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Translocation in Medical News

June 2008 highlights

... for oscillin. Eventually PLCZ1 undergoes nuclear translocation to the zygotes pronuclei where its ability to ... This study shows, for example, that PLCZ1 nuclear translocation does not occur in the rat, yet oscillations cease appropriately. Thus mechanisms controlling PLCZ1 translocation and its ability to promote calcium oscillations ...

St. Jude Discovery Offers New Avenues to Understanding an Aggressive Form of Leukemia

... Philadelphia chromosome, which results from the translocation (joining) of parts of two different chromosomes. The result of this translocation is the expression of BCR-ABL1, an oncogene. ... that all you need to get CML is that chromosomal translocation and BCR-ABL1 expression," Downing said. In ...

St. Jude discovery offers new avenues to understanding an aggressive form of leukemia

... Philadelphia chromosome, which results from the translocation (joining) of parts of two different chromosomes. The result of this translocation is the expression of BCR-ABL1, an oncogene. ... that all you need to get CML is that chromosomal translocation and BCR-ABL1 expression," Downing said. In ...

Scientists reveal structure of new botulism nerve toxin subtype

... protein-cleaving domains "flanking" a longer central region known as the translocation domain, essential for moving the toxin into the cell. "Because the ... and protein-cleaving domains of subtype E are both on the same side of the translocation domain. In addition, while all other subtypes are made of two protein ...

Janet Rowley, MD, A Researcher Funded by The Leukemia & Lymphoma Society, Receives Presidential Medal of Freedom

... patients with cancer. In 1973, Dr. Rowley showed that the Philadelphia Chromosome associated with chronic myelogenous leukemia (CML) was an abnormal translocation of two chromosomes. Her discovery was a key step in the eventual discovery of Gleevec, a targeted therapy for CML patients. Rowley, 84, is ...

Comprehensive Look at Rare Leukemia Finds Relatively Few Genetic Changes Launch Disease

... cancer, had that much DNA damage. Even more surprising, 34 percent of patients in this study lacked any apparent CNA, and 28 percent of those with a translocation lacked additional DNA abnormalities. Certain chromosomal re-arrangements are known as translocations. The investigators also found no ...
Translocation in Medical Technology

Medivation Announces Positive New Efficacy Data From Phase 1-2 Trial of MDV3100 in Advanced Prostate Cancer Patients

... with greater binding affinity than bicalutamide; impairs nuclear translocation and blocks DNA binding of the androgen receptor, one of the key steps ... antagonist that inhibits androgen receptor function by blocking nuclear translocation of the androgen receptor and DNA binding. About Medivation ...

Medivation Completes Enrollment of Phase 1-2 Trial of MDV3100 in Castration-Resistant Prostate Cancer Patients

... prostate cancer. MDV3100 is a novel small-molecule androgen receptor antagonist that inhibits androgen receptor function by blocking nuclear translocation of the androgen receptor and DNA binding. About Medivation Medivation, Inc. is a biopharmaceutical company focused on the ...

Mymetics' HIV Vaccine Achieves Research Breakthrough, Eliciting Protective Antibody Response in Mucosal Tissues of Non-Human Primate Model

... IgA antibodies, with strong potential for preventing in vitro virus translocation across the mucosal barrier and/or to inhibit cell infection, thus ... different anatomical compartments and block the early event of HIV translocation at the genito-reproductive and intestine tracts and subsequent ...

Mymetics' HIV Vaccine Demonstrates First-Ever Production of Neutralizing IgA Antibodies in Non-Human Primate Model

... IgA antibodies, with strong potential for preventing in vitro virus translocation across the mucosal barrier and/or to inhibit cell infection, thus ... different anatomical compartments and block the early event of HIV translocation at the genito-reproductive and intestine tracts and subsequent ...

Avalon Pharmaceuticals to Present at the American Association for Cancer Research 2007 Annual Meeting

... that will discuss AVN944 will be presented by the lab of Dr. Beverly Mitchell of Stanford University. The poster is titled, "GTP depletion induces translocation of TIF-IA and PAF53, inhibition of pre-rRNA synthesis and dislocation of nucleolar proteins." The presentation cites AVN944 as a compound that ...

DOR BioPharma Announces Issuance of European Patent for Its Oral Multivalent Botulinum Toxin Vaccine BT-VACC

... The claims in the granted European patent provide protection for the use of certain non-toxic mutants of botulinum toxin that are capable of translocation from the gut to the general circulation for preparation of an oral vaccine. "The grant of the European patent describing the ...
Translocation in Medical Products

TEL-AML1, t(12;21) Translocation by RT-PCR

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories

t(11;14) IgH-CCND1 Translocation by FISH

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories

PML/RARa t(15;17) Translocation by RT-PCR

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories

PAX-FKHR Translocation by RT-PCR

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories

MLL-AF4, t(4;11) Translocation by RT-PCR

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories

E2A-PBX1, t(1;19) Translocation by RT-PCR

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories
Translocation in Medical Dictionary

Translocation

... translocation Down syndrome refers to the rearranged ... chromosome , instead of being separate. translocation , reciprocal: A type of chromosome ... not belong to the same pair of chromosomes . translocation s may be balanced or unbalanced. For example, ...

Chromosomes

... who have had more than one miscarriage (spontaneous abortion ) have about a 5% chance that one member of the couple is carrying a chromosome translocation responsible for the miscarriage s. Chromosomes are the units of genetic information that exist within every cell of the body. Twenty-three ...

Fertility

... Part 1 Fertility FRIGIDITY SYMPTOMS"Absence of sexual desire, or an inability to find pleasure, in sexual intercourse . Parents with balanced translocation s may have fertility problems (trouble becoming pregnant), miscarriage s, or have an increased chance of having a child with health problems. ...

Miscarriage

... uterus , usually in the fallopian tube s, which are organ s that transport the egg from the ovary to the uterus ). Parents with balanced translocation s may have fertility problems (trouble becoming pregnant), miscarriage s, or have an increased chance of having a child with health problems. ...

Mosaicism

... in 400; by age 40 the risk increases to one in 110; and by age 45 the risk becomes one in 35. There is no increased risk of either mosaicism or translocation with increased maternal age. ...

Sickle-cell disease

... disease , systemic lupus erythematosus ( lupus or SLE) and many others ... Added text about the association of renal cell carcinoma with translocation s, sickle-cell disease , and neuroblastoma (cited Altinok et al. as reference 20). These conditions include infected burns , cat or dog bites ...

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Translocation in Biological News

Media highlights for February in Biophysical Journal

... article entitled Passage Times for Polymer translocation Pulled through a Narrow Pore appears in Volume ... available online. Passage Times for Polymer translocation Pulled through a Narrow Pore When polymeric ... at the pore. Present-day techniques can exploit translocation to recognize individual polymeric molecules by ...

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

... cancer, had that much DNA damage. Even more surprising, 34 percent of patients in this study lacked any apparent CNA, and 28 percent of those with a translocation lacked additional DNA abnormalities. Certain chromosomal re-arrangements are known as translocations. The investigators also found no association ...

Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals

... that the efficacy of the Opioid Growth Factor (OGF, [Met5]-enkephalin), a clinically important antitumor agent, is dependent on nucleocytoplasmic translocation and reliant on the integrity of nuclear localization signals in the OGF receptor (OGFr). This discovery, reported in the May 09 issue of ...

Scripps Research scientists shed light on how DNA is unwound so that its code can be read

... looks like a vise grip. They then found that RSC creates a little bulge in the DNA that can be propagated around the nucleosome and make possible translocation of the DNA with respect to the histones, exposing the DNA so that it can be read. "Imagine a rubber band wrapped twice around a water glass. The ...

Immunotherapy in high-risk pediatric sarcomas shows promising response

... Current studies are underway to test a new version of the vaccine, which utilizes more mature dendritic cells and tumor lysate in lieu of the translocation peptides. Ultimately, effective immunotherapy requires that one is capable of reproducing a strong and sustained immune response to tumor antigens," ...

Global warming experts recommend drastic measures to save species

... movement will prevent many species from shifting where they live in response to changes in local climate. They suggest that human-assisted translocation of individuals, often termed "assisted migration" or "assisted colonization," may be necessary to ensure colonization of new geographic regions as ...

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Translocation in Biological Technology

Biological electron transfer captured in real time

... The role of the respiratory chain is to couple electron transfer to the translocation of positively charged protons across the membrane, so that the ... ubiquinol. This reaction, as catalysed by Complex I, is linked to proton translocation across the membrane and thus leads to "charging the battery". At a later ...

Tigris Pharmaceuticals Presents Results of Breast Cancer Research at AACR Annual Meeting

... ovarian, lung and renal lines exhibiting particular sensitivity. The mechanism of action of AF is believed to be that treatment with AF results in translocation of the arylhydrocarbon receptor (AhR; a transcriptional regulator of CYP1A1) from the cytoplasm to the nucleus, and its subsequent interaction with ...

Medivation Announces New Positive Efficacy Data From Phase 1-2 Trial of MDV3100 in Castration-Resistant Prostate Cancer Patients

... prostate cancer. MDV3100 is a novel small-molecule androgen receptor antagonist that inhibits androgen receptor function by blocking nuclear translocation of the androgen receptor and DNA binding. About Medivation Medivation, Inc. is a biopharmaceutical company focused on the rapid ...

Japanese Cancer Association and Debiopharm Honour Japanese Research

... EML4-ALK (echinoderm microtubule associated protein like 4 - anaplastic lymphoma kinase) is a fusion protein resulting from a chromosomal translocation present in a relatively large percentage of NSCLCs (non-small cell lung cancers), a disease in which cancer cells form in the tissues of the lung. ...

Medivation Announces Presentation of 24-Week Clinical Data of MDV3100 in Castration-Resistant Prostate Cancer Patients

... prostate cancer. MDV3100 is a novel small- molecule androgen receptor antagonist that inhibits androgen receptor function by blocking nuclear translocation of the androgen receptor and DNA binding. About Medivation Medivation, Inc. is a biopharmaceutical company focused on the rapid development of ...

Performance of Ad-A-Gene EGFP-MAPKAP-k2: an adenoviral vector gene delivery system

... of an EGFP reporter assay for assessing the translocation of mitogen-activated protein kinase-activated ... of MAPKAP-k2 by p38 MAPK , and subsequent translocation of phosphorylated MAPKAP-k2 from the cell nucleus to the cytoplasm. translocation is thought to occur via phosphorylation-mediated ...

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Translocation in Biological Products

Canine Pancreatic Microsomal Membranes from Promega

Description:... Processing events such as signal peptide cleavage, membrane insertion, translocation and core glycosylation can be examined by the translation of the ... Applications: Examination of signal peptide cleavage, membrane insertion, translocation and core glycosylation. • Compatible with the TNT® Lysate ...
Company:Promega

Rabbit Anti-JTB Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.

Description:... Homo sapiens jumping translocation ...
Company:Proteintech Group, Inc.

MHC Volume 1 from Promega

Description:... of antigen-presenting cells analysis of MHC class II endocytosis and peptide turnover analysis of signalling via MHC class II molecules peptide translocation into the ER ...
Company:Promega

Rabbit Anti-SKAP55 Polyclonal Antibody, Unconjugated from ABR-Affinity BioReagents

Description:... with F-actin at the T cell-antigen-presenting cell synapse and promotes the clustering of LFA1 and TCR ligation. TCR engagement induces the translocation of SKAP55 to lipid rafts, where the interactions with Fyn take place. CD45 also plays a very important role in SKAP55/TCR-mediated signaling. SKAP55 ...
Company:ABR-Affinity BioReagents

Goat Anti-PAX3 Polyclonal Antibody, Unconjugated from GeneTex

Description:... Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative ...
Company:GeneTex

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Translocation in Biological Definition

Patau syndrome

... of the chromosome. Patau syndrome due to a translocation can be inherited. An unaffected person can carry ... This rearrangement is called a balanced translocation because there is no extra material from ... syndrome, people who carry this type of balanced translocation are at an increased risk of having children with ...

Proton pump

... provided by electron transfer or photosynthesis power this translocation of protons. For example, the translocation of protons by cytochrome c oxidase is powered by reducing equivalents ...

Cancer

... promote cancer when "switched on" by a mutation, whereas tumor suppressor genes prevent cancer unless "switched off" by a mutation. Chromosomal translocation , such as the Philadelphia chromosome , is a special type of mutation and may involve oncogenes or tumor suppressor genes. In general, mutations in ...

Infertility

... for another third, combined male and female infertility for another 15%, and the remainder of cases are "unexplained" 2 . A Robertsonian translocation in either partner may cause recurrent abortions or complete infertility. Female infertility Factors relating to female infertility are: ...

Phloem

... by negative pressures (tension) most of the time, movement through the phloem is driven by positive hydrostatic pressures . This process is termed translocation , and is accomplished by a process called phloem loading and unloading . Cells in a sugar source "load" a sieve-tube element by actively ...

Protein biosynthesis

... first tRNA is released, but the amino acid that is attached to the first tRNA is now moved to the second tRNA, and binds to its amino acid. This translocation continues on, and a long chain of amino acid (protein), is formed. When the entire unit reaches the end codon on the mRNA, it falls apart and a ...

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Translocation in Biological Dictionary

Translocation

... In genetics, a chromosome translocation is a chromosome abnormality caused by ... A fusion gene may be created when the translocation joins two otherwise separated ... translocation in plants, transport of food or pesticides ...

Signal Sequence

... is know as a " signal sequence " or leader peptide. ... The signal sequence is then threaded through a pore called the translocon. ... Upon translocation into that organelle, the signal sequence is removed. ... (proteins that go to the latter have their signal sequence at the C terminus) ... ...

Phospholipid bilayer

... in bilayer membranes ... measure phospholipid distributions and rates of membrane ... Schematic representation of phospholipid translocation or flip-flop across a bilayer . ... ... phospholipid bilayer by an external agent also alters the lateral organization ... Consider a ...

Phloem

... organic nutrients, ... In trees, the phloem is the innermost layer of the bark, hence the name, derived ... Phloem is responsible for the translocation of Carbohydrates and some other metabolites. It is important to remember however, that Phloem Sap is mostly Water. ... Information about ...

Olfactory bulb

... and centrifugal projections to the bulb ... We analyzed Mn in lung, liver, olfactory bulb , and other brain regions, and we ... Figure 5. translocation of instilled Mn to olfactory bulb in separate experiments. ... two main types of cells in the olfactory bulb , the mitral and granule ...

Dicentric

... and/or check the Send me a copy checkbox. ... We report a case of acute promyelocytic leukemia with dicentric chromosome resulting from translocation of chromosomes 11, 17, and 18. Dicentric Y chromosome in mixed gonadal dysgenesis. A Hayek and E Yunis ... The identity of the dicentric ...

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