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Transduction in Medical News

Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells

... native cellular binding sites reduced adenoviral transduction at least 100-fold. Insertion of the YSA peptide in the HI loop restored adenoviral transduction of EphA2R-expressing cells but not of cells lacking this receptor. YSA-mediated transduction was inhibited by addition of synthetic YSA ...

Potential Brain Cancer Drug for Children May Damage Bones

... - Animal Study Raises Caution on Using Signal transduction Inhibitors in Children - PHILADELPHIA, March ... would also occur in children, and while signal transduction inhibitors may still represent a highly promising ... patients who are adults. "Signal transduction inhibitors such as this drug may still ...

Potential brain cancer drug for children may damage bones

... Cell. The drug in question, HhAntag, is a signal transduction inhibitor--an agent that blocks signals along a ... current cancer research has focused on signal transduction inhibitors (STIs) because of their potential to ... would also occur in children, and while signal transduction inhibitors may still represent a highly promising ...

Pezcoller Foundation-AACR International Award for Cancer Research recognizes Axel Ullrich

... cited cancer scientists in the area of signal transduction research. We are proud to honor Axel ... the cancer problem through his study of signal transduction and genetics. For more than 25 years, ... signal transduction. Ullrichs work in signal transduction research has uncovered fundamental molecular ...

Brown researchers make major signal transduction discovery

... known as acetylation plays a central role in cytokine receptor signal transduction a fundamental biochemical cascade inside cells that controls the activity ... diseases, such as diabetes, cancer and heart disease, occur when signal transduction goes awry. That is why some drugs either inhibit or amplify signaling ...

Penn Veterinary Medicine report new strategy to create genetically modified animals

... to germ line genetic modification. It also demonstrates that germline transduction and germ cell transplantation in large animals provides an approach that ... transplantation model in the mouse to investigate whether AAV-mediated transduction of germ cells was possible and could result in transgene transmission, ...

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Transduction in Medical Technology

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

... anticancer agent that modulates Akt and several other important signal transduction pathways. Keryx is currently in the process of finalizing late-stage ... survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways ...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting

... to the retina. This suggests that inhibiting the PI3K/Akt/mTor signal transduction pathway by Palomid 529 may be neuroprotective to photoreceptors and ... one of which, TORC1, regulates cell growth by acting on the signal transduction protein S6K, while the other, TORC2, regulates cell survival through Akt. ...

Keryx Biopharmaceuticals, Inc. Reports Phase 1/2 Data on KRX-0401 (Perifosine) at 50th Annual Meeting of American Society of Hematology

... oral anti-cancer agent that modulates Akt and a number of other key signal transduction pathways, including the JNK and MAPK pathways, all of which are pathways ... survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways ...

Cytokine PharmaSciences Initiates Phase I Study of Oral Anti-Inflammatory Agent, CPSI-2364

... time." CPSI-2364 is a chemically-modified form of the synthetic guanylhydrozone, semapimod. Semapimod has been shown to inhibit the signal transduction pathways that lead to the production of nitric oxide and important pro-inflammatory cytokines, including TNF-alpha, IL-1, IL-6, and IL-8. Semapimod ...

Keryx Biopharmaceuticals Announces Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals Reports Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

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Transduction in Medical Dictionary

Adhesion

... another. DioxinA toxic chemical found in weed killers that has been linked to the development of endometriosis . Cell Adhesion and Signal transduction Research Interest: INTEGRIN-mediated interactions between cells and extracellular matrix protein s influence a variety of biological processes, such ...

Beta

... procedures. Local beta radiation is delivered to the site to inhibit re stenosis . Mfg: Novoste Corporation. The Wnt/ beta -catenin signal transduction pathway plays a critical role in axis formation and head versus trunk induction during early vertebrate embryogenesis. - A lack of beta ...

Inspection

... called a sigmoid oscope. Samples of tissue or cells may be collected for examination under a microscope. Also called procto sigmoidoscopy . signal transduction inhibitor ... Une inspection plus minutieuse des disques a indiqu que les bbs qui ont eu besoin de la plupart d'aide (IE. ces enfants en bas âge ...
Transduction in Biological News

Science expands Science Signaling, featuring research related to medical advances, and more

... by how cells talk to each other, through signal transduction pathways. By tracing the intricate pathways ... established an online journal, Sciences Signal transduction Knowledge Environment (STKE). Since then, the ... and Protocol articles offering context for signal transduction research. The site also includes a Database of ...

Investigating the development of mechanosensitivity

... it into electrical signals that are conveyed to the brain. Signal transduction has been investigated very thoroughly, which has led to the development of drugs that block the transduction of pain signals to the brain. Very little, however, is known about how ...

Magnetic nanoparticles navigate therapeutic genes through the body

... gene transfer under clinically relevant experimental conditions. For the transduction of human cells, gene carriers were coupled to magnetic nanoparticles and ... into the cells by magnetic field gradients. The efficiency of magnetic transduction turned out to be much higher than the nonmagnetic procedure. An additional ...

Irritable bowel syndrome can have genetic causes

... the composition or number of receptors on the cell surface. "The signal transduction in the digestive tract may be disturbed and this may lead to ... shows interesting correlations sero-tonin receptors are located on neural transduction pathways involved in pain perception and influence them which could ...

Scripps research scientists identify compounds for stem-cell production from adult cells

... DNA-associated packaging protein modificationbut rather at the cell signal transduction level. The scientists found that when transduced general cells were ... with BIX alone. In vitro and in vivo characterizations confirmed that transduction of only two factors with simultaneous treatment with small molecules BIX ...

Plant steroids offer new paradigm for how hormones work

... play the same role in the cell). To identify the links in the signal transduction chain, the researchers used the techniques of proteomics. "Proteomics is ... by Wang's study will have a major impact on studies of other signal transduction pathways. ...

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Transduction in Biological Technology

Laureate Announces Manufacturing Agreement with ARIUS for Trop-2 Targeting Antibody

... Candidate Trop-2 Signal transduction Antibody - PRINCETON, N.J., Jan. 31 ... cancer and other diseases, for its Trop-2 Signal transduction Antibody Program. Laureate will produce ARIUS' ... and the manufacturing of their Trop-2 Signal transduction Antibody," said Robert J. Broeze, ...

ARIUS announces manufacturing Agreement with Laureate Pharma For Trop-2 targeting antibody

... and the manufacturing of their Trop-2 Signal transduction Antibody," said Robert J. Broeze, ... manufacturing objectives." ARIUS' Trop-2 Signal transduction Antibody Program has produced the only ... Trop-2 was one of 12 selected. The Trop-2 Signal transduction Program was generated using ARIUS' ...

AEterna Zentaris Discloses Preliminary Phase 2 Trial Results for Perifosine in Combination with Radiotherapy for Non-Small Cell Lung Cancer

... cell lung cancer (NSCLC) with its novel, first-in-class, oral signal transduction inhibitor compound, perifosine. In 177 patients receiving radiotherapy for ... first-in-class, oral anti-cancer agent that modulates several key signal transduction pathways, including Akt, MAPK, and JNK that have been shown to be critical ...

GeneCopoeia Introduces Genome-Wide MicroRNA (miRNA) Functional Analysis Tools

... (270). These lentiviral vector based expression constructs allow efficient transduction of miRNAs into dividing and non-dividing cells transiently or stably, and can be used for in vitro assays and in vivo animal studies. The transduction efficiencies are monitored by the expression level of an ...

Keryx Biopharmaceuticals, Inc. Announces Second Quarter 2009 Financial Results

... adult and pediatric tumor types, both as a single agent and in combination with novel therapies. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Second Quarter 2009 Financial Results on Thursday, August 6, 2009 at 8:30am EDT

... adult and pediatric tumor types, both as a single agent and in combination with novel therapies. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

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Transduction in Biological Products

Mouse Anti-Cohesin (Scc1 / Rad21) Monoclonal Antibody, Unconjugated, Clone CM110-2C10 from MBL International

Description:... Anti-Cohesin (Scc1/Rad21) Monoclonal Antibody Research Focus: signal transduction Storage: -20C Shipping Temperature: ...
Company:MBL International

Mouse Anti-Rat GM130 Monoclonal Antibody, Unconjugated, Clone NN 2C10/1 from ABR-Affinity BioReagents

Description:... GM130 Immunogen: Recombinant purified rat GM130 Family / Subclass 1: Signal transduction Storage: 4 ...
Company:ABR-Affinity BioReagents

293FT Cell Line from Invitrogen

Description:... Normal;heading 1;heading 2;Many mammalian cell types and experimental situations create challenges for standard transfection and other viral transduction systems. ViraPower Lentiviral Expression System overcomes these challenges by efficiently ...
Company:Invitrogen

pLenti6/V5 Directional TOPO Cloning Kit from Invitrogen

Description:... Normal;heading 1;heading 2;Many mammalian cell types and experimental situations create challenges for standard transfection and other viral transduction systems. ViraPower Lentiviral Expression System overcomes these challenges by efficiently ...
Company:Invitrogen

Antibody MicroArray from Lab Vision

Description:... as internal control. Antibodies belonging to many important biological processes such as angiogenesis, apoptosis, cell cycle progression, signal transduction and gene expression are present on these microarrays. A reference chart showing all the antibody names and their respective coordinates on the array ...
Company:Lab Vision

Goat Anti-Wnt2 Polyclonal Antibody, Unconjugated from MBL International

Description:... Description: 100 g purified goat polyclonal antibody. Reacts with human/mouse/rat. Tested in Western blot/IP/IHC. Research Focus: signal transduction Storage: -20C Shipping Temperature: ...
Company:MBL International

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Transduction in Biological Definition

Signal transduction

... In biology , signal transduction is any process by which a cell converts one ... into another. Processes referred to as signal transduction often involve a sequence of biochemical ... referred to as signal transduction. In many transduction processes, an increasing number of enzymes and ...

Developmental biology

... the possible proteins. The transcription factors are regulated by signal transduction pathways that relay signals from outside of cells to the cell nucleus. Signal transduction pathways often involve receptors , receptor ligands and enzymes such as ...

Insulin

... metabolic level 4 Regulatory action on blood glucose 5 Signal transduction 6 The brain and hypoglycemia 7 Diseases and syndromes caused by ... inhibited by the stress hormone adrenalin (epinephrine). Signal transduction There are special transport channels in cell membranes through which ...

Oncogene

... Protooncogene A proto oncogene is a gene that is involved in signal transduction and execution of mitogenic signals, usually through its protein ... kinases (through overexpression ). Adaptor proteins in signal transduction . Transcription factors . Related articles Tumor ...

Transmembrane receptor

... play a unique and important role in cellular communications and signal transduction . Many transmembrane receptors are composed of two or more protein ... and internalization (see ubiquitin ). See also Signal transduction G protein Second messenger Neuromodulators ...

Bacterium

... in bacteria: transformation (the transfer of naked DNA from one bacterial cell to another in solution, this can include dead bacteria), transduction (the transfer of viral, bacterial, or both bacterial and viral DNA from one cell to another via bacteriophage) and; bacterial conjugation (the ...

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Transduction in Biological Dictionary

Transduction

... transduction is the process by which DNA is transferred from ... a viral vector. This is a common ... transduction (biophysics) is the conveyance of energy from a donor electron to a ... transduction (cybernetics) is a process or mechanism that ...

Signal transduction

... In biology, ' signal transduction ' refers to any process by which a cell ... stimulus into another. Most processes of signal transduction involve ordered sequences of biochemical reactions inside ... signal transduction ( ′signəl tranz′dəkshən ) ( cell and molecular ...

Transmembrane receptor

... tyrosine kinase binding to its ... GO:0007169 : transmembrane receptor protein tyrosine kinase signaling pathway ... 3.1.2 Signal transduction of transmembrane receptors by structural changes ... 4.1 Signal amplification at the transmembrane hormone receptor ... Online ...

Spermatogonia

... 1st order, 4 spermatocyte 2nd Spermatogonia represent a new route to transgenesis in mice ... But the factors influencing retroviral transduction into spermatogonia are not well understood. ... The mitosis of differentiating spermatogonia , the meiosis of spermatocytes, and ... ...

Oocytes

... In vitro maturation of oocytes . In vitro fertilization. Embryo culture and development ... Oocytes and embryos need to summon many signal transduction mechanisms, ... Abstract and Introduction: The authors discuss their experience with 2 new applications of in vitro maturation for oocyte ...

Olfactory nerve

... mucosa of the upper parts of the nasal cavity. ... An olfactory receptor neuron, also called an olfactory sensory neuron, is the primary transduction cell in the olfactory system. receptor neuron' target='_blank'>Full article >>> Aspects of the topic olfactory - nerve are discussed in ...

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