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Tropism in Medical News

Monogram Biosciences Announces Immediate Availability of Enhanced Sensitivity Trofile(TM) HIV Tropism Assay

... of Monogram's Trofile(TM) HIV co-receptor tropism assay has made it substantially more sensitive at ... patients for CCR5 antagonist therapy. tropism refers to the chemokine co-receptor on the ... "Pfizer welcomes advances and innovation in tropism detection, such as the enhanced sensitivity of ...

Quest Diagnostics Licenses Technology Underlying SensiTrop(TM) HIV Co-Receptor Tropism Test from Pathway Diagnostics

... Diagnostics' SensiTrop(TM) HIV co-receptor tropism test. Tropism refers to the way a virus targets ... A molecular-based assay for HIV co-receptor tropism will help physicians personalize therapy for HIV ... and chief laboratory officer. "HIV co-receptor tropism tests can help physicians identify which ...

Monogram Announces First Medicare Payment for Trofile(TM)

... for healthcare providers references the need for tropism testing as indicated in the FDA labeling for ... that Monogram's Trofile Assay was the test for tropism on which the FDA clinical trials of ... the only clinically validated assay for assessing tropism of patients, is the only assay that has been used ...

Pathway Diagnostics Announces Commercial Availability of SensiTrop(TM) HIV Co-receptor Tropism Assay

... highly sensitive diagnostic provides patient HIV tropism status needed to initiate therapy with Pfizer's ... FDA label states that when initiating therapy, tropism testing and treatment history should guide the ... and patients when utilizing co-receptor tropism status to guide the use of Selzentry," said ...

Sales of Antiretroviral Agents Will Drive Substantial Six Percent Annual Growth in the HIV Drug Market Through 2013

... obstacles that include its limited patient eligibility and the lengthy tropism test required for its prescription. The landscape for CCR5 antagonists is expected to improve, however, once better tropism tests and improved protocols are established. About Decision ...

Monogram Biosciences Collaborates with Gilead Sciences for Elvitegravir Phase III Studies

... selection. Monogram is a leader in providing drug susceptibility and tropism assays for pharmaceutical development. PhenoSense GT(TM) is the only assay ... statements include references to the demand for our resistance and tropism assays, the size and timing of clinical trials utilizing our products and ...

Monogram Announces 2008 Second Quarter Financial Results

... cash, cash equivalents and short-term investments at June 30, 2008. Cash used in operations for the first six months of 2008 was $8.4 million. HIV tropism and Resistance Testing Recent significant developments in Monogram's HIV business include: -- Introduction in June of sensitivity enhancements to ...

Is it pancreatitis in acute abdominal pain in acute viral hepatitis?

... Hepatitis viruses have a strong tropism for hepatocytes; viral antigen also has been detected in pancreas and gallbladder. Acute pancreatitis is common in Fulminant hepatic failure but ...

Mixed HIV Coreceptor Use Associated With Lower CD4 Count

... of 37 days). The authors say they believe that this evidence of change in tropism is more likely to reflect the variability of the Trofile coreceptor assay used in the study rather than the speed at which tropism can switch in a treatment-experienced population. Dual-tropic viral ...
Tropism in Medical Technology

Monogram Biosciences Provides Progenics Pharmaceuticals with HIV Assays for Use in Clinical Trials

... Inc. (Nasdaq: PGNX) to provide resistance and tropism testing for Progenics' clinical development ... is using Monogram's Trofile(TM) tropism test to screen and monitor HIV infected ... Trofile is a patient selection co-receptor tropism assay that determines whether a patient is ...

DHHS Guidelines Support Use of Trofile(TM) Assay Prior to CCR5 Inhibitor Use

... Services (DHHS) recommend that a co-receptor tropism test, such as Monogram's Trofile(TM) assay, ... on Selzentry's label, which call for tropism testing prior to prescribing the drug. Pfizer's ... the importance of using a clinically validated tropism test to determine whether a patient should be ...

Monogram Provides Update on Trofile(TM) Co-Receptor Tropism Assay

... throughout the U.S. Monogram's co-receptor tropism assay, Trofile(TM), was used for patient ... for viral entry. Monogram's Trofile co-receptor tropism assay identifies whether individual strains of ... Trofile is a patient selection co-receptor tropism assay that determines which co-receptor a ...

Medicare Contractor Establishes Reimbursement Coding Guidance for Monogram's Trofile Assay

... of claims to Medicare for Trofile(TM) as tropism test for Pfizer's Selzentry(TM) SOUTH SAN ... browser). The article references the need for tropism testing as indicated in the FDA labeling for ... that Monogram's Trofile Assay was the test for tropism on which the FDA clinical trials of ...

Data Reported at ICAAC Indicates Selzentry(TM) Phase III Treatment-Naive Trial Shows Increased Efficacy When Used With Enhanced Trofile(TM) Assay

... assumes no obligation to provide updated information except as required by law. About Trofile Trofile is a clinically validated patient selection tropism assay that determines whether a patient is infected with a strain of HIV that uses either the CCR5 coreceptor, the CXCR4 coreceptor, or a combination ...
Tropism in Biological Technology

New Test from Quest Diagnostics Helps Physicians Choose HIV Antiretroviral Therapy in Patients with History of Drug Resistance

... antiretroviral therapies. The HIV-1 Coreceptor tropism Test, which reports results in approximately half ... medical officer, Quest Diagnostics. "Our new HIV tropism test will advance personalized medicine for HIV ... spent on a different drug." HIV coreceptor tropism refers to the preference of strains of HIV to ...

Sensitivity Enhancements to Monogram's Trofile(TM) Assay Demonstrate Improved Power to Select Patients for CCR5 Antagonist Therapy

... to the enhanced performance of the company's HIV tropism assay were presented in an oral presentation at ... is a clinically validated patient selection tropism assay that determines whether a patient is ... cells or both cell types defines the co-receptor tropism of the patient virus. Trofile is the only ...

Pathway Diagnostics Announces Commercial Availability of Second Generation SensiTrop(TM) II Molecular HIV Co-receptor Tropism Assay

... for determining the co-receptor tropism status of HIV infected patients. Pathway performs ... to the currently available biological HIV tropism assay," said Walter Narajowski, ... II is the first HIV genotype co-receptor tropism test that combines the sensitivity of HTA and the ...

Data Presented on Monogram HIV Tropism Tests at Retrovirus Conference sets New Standards of Assay Sensitivity

... Company Continues to Lead tropism Testing Field SOUTH SAN FRANCISCO, Calif., Feb. ... that data related to the company's advanced HIV tropism assay have been presented as multiple posters ... Enhanced Version of the Trofile HIV Co-receptor tropism Assay Predicts Emergence of CXCR4 Use in ...

Study Reaffirms Superiority of Trofile(TM) Assay

... Assay Is Discordant in Detecting HIV tropism with Clinically Validated Trofile SOUTH SAN ... have received Selzentry based on an inaccurate R5 tropism reading. Selzentry is only indicated for use ... which is the only clinically validated tropism assay," continued Young. "At Monogram, we believe ...

Pathway Diagnostics Announces Patent Issuance for the Diagnostic Measurement of HIV Tropism for the Initiation or Modification of HIV Therapy

... HIV tropism status needed to initiate therapy with Pfizer's ... technical foundation of Pathway's SensiTrop HIV tropism assay. "The patented technology underlying ... of Pathway Diagnostics. About HIV Co-receptor tropism and the SensiTrop(TM) assay The ability of the ...

Half of Surveyed Physicians Expect to Replace Between 6 Percent and 15 Percent of Their Sustiva Prescriptions with Isentress

... drug treatment. Physicians consider the prerequisite co-receptor tropism test for HIV patients to be a critical deterrent to prescribing CCR5 ... subsequent members of the CCR5 antagonist drug class will necessitate a tropism test prior to prescribing," said Sylvia Eash, Ph.D., analyst at Decision ...

Monogram Announces Third Quarter 2007 Financial Results

... the third quarter of 2006. Trofile(TM), Monogram's proprietary co-receptor tropism assay, was introduced commercially in August 2007 and, in September, ... of maraviroc for use in treatment-experienced patients selected by tropism testing -- availability, in mid September, of maraviroc throughout ...

Monogram Announces 2008 Third Quarter Financial Results

... $21.8 million in cash and cash equivalents at September 30, 2008. Cash used in operations for the first nine months of 2008 was $13.0 million. HIV tropism Testing "Monogram's enhanced Trofile Assay, introduced earlier this year with a thirty-fold improvement in sensitivity, has allowed a very ...

Medical Policy Guideline for Trofile(TM) Established By Wellpoint, Inc.

... that Wellpoint, Inc. has established a national Medical Policy Guideline for Monogram's Trofile Assay. Wellpoint's guidelines provide that HIV tropism testing with Trofile is considered medically necessary for selecting individuals for treatment with CCR5 antagonists (i.e. Selzentry(TM)) for ...
Tropism in Biological Dictionary

Tropism

... A tropism is a biological phenomenon, indicating growth or ... bending (biologists say, turning; see tropism ) upwards. ... A " tropism " is a plant movement triggered by ...

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