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Ubiquitin in Medical News

Blocking molecular pathway with whimsical name possible therapeutic target for pancreatic cancer

... SINA produces a family of RING domain E3 ubiquitin ligases. In all creatures, ubiquitin ligases turn cell pathways on or off by degrading proteins. In humans, the SIAH ubiquitin ligases sit smack in the middle of the molecular ...

Penn scientists find a protein that inhibits Ebola from reaching out to infect neighboring cells

... host proteins such as tsg101 and Nedd4, an E3 ubiquitin ligase. ubiquitin itself is thought to be exploited by Ebola virus ... demonstrated that ISG15 interacts with Nedd4 ubiquitin ligase and inhibits ubiquitination of VP40, thus ...

Quality control mechanism tags defective sperm cells inside the body

... without a tag. A small protein called ubiquitin marks abnormal sperm cells, including cells that ... optimal chance of fertilization. High levels of ubiquitin in the sperm can indicate low-sperm count or ... In many cases, the cells that are tagged with ubiquitin are obviously abnormal with two tails or two ...

Cancer stem cell marker also drives transcription in normal cells

... that the newly identified subunits work together to remove the ubiquitin moiety from monoubiquitylated histone H2B, similarly to what has been previously described in yeast, but also remove the ubiquitin moiety from monoubiquitylated histone H2A. The latter modification is not ...

JCI table of contents: Sept. 4, 2007

... fibers. Furthermore, in slow fibers, class II HDACs were degraded by the ubiquitin proteasome system such that slow fiber identity was maintained. In the ... cardiomyopathy because degradation of their sarcomere proteins by the ubiquitin proteasome system was reduced. Inhibitors of MuRF proteins have been ...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists

... St. Jude Children's Research Hospital, Memphis, Tennessee, is studying how cell division is regulated, in part, by the attachment of a protein called ubiquitin to other proteins throughout the cell. Understanding how ubiqutin is attached to its targets and how this attachment is recognized by cellular ...

Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment

... expression and activity went down. βarrestin2 locks up an androgen receptor by binding to it, then the pair bind to yet another protein, ubiquitin ligase, which tags the receptor as waste and the trio make their way to the cell's garbage dump. "The neat thing about it is βarrestin2 inhibits ...

Penn Medicine, CHOP researchers demonstrate first common genetic risk factors for autism

... deleted or duplicated genes along two major central nervous system gene networks in children with autism spectrum disorders. The changes were on the ubiquitin pathway, which is responsible for regulating synaptic operations and nervous system development. One ubiquitin-related gene studied, UBE3A, was ...

Gene helps protect tumor suppressor in breast cancer

... is destroyed when it is bound by the enzyme NEDD4-1, which attaches targeting molecules called ubiquitins that mark PTEN for destruction by the ubiquitin proteasome complex. Lin and colleagues showed that Rak saves PTEN from degradation by attaching a phosphate group to the protein, blocking ...

Proteasome inhibition affects epigenetic mechanisms

... and Western blot analysis were performed using isolated nuclei. They found that chronic ethanol feeding caused a significant inhibition of the ubiquitin proteasome pathway in the nucleus, which led to changes in the turnover of transcriptional factors, histone modifying enzymes, and, therefore, ...

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Ubiquitin in Medical Technology

St. Jude Study Gives New Insights Into How Cells Accessorize Their Proteins

... given environment. One of the major functions of ubiquitin is to mark a protein for disposal when its job ... CAND1, activating cullin-RING to then put ubiquitin onto a different target protein. The open state ... to function, helping cullin-RING transfer ubiquitin to its target protein. Schulman said that their ...

Autism Genes Discovered; Help Shape Connections Among Brain Cells

... The other gene cluster impacted by copy number variations belongs to the ubiquitin degradation pathway. Ubiquitins are a class of enzymes that eliminate ... ) Glessner et al, "Autism genome-wide copy number variation reveals ubiquitin and neuronal genes," Nature , published online April 28, 2009. ( ...

Rigel Ubiquitin Ligase Program Identifies Molecules With Anti-HIV Activity

... called Apobec3G. By recruiting Apobec3G into an ubiquitin ligase complex, Vif enables the ... compounds aimed at modulating the intracellular ubiquitin ligase signaling pathways utilized by Vif so that ... natural ability to fight the virus by means of a ubiquitin ligase target. By focusing on a host target, ...
Ubiquitin in Medical Definition

Muscle atrophy

... muscle undergoing atrophy is the "ATP-dependent, ubiquitin / proteasome pathway. In this system, particular ... at least four copies of a small peptide called ubiquitin onto a substrate protein. When a substrate is ... gained by coupling targeted proteins to an "E3 ubiquitin ligase ". Each E3 ...
Ubiquitin in Medical Dictionary

Semen

... -ubiquitin tag immunoassay) Test detects ubiquitin, a human protein that appears to be a universal marker of semen abnormalities; high levels of ubiquitin in sperm relate to a male infertility problem. BODY FLUIDS: Any fluid in the human body, such as blood , urine , saliva (spit), sputum , ...
Ubiquitin in Biological News

Muscle atrophy through thick but not thin

... not known. MuRF1, an atrophy-related gene, is a ubiquitin ligase that "ubiquitylates," or tags a protein, by attaching a ubiquitin molecule, marking it for degradation by the cell. ... components, whereas others fall victim to other ubiquitin ligases and autophagy. Inhibitors that work ...

A paradigm shift in immune response regulation

... Their results show that interaction with a linear ubiquitin chain is crucial for nuclear factor kappa B ... or the conjugation of small modifier ubiquitin (ubiquitination) - play a central role in ... collaboration to investigate the role of ubiquitin modification in these pathways. The ...

CSHL scientists discover new way in which ubiquitin modifies transcriptional machinery

... the addition of small protein molecules called ubiquitin to other, larger proteins. When ubiquitin "tags" are added to these larger molecules, it ... and colleagues to more comprehensively grasp how ubiquitin functions. They have discovered that Asr1 ...

St. Jude study gives new insights into how cells accessorize their proteins

... given environment. One of the major functions of ubiquitin is to mark a protein for disposal when its job is ... to cullin-RING, it activates the enzyme to attach ubiquitin to its target protein. In this activation process ... CAND1, activating cullin-RING to then put ubiquitin onto a different target protein. The open state ...

Glue inside the cell

... which constitute a subgroup of lymphocytes, ubiquitin is attached to the Malt1 protein in response to ... of T cell activation. Mechanistically, ubiquitin is virtually acting as all-purpose glue that ... to demonstrate the potential of targeting the ubiquitin system for the development of novel therapeutic ...

A study by the MUHC and McGill University opens a new door to understanding cancer

... In a cells interior, the function of the ubiquitin molecule is to clean house. It attaches itself to ... minutely controlled. This new study reveals that ubiquitin also promotes interactions between proteins known ... does not appear to function, partly because the ubiquitin does not attach itself correctly to the cell ...

Self-digestion as a means of survival

... which are destined to be discarded are marked with the small protein ubiquitin and this is recognised by a receptor located at the gateway to the ... proteins have a similar chain-like structure. At one end they bind to the ubiquitin that marks the protein aggregates and organelles that are to be degraded. ...

Conaway Lab identifies novel mechanism for regulation of gene expression

... tags (called ubiquitin) from other proteins. The presence of one kind of ubiquitin tag on a protein can mark it for destruction, but others serve as marks to ... to regulate these enzymes is very important because promiscuous removal of ubiquitin marks could lead to a failure to regulate properly the activities or ...

Model for angelman syndrome developed by University of Texas at Austin biologists

... The UBE3A protein is an enzyme that attaches a small protein called ubiquitin to other proteins. ubiquitin attachment signals that the tagged protein needs to be degraded. "The ...

RING finger protein 5 may guide treatment for muscle disease in older adults

... identify and remove those proteins that are not properly folded. ubiquitin ligase RNF5 (or RING Finger Protein 5) acts much like one of these ... he explains, still need to be addressed. We know the substrates for this ubiquitin ligase in C. elegans, but not yet in human muscle. ...

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Ubiquitin in Biological Technology

Scotland Highlights New Partnerships and Cutting-Edge Drug Discovery Research

... At this year's conference, Scotland will present a panel on 'The ubiquitin Story,' a look at an exciting new research area in which Scotland has ... for Cell Signaling (SCILLS) and the $14 million ITI Life Sciences ubiquitin Proteasome System (UPS) drug discovery program. Participating in the ...

United States Recognizes Leading Scottish Scientist for Disease Research

... field of life sciences is demonstrated by his longstanding commitment to collaboration across the industry. Recently, Sir Philip helped identify the ubiquitin Proteasome System (UPS) as a promising new source for key drug targets and is part of a global UPS research program partnering life sciences company ...

Cystic Fibrosis - Axentis Pharma Takes Over Patents and Continues Development of Innovative Platform Technology

... About the patent families The inventions which have now been acquired by Axentis Pharma describe the use of molecules for the enzymatic removal of ubiquitin markers in incorrectly folded proteins. The inventions also protect the use of the proteasome inhibitor Bortezomib (Velcade (R)) for second medical ...

Measurement of proteasome inhibition in live cells in Molecular Devices microplate fluorometers

... an ATP-dependent process where unwanted proteins are multiply-tagged with ubiquitin (a 76-amino acid protein). 1 The tagged proteins are then transported to ... zFP506.1) that is degraded by the proteasome without the requirement for ubiquitin modification. 5 To convert ZsGreen into a proteasomal substrate, its ...

Single-Cell Complementation of Barley Mlo Mutants Using a PDS-1000/He Hepta System

... sequences under the control of the strong constitutive maize ubiquitin 1 promoter was used for the barley experiments. For ... wild type and the GFP reporter genes whose expression is driven by a ubiquitin promoter. Approximately 24 hr after the biolistic transfer, we ...
Ubiquitin in Biological Products

Ubiquitin Fraction I Extract from GeneTex

Description:... is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted ... exchange resin. GTX80876 contains ubiquitin, ubiquitin conjugating enzymes (E2s), and ubiquitin ligases (E3s). GTX80876 is ideal for ...
Company:GeneTex

IRS Extract from GeneTex

Description:... is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted ... ubiquitin-free and ATP-free. GTX80877 contains ubiquitin activating enzyme (E1), most ubiquitin conjugating enzymes ...
Company:GeneTex

26S Proteasome Fraction Extract from GeneTex

Description:... is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted ... contains the full Hela cell compliment of ubiquitin activating enzyme (E1), ubiquitin conjugating enzymes (E2s), 20S and 26S ...
Company:GeneTex

Ubiquitin Fraction I from ABR-Affinity BioReagents

Description:... is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted ... anion exchange resin. EP-500 contains ubiquitin, ubiquitin conjugating enzymes (E2s), and ubiquitin ligases (E3s). EP-500 is ideal for demonstrating ...
Company:ABR-Affinity BioReagents

Ubiquitin/Proteasome Fraction II Extract from GeneTex

Description:... is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted ... ubiquitin-free and ATP-free. GTX80878 contains ubiquitin activating enzyme (E1), most ubiquitin conjugating enzymes ...
Company:GeneTex

UBC Fractions Extract from GeneTex

Description:... is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted ... These conjugation fractions contain ubiquitin c-terminal hydrolases. The addition of ubiquitin aldehyde is recommended for the inhibition of ...
Company:GeneTex

Goat Anti-FbxL7 Polyclonal Antibody, Unconjugated from GeneTex

Description:... cyclin F in which it was originally observed, is an approximately 40-amino acid motif that binds SKP1. F-box proteins are components of modular E3 ubiquitin protein ligases called SCFs (SKP1, cullin, F-box proteins), which function in phosphorylation-dependent ubiquitination. Immunogen: Synthetic ...
Company:GeneTex

Rabbit Anti-Human COP9 signalosome complex subunit 2 Polyclonal Antibody, Unconjugated from Aviva Systems Biology

Description:... COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes. The complex is also involved in ...
Company:Aviva Systems Biology

26S Proteasome Fraction Extract from GeneTex

Description:... role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome ...
Company:GeneTex

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Ubiquitin in Biological Definition

Proteasome

... and has openings at the two ends to allow entry of the targeted protein. 26S proteasome The 26 S proteasome is used for the digestion of ubiquitin -marked proteins. It is located on both sides of a cell's nuclear membrane and consists of a 20S core protease particle and two 19S regulatory ...

Signal transduction

... engaged in a hormone-receptor-complex can be deactivated, either by covalent modification (for example, phosphorylation), or by internalization (see ubiquitin ). Intracellular signal transduction Intracellular signal transduction is largely carried out by second messenger molecules. Ca ...

Transmembrane receptor

... transmembrane receptor. Most of them work through the intracellular domain. The most important ways are phosphorylation and internalization (see ubiquitin ). See also Signal transduction G protein Second messenger Neuromodulators ...
Ubiquitin in Biological Dictionary

Ubiquitin

... ubiquitin is a small, highly-conserved regulatory protein ... by the covalent attachment of one or ... ubiquitin ( yü′bikwə′tin ) ( biochemistry ) A small, ... cytoplasm and nucleus of all eukaryotes ubiquitin ligase A ...

Proteasome

... cells that is the site The scientific resource for elucidating the ubiquitin / Proteasome Pathway. ... Apoptosis meets proteasome , an invaluable therapeutic target of anticancer drugs. ... ubiquitin and Proteasome Proteasome , signalosome, & TPPII ('Zomes') ...

S phase

... the mitotic cycle during which DNA ... S phase . ( 2009) ... Cell cycle articles relating to ' S phase inhibitors' ... Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase . ... ... activity is restricted to the G1- S phase of the cell cycle. ... During S ...

Proteome

... -based plasma biomarkers for Alzheimer's disease" ... Proteome Resources provides enzymes, nucleases and protein expression services to ubiquitin and apoptosis research scientists in academic, government, ... Proteome Software would like to hear what you have to say about Proteomics, ...

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(Date:7/22/2014)... July 22, 2014 Getting breast implants is ... completely optional or due to medical necessity. Either way, women ... to prepare for it, says Robert Kraft, MD, Plastic Surgeon ... implant removal surgeries are performed each year in the United ... 70 percent of those procedures stem from three main problems: ...
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(Date:7/21/2014)... human nature to hate losing. , Unfortunately, it,s ... abandoning a solid strategy and thus increasing your chances ... conclusion of a Brigham Young University study published this ... finding is based on an analysis of two decades ... focused on whether coaches adjusted their personnel following games ...
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(Date:7/21/2014)... are reasons mammoths and mastodons could have been the ... from the University of Cincinnati, the famously fuzzy relatives ... it was trendy at the end of the ... an assistant professor of geology and anthropology, shows the ... were year-round residents and not nomadic migrants as previously ...
(Date:7/21/2014)... La. Dr. Mark DeCoster, the James E. ... Louisiana Tech University, will present as an invited ... at the Biopolis Research and Development Center in ... faculty member in Louisiana Tech,s Institute for Micromanufacturing, ... 2D and 3D cell and tissue models." ...
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