Indian Scientists Identify Second Pancreatitis Gene
... its online edition, the mutation of cathepsin B works like a trigger for trypsinogen to become active prematurely inside the pancreas and thus damage the ... the west, the disease is caused by the mutation of another gene - cationic trypsinogen - and this mutation is not found among the populations of tropical ...Cellular self-eating promotes pancreatitis
... until it reaches the small intestine. But if trypsinogen converts to trypsin before its release, it can ... promotes this early activation by delivering trypsinogen to the lysosome, where enzymes turn it on. The ... symptoms. To determine whether autophagy promotes trypsinogen activation, the team dosed pancreatic cells from ...