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Transporter in Medical News

Raptor Pharmaceuticals to Collaborate with Roche on Therapeutic Delivery Across Blood-Brain Barrier

... with Raptor's proprietary NeuroTrans(TM) BBB transporter platform. Under terms of the agreement, Roche ... has resulted in an intensive search for "BBB transporter molecules" that could be attached to these ... the development of Raptor's NeuroTrans(TM) BBB transporter molecules, in conjunction with Roche's ...

Transporter could help breast cancer cells commit suicide

... cancer. Tumor cells are smart; they silence the transporter to avoid death. No transporter means no pyruvate is getting into the cells." ... will try to force cancer cells to express the transporter and open the door for pyruvate. ...

2 Genes Implicated in Autism

... susceptibility genes -- PTEN and the serotonin transporter gene -- had more severe symptoms than mice with ... with a mutation in PTEN alone or in the serotonin transporter gene alone had brains that were larger than ... with mutations in both PTEN and the serotonin transporter gene had more severe symptoms. "We found that ...

New Approach Keeps Tumor Cells From Refueling

... which lactic acid enters oxygenated cells -- a transporter protein called MCT1 (monocarboxylate transporter 1). "The same transporter is present in the muscle where it helps to clear ...

PET scans help identify mechanism underlying seasonal mood changes

... tomography (PET) scan to assess serotonin transporter binding potential value, an index of serotonin transporter density. The higher the binding potential value, ... and winter or spring and summer. "Serotonin transporter binding potential values were significantly ...

New method to overcome multiple drug resistant diseases developed by Stanford researchers

... as other mammalian bodies. Using such a common transporter to ferry a potent medication inside a resistant ... of bonding a medication to an arginine-rich transporter to slip it past the cellular sentries could, in ... as well as other types of cancer. The arginine transporter manages to avoid ejection by slipping through the ...

DIA And FDA To Host Two Important Critical Path Workshops

... 15 -16; Bethesda, MD) and the Critical Path transporter Workshop (October 2-3; North Bethesda, MD). ... [Critical Path transporter Workshop] (October 2-3; North Bethesda, MD). ... [Critical Path transporter Workshop] will be held in collaboration with ...

Research shines spotlight on a key player in the dance of chromosomes

... The question is whether CENP-E acts like a transporter or like an anchor, Selvin said. A transporter moves things around the cell, whereas an anchor ... Selvin said. That is, we showed that it is a transporter in vitro, hauling around a little bead. Now we ...

Sticky blood protein yields clues to autism

... associates with and regulates the serotonin transporter (SERT), a protein that controls serotonin ... found that integrin beta3 can put the serotonin transporter into high gear, said Blakely. Notably, Edwin ... but rather we believe that the brains serotonin transporter may be controlled by integrin proteins in a very ...

New cataract gene discovered

... for the molecule that is carried by this new transporter across the membrane has now begun. The ... assume that defects in this newly discovered transporter may also be a cause of age-related cataract. ... gene. Understanding the exact function of this transporter may open new venues for non-surgical treatment of ...

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Transporter in Medical Technology

Genaera Corporation Announces MSI-1436 Data Presented at Society of Neuroscience Meeting

... that MSI-1436 does not inhibit the dopamine transporter in vivo by directly measuring dopamine levels in ... of dopamine reuptake by inhibiting the dopamine transporter (DAT), such as amphetamine and bupropion. Such ... that MSI-1436 may interact with the dopamine transporter but in vivo behavioral tests in rats did not show ...

Isis Highlights Robust Drug Portfolio for Diabetes and Obesity at ADA Conference

... that antisense drugs potently reduce levels of sodium dependent glucose transporter type 2 (SGLT2), a key component in controlling glucose re-absorption in ... diseases." About SGLT2 and ISIS 388626 The sodium dependent glucose transporter type 2 (SGLT2) is the primary mechanism responsible for glucose ...

Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594

... of serum uric acid observed with RDEA806. URAT1 is a specific urate transporter expressed in the kidney responsible for regulation of uric acid levels, ... in preclinical development and is believed to be an inhibitor of the URAT1 transporter in the kidney, which is responsible for regulation of uric acid levels. We ...

Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007

... an antidepressant. ITI-007 acts as a potent inhibitor of the serotonin transporter (SERT), a major target for most antidepressant drugs. To examine whether ... bipolar disorders. ITI-007 also has nanomolar affinity for the serotonin transporter (SERT). ITI-007 has a much lower propensity than several currently ...

Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007/ITI-722

... an antidepressant. ITI-007 acts as a potent inhibitor of the serotonin transporter (SERT), a major target for most antidepressant drugs. To examine whether ... bipolar disorders. ITI-007 also has nanomolar affinity for the serotonin transporter (SERT). ITI-007 has a much lower propensity than several currently ...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

... in Multiple Species and is Safe and Well-Tolerated," Dr. Sanjay Bhanot highlighted data that demonstrated that antisense reduction of SGLT2, a key transporter involved in glucose re-absorption in the kidney, produced the following results in preclinical models: Dose-dependent reduction in ...

Celladon Provides MYDICAR(R) Program Update of First-In-Human Trial for Advanced Heart Failure at American Society of Gene Therapy Annual Meeting

... M.D., Director of the Cardiovascular Research Center at Mount Sinai School of Medicine, New York, developed MYDICAR for restoring the SERCA2a calcium transporter in heart failure and validated the overall beneficial effects on cardiac function. MYDICAR is a recombinant adeno-associated viral (rAAV) vector that ...

Alseres Pharmaceuticals Completes Enrollment in First Stage of the Altropane(R) POET-2 Phase III Program

... medical facilities throughout the U.S. About Altropane Altropane is a molecular imaging agent that specifically binds to the dopamine transporter (DAT) protein found on the surface of dopamine-producing neurons, making it visible during Single Photon Emission Computed Tomography or "SPECT" ...

Intra-Cellular Therapies Announces Successful Outcome of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia

... dose tested (10 mg) we expect to have full occupancy of 5HT2A receptors while adding incremental amounts of D2 receptor and serotonin reuptake transporter (SERT) occupancy. This has been confirmed in an ongoing human Positron Emission Tomography (PET) study where we have demonstrated that this dose is ...

Ardea Biosciences Presents Preclinical Anti-Inflammatory Data on its Lead MEK Inhibitor, RDEA119, at the ACG 2008 Annual Meeting

... our lead product candidate for the treatment of gout, is being evaluated in a Phase 1 clinical trial and is believed to be an inhibitor of the URAT1 transporter in the kidney, which is responsible for regulation of uric acid levels. We are evaluating our lead MEK inhibitor, RDEA119, in a Phase 1 study in ...

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Transporter in Biological News

Scripps research scientists identify blood component that turns bacteria virulent

... factors. Without the presence of the bicarbonate transporter in the bloodstream, the scientists found, the ... treatment more urgent. Now, the bicarbonate transporter pathway may be investigated as a potential new ... a previously unknown ATP-binding cassette transporter (ABC-transporter)which is identified by the gene ...

Likely cause of postpartum blues and depression identified

... Ganapathy first reported evidence of serotonin transporter gene expression in the placenta back in 1989 in ... polymorphisms or variations of the serotonin transporter gene which already have been linked to ... have some of the same variations of the serotonin transporter gene already identified with non-pregnancy ...

N.Y. research team discovers how antidepressants and cocaine interact with brain cell targets

... the drug molecules bind in the neurotransmitter transporter -- their target in the human nervous system. ... was the realization that two binding sites on the transporter molecule need to be filled simultaneously and ... used the crystal structure of a bacterial transporter that is very similar to human neurotransmitter ...

News tips from the Journal of Neuroscience

... 1. Dopamine transporter Efflux in ADHD Michelle S. Mazei-Robison, Erica ... Elevated dopamine efflux through the dopamine transporter may underlie some forms of attention-deficit ... The authors identified a mutant form of dopamine transporter in two siblings with ADHD and expressed the ...

UCLA researchers clarify function of glucose transport molecule

... made during the determination of the glucose transporter structure was the possibility for structural ... with a previously crystallized neurotransmitter transporter molecule. Exploiting these similarities, along ... examining the manner in which inhibitors of the transporter proteins modulate function with the goal of ...

Defining gene's role may lead to prevention of dangerous corn toxin

... verticillioides - has a number of putative sugar transporter genes that are expressed during its growth on ... of ZFR1 also affects expression of the sugar transporter genes." Woloshuk and his colleague, Bert ... glucose recognition and the expression of sugar transporter genes. From this information, Woloshuk and his ...

Brain protein central to both Parkinson's, drug addiction identified

... addictive drugs. The action of the protein, known as organic cation transporter 3 or oct3, fills a longstanding gap in scientists' understanding of the ... dopamine neurons. That's where another molecule known as the dopamine transporter picks it up and brings it into the neuron itself. When the team blocked ...

The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders

... in two genes thought to play a role in anxiety disorders: the serotonin transporter gene and the gene for the enzyme COMT. Serotonin is a brain chemical ... that while the participants with the shorter version of the serotonin transporter gene developed a very strong physiological fear response to picture A, ...

Researchers iron out new role for serotonin

... novel traits linked to subtle genetic variation. The serotonin transporter protein (SERT) regulates serotonin availability in the brain and ... was eliminated (SERT "knock-out" mice) verified a critical role for the transporter in controlling brain iron levels. "Because SERT is such an important drug ...

Toxic bile damages the liver

... unknown and the appropriate treatment cannot be initiated. Defective transporter protein makes the bile toxic The Heidelberg University Hospital team, ... or at an adult age and lead to death. The gene ensures the production of a transporter protein that is responsible for the excretion of phosphatidylcholine into ...

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Transporter in Biological Technology

Genomas and Institute of Living Among Organizers of Pharmacogenetics Symposium at 2009 Annual Meeting of the American Psychiatric Association

... Hospital, Hartford, CT Cytochrome P-450 2D6, 2C19, and Serotonin transporter Genotyping for Depressed Inpatients at the Mayo Clinic Mood Disorders Unit ... M.F.A. Medical College of Wisconsin , Milwaukee, WI The Serotonin transporter Gene ( SLC 6A4): Understanding Variability and Enhancing the Clinical ...

Neurocrine Biosciences Reports Second Quarter 2009 Results

... to standard-of-care treatment; enrollment of 50 subjects is planned. VMAT2 Update The highly selective blockade of the Vesicular Monoamine transporter 2 (VMAT2) with NBI-98854 should be of clinical benefit in patients with a variety of CNS diseases, especially those with involuntary hyperkinetic ...

Neurocrine Biosciences Reports First Quarter 2009 Results

... and efficacy of UCN2 in this group. Initiation of this trial is expected in mid-2009 pending regulatory approval. Vesicular Monoamine transporter 2 Inhibitor (VMAT2 ) VMAT2 is a protein concentrated in the human brain that is essential for the transmission of nerve impulses between ...

Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia

... highest dose tested (10 mg) is thought to fully occupy 5HT2A receptors while adding incremental amounts of dopamine receptor and serotonin reuptake transporter (SERT) occupancy. Together, these data suggest that ITI-007 induces a novel pattern of sleep improvement. Doses of ITI-007 were safe and ...

Isis Initiates Phase 1 Clinical Trial of SGLT2 Antisense Drug

... study of ISIS-SGLT2Rx, an antisense drug that inhibits the production of sodium dependent glucose co-transporter type 2 (SGLT2). SGLT2 is the major transporter responsible for glucose re-absorption in the kidney. Decreasing SGLT2 levels promotes glucose excretion in the urine and reduces blood sugar levels, ...

Study Shows Machine Perfusion Significantly Improves Transplant Results

... in kidney survival and function when compared to those stored in a traditional "ice box", or cold storage. Unlike the icebox, the LifePort(R) Kidney transporter monitors the temperature and vascular performance of the organ in real time, while preserving it by pumping the kidney continuously with a cold ...

Ardea Biosciences to Present at the UBS Global Life Sciences Conference and the Third Annual JMP Securities Healthcare Focus Conference

... our lead product candidate for the treatment of gout, is being evaluated in a Phase 1 clinical trial and is believed to be an inhibitor of the URAT1 transporter in the kidney, which is responsible for regulation of uric acid levels. We are evaluating our lead MEK inhibitor, RDEA119, in a Phase 1 study in ...

Ardea Biosciences to Present Data on Gout and Inflammation Programs at the 2008 ACR/ARHP Annual Scientific Meeting

... our lead product candidate for the treatment of gout, is being evaluated in a Phase 1 clinical trial and is believed to be an inhibitor of the URAT1 transporter in the kidney, which is responsible for regulation of uric acid levels. We are evaluating our lead MEK inhibitor, RDEA119, in a Phase 1 study in ...

Ardea Biosciences to Present Data on Lead MEK inhibitor, RDEA119, at EORTC-NCI-AACR Symposium

... our lead product candidate for the treatment of gout, is being evaluated in a Phase 1 clinical trial and is believed to be an inhibitor of the URAT1 transporter in the kidney, which is responsible for regulation of uric acid levels. We are evaluating our lead MEK inhibitor, RDEA119, in a Phase 1 study in ...

Ardea Biosciences' Advances RDEA806 Into Phase 2a Proof-of-Concept Study for Gout

... RDEA594, our lead development candidate for the treatment of gout, is in preclinical development and is believed to be an inhibitor of the URAT1 transporter in the kidney, which is responsible for regulation of uric acid levels. We are evaluating our lead MEK inhibitor, RDEA119, in a Phase 1 study in ...
Transporter in Biological Products

Rabbit Anti-Human TAP2 Polyclonal Antibody, Unconjugated from Atlas Antibodies

Description:... Antigen peptide transporter 2 (APT2) (Peptide transporter TAP2) (Peptide transporter PSF2) (Peptide supply factor 2) (PSF-2) ...
Company:Atlas Antibodies

Mouse Anti-Vesicular Glutamate Transporter 2 (VGLUT2) Antibody, Unconjugated from CHEMICON

Description:... Vesicular Glutamate transporter 2 ...
Company:CHEMICON

Anti-Monocarboxylate Transporter 2 (MCT2) Polyclonal Antibody, Unconjugated from CHEMICON

Description:... Monocarboxylate (lactate) transporter ...
Company:CHEMICON

Anti-Glycine Transporter 2, Neuronal (GLYT2) Polyclonal Antibody, Unconjugated from CHEMICON

Description:... Glycine transporter 2, Neuronal (GLYT2). The antiserum has been tested on tissue sections from the central nervous system. The staining pattern obtained with AB1773 ...
Company:CHEMICON

Anti-Vesicular Monoamine Transporter 2 (VMAT2) Polyclonal Antibody, Unconjugated from CHEMICON

Description:... Vesicular Monoamine transporter 2 (VMAT2). An antibody made to the C-terminal VMAT2 peptide detected a major band at ~55 kDa in postnuclear supernatants of CHO transfected with ...
Company:CHEMICON
Transporter in Biological Definition

Blood

... of oxygen The amount of oxygen dissolved in blood is directly proportional to the PO2 of the blood. The hemoglobin molecule is the primary transporter of oxygen. 98.5% of the oxygen is chemically combined with the Hb . Only 1.5% is physically dissolved. Transport of carbon dioxide When ...

Endoplasmic reticulum

... in carbohydrate metabolism , detoxification of the cell (enzymes in the smooth ER detoxify chemicals), and calcium storage. It also is a large transporter of nutrient found in each cell. Functions The endoplasmic reticulum serves many general functions, including the facilitation of protein ...

Insulin

... in blood glucose levels through the following mechanism (see figure to the right): Glucose enters the beta cells through the glucose transporter GLUT2 Glucose goes into the glycolysis and the respiratory cycle where the high-energy ATP molecule is produced by oxidation Dependent ...

Endoplasmic reticulum

... in carbohydrate metabolism , detoxification of the cell (enzymes in the smooth ER detoxify chemicals), and calcium storage. It also is a large transporter of nutrient found in each cell. Functions The endoplasmic reticulum serves many general functions, including the facilitation of protein ...

Endoplasmic reticulum

... in carbohydrate metabolism , detoxification of the cell (enzymes in the smooth ER detoxify chemicals), and calcium storage. It also is a large transporter of nutrient found in each cell. Functions The endoplasmic reticulum serves many general functions, including the facilitation of protein ...

Endoplasmic reticulum

... in carbohydrate metabolism , detoxification of the cell (enzymes in the smooth ER detoxify chemicals), and calcium storage. It also is a large transporter of nutrient found in each cell. Functions The endoplasmic reticulum serves many general functions, including the facilitation of protein ...

Virus

... involved in attachment and entry into the host-cell. The complete virus particle is referred to as a virion . A virion is little more than a gene transporter and components of the envelope and capsid provide the mechanism for injecting the viral genome into a host cell. Viral replication Because ...

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Transporter in Biological Dictionary

Membrane transporter

... membrane proteins; that ... The dopamine transporter is a membrane -spanning protein that binds ... PharmTao Home ... region 1, candidate A; efflux transporter -like protein; imprinted multi- membrane ... Membrane transporter Glossary. Relevant Databases and Web Sources. ...

Intermembrane space

... European Bioinformatics Institute ... GO:0005758 mitochondrial intermembrane space ... 0042719 mitochondrial intermembrane space protein transporter ... ,biological,biology definition,biology terminology,biology terms,biology ... The intermembrane space is the region between the inner ...

Amp resistance

... to two well-known mechanisms. ... resistance due to the latter mechanism are termed β-lactamase-negative AMP ... In addition, the regulated transporter system may be involved in AMP resistance . ... bacterial metabolism that goes beyond the control of AMP resistance mechanisms. ... We are ...
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