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tubule in Medical News

Bioartificial Kidney Cuts Death Risk, Improves Outcomes

... found that short-term replacement of renal cell function using the renal tubule assist device (RAD) -- the living cartridge that's critical to the ... of hollow fibers lined with a type of kidney cell called renal proximal tubule cells, which reclaim vital electrolytes, salt, glucose and water, and ...

'Renal Assist Device' reduces risk of death from acute kidney failure

... Journal of the American Society of Nephrology. The experimental renal tubule assist device (RAD) appears safe and effective for desperately ill ... The RAD is a conventional blood filter device lined with human renal tubule cells, grown from donor kidneys. "The cells are made available to carry ...

Head-to-Head 96-Week Study Shows EPZICOM(R) is Comparable to Truvada(R) in Efficacy and Safety Measures in HIV Treatment-Naive Patients

... (4% vs. <1%). Prospective HLA-B*5701 screening was not employed in this study. One percent of patients receiving Truvada developed proximal renal tubule dysfunction (vs. 0% for EPZICOM). Overall, treatment-limiting adverse events were comparable between the two arms. Important Information about ...

New treatment option studied for bladder cancer

... common cancer, often obstructs tubules that connect the kidney to the bladder, says Dr. Coleman. While the cancer typically doesnt spread upward, tubule blockage damages the kidneys. Additionally, bladder cancer incidence peaks in the 60s and 70s when other diseases, such as type 2 diabetes and ...

Triptolide: A Potential Drug for Polycystic Kidney Disease

... arrest in certain cell types. Normal kidney tubule cells have a built in switch for regulating their ... development, cells destined to line a kidney tubule grow and divide until the tubule is formed, as sensed by fluid flow in the tubule. ...

New Hope for Kidney Failure

... -- or kidney failure -- occurs because of renal tubule cell death. When the researchers examined the ... high level of HGF actually protected the renal tubule cells. These cells play an important role in the ... that gene delivery of HGF to the proximal tubule may be an interesting approach in designing ...

Hope for Patients With Kidney Failure

... mice, they discovered the high level of HGF actually protected the renal tubule cells. These cells play an important role in the kidney's ability to ... the study researchers conclude that gene delivery of HGF to the proximal tubule may be an interesting approach in designing future strategies aimed at the ...

Chinese Medicinal Compound Stops Formation of Cysts in Polycystic Kidney

... compound. During normal kidney development, cells lining the kidney tubules continue growing and dividing until they receive a signal that the tubule is fully formed. The switch that turns on that signal consists of the growth regulatory proteins PKD1 and PKD2, located on hair-like cilia in the ...

Prestigious Wilson Award Goes To Yale Cell Biologist Joel Rosenbaum

... not flow in, because the cilia are missing, or the polycystins on the membrane are missing or ineffective, a signal is sent to the nucleus and the tubule cells divide—and continue to divide. PKD is, therefore, a cancer of the kidney, where cells that should not be dividing start to divide because of a ...

The Exposure Of Cadmium And Its Effects On Kidneys

... to calculate glomerular function. Urinary concentrations of calcium, human complex-forming protein, and N-acetyl-a-D-glucosaminidase--all markers of tubule function--were available for 813 women. The researchers additionally collected data on medications taken, smoking history, lead exposure, and ...

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tubule in Medical Technology

Telik Announces Telcyta Clinical and Preclinical Presentations at AACR Meeting

... Analog Prodrug, Exhibits Antiangiogenic Effects Including the Inhibition of Human Endothelial Cell Proliferation and Capillary tubule Formation In Vitro; Tuesday, April 17, 2007, 1:00 - 5:00 pm; Angiogenesis II: Novel Inhibitors; Abstract # 4622 Telik, Inc. of ...

First Phase II Short-Term Study on Dapagliflozin Shows Results on Safety, Tolerability and Glycemic Markers in Subjects With Type 2 Diabetes

... in Phase IIb development. About SGLT2 Inhibitors Glucose is normally filtered by the kidney, but nearly all of it is reabsorbed in the proximal tubule by SGLT2, which is located almost exclusively in the kidney. For patients with diabetes, retention of excess glucose by this pathway contributes ...
tubule in Medical Dictionary

Acute tubular necrosis

... Acute tubular necrosis Definition: Acute tubular necrosis is a kidney disorder involving damage to the renal tubule cells, resulting in acute kidney failure . Acute tubular necrosis Dehydration Diabetic nephropathy Eclampsia (a condition of pregnancy ...

Nephrocalcinosis

... . Some types of stones tend to run in families. Some types may be associated with bowel disease , ileal bypass for obesity , or renal tubule defects. ...

Renal

... be treated promptly. Levels of calcium and phosphorus should be monitored regularly in people who have renal disorders. renal collecting tubule The last part of a long, twisting tube that collects urine from the nephrons (cellular structures in the kidney that filter blood and form ...

Renal tubular acidosis

... . Some types of stones tend to run in families. Some types may be associated with bowel disease , ileal bypass for obesity , or renal tubule defects. Other causes of metabolic acidosis include severe dehydration -- resulting in decreased tissue perfusion (decreased blood flow), ...
tubule in Biological News

Rong Li Lab identifies new role of inflammatory protein in PKD and a possible treatment

... in the Rong Li Lab and first author on the paper. "We believe that this interaction could play a significant role in the transition from normal tubule development to the onset of Polycystic Kidney Disease (PKD) in individuals predisposed for the disease." Additionally, the team found that the ...

Bioartificial kidney under study at MCG

... system. The new device for kidney failure adds billions of kidney cells that can perform many of these important kidney functions. Human proximal tubule cells are collected from kidneys obtained by the National Disease Research Interchange, a nonprofit organization that provides researchers with ...
tubule in Biological Technology

An Image-Based Assay of Endothelial Cell Tube Formation as a Model of Angiogenesis

... Cells were imaged on the BD Pathway Bioimager in confocal and non-confocal mode using the 4 (NA 0.13) objective for quantification of tubule formation and 10 (NA 0.3) to generate higher resolution images. Results Initial results suggested that the tube formation ...
tubule in Biological Definition

Kidney

... (or Malpighian corpuscle ), and a renal tubule that extends from the renal corpuscle. Each ... . Kidney tissue The renal tubule is continuous with Bowman's capsule. The segment ... the Bowman's capsule is the proximal convoluted tubule . The next portion of ...

Nephron

... functional unit of the kidney . It is a tiny tubule consisting of a cluster of capillaries called the ... . Bowman's capsule leads into a long, convoluted tubule consisting of four sections: the proximal tubule , loop of Henle , ...

Spermatogenesis

... developing sperm cells - moving them towards the lumen of the semiferous tubule as they develop until maturity when they are released. The Sertoli cell ... spermatozoa. They are then released into the lumen of the seminiferous tubule and travel with fluid from the testis into the epididymis for further ...

Osmoregulation

... kidney) structure known as the glomerulus into Bowman's capsule or glomerular capsule (in the kidney's cortex) and flows down the proximal convoluted tubule to a "u-turn" called the Loop of Henle (loop of the nephron) in the medulla portion of the kidney. reabsorption - most of the viscous glomerular ...
tubule in Biological Dictionary

Proximal

... used as relative terms to ... The proximal tubule is the portion of the duct system of the nephron ... capsule to the loop of Henle. Proximal tubule Proximal Convoluted tubule Scheme of renal ...

Malpighian tubule

... The Malpighian tubule system is a type of excretory and osmoregulatory ... Information for research on the Malpighian tubule (insect kidney) ... The Drosophila melanogaster Malpighian tubule provides a unique opportunity to ... Fluid ...

Loop of Henle

... that leads from the proximal convoluted tubule to the distal convoluted tubule. The loop has ... insufficiency. long, U-shaped portion of the tubule that conducts urine within each nephron of ... of henle : The U-shaped portion of the renal tubule ... Encyclopedia article about loop of ...

Collecting tubules

... In the kidney, the collecting tubule is a tubular segment of the renal collecting ... duct system that connects the distal convoluted tubule to the cortical collecting duct. The ... hormones aldosterone ... collecting tubule ( kə′lektiŋ ′tü′byül ) ( anatomy ) One of the ...

Seminiferous tubules

... seminiferous tubules . G C Harris and H D Nicholson ... seminiferous tubule contractility ... seminiferous tubules in vitro (Niemi & Kormano 1965) ... In brief, that the seminiferous tubule is solely responsible for ... The seminiferous tubules of the testis ...

Sarcolemma

... in association with a highly organized ... dystrophin complex at the sarcolemma , but is secondarily reduced in the absence ... ... Plate T tubule Sarcolemma . Terminal Cisternae & Sarcoplasmic ... a. Invaginations of the sarcolemma penetrating deep into the interior of the muscle cell. ...

Glomerulus

... attacking the glomeruli , the tiny units. within the kidney where ... filtered in the glomerulus , and extra water. and wastes pass into the tubule and become ... Blood leaving the glomerulus passes into a second capillary network (not shown ... only 50% of the urea filtered at the ...

Endocytosis

... cell. ... The web site charts the history of our investigations into various aspects of clathrin-mediated endocytosis and other vesicle and tubule budding pathways. Research on the mechanism of dynamin in vesicle scission and endocytosis . ... of the PH domain of dynamin in ...

Brush border

... the body. Microvilli are approximately 100 nanometers in diameter and their length varies from ... (Redirected from Kidney proximal tubule brush border cell) ... 1.1 Brush border cell. 2 Divisions. 2.1 Pars convoluta. 2.2 Pars recta. 3 Absorption. 4 Secretion ... ...

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