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Untranslated in Medical News

Monitoring whether patients take medicines can help anticipate HIV treatment failure in Africa

... Related PLoS Medicine Perspective article: Citation: Hughes TA, Jones PF (2008) Regulatory RNAs: Have mRNA untranslated regions joined the party? PLoS Med 5(5): e110. doi:10.1371/journal.pmed.0050110 IN YOUR COVERAGE PLEASE LINK TO THIS URL, WHICH WILL PROVIDE ...

Drug Strategy Makes Cancer Genes Get Lost in Translation

... machinery that does the translating, making it a challenge to determine where to begin, he added. In contrast, strong mRNAs have only short 5' untranslated regions that allow for easier protein formation. The successful translation of weak mRNAs therefore depends more heavily on other protein factors, ...
Untranslated in Biological News

Modification of program enables prediction of gene transcription

... the protein sequences produced by genes and their untranslated regions. Researchers in recent years have grown increasingly enthusiastic about the significance of untranslated regions. By understanding the functions of these ... protein- coding region. Most of this extra-long untranslated region is then discarded by splicing the ...
Untranslated in Biological Technology

Get the 5'-End

... for translation is obvious, but without knowledge of the 5' untranslated sequence, it is difficult to be certain that 'an' AUG in the cDNA sequence is 'the' AUG start site. The upstream, untranslated region will typically contain stop codons in-frame with the ...

Getting Started with MicroRNA Research

... represses protein translation by binding to sequences in the 3' untranslated region of specific mRNAs. The exact mechanism of translation ... miRNA activity levels. The cloning site in the 3' untranslated region (3' UTR) of the luciferase gene allows ...

The GeneZoo or the GeneJungle?

... splice variants, which occur less frequently in the 3 untranslated regions of transcripts (Table 1). Utilizing the 3 sequences as ... cluster sequences from different gene family members, since the untranslated regions tend not to align. In contrast, sequencing artifacts are ...

FlexiPlate siRNA

... shown that off-target effects are frequently caused by matches of the seed region of the siRNA antisense strand with the 3' untranslated region of mRNA (2). siRNA designs are analyzed for 3' UTR/seed region complementarity and siRNAs with the least potential to cause ...

The let-7 microRNA Family Regulates RAS: Implications for Development and Oncogenesis

... identified genes, let-60/RAS stood out because it has eight LCSs and ten nonconforming sites in the 3' untranslated region (3'UTR), as well as three LCSs in the coding sequence. The role of let-60/RAS in C. elegans ...

MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers

... least two genes, lin-14 and lin-28 [13]. The activity of lin-4 depends on the partial homology of the miRNA to specific regions of the 3' untranslated regions (UTRs) of lin-14 and lin-28 mRNAs [5, 14]. Additional miRNAs have been functionally characterized (Figure 2). The range ...

miRNA Expression in White Blood Cells

... are endogenous, 21-24 nt RNAs that mediate post-transcriptional gene regulation by pairing with the 3' untranslated region of messenger RNAs and acting as translational repressors. The study of miRNA is an emerging and ...

Detecting miRNA & siRNA

... regulation. Some of these miRNAs (e.g. lin-4 and let-7 ) inhibit protein synthesis by binding to the 3' untranslated region of target mRNAs. Others bind to perfectly complementary mRNA sequences to destroy target transcripts ...

Cancer-Related miRNAs Uncovered by the mirVana miRNA Microarray Platform

... specific miRNAs might be participating in cancer through the mis-regulation of oncogenes, we scanned the 3' untranslated regions (UTRs) of 150 well-known oncogenes for sequences with significant homology to the miRNAs identified ...

Human Universal cDNA Library Array I

... to hybridize to the beginning of the 5 translated region (ATG included) while the other corresponded to the end of the 3 untranslated region ( Figure 5 and Figure 6 ). The percentage of full-length cDNAs was determined by comparing the two results. ...

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Untranslated in Biological Definition

Barr body

... X inactivation centre or Xic , usually found near the centromere . The centre contains twelve genes, seven of which code for proteins , five for untranslated RNAs , of which only two are known to play an active role in the X inactivation process, Xist and Tsix. The centre also appears to be important ...

Morphogenesis

... factors. Bicoid has a DNA-binding homeodomain that binds both DNA and the nanos mRNA. Bicoid binds a specific RNA sequence in the 3' untranslated region of caudal mRNA and blocks translation. Hunchback protein levels in the early embryo are significantly augmented by new hunchback gene ...

Morphogenesis

... factors. Bicoid has a DNA-binding homeodomain that binds both DNA and the nanos mRNA. Bicoid binds a specific RNA sequence in the 3' untranslated region of caudal mRNA and blocks translation. Hunchback protein levels in the early embryo are significantly augmented by new hunchback gene ...
Untranslated in Biological Dictionary

Untranslated RNA

... protein synthesis: ... DsrA is a small untranslated RNA that regulates expression of two global ... The untranslated RNA DsrA regulates at least two global ... by ... An RNA domain within the 5' untranslated region of the tomato bushy stunt virus ... of ...

Untranslated region

... The five prime untranslated region (5' UTR), also known as the leader ... of the coding region . ... The three prime untranslated region (3' UTR) is a particular section of ... It follows the coding region . Five prime untranslated region The five prime ...

Leader sequence

... a sequence of mRNA ... The five prime untranslated region (5' UTR), also known as the leader ... shorter than that of LV and ... Five prime untranslated region The five prime untranslated region ( 5' UTR ), also known as the leader ...

Triplet repeat expansion

... ... Triplet Repeats in Noncoding Regions Fragile X syndrome (CGG repeat ) Fragile ... is caused by the expansion of a (CGG)n repeat in the 5′ untranslated region ... Fragile X Syndrome Triplet Repeat Expansion Disease ... Trinucleotide repeat expansion and human disease. Annu. Rev. ....

Start codon

... AUG is the start codon , methionine is therefore the first amino acid of many proteins. The start codon is almost always preceded by an untranslated region ... Determining the accuracy of start codon prediction is more ... start codon predictions on Escherichia coli genes using ... ...

Gene insertion

... changes the number of DNA bases in a gene by adding a piece of DNA. ... This insertion occurs in a part of the gene known as the 3' untranslated region, ... DNA ; extracellular ; extracellular matrix ; gene ; insertion ; kilobase ; ... Gene , insertion ,biological ,biology ...

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