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Transgenic in Medical News

Researchers identify 4 new targets for breast cancer

... resistant to breast cancer and then created four transgenic strains, each strain expressing one of the ... receptors and autotaxin, Mills said. "Now we have transgenic mouse models to test drugs to go forward against these targets." The four transgenic strains of mice have three unusual ...

Researchers identify four new targets for breast cancer

... resistant to breast cancer and then created four transgenic strains, each strain expressing one of the ... receptors and autotaxin, Mills said. "Now we have transgenic mouse models to test drugs to go forward against these targets." The four transgenic strains of mice have three unusual ...

Scripps Florida scientists devise accelerated method to determine infectious prion strains

... distinguishing among various strains combines a transgenic mouse model with a rapid and sensitive cell-based ... new test developed by Lasmzas and Weissmann, a transgenic mouse line called Tga20 plays an important role, ... target the brainstem and the thalamus of this transgenic mouse, explaining why these animals have a ...

A high-fat diet could promote the development of Alzheimer's

... this, the team led by Frdric Calon used a type of transgenic mice that produce two proteins found in the ... of afflicted patients. The researchers fed transgenic and regular mice different diets for nine months, ... any certainty that what we have observed among transgenic mice also occurs in humans, but there is no harm ...

Chemical liberated by leaky gut may allow HIV to infect the brain, Einstein scientists find

... and his colleagues had previously created a transgenic mouse line, HIV-TG mice, equipped with all the ... The HIV-TG mice were then bred with another transgenic mouse line, GFP-TG mice, containing the gene that ... fluorescent protein (GFP). The result: a double transgenic mouse line, HIV/GFP-TG mice, whose HIV-infected ...

Researchers develop first transgenic monkey model of Huntington's disease

... macaque model of a specific human disease using transgenic technologies, a marked improvement over mouse models. transgenic animals are created using a recombinant DNA ... at NIH. The Emory research team developed this transgenic monkey model by introducing altered forms of the ...

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Transgenic in Medical Technology

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

... for genome engineering in cells, plants and transgenic animals." In the first commercial ... exclusively express human antibodies encoded by transgenic human immunoglobulin genes. "Creating a knockout ... patients annually. For more information on our transgenic services offering, see ...

Sangamo BioSciences Provides Update on Company's 2008 Progress and 2009 Objectives

... Open Monoclonal Technologies (OMT) and Roche for transgenic animal generation. Financial -- ... the utility of ZFNs in the generation of transgenic animals and the potential broadening of the production of knockout transgenic models beyond mouse models (Doyon et al., 2008, ...

PharmAthene Initiates Phase I Clinical Trial of Nerve Agent Bioscavenger Protexia(R)

... and tolerability in humans. Protexia(R), which is produced in the milk of transgenic goats, is a recombinant version of human butyrylcholinesterase (BChE), ... About Protexia(R) Protexia(R), which is produced in the milk of transgenic goats, is a recombinant version of human butyrylcholinesterase (BChE), a ...

Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells

... revolutionized biology and enabled the generation of mouse cell-lines and transgenic mouse models of human disease. However, until now and the development of ... of knock-out cell lines for drug discovery, as well as novel stem cell and transgenic animal models. About Sigma-Aldrich Sigma-Aldrich is a leading Life ...

Awardees for the 2009 Young Investigator Grant for Probiotics Research Announced

... and International Health at the University of Virginia was selected for her research proposal, "The Influence of Novel Oligopeptides Produced by transgenic Bacteria on Intestinal Injury Due to C. difficile Infection." After certain inflammatory conditions, drug treatments, or infections, human gut ...

BN ImmunoTherapeutics Updates on Phase I/II Studies With Breast Cancer Vaccine

... immune response as compared to the original version. Furthermore, it proved to be efficacious in additional tumour immunotherapy models in HER2 transgenic mice. The immunological situation regarding HER2 in those mice strongly resembles the situation in humans. Based on those encouraging data ...

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Transgenic in Medical Definition

Autoimmune regulator

... chronic mucocutaneous candidiasis. [1] AIRE is expressed primarily in the thymus. A gene knockout of the murine homolog Aire has created a transgenic mouse model to study the mechanism of disease in human patients. [2] Research on the knockout mouse has demonstrated that Aire functions through ...
Transgenic in Medical Dictionary

Antithrombin III

... for chickenpox [Medication] ... antithrombin III (ATIII), transgenic form Antithrombin III is a plasma protein that helps prevent harmful ... definition, see listing in Dorland's Medical Dictionary, 28th, p. 100.) A transgenic form of antithrombin III is in ... [82,90,91,104,105] Clotting factor ...
Transgenic in Biological News

Restoring a natural root signal helps to fight a major corn pest

... pest include insecticides, crop rotation and transgenic Bt maize lines that are not yet approved in ... Subsequent laboratory studies confirmed that transgenic plants attracted significantly more nematodes ... of chemical pesticides," Degenhardt says. "The transgenic corn plants used in these experiments have no ...

Research uncovers promising target to treat chronic abdominal pain

... known to generate extra EAAT2 in the body. The transgenic mice had about twice the normal level of EAAT2, ... protein than would a normal mouse. Both the transgenic mice and mice treated with the antibiotic that ... superficial tissues or muscles and bones. The transgenic mice engineered to contain higher-than-normal ...

Growing fuel and medicine: Advancing biofuels and plant-produced therapeutics

... is often political resistance to field culture of transgenic plants. Here we show two examples of how both native and transgenic plants can be used in inexpensive bioreactors for ... protein, murine interleukin-12 (m-IL-12) in transgenic tobacco roots, and the sesquiterpene lactone ...

Bitter-tasting nectar and floral odors optimize outcrossing for plants

... plants that had received only a blind copy of the transgenic DNA fragment, transgenic lines were created (by means of RNA interference) ... smell of jasmine and strawberry. A fourth line of transgenic plants could produce neither nicotine nor benzyl ...

In scientific first, Einstein researchers correct decline in organ function associated with old age

... as well? To find out, Dr. Cuervo created a transgenic mouse model equipped with an extra gene one that ... 80 years old in humans), the liver cells of transgenic mice digested and recycled protein far more ... by injecting a muscle relaxant into very old transgenic mice and very old normal mice. The very ...

Scientists demonstrate means of reducing Alzheimer's-like plaques in fly brain

... illnesses, helped develop a line of transgenic fruit flies that was central in the experiments. transgenic organisms express genes that occur naturally in ... Dr. Zhong explained. Past experiments in transgenic mice expressing human beta amyloid had shown that ...

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Transgenic in Biological Technology

EnVivo Pharmaceuticals Announces Reversal of Cognitive Deficits in Alzheimer's Disease Transgenic Mouse Model With Gamma-Secretase Modulator

... deficits observed in an Alzheimer's disease transgenic animal model after chronic oral dosing of a ... reduces the production of AB42 in the brains of transgenic mice after two months of daily oral administration. In the same transgenic Alzheimer's disease model, mice developed ...

Sangamo BioSciences Reports Fourth Quarter and Full Year 2008 Financial Results

... use of ZFP technology to develop cell lines and transgenic animals . In July, Sangamo and Sigma-Aldrich ... (ZFN(TM)) technology to develop cell-lines and transgenic animals with targeted modifications in a ... for the commercial use of such ZFN-generated transgenic animals in the production of therapeutic and ...

Gene-engineered flies are pest solution

... reproductive sterility system for medfly based on transgenic embryonic lethality". The medfly is a ... degree of sterility. According to Wimmer, "When transgenic males carrying our transgenic system mate with wild females, all progeny die ...

Sangamo BioSciences Reports Second Quarter 2008 Financial Results

... (Roche) for the use of ZFP technology to develop transgenic animals. In July, Sangamo and ... (ZFN(TM)) technology to develop cell-lines and transgenic animals with targeted modifications in a ... the commercial use of such ZFN-generated transgenic animals in the production of therapeutic and ...

Sangamo BioSciences and Sigma-Aldrich Announce Research and License Agreement With Roche for the Use of ZFN Technology for Generation of Transgenic Animals

... transgenic Animals to be Developed for Therapeutic and ... high-value ZFN reagents for the generation of transgenic animals. ZFN technology promises to enable the generation of a variety of transgenic models of human disease, expediting drug ...

Sangamo BioSciences Announces License Agreement For the Use of ZFP Technology For Generation of Transgenic Animals

... problem that has long hampered the development of transgenic models in species other than mice," said Philip ... opens up the potential to more easily generate transgenic animals of any species." "We are pleased to ... with a non-exclusive, commercial license to use transgenic animals generated using our ZFN technology," said ...

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Transgenic in Biological Products

Immunodetection of Specific Proteins from QualTek Molecular Laboratories

Description:... Tissues Peroxidase, Alkaline Phosphatase, Immunogold, and Fluorescent detection Light, Fluorescent, or Electron Microscopy Protein Localization in transgenic Animals Hundreds of Specialty Markers, Including: Vector Detection with - Galactosidase Proliferation Markers - PCNA, Brdu, Ki67 Neural and ...
Company:QualTek Molecular Laboratories

In situ detection of RNA and DNA from QualTek Molecular Laboratories

Description:... RNA and DNA Screenings in Animal or Human Cells and Tissues Double Labeling of RNA / Protein in Cells and Tissues RNA and DNA Localization in transgenic Animals Light, Fluorescent, or Electron ...
Company:QualTek Molecular Laboratories

Neurobiology of Alzheimer's Disease from Promega

Description:... through clinical and diagnostic aspects, the molecular nature of beta-amyloid and tau proteins, the role of apolipoprotein E and the use of transgenic models. The neurochemistry, in particular potential areas for pharmacological intervention are also ....
Company:Promega

* Quick & Easy Conditional Knock Out Kit - FRT from Gene Bridges GmbH

Description:... This kit is designed for the fast and simple integration of FRT-sites into large vector plasmids at any position (for the generation of transgenic mouse models). The included FRT-PGK-gb2-neo-FRT cassette is designed to allow neomycin / kanamycin selection in prokaryotic and eukaryotic cells. It ...
Company:Gene Bridges GmbH

* Quick & Easy Conditional Knock Out Kit - loxP from Gene Bridges GmbH

Description:... This kit is designed for the fast and simple integration of loxP-sites into large vector plasmids at any position (for the generation of transgenic mouse models). The included loxP-PGK-gb2-neo-loxP cassette is designed to allow neomycin / kanamycin selection in prokaryotic and eukaryotic cells. ...
Company:Gene Bridges GmbH
Transgenic in Biological Definition

Biotechnology

... of substances like insulin or antibiotics . It can also refer to transgenic animals or transgenic plants , such as Bt corn. Genetically altered Mammalian cells, such as ...

Malaria

... Researchers at Imperial College London created the world's first transgenic malaria mosquito [3] , with the first plasmodium resisting species ... References Ito J, Ghosh A, Moreira LA, Wimmer EA, Jacobs-Lorena M. transgenic anopheline mosquitoes impaired in transmission of a malaria parasite . ...

Long-term potentiation

... PMID 8980239 Tang YP, Wang H, Feng R, Kyin M, Tsien JZ. "Differential effects of enrichment on learning and memory function in NR2B transgenic mice." Neuropharmacology . 2001 Nov;41(6):779-90. PMID 11640933 Hebb, D.O. (1949) The organization of behavior. Wiley, New York. ...

Molecular genetics

... induction of DNA deletions and subsequent selection for deletions in a gene of interest, the application of RNA interference and the creation of transgenic organisms that overexpress a gene of interest. Related topics The study of macromolecules important in biological inheritance forward ...

Reverse genetics

... systems ranging in complexity from cell-free translation in a test tube to humans. Finally, a more difficult genetics technique is the creation of transgenic organisms that overexpress a gene of interest. The resulting phenotype may reflect the normal function of the gene. ...

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Transgenic in Biological Dictionary

Transgenic mouse

... as recombinant ... Explanations about transgenic mouse and the history of biological experimentations ... ©2005 transgenicmouse.com - transgenic mice - TOP 100 BIOLOGY SITES ... Trangenic Mouse Facility - Home Page ... The UC Irvine transgenic Mouse Facility is a core facility that ...

Transgenic plant

... transgenic plants possess a gene or genes that have been ... genome by natural processes, the term " transgenic plants" refers ... transgenic Plants ...

Transgenic animals

... generally known as recombinant ... transgenic animals , i.e., engineered to carry genes from other species, have the ... Some transgenic animals are produced for specific economic traits. ... transgenic Animals The term ' transgenics ' refers to the ...

Transgenic animal

... transgenic animals are also becoming useful ... Animal Models - BSRC Alexander Fleming. transgenic Animal Models - Biomedcode ... A transgenic animal is one whose genome has been changed ...

Transgenic

... transgenic plants possess a gene or genes that have been ... genome by natural processes, the term " transgenic plants" refers ... A genetically ... ... The technology has already produced transgenic animals such as mice, rats, ... For example, ...

Satellite RNA

... category. ... Protective effect of a satellite RNA expressed in transgenic plants on disease ... transgenic tomato plants expressing satellite RNA are tolerant to some strains ......

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