expression of N- and ...

DNA clone

... the processes ... DNA Cloning with Plasmid vectors The ... Human Molecular Genetics 2 conveys the ... on Religious Tolerance. ... ... into vectors of your choice, DNA Cloning Service is based ... of the genes we do not purify the DNA and the vectors on an ... Home > Research > Research ...

Cloning vector

... DNA with the ... Modern cloning vectors include selectable markers (most frequently ... ... and cancer research tools: multigenic vectors , plasmid vectors , cytokines genes, chemokines genes, ...

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Other Contents
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