telomere

Combination therapy boosts effectiveness of telomere-directed cancer cell death

...ibitors.Importantly, tankyrase inhibition enhanced telomere shortening upontreatment with a telomerase inhibit...of drug treatment that isrequired for the onset of telomere crisis and reduce the potential riskof acquired drug resistance, " writes Dr. Seimiya.Hiroyuki Seimi...

GATA: a graphic alignment tool for comparative sequence analysis

...ibitors.Importantly, tankyrase inhibition enhanced telomere shortening upontreatment with a telomerase inhibit...of drug treatment that isrequired for the onset of telomere crisis and reduce the potential riskof acquired drug resistance, " writes Dr. Seimiya.Hiroyuki Seimi...

Tiny roundworm's telomeres help scientists to tease apart different types of aging

...cs, available online now. In the past, preventing telomere shortening has often been portrayed as the key to ... C. elegans is the perfect model organism to study telomere biology since their regulation is similar to human telomeres," says first author Marcela Raices, a p...

A little telomerase isn't enough

...ese animals turns out to be the animal's inherited telomere length, not the status of the telomerase gene, say...eres. "We know it only takes one critically short telomere to make a cell die, so it's clear that the more really short telomeres a person has the faster probl...

Aging cells, aging body: Fresh evidence for a connection

...cative senescence, the most important biomarker is telomere dysfunction-induced foci, or TIFs. Presence of these structures signals that the protective chromosome caps called telomeres have dwindled enough to halt cell division. Scientists painstakingly counted the cells with aging biomarkers. What they foun...

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Vector

...somal elements such as origin of replication , telomere s and centromere (in eukaryotes ). Full article >>> To analyze splicing in vitro, a plasmid vector was prepared that contained the intron and parts of the exons downstream of a phage RNA polymerase promoter . Full ...

Telomere

...irpin structure. Full article >>> telomere The protective structure at each end of a eukaryo...the concept of how the ends of chromosomes , the telomere s, shorten each time the cell divides. View QuickTime Movie Test Strip—Cedar Creek ... Full...

Telomerase

...transcriptase s that are involved in synthesis of telomere s in most organ isms. They prevent the subsequent...se An enzyme that catalyzes the lengthening of telomere s; the enzyme includes a molecule of RNA that serves as a template for new telomere segme...

T cell

...somal elements such as origin of replication , telomere s and centromere (in eukaryotes ). Full article >>> The migration of different cell types, such as leucocyte s and tumour cells , involves cellular strategies to overcome the physical resistance of three-dimensional tissue n...

Synapsis

...ing over occurs. Normally syndesis starts at the telomere s and passes on to the centromere s like a zipper. Full article >>> The zygotene stage sees the completion of synapsis . The combined homologous chromosomes are said to be bivalent , a reference to the two homologous chromosome...

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Gene That Might Be Responsible For Aging

...to daughters) was strongly correlated with similar telomere length between parents and children. Results also confirm telomere length is longer in women than in men. Previous studies show the relative length of telomeres is a...

Chromosome Ends Trigger DNA Damage Response For Telomere Protection

...stability and the DNA damage machinery. An exposed telomere could readily be taken for a break and recognized as damage, and thus, have to be distinguished from DNA breaks that initiate a DNA damage response. To prevent the cell's DNA repair machinery from confusing telomeres with broken strands of DNA that ...

Telomerase Vital In Maintaining Ability of Stem Cell to Multiply

...e genetic basis gets obscured due to the inherited telomere length and not the gene. "If you were to search for the genetic mutation behind this mouse's disease, you wouldn't find it -- there isn't one," says Greider. "These mice develop disease only because their telomeres are short, and having telomerase do...

Link between Old Cells and Ageing probed

... important indicator for replicative senescence is telomere dysfunction that stops the division of cells. Infact, scientists did the hair splitting task of counting the cells with bio markers. Their finding revealed that the number of senescent cells increased with advancing age, with cells present in 5 yr ol...

Inactivation of Rad9 in Tumor Cells Would Be Advantageous In Cancer Therapy

...ion. Rad9 proteins interact with proteins called telomere binding proteins. During the experiment if Rad9 in human cells were inactivated it resulted in damaging the chromosomes and caused end-to-end fusion at telomeres. This disrupted the cell cycle and caused cell death. Because radiation treatments inc...

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Geron's Telomerase Inhibitor Cancer Drug Demonstrates Good Pharmacokinetics and Tolerability in Phase I/II Trial

...s, no significant changes intelomerase activity or telomere length in the bulk circulating CLLcells of treated patients have been observed. These pharmacodynamicresults are consistent with expectations because of the relativelyshort exposure of CLL cells in patients' blood to concentrations ofdrug capable of ...

Telomerase Presentations at the AACR 2007 Annual Meeting

... control genes in mouse models of cancershowed how telomere loss is a tumor suppressive mechanism whengrowth c... the latter setting, telomeraseupregulation quells telomere dysfunction and genomic instability,and confers replicative immortality to highly mutated cells whic...

telomere at Medicine Dictionary

Autosomal recessive

... and aging , which are believed to be related to telomere dysfunction. Full article >>>...