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Transcriptome in Medical News

Next generation data analysis for next generation sequencing data

... extraction of relevant biological knowledge from mammalian ChIP-seq and transcriptome studies. A typical analysis of a ChIP-seq experiment with 10 million ... conserved functional elements add another dimension of analytic power. transcriptome studies result in normalized and quantified expression values and allow ...

Salivary diagnostics, the 'magic mirror' to your health ... at your personal computer

... the proteome and the transcriptome. In the SKB, the salivary proteome and transcriptome are mapped to 23 human chromosomes, totaling1166 distinct proteins and 851 ... example, if one wants to know the differences in the salivary protein or transcriptome profiles of males and females, the user-friendly interface can be utilized ...

Genomatix takes a lead in Next Generation Sequencing

... Genomatix already provides the most complete genome annotation in terms of transcriptome and promoters available in its ElDorado database surpassing alternative ... processing and interpretation, providing additional information about the transcriptome and its regulation. Result data can be visualized by ElDorado in the full ...

TGen-led team is 1 of 7 selected for $1 million skin-cancer grants

... Garraway, M.D., Ph.D., Dana-Farber Cancer Institute Dan Gioeli, Ph.D., University of Virginia Proposal Title: Sequencing of the Melanoma Exome, transcriptome and Epigenome Principal Investigators: Team Lead: Ruth Halaban, Ph.D., Yale University Marcus Bosenberg, M.D., Ph.D., Yale University Michael ...

Paper Highlights Antimicrobial Effectiveness of Medical-Grade Honey in Topical Wound Care

... is an issue. Entitled, "The unusual antibacterial activity of medical-grade Leptospermum honey: antibacterial spectrum, resistance and transcriptome analysis," the report describes the palliative effects of Leptospermum honey. Indigenous to New Zealand and Australia, Leptospermum honey ...

Best New Product Awards Winners Named at Molecular Medicine Tri-Conference

... and analyze their data. Ovarian Cancer DSA Research Tool The Ovarian Cancer DSA(TM) research tool is the first high-density disease focused transcriptome based microarray for the study of ovarian. With ~100,000 transcripts derived from ovarian tissue, the Ovarian cancer DSA(TM) research tool represents ...

Newly discovered virus linked to deadly skin cancer

... analyzed nearly 400,000 messenger RNA genetic sequences from four samples of MCC tumor tissue using a technique refined in their lab called digital transcriptome subtraction (DTS). Comparing the sequences expressed by the tumor genome to gene sequences mapped by the Human Genome Project, the researchers ...

Scientists Use Saliva's 'diagnostic Alphabets' to Diagnose Disease

... in saliva. The salivary proteome and the salivary transcriptome are two diagnostic alphabets that are ready for ... of over 1,500 proteins in saliva. The salivary transcriptome revealed ~3,000 mRNA species in saliva, of which ... examined. Using the salivary proteome and transcriptome as diagnostic alphabets to search for diagnostic ...

Scientists Identify Genes Activated During Learning and Memory

... have not focused on a complete set of genes, nor has the work been searchable, according to Barth. But now, their online database of the plasticity transcriptome includes the gene name, symbol and reference number — data that are not usually all collected and made freely available. 'By using standard ...
Transcriptome in Medical Technology

Research Teams at J. Craig Venter Institute and Ludwig Institute for Cancer Research Uncover New Chromosomal Alterations in Cancer Using Transcriptome Sequencing Approach

... breast cancer cell line, HCC1954 and performed high-throughput transcriptome sequencing. Previous studies on this cell line have uncovered certain ... that this gene might be implicated in cancer. The team concluded that transcriptome sequencing with next generation sequencing technologies such as the 454 ...

ALS Therapy Development Institute Partners with Clinical Centers to Establish Pathological Mechanisms of Lou Gehrig's Disease

... for treating the disease. The data analysis from this developing translational database has already begun and will be compared with the ALS TDI transcriptome database for the SOD1 mouse collected last year. To date, the Institute has cataloged and analyzed the world's largest collection of information on ...

454 Sequencing(TM) in Science Today: Researchers Uncover a Genetic Basis for Different Social Behaviors in Wasps

... Sequencer generates hundreds of thousands of long, highly- accurate reads in a single run, giving researchers unprecedented detail and accuracy for transcriptome profiling and gene expression applications," explained Michael Egholm, Ph.D., Vice President of Research and Development at 454 Life Sciences. "These ...
Transcriptome in Biological News

New genomic technique uncovers coral transcriptome

... methods, researchers have uncovered the larval transcriptome of a reef-building coral ( Acropora millepora ). ... and John Colbourne, developed a new method for transcriptome analysis based on next-generation 454 sequencing technology. De novo transcriptome analysis is a cost-efficient alternative to ...

New technique used to profile anthrax genome

... but going to a deeper level and defining the transcriptome has been a much more difficult task," said ... one gene at a time, and a completely defined transcriptome was out of reach for even the most widely studied ... Bergman noted. "Sequencing-based transcriptome profiling has several huge advantages over ...

New plant study reveals a 'deeply hidden' layer of the transcriptome

... La Jolla, CA Cells keep a close watch over the transcriptome the totality of all parts of the genome that are ... in plants and a deeply hidden layer of the transcriptome that is tightly regulated by exosome activity, ... down exosome activity, you see changes in the transcriptome that are not visible under any other ....

Cancer signatures uncovered

... analysis of the relationship between the neoplastic and developmental transcriptome provides an outline of trends in cancer gene expression. The research, ... genes or processes to the biology of aggregates on the order of the entire transcriptome is likely to be useful in establishing highly robust molecular ...

Deep sequencing study reveals new insights into human transcriptome

... of the human transcriptome. They found that 34% of the polyadenylated transcriptome mapped to so far non-annotated genomic regions. Obviously a large number ... first time to explore directly the complexity and dynamics of the human transcriptome with a reasonable effort. This will lead to a new picture of the mammalian ...

Charting the epigenome

... postdoctoral researcher and co-first author Ryan Lister, Ph.D. The transcriptome encompasses all RNA copies or transcripts made from DNA. The bulk of ... methylation at single-base resolution and to sequence the complete transcriptome within a reasonable timeframe. Collaborating scientists at the ARC ...

Landmark project to map genomics of complex ant systems

... other microbes that benefit the ants and their crops. As a recipient of the highly competitive 10 Giga-base Grant Program for DNA sequencing and transcriptome analysis from Roche Applied Sciences, Gerardo put together a project to not only sequence ant genomes for the first time, but also the genomes of ...

New early detection studies of lung cancer in non-smokers launched today

... from Subjects with Lung Cancer Arising in Current, and Never Smokers (Principal Investigator (PI): Hanash) Genome analysis: Mining the Genome and transcriptome in Lung Cancer from Never Smokers (PI: Gazdar) Cellular alterations: Mitochondrial Mutations in Lung Cancer from Never Smokers (PI: David Sidransky, ...

GEN highlights increasing use of digital gene expression profiling

... of expression profiling data. The scientists predict that with the continuously increasing number of reads at reduced costs, RNASeq, a.k.a. whole transcriptome shotgun sequencing, will become affordable for standard differential gene-expression analysis. DNAStar recently introduced QSeq, the first product ...

Earthworm detectives provide genetic clues for dealing with soil pollution

... soil contaminants on L. rubellus in the open access journals, BMC Biology and BMC Genomics. Using a new 8,000-element microarray, they describe the transcriptome profile of L. rubellus exposed to copper, cadmium, the polyaromatic hydrocarbon fluoroanthene, and the agrochemical atrazine. In both studies this ...

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Transcriptome in Biological Technology

Jivan Focuses on Solutions for Transcriptome Sequencing

... bioinformatics solutions for high-throughput transcriptome sequencing (RNA-Seq) and expression. Leveraging ... situated to address the informatics challenges of transcriptome sequencing," said Subha Srinivasan, PhD, CEO of ... a database for analysis of mRNA expression from transcriptome sequencing. It enables advanced expression counts ...

First Catalog Cancer Biochip for Sequence Capture Now Available from febit

... For its main applications -- HybSelect, febit's innovative DNA capture method for Next-Generation-Sequencing and protein-coding or non-coding transcriptome profiling -- the highly advanced microfluidics of the patented Geniom Biochip offers the highest degree of automation, flexibility and efficiency ...

febit First to Offer Newly Published Mouse Genome on a Chip for DNA/RNA Detection and Enrichment

... For its main applications - HybSelect, febit's innovative DNA capture method for Next-Generation-Sequencing and protein-coding or non-coding transcriptome profiling - the highly advanced microfluidics of the patented Geniom Biochip offers the highest degree of automation, flexibility and efficiency ...

Paul Keim Appointed to febit's Scientific Advisory Board

... For its main applications -- HybSelect, febit's innovative DNA capture method for Next-Generation-Sequencing and protein-coding or non-coding transcriptome profiling -- the highly advanced microfluidics of the patented Geniom Biochip offers the highest degree of automation, flexibility and efficiency ...

Norgen Biotek Corp. Announces OEM Manufacturing & Supply Agreement with Exiqon A/S

... approach. Such powerful tools are of a significant benefit to researchers who are interested in studying the genome, proteome and transcriptome of a single precious sample for gene expression and biomarker discovery. Norgen is a pioneer in macromolecular fractionation and is enabling ...

Automated Sequence Capture for Next-Generation Sequencing Paves the Way for Personalized Medicine

... For its main applications, HybSelect -- febit's innovative DNA capture method for Next-Generation-Sequencing -- and protein-coding or non-coding transcriptome profiling, the highly advanced microfluidics of the patented Geniom Biochip offers the highest degree of automation, flexibility and efficiency ...

Applied Biosystems SOLiD System Named Life Science Innovation of the Year : The Scientist Magazine Cites the Technology's High Throughput, Lower Sequencing Cost, and Rapid Technology Innovation for Unlocking New Approaches to Clinical Research

... In total, the SOLiD 3 System offers a complete workflow solution for many applications such as whole genome sequencing, targeted resequencing, whole transcriptome analysis, gene expression profiling, small RNA characterization, methylation profiling, and chromatin-immuno precipitation sequencing analysis. These ...

Sigma-Aldrich Releases WTA2, a Transplex Whole Transcriptome Amplification Technology for Degraded RNA Samples

... research community," said Helge Bastian, Vice President of Marketing for Sigma-Aldrich's Research Biotech Business Unit. "The TransPlex(R) Whole transcriptome Amplification product line adds an important tool for researchers who work with limited quantity and quality of RNA samples." The TransPlex WTA ...

Compendia Bioscience Announces the Receipt of a $2.4M SBIR Award and Related Management Changes

... continued commercial adaptation of this important product." Oncomine, a dynamic system that combines a rapidly growing compendium of 20,000+ cancer transcriptome profiles with a sophisticated analysis engine and a powerful web application for data mining and visualization, facilitates rapid and reliable ...
Transcriptome in Biological Dictionary

Transcriptome

... The transcriptome is the set of all messenger RNA (mRNA) ... transcripts present in a ... No, a transcriptome is different from a genome, which is the entire DNA sequence ... A transcriptome represents the very small percentage of the ...

Nuclear genome

... ... Background Nuclear genome size varies 300 000-fold, whereas transcriptome size ... Background Nuclear genome size varies 300 000-fold, whereas transcriptome size ... on protist test cases of the basic principles of nuclear ...

Xenopus

... ... The GeneChip® Xenopus tropicalis Genome Array contains ... It did not emerge from prion research per se but rather a Xenopus genomic transcriptome project. ... Like doppels, xenopus prion has post-signal region, here ... Xenopus tropicalis is a unique resource for two critical areas in ...

Splicing

... transcription splicing sirna silencing regulation gene alternative by ... Deep surveying of alternative splicing complexity in the human transcriptome by ... Incorporates information about alternatively spliced genes, their products and expression patterns. ... Alternative pre-mRNA splicing ...

Poikilothermic

... a software that helps define phenological models of poikilothermic organism (insects) based on temperature ... ... multitissue analysis of the transcriptome of a poikilothermic vertebrate ... such as yeast and a higher organism like carp suggest that all poikilothermic ... a. The poikilothermic ...

Mature transcript

... how mature CheB42a and llz transcripts may be generated. ... Understanding the molecular mechanisms responsible for the regulation of the transcriptome present in eukaryotic ... different mature transcripts from the ... ... transcript , resulting in a mature transcript sequence that is ...

Haploid gametophyte

... haploid ( gametophyte ) and diploid ... Gametophyte : The multicellular haploid phase in the lifecycle of organisms with zygotic or ... transcriptome analysis of haploid male gametophyte development in Arabidopsis ... The haploid male gametophyte generation of flowering plants has a simple ...

CDNA library

... cDNA library is a collection of cloned cDNA fragments inserted into a collection of host cells, which together constitute some portion of the transcriptome of the organism. cDNA is produced from fully transcribed mRNA ... In genetics, complementary DNA ( cDNA ) is DNA synthesized from a mature ...
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