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toxicity in Medical News

Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding DOXIL(R) for Treatment of Advanced Breast Cancer

... of total cumulative dose Cardiac toxicity may also occur at lower cumulative doses (400 ... or AIDS-related Kaposi's sarcoma, hematologic toxicity (based on platelet count or absolute neutrophil ... In patients with multiple myeloma, hematologic toxicity (based on platelet count, absolute neutrophil ...

Hamner Institutes and UNC Launch International Drug Safety Institute

... in vitro assays, starting with evaluating liver toxicity and expanding into cardiovascular and kidney drug ... cause of acute liver failure in the U.S., liver toxicity is also the major reason global regulatory ... a study in patients who have experienced liver toxicity as a result of taking drugs to treat ....

BioTech Medical Well-Positioned to Immediately Respond to Swine Flu Emergency with SDC-Based SpectraSan 24 Disinfectant

... currently on the market, while maintaining lower toxicity ratings. Based on the EPA toxicity ratings from Category I (high toxicity) down to ... (MRSA). PURE's proprietary high efficacy/low toxicity bioscience technologies, including its silver ...

Metametrix Announces New Toxic Effects Profiles to Help Combat Growing Concerns About Toxicity and Health

... exposure to environmental toxins and pollutants, toxicity is becoming a major concern to overall health. ... for their patient treatment plans." These toxicity tests are beneficial for patients who have been ... "Finding the burden and removing the sources of toxicity are the critical steps in the road to recovery of ...

Sterifide Laboratories to Launch 'Powered by SDC' OneShot Plus Disinfectant and Deodorizer

... currently on the market, while maintaining lower toxicity ratings. Based on the EPA toxicity ratings from Category I (high toxicity) down to ... (MRSA). PURE's proprietary high efficacy/low toxicity bioscience technologies, including its silver ...

Genstruct and Gene Logic Collaborate on Systems Toxicology

... its state-of-the-art methodology and expertise in toxicity mechanisms, Genstruct will apply its Causal ... to create network models that fully capture the toxicity potential of any compound. "We are excited ... complex and poorly understood mechanisms of toxicity such as idiosyncratic drug-induced liver injury ...

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toxicity in Medical Technology

Pixantrone in Combination with Chemotherapy Regimens Produces Overall Response Rates of 58-74% with Complete Remission Rates of 37-57% in Relapsed/Refractory Aggressive or Indolent NHL

... reported, neutropenia was the dose limiting toxicity when used as a single agent. "In both ... studies pixantrone exhibited lower cardiac toxicity and better anti-tumor activity than that observed ... as it is devoid of the putative cardiac toxicity generating chemical structure," said Barry W. ...

Medarex Announces Preclinical Data from Multiple Research Programs Demonstrating Anti-Tumor Activity in Cancer

... MDX-1110 showed a favorable safety and toxicity profile. MDX-1110 also demonstrated potent ... treatment for liver cancer. Efficacy and toxicity of anti-mesothelin antibody drug conjugate ... a cleavable linker also showed a more favorable toxicity and safety profile over conjugates using a ...

Novagali Pharma Presents Results of its Innovative Latanoprost Formulation for Glaucoma

... of prostaglandin analogues: an in vivo toxicity assay" at the 9th Scientific Meeting of ... studies confirmed the ocular surface toxicity of anti-glaucomatous eye drops containing ... importance taken into account that BAK exerts toxicity after long term use and that glaucoma is a ...

Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer

... breast cancer, but concerns about cardiac toxicity have prevented oncologists from using them ... continued until an unacceptable treatment-related toxicity or disease progression occurred. The ... of total cumulative dose - Cardiac toxicity may also occur at lower cumulative doses (400 ...

BioNumerik Pharmaceuticals Observes Evidence of a Survival Increase in Lung Cancer Patients Participating in Tavocept(TM) Clinical Trial

... reduction in chemotherapy-induced renal (kidney) toxicity and nausea/vomiting was also observed in ... in the Tavocept group with no dose limiting toxicity observed for Tavocept in either trial. These ... without any substantial dose-limiting toxicity of its own. Based on these results, we are ...

Poniard Announces Positive Efficacy and Safety Data From Phase 1 Trial of Picoplatin in Multiple Tumor Types Including Ovarian Cancer

... signals of clinical activity and acceptable toxicity with this combination. Picoplatin, the ... both agents could be combined with an acceptable toxicity profile," said Don S. Dizon, M.D., assistant ... cancer). Hematologic and non-hematologic toxicity were mild. This study suggests that picoplatin ...

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toxicity in Medical Products

TECHNI-CARE Surgical Scrub

Description:... efficacy on all gram-negative and gram-positive organisms tested in 30 seconds. Techni-Care represents a new molecular structure and has a lower toxicity rating than commercial soaps and ....
Company:Care-Tech Laboratories, Inc.

Resolve® Immersion Oil

Description:... in both low and high viscosity, is non-drying and non-hardening, and has a refractive index of 1.5150. Resolve contains no PCBs, eliminating toxicity and disposal ....
Company:Richard-Allan Scientific

ULTRA Evolution Multi-Detection Microplate Reader

Description:... Luminescent-based reporter assays and bioluminescence energy transfer-based assays Cell-based assays including migration, proliferation and toxicity assays All general fluorometric and colorimetric assays used in a wide variety of application settings ...
Company:Tecan

Preservative-Free TheraTears Liquid Gel

Description:... regarding preservative-induced irritation. And because of its patented electrolyte balance, you will never experience the "electrolyte imbalance toxicity you may get from other ....
Company:Advanced Vision Research, Inc.

AQT-10

Description:... vision tests. It is specifically designed to detect the subtle red/green or blue/yellow color vision losses that accompany such disorders as retinal toxicity (that from Plaquenil, for example), early optic neuritis, glaucoma, diabetic retinopathy, and macular degeneration. Additionally it is fast and ...
Company:LKC Technologies, Inc.

Physicians' Cancer Chemotherapy Drug Manual 2005

Features:... Special information profiling anti-emetic drugs Complete discussion of clinical pharmacology, indications, and dosages Coverage of toxicity and interactions Section on chemotherapy regimens for specific cancers Overview of basic principals of cancer drug therapy ...
Company:Skyscape, Inc.

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toxicity in Medical Definition

Proteopathy

... (Proteo- [ pref . protein]; -pathy [ suff . disease]; proteopathies pl .; proteopathic adj .). Proteopathy is the abnormal accumulation and toxicity of proteins in certain disease states. [1] Also, selective hyperproteolytic diseases have been referred to this category, e.g. critical illness ...
toxicity in Medical Dictionary

Alport syndrome

... metabolic causes Dermatomyositis Digitalis toxicity Ectopic Cushing's syndrome End-stage renal ... Diabetic nephropathy / sclerosis Digitalis toxicity End-stage renal disease Epilepsy ... ... Diabetic nephropathy / sclerosis Digitalis toxicity End-stage renal disease Epilepsy ...

Atheroembolic renal disease

... metabolic causes Dermatomyositis Digitalis toxicity Ectopic Cushing's syndrome End-stage renal ... Diabetic nephropathy / sclerosis Digitalis toxicity End-stage renal disease Epilepsy ... Diabetic nephropathy / sclerosis Digitalis toxicity End-stage renal disease Epilepsy ...

Digitalis toxicity

... DIGITALIS toxicity - A result of the over-accumulation of digit ... , anorexia , and palpitations . Digitalis toxicity is the result of the body accumulating more ... decreased tolerance by the body. Digitalis toxicity ( Digoxin Toxic ity) Digoxin Overdose ( ...

Digit

... DIGIT ALIS toxicity - A result of the over-accumulation of digit alis glycosides in the ... of hands and ankles in patients with heart problems. Digit alis toxicity is the result of the body accumulating more digit alis than it can ...

Hypotension

... nausea , heartburn , diarrhea ) Cough Muscle cramps Digitalis toxicity ... Low blood pressure ( hypotension ) Light-headedness, fainting ... as nausea , heartburn , diarrhea ) Cough Muscle cramps Digitalis toxicity ... Their cardiovascular effects include tachycardia , ...

Acute nephritic syndrome

... Chronic renal failure Complicated UTI ( pyelonephritis ) Cushing's syndrome Dementia due to metabolic causes Dermatomyositis Digitalis toxicity Ectopic Cushing's syndrome ... Acute nephritic syndrome is unlikely to recur but if it does, there is at least a one in three chance that an ...

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toxicity in Biological News

Scientists report first remote, underwater detection of harmful algae, toxins

... in NOAA's effort to monitor the type and toxicity of harmful algal blooms (HABs). HABs are ... only the organism causing a bloom, but also the toxicity of the event, which ultimately dictates whether ... impacts on the coastal ecosystem, since the toxicity of these algae can vary widely from little or ...

Chemicals in common consumer products may play a role in pre-term births

... many other consumer and industrial products. The toxicity varies by specific phthalates or their breakdown ... phthalates cause reproductive and developmental toxicity in animals. A couple of human studies have ... products based on the growing amount of animal toxicity data and since national human data show that a ...

American Chemical Society's Weekly Presspac -- June 17, 2009

... tubes on four feet? EPA moves toward animal-free toxicity tests Chemical & Engineering News The ... of animal-free tests for predicting the toxicity of chemicals to humans, according to an article ... tests. Meanwhile, new technologies for predicting toxicity may emerge and complement conventional animal ...

Countries unite to reduce animal use in product toxicity testing worldwide

... scientific recommendations on alternative toxicity testing methods that should speed their adoption ... scientific validation of non- and reduced-animal toxicity testing methods. If the toxicity testing methods are shown to be reproducible ...

Researchers report 'moderately large' potential for red tide outbreak in Gulf of Maine region

... and the lead investigator of the Gulf of Maine toxicity (GOMTOX) study, spent 10 days collecting seafloor ... Massachusetts. The researchers have found that toxicity in near-shore shellfish is the highest for years ... there are a lot of cells in the Gulf of Maine, toxicity can be confined to offshore waters if the winds ...

Calculating gene and protein connections in a Parkinson's disease model

... scientists have analyzed alpha-synuclein toxicity to identify genes and pathways that can affect ... identified several links between alpha-synuclein toxicity and basic cell processes, including those used to ... ResponseNet also tied alpha-synuclein toxicity to a highly-conserved pathway targeted by ...

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toxicity in Biological Technology

Celsis Outlines the Top Five Advantages of Cryo-plateable Hepatocytes

... the metabolism, drug-drug interaction and toxicity of drug candidates in a cost-effective manner) ... research products, especially in metabolism, toxicity and drug-drug interaction testing. Several large ... study of metabolism, drug-drug interactions and toxicity in drug discovery and development. Since 1990, ...

Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... of total cumulative dose Cardiac toxicity may also occur at lower cumulative doses (400 ... or AIDS-related Kaposi's sarcoma, hematologic toxicity (based on platelet count or absolute neutrophil ... In patients with multiple myeloma, hematologic toxicity (based on platelet count, absolute neutrophil ...

Solidus Bioscience Protect their Research and Improve Efficiency With Amphora's PatentSafe Solution

... York and California, currently offers an in vitro toxicity screening service that determines compound and metabolite toxicity using a novel platform that supports arrays of ... assay platform that generates metabolic toxicity data to assess the safety of compounds at a speed ...

EPA Presents Initial Results from Caliper Life Sciences' ToxCast Screening Effort

... that the database was predictive of in vivo toxicity profiles. Initial analyses of the data generated ... in vitro results generated at CDAS and in vivo toxicity parameters have already been identified. In ... profiling as a tool for predicting potential toxicity liabilities of compounds and highlights the high ...

Poniard Pharmaceuticals Announces Positive Tumor Response and Neuropathy Data from Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer

... colorectal cancer who cannot tolerate the toxicity profile of currently marketed platinums." ... in multiple indications with less severe kidney toxicity (nephrotoxicity) and nerve toxicity (neurotoxicity) than is commonly observed with ...

Poniard Announces Positive Incremental Efficacy and Safety Data from Phase 2 Picoplatin Trial in Patients With Metastatic Colorectal Cancer

... the two treatment groups. Acute gastrointestinal toxicity was similar in the two groups, while ... in multiple indications with less severe kidney toxicity (nephrotoxicity) and nerve toxicity (neurotoxicity) than is commonly observed with ...

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toxicity in Biological Products

In Vitro Toxicity Testing Protocols, Vol 43 from Promega

Description:... S. O'Hare & C.K. Atterwill • In vitro toxicity techniques for regular lab use. Ex vivo techniques are also covered with the aim of reducing and refining the use of animals in the ....
Company:Promega

ProteoJuice Protein Transfection Reagent from Novagen

Description:... ProteoJuice Protein Transfection Reagent is an effective reagent for the transfection of intact functional protein into mammalian cells with minimal toxicity and broad cell ....
Company:Novagen

Freedom EVO 150 from Tecan

Description:... (HTS), ultrahigh throughput screening (UHTS) & secondary screening toxicity assays Compound management Hit picking and plate reformatting Cell ... Automated assays for Absorption, Distribution, Metabolism, Excretion, toxicity (ADMET) include: Micosome and hepatocyte metabolic stability assays ...
Company:Tecan

TransIT-TKO siRNA Transfection Reagent from Mirus Bio Corporation

Description:... Designed specifically for high efficiency siRNA delivery in mammalian cells. Low toxicity reagent proven to work effectively in a wide range of cell types. Results in silencing of greater than 95% of target gene expression. One step, serum ...
Company:Mirus Bio Corporation

Metabolic Profiler from Bruker Daltonics

Description:... to distinguish between normal and altered states Discovery and identification of potential biomarkers Study mechanism of drug induced toxicity and/or efficacy at pre-clinical or clinical stages of development Research in pharmaco-metabolomics, clinical disease diagnosis and prognosis ...
Company:Bruker Daltonics

Label IT siRNA Tracker Biotin Intracellular Localization Kit with TransIT-TKO siRNA Transfection Reagent from Mirus Bio Corporation

Description:... transfections in 24-well plates. TransIT-TKO Transfection Reagent, which is included in the kit, is designed specifically for high efficiency, low toxicity siRNA transfections in a variety of cell ....
Company:Mirus Bio Corporation

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toxicity in Biological Definition

Alcohol

... 6 Physical and chemical properties 7 toxicity 8 Chemistry of alcohols 8.1 ... than gasoline or diesel . Because of its low toxicity and ability to dissolve non-polar substances, ... the #Chemistry of alcohols section below. toxicity Alcohols often have an odor described as ...

Colchicine

... 2.1 Biological function 2.2 Colchicine as medicine 2.3 toxicity 2.4 Laboratory use 3 External links History The ... cancer , as the dose required would lead to intolerable side-effects. toxicity Poisoning resembles intoxication with arsenic : symptoms start 2 to 5 ...

Extinction

... resources or against new competitor species. Habitat degradation through toxicity can kill off a species very rapidly, by killing all living members through ... or sterilizing them. It can also occur over longer periods at lower toxicity levels by affecting life span, reproductive capacity, or competitiveness. ...

Antibiotic

... by Bacillus pyocyaneus, retarded the growth of other bacteria in situ and was toxic to many disease-causing bacteria. Unfortunately, pyocyanase's own toxicity and unstable character prevented its use as an effective, safe antibiotic within the human body. The first effective antibiotic discovered was ...

Apoptosis

... cervical cancer . Response to stress or DNA damage Stress conditions (such as starvation) as well as damage to the cell's DNA resulting from toxicity or exposure to ionizing radiation, such as ultraviolet or X-rays, can induce a cell to begin an apoptotic process. A fascinating example, resulting ...

Vitamin

... a deficiency condition, while Vitamin B 1 stores may only last a couple of weeks. Fat-soluble vitamins may be stored in the body and can cause toxicity when taken in excess. Water-soluble vitamins are not stored in the body, with the exception of Vitamin B 12 , which is stored in the liver . ...

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toxicity in Biological Dictionary

Urea

... Medical Dictionary and glossary with medical definitions ... Urea is of major historical significance. ... Ammonium cyanate is urea . ... toxicity should not be a problem if urea is fed ... Urea can be fed to ruminants as an economical replacement for a part of the protein in a ration. ... ...

Nontarget organism

... due only to the gene directly ... ... Nontarget Organisms , U.S. Fish and Wildlife Service-LaCrosse, WI and The ... lack comparable toxicity data and have not been tested on nontarget organisms . ... ... and Selected Nontarget Organisms ... and the effects on nontarget ...

Micronucleus

... Analysis Kits can save weeks of time ... Loats Associates, Inc. creates systems for medical research, specializing in the automation of genetic toxicity assays; micronuclei assay, comet, metaphase spread ... micronucleus ... micronucleus - A nucleus, distinct from and smaller than the main ...

Endophyte

... Missouri's most widely used forage crop. ... How does the endophyte affect grazing animals? ... rural heritage vet clinic - endophyte fescue toxicity in horses ... Additionally, some so-called endophyte -free seeds are derived from infected seed ... when the connection between endophyte in ...

Buccal cavity

...... in an 11-mm die cavity and core was ... ... was to establish mucoadhesive buccal devices of propranolol hydrochloride (PRH) ... in cases of toxicity by removing the dosage form from the buccal cavity . ... buccal - Ecology of buccal from A Dictionary of Ecology at Encyclopedia.com ... No ...

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