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Thalassemia in Medical News

BMP Sunstone Announces Official Launch of Ferriprox in PRC

... that can lead to organ damage and heart failure. thalassemia is particularly prevalent in humid ... of the 15.0 million people in China who develop thalassemia each year. While many physicians are already ... Gao continued, "Ferriprox is a cost-effective thalassemia treatment, which we believe will result in ...

Medifacts Systems, Inc. Grants Exclusive License for Genetic Test Patent to Mayo Clinic

... to Mayo Clinic. The patented test detects Alpha thalassemia mutations and their use as predictors of ... make the test available to patients worldwide. thalassemia is an inherited blood disease particularly ... subcutaneously. The severity of alpha thalassemia is correlated with the number of affected globin ...

Gene Behind Childhood Anemias Found

... Finding could usher in new treatments for sickle cell disease and thalassemia THURSDAY, Dec. 4 (HealthDay News) -- Scientists have ... cell disease can cause severe pain and eventual organ damage. Treating thalassemia requires frequent blood transfusions and then chelation therapy, which ...

StemCyte, Inc. Reaches 1,000th Cord Blood Stem Cell Shipment for Transplant Milestone

... have become a viable option to treat a variety of illnesses including leukemia, lymphomas, Autoimmune diseases and Genetic Blood disorders such as thalassemia sickle-cell disease. "With over 20 years of human safety and efficacy data, umbilical cord blood stem cells are emerging as a prime source of ...

Schering-Plough Completes Enrollment of Boceprevir Registration Studies in Treatment-Naive and Treatment-Experienced HCV Patients

... or may become pregnant (see Boxed Warning and Pregnancy section), men whose female partners are pregnant, patients with hemoglobinopathies (e.g., thalassemia major, sickle-cell anemia), and patients with creatinine clearance less than 50 mL per min. Pregnancy REBETOL therapy should not be started ...

PEGASYS(R) Proven Effective as Hepatitis C Treatment for Latino Patients, According to Article in The New England Journal of Medicine

... to COPEGUS or any of its components, in women who are pregnant, men whose female partners are pregnant, and patients with hemoglobinopathies (eg, thalassemia major, sickle-cell anemia). COPEGUS THERAPY SHOULD NOT BE STARTED UNLESS A REPORT OF A NEGATIVE PREGNANCY TEST HAS BEEN OBTAINED IMMEDIATELY ...

Schering-Plough Announces FDA Approval of PEGINTRON(TM) and REBETOL(R) Combination Therapy for Treating Pediatric Hepatitis C

... or may become pregnant (see Boxed Warning and Pregnancy section), men whose female partners are pregnant, patients with hemoglobinopathies (e.g., thalassemia major, sickle-cell anemia), and patients with creatinine clearance less than 50 mL per min. Pregnancy REBETOL therapy should not be ...

Studies examine quality of care for hospitalized sickle cell disease patients

... number of patients who received the therapy over a long period of time. The medical records of 330 patients with sickle cell disease treated at the thalassemia Center of Laikon Hospital in Athens, Greece, over the course of 20 years were retrospectively analyzed. Patients were divided into two groups: a ...

Turning back the Clock in Inherited Anemias

... Reawakening a dormant gene could ease sickle-cell disease and thalassemia (Vocus) December 4, 2008 -- Researchers at Children's Hospital Boston ( www.childrenshospital.org ) and Dana-Farber Cancer ...

A Thanksgiving Message From New York Blood Center

... by diagnoses that require frequent blood transfusions for recovery and survival. Among these diseases are: Leukemia and other forms of cancer, thalassemia and aplastic anemias, sickle cell disease, hemophilia and other diseases for which there is no universal cure. Please take a moment from the ...

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Thalassemia in Medical Technology

Research Identifies Need for Improved Understanding of Sickle Cell Disease in Adulthood

... to deferiprone monotherapy, the current "gold standard" in patients with thalassemia major [Abstract #575] Aurelio Maggio, MD, Hospital 'V. Cervello', ... randomized trial evaluated two chelating regimens in 140 patients with thalassemia major, a genetic disorder characterized by the underproduction of ...

Schering-Plough Highlights Hepatitis C Clinical Data Presentations at the European Association for the Study of the Liver (EASL) Annual Meeting

... or may become pregnant (see Boxed Warning and Pregnancy section), men whose female partners are pregnant, patients with hemoglobinopathies (e.g., thalassemia major, sickle-cell anemia), and patients with creatinine clearance less than 50 mL per min. Pregnancy REBETOL therapy should not be started ...

Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen

... to COPEGUS or any of its components, in women who are pregnant, men whose female partners are pregnant, and patients with hemoglobinopathies (eg, thalassemia major, sickle-cell anemia). COPEGUS THERAPY SHOULD NOT BE STARTED UNLESS A REPORT OF A NEGATIVE PREGNANCY TEST HAS BEEN OBTAINED IMMEDIATELY ...

Roche and Pharmasset Initiate Phase IIb Clinical Trial of R7128, Most Advanced Nucleoside Polymerase Inhibitor in Development for Chronic Hepatitis C

... to COPEGUS or any of its components, in women who are pregnant, men whose female partners are pregnant, and patients with hemoglobinopathies (eg, thalassemia major, sickle-cell anemia). COPEGUS THERAPY SHOULD NOT BE STARTED UNLESS A REPORT OF A NEGATIVE PREGNANCY TEST HAS BEEN OBTAINED IMMEDIATELY ...

Final Results of Boceprevir Phase II HCV SPRINT-1 Study Showed Significantly Higher SVR Rates Compared to Standard of Care in Treatment-Naive Genotype 1 Hepatitis C Patients

... or may become pregnant (see Boxed Warning and Pregnancy section), men whose female partners are pregnant, patients with hemoglobinopathies (e.g., thalassemia major, sickle-cell anemia), and patients with creatinine clearance less than 50 mL per min. Pregnancy REBETOL therapy should not be started ...

FDA Approves an Expanded Indication for Peginterferon-Based Combination Therapy for Patients With Chronic Hepatitis C

... or may become pregnant (see Boxed Warning and Pregnancy section), men whose female partners are pregnant, patients with hemoglobinopathies (e.g., thalassemia major, sickle-cell anemia), and patients with creatinine clearance less than 50 mL per min. Pregnancy REBETOL therapy should not be started ...

Studies Examine Quality of Care for Hospitalized Sickle Cell Disease Patients and Effective Methods for Detecting Risk of Stroke in Children With This Disorder

... number of patients who received the therapy over a long period of time. The medical records of 330 patients with sickle cell disease treated at the thalassemia Center of Laikon Hospital in Athens, Greece, over the course of 20 years were retrospectively analyzed. Patients were divided into two groups: a ...

Schering-Plough Provides Update on Boceprevir Clinical Development and Introduces Potent Next-Generation Oral HCV Protease Inhibitor for Treating Patients With Chronic Hepatitis C

... or any other component of the product, women who are pregnant, men whose female partners are pregnant, patients with hemoglobinopathies (e.g., thalassemia major, sickle-cell anemia), and patients with creatinine clearance less than 50 mL/min. Avoid Pregnancy REBETOL therapy should not ...

Boceprevir Phase II Study Showed High Rate of Sustained Response With 28- and 48-Week Regimens in Genotype 1 Treatment-Naive Hepatitis C Patients

... or any other component of the product, women who are pregnant, men whose female partners are pregnant, patients with hemoglobinopathies (e.g., thalassemia major, sickle-cell anemia), and patients with creatinine clearance less than 50 mL/min. Avoid Pregnancy REBETOL therapy should not be started ...

Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients

... or any other component of the product, women who are pregnant, men whose female partners are pregnant, patients with hemoglobinopathies (e.g., thalassemia major, sickle-cell anemia), and patients with creatinine clearance less than 50 mL/min. Avoid Pregnancy REBETOL therapy should not be started ...
Thalassemia in Medical Products

Alpha Thalassemia Analysis

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories
Thalassemia in Medical Definition

Hematopathology

... ( Iron deficiency anemia , Plummer-Vinson syndrome , Pernicious anemia , Megaloblastic anemia ) • Hemolytic anemia : ( G6PD Deficiency , thalassemia , Sickle-cell disease / trait , Hereditary spherocytosis , Hereditary elliptocytosis , Hereditary stomatocytosis , Warm autoimmune hemolytic ...

Pathology

... ( Iron deficiency anemia , Plummer-Vinson syndrome , Pernicious anemia , Megaloblastic anemia ) • Hemolytic anemia : ( G6PD Deficiency , thalassemia , Sickle-cell disease / trait , Hereditary spherocytosis , Hereditary elliptocytosis , Hereditary stomatocytosis , Warm autoimmune hemolytic ...
Thalassemia in Medical Dictionary

Alpha

... you can expect when taking them. Alpha thalassemia trait This condition is caused by defects on or ... alpha and two called beta . In the type of thalassemia classified as beta thalassemia , there are too few beta chains, and as a ...

Anemia

... ... Anemia , Cooley's: Better known today as thalassemia (or as beta thalassemia or thalassemia major). The clinical picture of this important ...

Serum sickness

... ( Sickle Cell Anemia ) Sickle Cell Anemia thalassemia thalassemia Major ( thalassemia ) ...

Sickle Cell Disease

... conditions, such as sickle cell disease , thalassemia , and glucose -6-phosphate dehydrogenase ... , sickle cell disease , cystic fibrosis , or thalassemia ), especially if either you or the father has a ... are called hemoglobin SC disease and sickle thalassemia . The 3 conditions differ in the types and ...

Sickle cell trait

... ( Sickle Cell Anemia ) Sickle Cell Anemia thalassemia thalassemia Major ( thalassemia ) ...

Thalassemia

... thalassemia - A genetic disease that results when there ... to as alpha or beta globin chains. thalassemia is an inherited disorder that affects the ... carries oxygen to the tissue s in the body). thalassemia includes a number of different forms of anemia ....

Thromboembolism

... ( Sickle Cell Anemia ) Sickle Cell Anemia thalassemia thalassemia Major ( thalassemia ) ...

Asymptomatic

... one copy of the gene have a much milder form of the disease called thalassemia minor or thalassemia trait and are usually asymptomatic and ... ...

Beta

... Beta thalassemia minor, or trait This form of thalassemia is caused when only one of the two beta genes is abnormal, causing ...

Sickle Cell

... the disease . inherited conditions, such as sickle cell disease , thalassemia , and glucose -6-phosphate dehydrogenase deficiency autoimmune ... disease , hemophilia , sickle cell disease , cystic fibrosis , or thalassemia ), especially if either you or the father has a family history of an ...

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Thalassemia in Biological News

Avoiding Spleen Removal for Cooley's Anemia SufferersAvoiding spleen removal for Cooley's anemia suf

... Mutations in the beta globin gene can lead to thalassemia or sickle-cell anemia. thalassemia and sickle-cell anemia are quite common, not only ... blood clots. Splenectomy is common for thalassemia patients because their red blood cells are ...

Birth defects: 8 million annually worldwide

... of all such birth defects in 2001: congenital heart defects (1,040,865 births); neural tube defects (323,904 births); the hemoglobin disorders thalassemia and sickle cell disease (307,897 births); Down syndrome (217,293 births); and G6PD deficiency (177,032 births). The database includes only birth ...
Thalassemia in Biological Technology

Therapure Biopharma Inc. Announces Manufacturing Agreement with Biomedical Frontiers Incorporated -- Contract will Support Phase II Trials for Thalassemia Treatment

... believes that their product offers advantages over existing treatments for thalassemia that will result in improved patient compliance and therefore better ... these studies and bring a more effective and user-friendly treatment for thalassemia and other iron overload disorders to markets." About Therapure ...

BMP Sunstone Reports Second Quarter 2008 Financial Results

... treatment for iron overload in the bloodstream which is often associated with thalassemia, a disease that can lead to organ damage and heart failure. thalassemia is particularly prevalent in humid environments, like that in Southern China, where it is estimated that 7-8% of the population needs treatment for ...
Thalassemia in Biological Definition

Blood

... the blood-forming tissues. Major blood loss, whether traumatic or not (e.g. during surgery), as well as certain blood diseases like anemia and thalassemia , can require blood transfusion . Several countries have blood banks to fill the demand for transfusable blood. A person receiving a blood ...

Full blood count

... as microcytic or macrocytic based on whether this value is above or below the expected normal range. Other conditions that can affect MCV include thalassemia and reticulocytosis . Mean cell hemoglobin (MCH) - the average amount of hemoglobin per red blood cell, in picograms . Mean cell hemoglobin ...

Eugenics

... or to submit to sterilization. A similar screening policy (including pre-natal screening and abortion ) intended to reduce the incidence of thalassemia exists on both sides of the island of Cyprus . Since the program's implementation in the 1970s , it has reduced the ratio of children born with ...

Malaria

... anemia is particularly common among people of African origin. There is a theory that another hemoglobin mutation, which causes the genetic disease thalassemia , may also give its carriers an enhanced immunity to malaria. Another disease that gives protection against malaria is glucose-6-phosphate ...

Promoter

... . 160 (3), 919-922. Beta-Thalassemia case study: Kulozik, A.E.; Bellan-Koch, A.; Bail, S.; Kohne, E.; and Kleihauer, E. (1991). thalassemia intermedia: moderate reduction of beta globin gene transcriptional activity by a novel mutation of the proximal CACCC promoter element . Blood . ...
Thalassemia in Biological Dictionary

Thalassemia

... thalassemia is an inherited autosomal recessive blood disease. In thalassemia , the genetic defect results in reduced rate of ... blood disorders. ... The two major types of thalassemia , alpha and beta, are named after defects in ... ...
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(Date:4/18/2014)... 18, 2014) ― A new study in the ... in health-related Google searches reveals a recurring pattern that ... , Investigators from San Diego State University, the ... Campaigns, analyzed "healthy" Google searches (searches that included the ... originating in the U.S. from 2005 to 2012. They ...
(Date:4/17/2014)... PHILADELPHIA The presence of chronic inflammation in ... aggressive, prostate cancer, and this association was found ... levels, according to a study published in ... of the American Association for Cancer Research. , ... some participants of the placebo arm of the ...
(Date:4/17/2014)... targets that could be used to provide relief ... London made the discovery when researching how pain ... body. , Dr Marzia Malcangio said: "We have ... and our findings could help chemotherapy patients who ... side effect of some chemotherapy drugs (such as ...
(Date:4/17/2014)... Biology and Medicine a multidisciplinary research team ... in the Institute of Genomic Biology (IGB) on ... describe their recent work on subcellular redox homeostasis. ... functions including energy metabolism, signaling, and transcriptional processes. ... cellular behavior, redox status has been recognized as ...
(Date:4/17/2014)... published in the April issue of Immunity , ... for Medical Research, says it,s time to take a ... treating sepsis, which kills millions worldwide every year, ... molecules released into the bloodstream to fight an injury ... necessary for maintaining good health without inflammation, wounds ...
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(Date:4/20/2014)... analysis growing in importance for both basic researchers ... and the University of Maryland have developed a ... of gene activity from RNA sequencing (RNA-seq) data., ... famously speedy fish, estimates of gene expression that ... a few minutes, with accuracy that equals or ...
(Date:4/20/2014)... Although doctors have long known that people with Down ... leukemia (ALL) during childhood, they haven,t been able to ... Institute investigators has uncovered a connection between the two ... the journal Nature Genetics , the researchers track ... abnormality in Down syndrome to the cellular havoc that ...
(Date:4/18/2014)... techniques like X-ray crystallography and nuclear magnetic resonance imaging ... of molecules, but such efforts have long been hampered ... a specific molecule and often in ordered and crystalized ... impossible to peer into the structure of most molecules. ... be a thing of the past. , A ...
Breaking Biology News(10 mins):Computational method dramatically speeds up estimates of gene expression 2Dana-Farber researchers uncover link between Down syndrome and leukemia 2Dana-Farber researchers uncover link between Down syndrome and leukemia 3MRI, on a molecular scale 2MRI, on a molecular scale 3
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