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Thrombocytopenia in Medical News

European Commission and United States Food and Drug Administration (FDA) Both Approve New Options for Patients With Certain Primary Brain Tumors

... events also reported: convulsions 6%, 11% and thrombocytopenia 4%; 8%. Of these adverse events, those grade ... 2%, 4%; constipation 1%, 0%; convulsions 3%, 3%; thrombocytopenia 3%, 4%. In the newly diagnosed GBM ... over age 70 experienced Grade 4 neutropenia or thrombocytopenia in the first cycle, respectively. For patients ...

Prescription Copay Assistance for Patients taking Gleevec or Tasigna for Philadelphia chromosome-positive Chronic Myelogenous Leukemia (Ph+ CML)

... common (>10%) Grade 3/4 adverse reactions were thrombocytopenia (28%), neutropenia (28%), elevated lipase (15%), ... common (>10%) Grade 3/4 adverse reactions were thrombocytopenia (37%), neutropenia (37%), anemia (23%), and ... neutropenia (3.6%-48%), anemia (1%-42%), thrombocytopenia (<1%-33%), and hepatotoxicity (approx 5%)--and ...

Data on VELCADE(R) (Bortezomib) for Injection Based Therapies to be Presented at the International Myeloma Workshop

... disturbances. VELCADE is associated with thrombocytopenia and neutropenia. There have been reports of ... and peripheral neuropathy aggravated) (39%), thrombocytopenia and appetite decreased (including anorexia) (each ... 1 episode of ¿Grade 4 toxicity, most commonly thrombocytopenia (5%) and neutropenia (3%). A total of 50% of ...

Novel therapeutic approaches may improve patient outcomes in several platelet disorders

... spots on the skin. If left untreated, thrombocytopenia can become a life-threatening condition when ... to 450,000 microliters in adults. Treatment for thrombocytopenia is dependent on the cause and severity of the ... A total of 1,272 patients with hypoproliferative thrombocytopenia (which is caused by failure of the marrow to ...

Eisai Inc. Supports Acting Surgeon General's Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism

... whose platelet counts fell below 100,000/mm3. thrombocytopenia of any degree should be monitored closely. Heparin- induced thrombocytopenia can occur with administration of FRAGMIN(R). ... at present. In clinical practice, rare cases of thrombocytopenia with thrombosis have also been observed. ...

FDA Approves VELCADE(R) (Bortezomib) for Injection for Patients with Previously Untreated Multiple Myeloma

... in combination with MP vs MP, respectively, were thrombocytopenia (52% vs 47%), neutropenia (49% vs 46%), nausea ... VELCADE is associated with thrombocytopenia and neutropenia. There have been reports of ... and peripheral neuropathy aggravated) (39%), thrombocytopenia and appetite decreased (including anorexia) (each ...

Study Showed ALIMTA(R) (pemetrexed for injection) Improved Survival in Certain Types of Non-Small Cell Lung Cancer

... (24 vs 4); leukopenia (16 vs 1); anemia (6 vs 0); thrombocytopenia (5 vs 0); infection without neutropenia (2 vs 0); ... vs 16); leukopenia (55 vs 20); anemia (33 vs 14); thrombocytopenia (27 vs 10); fatigue (80 vs 74); ... were neutropenia (57 vs 4, 64 vs 76); thrombocytopenia (50 vs 4, 55 vs 13); leukopenia (46 vs 3, 29 vs ...

VELCADE(R) (Bortezomib) for Injection Based Therapy Produced Significant Complete Remission Rates Pre- and Post-Transplantation in IFM Phase III Front-Line Multiple Myeloma Trial

... disturbances. VELCADE is associated with thrombocytopenia and neutropenia. There have been reports of ... than or equal to Grade 4 toxicity, most commonly thrombocytopenia (5%) and neutropenia (3%). A total of 50% of ... neuropathy (8%), asthenic conditions (3%) and thrombocytopenia and diarrhea (each 2%). In total, 2% of the ...

Video and Photo: Tasigna(R) Receives US Approval Providing New Hope to Chronic Myeloid Leukemia Patients With Resistance or Intolerance to Existing Therapies

... Myelosuppression: Associated with neutropenia, thrombocytopenia and anemia. CBC should be done every 2 weeks for ... serious drug-related adverse reactions were thrombocytopenia and neutropenia. In accelerated-phase CML ... neutropenia (3.6%- 48%), anemia (1%-42%), thrombocytopenia (<1%-33%), and hepatotoxicity (approx 5%) -- and ...

Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding DOXIL(R) for Treatment of Advanced Breast Cancer

... VELCADE, respectively) included: neutropenia (36 percent vs 22 percent), thrombocytopenia (33 percent vs 28 percent), anemia (25 percent vs 21 percent), fatigue (36 ... anemia (Hb less than 10 g/dL, 58 percent; less than 8 g/dL, 16 percent), thrombocytopenia (less than 150,000 platelets/mm3, 61 percent), nausea (18 percent), ...
Thrombocytopenia in Medical Technology

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

... neutropenia (3.6%-48%), anemia (1%-42%), thrombocytopenia (<1%-33%), and hepatotoxicity (approx 5%)--and ... 3/4) lab abnormalities included anemia (17%), thrombocytopenia (17%), neutropenia (8%), and increased creatinine ... neutropenia (10%; 11%), anemia (3%; 9%), thrombocytopenia (0%; 1%), and hepatotoxicity (6%; 8%)--and severe ...

Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP)

... syndromes (MDS) and chemotherapy-induced thrombocytopenia (CIT). Important EU Nplate Safety ... insomnia and pruritus. Reoccurrence of thrombocytopenia and bleeding after cessation of treatment and ... bone marrow reticulin deposition and worsening thrombocytopenia after Nplate discontinuation. Additional risks ...

Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma

... disturbances. VELCADE is associated with thrombocytopenia and neutropenia. There have been reports of ... and peripheral neuropathy aggravated) (39%), thrombocytopenia and appetite decreased (including anorexia) (each ... episode of >/=Grade 4 toxicity, most commonly thrombocytopenia (5%) and neutropenia (3%). A total of 50% of ...

Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia

... ( > 10%) Grade 3/4 adverse reactions were thrombocytopenia (28%), neutropenia (28%), elevated lipase (15%), ... ( > 10%) Grade 3/4 adverse reactions were thrombocytopenia (37%), neutropenia (37%), anemia (23%), and ... neutropenia (3.6%-48%), anemia (1%-42%), thrombocytopenia ( > 1%-33%), and hepatotoxicity (approx 5%) -- ...

Prolonged Progression-Free Survival Demonstrated by VELCADE(R) (Bortezomib) for Injection Based Induction Regimens in Transplant-Eligible Previously Untreated Multiple Myeloma Patients

... disturbances. VELCADE is associated with thrombocytopenia and neutropenia. There have been reports of ... and peripheral neuropathy aggravated) (39%), thrombocytopenia and appetite decreased (including anorexia) ... episode of >/= Grade 4 toxicity, most commonly thrombocytopenia (5%) and neutropenia (3%). A total of 50% of ...

Long-term Follow Up Interim Data Show Nplate(TM) Increased and Sustained Platelet Counts in Adult Chronic ITP Patients

... Nplate is not indicated for the treatment of thrombocytopenia due to MDS or any cause of thrombocytopenia other than chronic ITP. About Nplate ... Nplate is indicated for the treatment of thrombocytopenia in patients with chronic immune (idiopathic) ...

CHMP Recommends Approval in the European Union (EU) for New Options for Patients With Certain Primary Brain Tumors

... events also reported: convulsions 6%, 11% and thrombocytopenia 4%; 8%. Of these adverse events, those ... 2%, 4%; constipation 1%, 0%; convulsions 3%, 3%; thrombocytopenia 3%, 4%. In the newly diagnosed GBM ... over age 70 experienced Grade 4 neutropenia or thrombocytopenia in the first cycle, respectively. For patients ...

Novel VELCADE(R) (Bortezomib) for Injection Based Four-Drug Combination Was Well Tolerated In Previously Untreated Multiple Myeloma Patients

... disturbances. VELCADE is associated with thrombocytopenia and neutropenia. There have been reports of ... and peripheral neuropathy aggravated) (39%), thrombocytopenia and appetite decreased (including anorexia) ... or equal to Grade 4 toxicity, most commonly thrombocytopenia (5%) and neutropenia (3%). A total of 50% of ...

Novel Therapeutic Approaches May Transform Treatment and Improve Patient Outcomes in Several Platelet Disorders

... spots on the skin. If left untreated, thrombocytopenia can become a life-threatening condition when ... to 450,000 microliters in adults. Treatment for thrombocytopenia is dependent on the cause and severity of the ... A total of 1,272 patients with hypoproliferative thrombocytopenia (which is caused by failure of the marrow to ...

GSK Reports PROMACTA(R) (eltrombopag) Significantly Increased Platelet Counts and Reduced Bleeding in Long-Term Study of Patients With Chronic ITP

... including staining for fibrosis. Worsened thrombocytopenia and Hemorrhage Risk After PROMACTA Cessation: Discontinuation of PROMACTA may result in thrombocytopenia of greater severity than was present prior to ... treatment of thrombocytopenia due to causes of thrombocytopenia (e.g., myelodysplasia or chemotherapy) other than ...

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Thrombocytopenia in Medical Products

PAP-4

Description:... cofactor), platelet aggregation and leukocyte aggregation. The PAP-4 may also be used for the evaluation and confirmation of Heparin Induced thrombocytopenia (HIT). Four channels allow four tests to be run simultaneously and independently. Select standard volumes or microvolume quantities to reduce sample ...
Company:Bio/Data Corporation

PAP-4CD

Description:... cofactor), platelet aggregation and leukocyte aggregation. The PAP-4CD may also be used for the evaluation and confirmation of Heparin Induced thrombocytopenia (HIT). Four channels allow four tests to be run simultaneously and independently. Select standard volumes or microvolume quantities to reduce sample ...
Company:Bio/Data Corporation

PAP-4D

Description:... cofactor), platelet aggregation and leukocyte aggregation. The PAP-4D may also be used for the evaluation and confirmation of Heparin Induced thrombocytopenia (HIT). Four channels allow four tests to be run simultaneously and independently. Select standard volumes or microvolume quantities to reduce sample ...
Company:Bio/Data Corporation

PAP-4C

Description:... cofactor), platelet aggregation and leukocyte aggregation. The PAP-4C may also be used for the evaluation and confirmation of heparin induced thrombocytopenia (HIT). Four channels allow four tests to be run simultaneously and independently. Select standard volumes or microvolume quantities to reduce sample ...
Company:Bio/Data Corporation
Thrombocytopenia in Medical Dictionary

Platelet count

... blood cell mass. Low platelet count ( thrombocytopenia ). Measles may lead to a decrease in ... blood vessel wall within the brain ... thrombocytopenia , heparin-induced: Low blood platelet count ... abnormal blood clotting. Heparin-induced thrombocytopenia can be mild or serious and fatal. Symptoms ...

Thrombocytopenia

... thrombocytopenia often occurs as a result of a separate disease ... the number of platelet s in your blood . thrombocytopenia may be caused by infections in the fetus or ... antibodies against the baby's platelet s. thrombocytopenia , heparin-induced: Low blood platelet count ...

Antepartum

... , hydatidiform mole , amniotic embolism ) Prostate cancer Shock thrombocytopenia purpura ... Extensive vascular ( blood vessel) trauma or ... , hydatidiform mole , amniotic embolism ) Prostatic cancer Shock thrombocytopenia purpura ... ...

Leukopenia

... ), a low lymphocyte count ( lymph openia), or a low platelet count ( thrombocytopenia ). Clotting profiles. SARS patients often have prolonged blood ... characterized by anorexia , diarrhea , loss of hair , leukopenia , thrombocytopenia , growth retardation , and eventual death brought about by the GRAFT ...

Thrombocyte

... bleeding by causing blood clots to form. Also called a platelet . thrombocytopenia ... platelet s ( thrombocyte s) - help in blood clotting. Fat ... the rest (55 percent) is plasma , a clear, watery, pale yellow fluid. thrombocytopenia An abnormally low number of platelet s ( thrombocyte s). If the ...

Absorption

... absorption of calcium . Absorption unreliable. Should not be used in children or patients prone to develop dependent edema or patients with thrombocytopenia . Transnasal ... Mal absorption syndrome s -- you are unable to absorb or digest certain nutrients. Common examples include lactose ...

Acute myelogenous leukemia

... by low red blood cells ( anemia ), low white blood cell count ( leukopenia ) with a tendency to infection , and low platelet count ( thrombocytopenia ) with bleeding problems. MDS may progress and transform into acute myelogenous leukemia ... ...

Agranulocytosis

... Lymphoblastic Leukemia ) AML ( Acute Nonlymphocytic Leukemia ) Anemia Aplastic Anemia A PTT ( Partial Thromboplastin Time) Auto immune thrombocytopenia ( Idiopathic Thrombocytopenic Purpura ) Bleeding Disorders Blood Transfusion ... Neutropenia is sometimes called agranulocytosis or ...

Anomaly

... as acquired Pelger-Huët anomaly , may be seen in the neutrophil s. Moderate anemia (often showing changes indicative of dyserythropoiesis) and thrombocytopenia are common. ...

Anorexia

... (ION Labor atories). Graft vs Host Disease - The clinical entity characterized by anorexia , diarrhea , loss of hair , leukopenia , thrombocytopenia , growth retardation , and eventual death brought about by the GRAFT VS HOST REACTION. Starving for Control: The Truth of Anorexia ...

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Thrombocytopenia in Biological News

Lancet study supports new, highly effective treatment for blood disorder

... U.S. Food and Drug Administration in November 2008 for the treatment of thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura who ... in populations like the 4 million Americans with hepatitis-C-related thrombocytopenia or patients receiving myelosuppressive chemotherapy. Collaborators on ...

Ireland Cancer Center researchers advance stem cell gene therapy

... cell formation) and stem cell engraftment. Dr. Shigemi Matsuyama and colleagues presented a novel way of treating chemotherapy -induced thrombocytopenia (decrease in number of platelets in the blood) using Bax Inhibiting Peptides to rescue the damaged cells. Dr. Keith McCrae and colleagues ...

Safe and effective therapy discovered for patients with protein-losing enteropathy

... sulfate and prevents protein leakage in vitro. However, long-term therapy with anticoagulant heparin has severe side effects, including bleeding, thrombocytopenia and osteoporosis. However, the study also revealed an alternative form of heparin as a potential therapy. By adapting well-established clinical ...
Thrombocytopenia in Biological Technology

Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... plus DOXIL vs VELCADE, respectively) included: neutropenia (36% vs 22%), thrombocytopenia (33% vs 28%), anemia (25% vs 21%), fatigue (36% vs 28%), pyrexia (31% vs ... 46%; <500/mm3, 11%), anemia (Hb <10 g/dL, 58%; <8 g/dL, 16%), thrombocytopenia (<150,000 platelets/mm3, 61%), nausea (18%), asthenia (7%), fever (8%), ...

ThromboGenics NV: Business Update

... for the continued development of Anti-VPAC for the treatment of thrombocytopenia - At the end of February 2009, ThromboGenics was awarded a grant of up to ... Cyclase-Activating Peptide Receptor 1) antibody for the treatment of thrombocytopenia (low platelet count) after chemotherapy. The grant was received ...

FDA Accepts Cell Therapeutics' Zevalin sBLA and Grants Priority Review

... Grade 3 or 4 hematologic side effects including neutropenia in 67 percent, thrombocytopenia in 61 percent, and anemia in 3 percent of patients. Nonhematologic ... therapeutic regimen were primarily hematologic, including neutropenia, thrombocytopenia and anemia. Infusion-related toxicities were associated with ...

Cell Therapeutics Submits Supplemental Biologics License Application for Zevalin Use in First-Line Consolidation Therapy

... Grade 3 or 4 hematologic side effects including neutropenia in 67 percent, thrombocytopenia in 61 percent, and anemia in 3 percent of patients. Nonhematologic ... therapeutic regimen were primarily hematologic, including neutropenia, thrombocytopenia and anemia. Infusion-related toxicities were associated with ...

FDA Meeting Provides Green Light for Cell Therapeutics Submission of Supplemental Filing for Zevalin(R) Label Expansion

... Grade 3 or 4 hematologic side effects including neutropenia in 67 percent, thrombocytopenia in 61 percent, and anemia in 3 percent of patients. Nonhematologic ... therapeutic regimen were primarily hematologic, including neutropenia, thrombocytopenia and anemia. Infusion-related toxicities were associated with ...

CTI Enters Into Agreement With Bayer Schering Pharma for Access to Phase III Zevalin(R) FIT Trial Data for Potential U.S. Supplemental Marketing Application

... Grade 3 or 4 hematologic side effects including neutropenia in 67 percent, thrombocytopenia in 61 percent, and anemia in 3 percent. Nonhematologic toxicities were ... therapeutic regimen were primarily hematologic, including neutropenia, thrombocytopenia and anemia. Infusion-related toxicities were associated with ...

Video: Higher Initial Dose of Gleevec Achieved Better Early Responses than Standard Dose for Patients with Chronic Myeloid Leukemia

... 3/4) lab abnormalities-including neutropenia (3.6%-48%), anemia (1%-42%), thrombocytopenia ( < 1%-33%), and hepatotoxicity (approx 5%) -- and severe adverse ... (18%). The most common ( > 10%) Grade 3/4 adverse reactions were thrombocytopenia (37%), neutropenia (37%), anemia (23%), and elevated lipase (17%). Other ...

Millennium Announces VELCADE(R) (Bortezomib) for Injection First-Quarter 2008 U.S. Net Sales

... 1 episode of greater than or equal to Grade 4 toxicity, most commonly thrombocytopenia (5%) and neutropenia (3%). A total of 50% of patients experienced serious ... included peripheral neuropathy (8%), asthenic conditions (3%) and thrombocytopenia and diarrhea (each 2%). In total, 2% of the patients died and the cause of ...

EMEA Accepts for Review Vidaza(R) Marketing Authorization Application for Higher-Risk Myelodysplastic Syndromes

... anemia with ringed sideroblasts (RARS) if accompanied by neutropenia or thrombocytopenia or requiring transfusions; refractory anemia with excess blasts (RAEB), ... adverse reactions by SC route were nausea (70.5%), anemia (69.5%), thrombocytopenia (65.5%), vomiting (54.1%), pyrexia (51.8%), leukopenia (48.2%), diarrhea ...

Millennium Announces 2008 Goals for Growth, Building on Record 2007 Results

... 1 episode of greater than or equal to Grade 4 toxicity, most commonly thrombocytopenia (5%) and neutropenia (3%). A total of 50% of patients experienced serious ... included peripheral neuropathy (8%), asthenic conditions (3%) and thrombocytopenia and diarrhea (each 2%). In total, 2% of the patients died and the cause of ...
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