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triphosphate in Medical News

Duska Therapeutics Receives Comments From FDA on Phase 3 ATPace(TM) Protocol Synopsis

... the acute treatment of PSVT." ATPace, adenosine triphosphate injection, is a proposed drug for the termination ... in terminating PSVT. While both adenosine triphosphate and adenosine inhibit atrio-ventricular nodal conduction, adenosine triphosphate is believed to have dual inhibitory action; one ...

Pharmasset Nominates PSI-938 as a New Nucleotide Analog Inhibitor of Hepatitis C for Preclinical Development

... purine analogs are also active against the S282T resistant variant selected in vitro by the pyrimidine analogs, and are metabolized to the active triphosphate form through a different phosphorylation pathway than the pyrimidines. Given these characteristics, purine and pyrimidine analogs have the potential ...

Unique Collaboration Between TB Alliance and Tibotec To Accelerate Tuberculosis Drug Development

... studies show that it is highly active against Mycobacterium tuberculosis ( M.tb) . TMC207 has a unique mechanism of action targeting adenosine triphosphate (ATP) synthase, which M.tb , requires to generate its energy supply. Currently, TMC207 is being studied in a Phase II clinical trial in people with ...

Pharmasset Initiates Phase 1b Multiple Ascending Dose Clinical Trial of PSI-7851 in Chronic Hepatitis C Patients

... have not shown evidence of any mitochondrial or other cellular toxicities that may be associated with some nucleoside analogs. The half-life of the triphosphate in primary human hepatocytes is approximately 38 hours, which suggests the possibility for once-daily dosing. Like R7128, PSI-7851 has demonstrated ...

Cordex Receives Special Protocol Assessment Approval from FDA for ATPace(TM)

... Inc. Cordex is a specialty pharmaceutical company that develops new cardiovascular medicines based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of which ...

Cordex Pharma to Collaborate with BG Medicine in a Clinical Study of Heart Failure Biomarkers

... Inc. Cordex is a specialty pharmaceutical company that develops new cardiovascular medicines based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of which ...
triphosphate in Medical Technology

Pharmasset Nominates PSI-7851 as a Lead Development Candidate for the Treatment of Chronic Hepatitis C

... we have focused on increasing intrahepatic triphosphate levels, which may lead to a higher level of ... ability to deliver higher levels of the active triphosphate form of the drug into infected cells. PSI-7851 ... can achieve concentrations of active triphosphate in the liver of up to 1,000 times higher than ...

Pharmasset Announces Clevudine and R7128 Presentations at HEP-DART

... assay. The mode of inhibition for clevudine triphosphate was determined to be non-competitive. ... resistance to clevudine in vitro, clevudine triphosphate may be binding at or near the active site of the ... Since PSI-6130 is metabolized to two active triphosphate forms, it is enticing to speculate that the ...

Cordex Signs European Development Partnership for ATPotent(TM) Sperm Motility Drug

... Inc. Cordex is a specialty pharmaceutical company that develops new cardiovascular medicines based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of which ...

Three Independent Studies Include the ImmuKnow(R) Assay to Manage and Optimize Immunosuppression Therapy in Transplant Patients

... cellular immune status by detecting cell-mediated immunity (CMI) in adult immunosuppressed patients. It measures the concentration of adenosine triphosphate (ATP) released from CD4 cells following cell stimulation. The ImmuKnow test is a qualitative assay and does not directly quantify the level of ...

Living Donor Kidney Transplants Using Alemtuzumab Pre-Conditioning and Tacrolimus Monotherapy: Long-Term Safety and Efficacy

... cellular immune status by detecting cell-mediated immunity (CMI) in adult immunosuppressed patients. It measures the concentration of adenosine triphosphate (ATP) released from CD4 cells following cell stimulation. The ImmuKnow test is a qualitative assay and does not directly quantify the level of ...

An Independent Study Reports on the Utility of ImmuKnow(R), the Cylex(TM) Immune Cell Function Assay, for Monitoring Heart Transplant Recipients

... cellular immune status by detecting cell-mediated immunity (CMI) in adult immunosuppressed patients. It measures the concentration of adenosine triphosphate (ATP) released from CD4 cells following cell stimulation. The ImmuKnow test is a qualitative assay and does not directly quantify the level of ...
triphosphate in Biological News

Protein regulates movement of mitochondria in brain cells

... how the brain responds to a pathological state." Mitochondria are cellular power plants that generate most of the cell's supply of adenosine triphosphate (ATP), which is used as a source of chemical energy. While mitochondria are present in all of the body's cells, some cells because of their size ...

Models of eel cells suggest electrifying possibilities

... by engineering proteinsalready have been demonstrated by other researchers. Like the natural counterpart, the cells energy source would be adenosine triphosphate (ATP), synthesized from the bodys sugars and fats using tailored bacteria or mitochondria. ...

Biosensing nanodevice to revolutionize health screenings

... is part of a complex of proteins key to creating energy in all living things, including photosynthesis in plants. F1-ATPase breaks down adenosine triphosphate (ATP) to adenosine diphospahte (ADP), releasing energy. Previous studies of its structure and characteristics have been the source of two Nobel ...

Researchers probe a DNA repair enzyme

... genes and chromosomes). They do so by moving along strands of DNA, much the same way cars move on roads, using an energy-packed molecule, adenosine triphosphate (ATP) as a fuel source. Their primary function is to unzip double-stranded DNA, allowing replication and repair of the strands. DNA is a ...

Molecular 'signature' protects cells from viruses

... of this string. The RNA in the cell's nucleus basically also contains this triphosphate end. However, on top of it there is an additional short molecule, a ... of virus infections and cancer cases: for example, RNA chains with a triphosphate end could be produced and fed into cancer cells. This could also trigger ...

Researchers create artificial enzyme that mimics the body's internal engine

... known as mitochondria. Embedded in the membrane of each mitochondrion is a structure called the electron transport chain, which produces adenosine triphosphate (ATP), a molecule that is the source of the cell's energy. The transport chain is made up of a series of proteins known as electron carriers. Each ...

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triphosphate in Biological Technology

Duska Therapeutics Submits Phase 3 ATPace(TM) Protocol to FDA for Comment

... data on the safety and efficacy of adenosine triphosphate (ATP), which is the active pharmaceutical ... About ATPace(TM) ATPace(TM) (adenosine triphosphate injection) is a proposed product for the ... upon the emerging new pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules ...

Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver

... oral nucleotide prodrug designed to enhance the formation of its active triphosphate in the liver, while minimizing systemic exposure to IDX184 and the ... half-life of the nucleoside metabolite were similar to that of its active triphosphate measured in vitro in human hepatocytes. In this healthy volunteer study, ...

Phase II Trial Demonstrates Elacytarabine May Increase Survival Threefold in Patients With Late-Stage Leukaemia

... is thought to be mediated through increased cellular uptake, decreased deactivation and prolonged exposure to the active metabolite ara-C triphosphate (ara-CTP) within the cell. In the Phase II trial, Elacytarabine was given as a single agent to patients with late stage AML who had received ...

PeriCor Therapeutics Reports Positive Preclinical Results of GP531 at the European Heart Failure Congress in Nice

... adenosine -- during episodes of cellular stress. Cellular stress, as occurs with ischemia and tissue hypoxia, triggers the breakdown of adenosine triphosphate (ATP). ATP is the key energy molecule of living cells. Endogenous adenosine has been termed a "retaliatory metabolite" that targets multiple pathways ...

Serial Monitoring With ImmuKnow(R) is Useful in the Risk Assessment of Kidney Transplant Recipients

... cellular immune status by detecting cell-mediated immunity (CMI) in adult immunosuppressed patients. It measures the concentration of adenosine triphosphate (ATP) released from CD4 cells following cell stimulation. The ImmuKnow test is a qualitative assay and does not directly quantify the level of ...

Cordex Pharma Forms Heart Failure Medical Advisory Board

... Inc. Cordex is a specialty pharmaceutical company that develops new cardiovascular medicines based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of which ...

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triphosphate in Biological Products

Flow Cytometry Kit for Apoptosis from Sigma-Aldrich

Description:... is incorporated more readily into the DNA fragments than deoxyuridine triphosphate labeled with larger dyes such as FITC, biotin or digoxigenin. One of the ... apoptotic cells by labeling the 3'-hydroxyl sites with bromodeoxyuridine triphosphate (Br-dUTP). Br-dUTP is enzymatically attached to the 3-hydroxyl sites of ...
Company:Sigma-Aldrich

Apo-BrdU Apoptosis Detection Kit from eBioscience

Description:... terminal deoxynucleotidyl transferase enzyme (TdT), bromodeoxyuridine triphosphate (Br-dUTP), and fluorescein labeled anti-BrdU antibody for labeling DNA ... cells by labeling the 3'-hydroxyl ends with bromolated deoxyuridine triphosphate nucleotides (Br-dUTP). The enzyme terminal deoxynucleotidyl transferase ...
Company:eBioscience

Apo-Direct Apoptosis Detection Kit from eBioscience

Description:... deoxynucleotidyl transferase enzyme (TdT), Fluorescein-deoxyuridine triphosphate and propidium iodide/RNase A solution for counterstaining the total DNA. ... the 3'-hydroxyl ends with directly conjugated fluorescein- deoxyuridine triphosphate nucleotides (FITC-dUTP). The enzyme terminal deoxynucleotidyl transferase ...
Company:eBioscience

ApoBrdU Red DNA Fragmentation Kit from MBL International

Description:... cells for conveniently detecting DNA fragmentation by fluorescence microscopy or flow cytometry. The kit utilizes Br-dUTP (bromolated deoxyuridine triphosphate nucleotides) which is more readily incorporated into DNA strand breaks than other larger ligands (e.g., fluorescein, biotin or digoxigenin). The ...
Company:MBL International

ApoBrdU DNA Fragmentation Assay Kit from MBL International

Description:... cells for conveniently detecting DNA fragmentation by fluorescence microscopy or flow cytometry. The kit utilizes Br-dUTP (bromolated deoxyuridine triphosphate nucleotides) which is more readily incorporated into DNA strand breaks than other larger ligands (e.g., fluorescein, biotin or digoxigenin). The ...
Company:MBL International

ScriptCap m7G Capping System from EPICENTRE Biotechnologies

Description:... ScriptCap™ m7G Capping system features the Vaccinia capping enzyme and all of the components needed to produce a Cap 0 on the end of di- or triphosphate RNA transcripts. These kits feature high efficiency capping (virtually 100%) at a significantly better price than competitive capping ....
Company:EPICENTRE Biotechnologies

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triphosphate in Biological Definition

Nucleotide

... AMP Adenosine diphosphate ADP Adenosine triphosphate ATP Guanosine monophosphate GMP Guanosine diphosphate GDP Guanosine triphosphate GTP Thymidine monophosphate TMP Thymidine diphosphate TDP Thymidine triphosphate TTP Uridine monophosphate UMP ...

Signal transduction

... Ca 2+ upon interaction with inositol triphosphate (thus the name) on its cytosolic side. It ... 2+ , which leads to the production of inositol triphosphate , which in turn activates the InsP 3 receptor. ... second messenger molecules consists of inositol triphosphate and diacylglycerol . Others are ceramide and ...

Adenosine triphosphate

... uses of the initials ATP, see ATP (disambiguation) Adenosine triphosphate ( ATP ) is the nucleotide known in biochemistry as the " molecular ... have other "high-energy" nucleoside triphosphates, such as guanosine triphosphate . Between them and ATP, energy can be easily transferred with reactions ...

ATPase

... are a class of enzymes that catalyze the decomposition of adenosine triphosphate (ATP) into adenosine diphosphate (ADP) and a free phosphate ion . ... molecule of adenosine diphosphate (ADP) to form a molecule of adenosine triphosphate (ATP). This enzyme works when a proton moves down the concentration ...

Coenzyme A

... Coenzyme A ( CoA , CoASH , or HSCoA ) is adapted from pantothenic acid and adenosine triphosphate and used in metabolism in areas such as fatty acid oxidization and the citric acid cycle . Its main function is to carry acyl groups such ...

ATP synthase

... An ATP synthase ( EC 3.6.3.14) is a general term for an enzyme that can synthesize adenosine triphosphate (ATP) from adenosine diphosphate (ADP) and inorganic phosphate by utilizing some form of energy. The overall reaction sequence is: ADP + P i ...

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triphosphate in Biological Dictionary

Adenosine triphosphate

... Adenosine -5'- triphosphate (ATP) is a multifunctional nucleotide, and plays ... C 10 H 16 N 5 O 13 P 3 , that ... Adenosine -5'- triphosphate (ATP) is a multifunctional nucleotide, and plays ... of adenosine ... Nave, C.R. Adenosine triphosphate . ... Adenosine ...

Adenosine diphosphate

... two or more heteroatoms ) Adenosine monophosphate, diphosphate , and triphosphate (AMP, ADP, and ATP, respectively) are important participants ... ... ADP ( Adenosine diphosphate ; ... Adenosine diphosphate . Adenosine triphosphate (ATP) anabolic. catabolic. chemiosmosis ... ... free inorganic ...

Adenine

... cellular respiration, in the form of both the energy-rich adenosine triphosphate (ATP) and the cofactors nicotinamide adenine dinucleotide (NAD) and ... listen to free streaming mp3s, & read Adenine's blog. Adenosine triphosphate (ATP) is a nucleotide composed of adenine and three phosphate groups. ....

Skeletal muscle

... ... Anatomy and Physiology of Skeletal Muscle . Produce movement of joints by contracting. ... Produce heat (through the splitting of Adenosine triphosphate (ATP) ... The strength of skeletal muscle is directly proportional to its length and cross ... Skeletal muscle cells are stimulated by ...

Respiration

... of the metabolic reactions and processes that take place in organisms' cells to convert biochemical energy from nutrients into adenosine triphosphate (ATP), and then release waste products. ... Cellular respiration , the process in which molecules are converted into usable energy ... ...

Phosphorylation

... cancer ... Oxidative phosphorylation is a metabolic pathway that uses energy released by the oxidation of nutrients to produce adenosine triphosphate (ATP). Although the many forms of life on earth use a range of different ... In living cells phosphorylation is associated with ...

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