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Transcriptase in Medical News

HIV Drugs Linked to Increased Risk of Heart Attack

... a protease inhibitor and a nucleoside reverse transcriptase inhibitor such as abacavir or didanosine. ... For commonly used drugs called nucleoside reverse transcriptase inhibitors such as zidovudine, stavudine or ... heart attack. However, the nucleoside reverse transcriptase inhibitors abacavir and didanosine were ...

Overlooked Mutation Can Spur HIV Drug Resistance

... into a broad category of drugs called reverse transcriptase inhibitors (RTIs), so named because they target a ... the key points of resistance lay on the reverse transcriptase molecule, and so they designed their tests ... that's also essential to proper reverse transcriptase function. "Our logic for the current study ...

HIV integrase inhibitor effective for patients beginning antiretroviral treatment

... inhibitor, is overall as effective as widely used efavirenz, a reverse transcriptase inhibitor, the researchers found. Raltegravir also had faster onset of ... FDA. Other types of antiretroviral drugs inhibit HIV's protease or reverse transcriptase enzymes. Guidelines from the U.S. Department of Health and Human ...

Ardea Biosciences Reports Progress of Clinical Development Programs; Provides 2008 Outlook; Announces 2007 Financial Results and Provides 2008 Financial Guidance

... and favorable resistance profiles for our non-nucleoside reverse transcriptase inhibitor (NNRTI) family of compounds against HIV at the 15th Annual ... Our most advanced drug candidate is RDEA806, a non-nucleoside reverse transcriptase inhibitor (NNRTI), which is in a Phase 2a study for the treatment of HIV. ...

AAHIVM Encouraged by TMC125 Approval

... anti-HIV medication TMC125 (etravirine), the first non-nucleoside reverse transcriptase inhibitor (NNRTI) to be introduced in nearly 10 years, and the first to ... that partially or completely stop the NNRTI from binding to the reverse transcriptase enzyme, causing the drug to lose effectiveness. "With the FDA's ...

Ardea Biosciences' Lead NNRTI for HIV, RDEA806, to Enter Phase 2a Proof-of- Concept Clinical Trial

... viral load. About RDEA806 RDEA806 is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) for the potential treatment of HIV infection. Based on ... programs include: RDEA806, the Company's lead non-nucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV, which entered a Phase 2a ...

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Transcriptase in Medical Technology

Tibotec Pharmaceuticals Announces Agreement to Develop and Commercialize a New Fixed-Dose Combination of TMC278 and Truvada(R) With Gilead Sciences

... Tibotec's investigational non-nucleoside reverse transcriptase inhibitor (NNRTI) TMC278 (rilpivirine ... in combination with a non-nucleoside reverse transcriptase inhibitor or a protease inhibitor as a preferred ... is an investigational non-nucleoside reverse transcriptase inhibitor, and the safety and efficacy of it, in ...

Schering-Plough Expands Vicriviroc Phase II Study in Treatment-Naive Patients With HIV

... product in the nucleoside(tide) reverse transcriptase inhibitor (NRTI) class. The standard ... two NRTIs with either a non-nucleoside reverse transcriptase inhibitor (NNRTI) or a ritonavir-boosted PI.(4) ... 7 The DAD study group. Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in ...

Ardea Biosciences Reports Additional Positive Phase 2a Results for Lead HIV Candidate, RDEA806, Demonstrating Up to 1.9 Log Reduction in Plasma Viral Load with Once-Daily Dosing

... its novel investigational non-nucleoside reverse transcriptase inhibitor (NNRTI), in patients with human ... RDEA806 is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) for the potential treatment of ... is RDEA806, a non-nucleoside reverse transcriptase inhibitor (NNRTI), which has completed a Phase 2a ...

Schering-Plough Initiates Phase II Study With Vicriviroc in Treatment-Naive HIV-Infected Patients

... a combination product in the nucleoside reverse transcriptase inhibitor (NRTI) class. "A nucleoside-sparing ... two NRTIs with either a non-nucleoside reverse transcriptase inhibitor (NNRTI) or a ritonavir-boosted PI.(6) ... 9 The DAD study group. Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction ...

Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC

... the majority of HIV strains carrying key reverse transcriptase mutations, including coverage of the 10 most ... RDEA806 is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) for the potential treatment of ... the Company's lead non-nucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV, which ...

Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806

... D. -- "RDEA806, a Potent Non-Nucleoside Reverse transcriptase Inhibitor with Less Potential for Drug-Drug ... RDEA806 is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) for the potential treatment of ... the Company's lead non-nucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV, which ...
Transcriptase in Medical Dictionary

Retrovirus

... material. It uses an enzyme called reverse transcriptase to become part of the host cells’ DNA. This ... that contains a unique enzyme called reverse transcriptase that allows it to replicate within new host ... . (A retrovirus has an RNA genome and a reverse transcriptase enzyme . HUMAN IMMUNO DEFICIENCY VIRUS ( ...

Hiv infection

... HIV infection : Protease inhibitors (PIs) for HIV , Nucleoside reverse transcriptase inhibitors (NRTIs) for HIV , Nonnucleoside reverse transcriptase inhibitors (NNRTIs) for HIV , ... HIV Infection and AIDS : An ...

Anti

... organ function and survival rates by interrupting the growth of the abnormal cells that produce amyloid protein . NON-NUCLEOSIDE REVERSE transcriptase INHIBITORS (NNRTIS): The third class of anti - HIV drugs, NNRTIs bind near reverse transcriptase's active site and subsequently inhibit its ...

Chill

... of ventricular tachycardia . Not FDA approved. Bur chill SA, Lewis IJ, Abrams KR, et al.: Circulating neuroblastoma cells detected by reverse transcriptase polymerase chain reaction for tyrosine hydroxylase mRNA are an independent poor prognostic indicator in stage 4 neuroblastoma in children over ... ...

Cytomegalovirus

... intravenous ) See CytoGam Coactinon (emivirine; formerly identified as MKC-442) A nucleoside analogue that functions as a non-nucleoside reverse transcriptase inhibitor in the treatment of HIV infection and ... CMV ( Cytomegalovirus ) CO Poisoning ( Carbon Monoxide Poisoning ) CoA (Coarctation of ...

Host

... and adult-each of which is dependent on a live host for food . A retrovirus is a virus that contains a unique enzyme called reverse transcriptase that allows it to replicate within new host cells. coli is produced by several species of bacteria , allowing intra and inter-species ...

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Transcriptase in Biological News

FANTOM findings boost for biologists

... ). Further research published in BMC Bioinformatics highlights two new data-driven normalization methods for quantitative reverse transcriptase polymerase chain reaction (qPCR) experiments with larger data sets. Another study published in Genome Biology includes the first genome-wide ...

Efavirenz-based initial therapies associated with better outcomes in HIV-infected adults

... countries in Africa with the majority in South Africa. Current World Health Organization guidelines recommend the use of a non-nucleoside reverse transcriptase inhibitor such as nevirapine or efavirenz in resource limited settings. Nearly 67 percent of countries in sub-Saharan Africa recommend ...

Landmark study opens door to new cancer, aging treatments

... crystals of a molecule, to determine the three-dimensional structure of the enzyme's active regionthe catalytic component called telomerase reverse transcriptase protein, or TERT. The study revealed surprising features, including the fact that the molecule's three domains are organized into a doughnut ...

UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes

... cancer cells in order to identify factors that impact human telomerase localization," said Michael Terns. "Our results indicate that human reverse transcriptase is a key determinant in human telomerase trafficking and is essential for the localization of telomerase RNA both to Cajal bodies and telomeres." ...

New field-deployable biosensor detects avian influenza virus in minutes instead of days

... channel changed creating this phase change, explained Xu. Current methods of identifying infected birds include virus isolation, real-time reverse transcriptase polymerase chain reaction (RRT-PCR) and antigen capture immunoassays. Virus isolation is a sensitive technique, but typically requires five to seven ...

Viral 'fitness' explains different resistance patterns to aids drugs

... Explaining the study results, Bangsberg said, "A non-nucleoside reverse transcriptase inhibitor (NNRTI), for example, can be taken one time by a pregnant woman ... potent PI) and two different antiretrovirals from the nucleoside reverse transcriptase inhibitor class. ...

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Transcriptase in Biological Technology

Ardea to Present Data on Lead HIV Candidate, RDEA806, at XVII International AIDS Conference

... novel investigational non-nucleoside reverse transcriptase inhibitor (NNRTI) for patients with human ... of RDEA806, a novel HIV non-nucleoside reverse transcriptase inhibitor, in treatment of naive HIV patients" ... is RDEA806, a non-nucleoside reverse transcriptase inhibitor (NNRTI), which has successfully ...

Ardea Biosciences to Present Preclinical Data on Three HIV Non-Nucleoside Reverse Transcriptase Inhibitors During 15th Annual Conference on Retroviruses and Opportunistic Infections

... data on the Company's non-nucleoside reverse transcriptase inhibitor (NNRTI) family of compounds, including ... RDEA806 is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) for the potential treatment of ... candidate is RDEA806, a non-nucleoside reverse transcriptase inhibitor (NNRTI), which is in a Phase 2a study ...

Ardea to Present Data on Lead HIV Candidate, RDEA806, at ICAAC/IDSA Joint Meeting

... Presentation Title: RDEA806, a Novel HIV Non-Nucleoside Reverse transcriptase Inhibitor, Shows Positive Outcome in Treatment of Naive HIV Patients ... most advanced development candidate is RDEA806, a non-nucleoside reverse transcriptase inhibitor (NNRTI), which has successfully completed a Phase 2a study for ...

Ardea Biosciences Presents Inflammation Program Data for Arthritis and Gout at 2008 Annual European Congress of Rheumatology

... RDEA594 is a metabolite of RDEA806, a non-nucleoside reverse transcriptase inhibitor (NNRTI) in development for the treatment of HIV. In Phase 1 ... most advanced development candidate is RDEA806, a non-nucleoside reverse transcriptase inhibitor (NNRTI), which is in a Phase 2a study for the treatment of HIV. ...

Ardea to Present Data on HIV Non-Nucleoside Reverse Transcriptase Inhibitor and Two MEK Inhibitors at Upcoming Medical Conferences

... data will be presented on its second generation non-nucleoside reverse transcriptase inhibitors (NNRTIs), at the 21st International Conference on Antiviral ... Our most advanced drug candidate is RDEA806, a non-nucleoside reverse transcriptase inhibitor (NNRTI), which is in a Phase 2a study for the treatment of HIV. ...

FDA Approves INTELENCE(TM) (etravirine) for HIV Combination Therapy

... INTELENCE (etravirine) tablets -- the first non-nucleoside reverse transcriptase inhibitor (NNRTI) to show antiviral activity in treatment- experienced ... that partially or completely stop the NNRTI from binding to the reverse transcriptase enzyme, causing the drug to lose effectiveness. As with other HIV ...

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Transcriptase in Biological Products

MultiScribe Reverse Transcriptase from Applied Biosystems

Description:... MultiScribe Reverse transcriptase is a recombinant Moloney murine leukemia virus (rMoMuLV) reverse transcriptase. MultiScribe Reverse transcriptase is similar to MuLV reverse transcriptase but differs in its recommended usage. MuLV ...
Company:Applied Biosystems

M-MLV Reverse Transcriptase from USB Corp.

Description:... of M-MLV Reverse Transcriptase. M-MLV Reverse transcriptase catalyzes the polymerization of DNA using ... mRNAs, >10 kb, may be synthesized. M-MLV Reverse transcriptase has a much lower RNase H activity than AMV Reverse transcriptase resulting in high yields of full length cDNA(2). ...
Company:USB Corp.

GeneRacer 3' Nested Primer from Invitrogen

Description:... technique that improves the efficiency of amplifying full-length 5' and 3' cDNA ends. The GeneRacer Kit is available with SuperScript II Reverse transcriptase (RT) for improved amplification of the full-length 5 end from long and complex mRNA. The RNase H portion of SuperScript II RT has been inactivated to ...
Company:Invitrogen

Mung Bean Nuclease from Promega

Description:... has been used for transcript mapping studies (3,4), for flushing staggered ends and for the separation of cDNA strands after synthesis with reverse transcriptase and DNA Polymerase I ....
Company:Promega

Rnase-free Ribonuclease Inhibitor from Chimerx

Description:... that is effective over a broad range of temperatures and pH's. This protein does not inhibit SP6, T7, or T3 RNA polymerase, AMV and M-MLV reverse transcriptase or Taq DNA polymerase. For bulk purchases contact ....
Company:Chimerx

SuperScript III RNase H- Reverse Transcriptase from Invitrogen

Description:... SuperScript™ III RNase H- Reverse transcriptase (RT) is an improved version of SuperScript™ II RNase H- RT. Like SuperScript™ II it synthesizes a complementary DNA strand from ...
Company:Invitrogen
Transcriptase in Biological Definition

Retrovirus

... plus sense RNA molecules. It relies on reverse transcriptase to perform a kind of reverse transcription of ... thought to only occur from DNA to RNA, reverse transcriptase transcribes RNA into DNA. The term "retro" in ... the Central dogma of molecular biology . Reverse transcriptase activity outside of retroviruses has been found ...

Enzyme

... group from an amino acid residue of a protein Restriction enzymes : those enzymes which cut DNA or RNA at specific locations Reverse transcriptase : used by retroviruses to transcribe information from RNA into DNA Ribulose bisphosphate carboxylase : fixes carbon in green plants. ...

Gene therapy

... a DNA copy from an RNA molecule is termed reverse transcription . It is carried out by one of the enzymes carried in the virus, called reverse transcriptase . After this DNA copy is produced and is free in the nucleus of the host cell, it must be incorporated into the genome of the host cell. That is, ...

Hepadnaviridae

... . They have a peculiar mode of replication, because they replicate through an RNA intermediate (which they translate back into DNA using reverse transcriptase ). Because of this mode of replication, Hepadnaviruses are classified as RNA viruses . ...

Hepatitis B

... nucleocapsid (core) enclosing a circular, double-stranded DNA genome. The virus is unique amongst the DNA viruses in that it uses a reverse transcriptase to generate the genomic DNA to deliver to its progeny. Additionally, the DNA genome is incomplete on one strand. Hepatitis D infection requires a ...

Lytic cycle

... into messenger RNA (mRNA) molecules that are then used to direct the ribosome. In retroviruses , or RNA viruses, a unique enzyme called reverse transcriptase transcribes the viral RNA into DNA, which is then transcribed again into mRNA. Replication and lysis After many virus copies are made, they ...

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Transcriptase in Biological Dictionary

Transcriptase

... In biochemistry, a reverse transcriptase , also known as RNA-dependent DNA polymerase, is ... in the formation of a double ... Reverse transcriptase inhibitors (RTIs) are a class of ... and cancer . RTIs inhibit activity of reverse transcriptase , a viral DNA polymerase enzyme that ...

Reverse transcriptase

... In biochemistry, a reverse transcriptase , also known as RNA-dependent DNA polymerase, is ... the formation of a double ... Reverse transcriptase inhibitors (RTIs) are a class of ... and cancer . RTIs inhibit activity of reverse transcriptase , a viral DNA polymerase enzyme that ...

RT-PCR

... describes DNase treatment, the RT reaction and PCR . ... ... transcriptase ( RT ), however, can be combined with traditional PCR to allow ... The ... target ... Sigma's RT - PCR kits, based on the DuraScript™ Reverse transcriptase are the most effective tool for reproducible reverse transcription of ...

DNA virus

... virus that is replicated in a host cell via the enzyme reverse transcriptase to produce DNA from its RNA genome. The DNA is then incorporated into ... double-stranded DNA . Hepatitis B ... These viruses contain a reverse transcriptase that copies their RNA genome into DNA . ... Using technology ...

Telomerase

... human aging. Focused on transcriptional regulation of telomerase to re-lengthen telomeres. The significance of human telomerase reverse transcriptase (hTERT) in cancer" ... Regulation of telomerase activity and anti-apoptotic function by protein-protein ... ...

Reverse transcription

... How HIV RNA is mapped into host DNA. ... Reverse Transcription : Converting viral RNA into DNA. Viral RNA (yellow) DNA (blue) ... reverse transcriptase n. A polymerase that catalyzes the formation of DNA on ... However, reverse transcription was at odds with the then-popular central dogma ......

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