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Telomere in Medical News

Multivitamins Might Prolong Life

... corresponds to about 9.8 years less age-related telomere shortening, the researchers noted. Vitamins C ... Chen said. But, whether the vitamins preserved telomere length or actually lengthened life is not clear, ... a healthy lifestyle," he said. "Although shorter telomere length has been linked to higher mortality and ...

RevGenetics Releases Its New Science-Based Telomere Health Supplement Formulation for DNA and Chromosome Health

... helps slow and repair some of the natural telomere DNA shortening that happens as we age MIAMI, ... update and release of its latest science-based telomere health supplements , Astral Fruit. To ... at a recent study entitled: "Proteins induced by telomere dysfunction and DNA damage represent biomarkers ...

First sister study results reinforce the importance of healthy living

... that cap the ends of a person's chromosomes. telomere length is one of the many measures being looked ... women who were obese for a long time had reduced telomere length. The researchers looked at the ... measures of current and past body size and telomere length in 647 women enrolled in the Sister Study. ...

Enhanced skin cancer risk linked to defects in cellular aging controls

... (DMM), dmm.biologists.org , describes how telomere dysfunction in skin cells can lead to increased ... the molecular mechanisms underlying skin cell telomere dysfunction using a mouse model of Xeroderma ... This study establishes a link between telomere dysfunction, cancer progression and the ...

The 2009 Leibniz Prize: Eleven new scientific discoverers

... division. Rudolph has studied this process of telomere shortening and its effects in numerous ... is in the enzyme telomerase, which inhibits the telomere shortening, thus allowing cells to divide more ... models and mutants, Rudolph was able to show that telomere shortening ultimately leads to a shorter lifespan ...

Science Fiction Has Become Reality with Remarkable Anti-Aging Treatment Breakthrough - Turning Back the Biological Clock in Aging

... is a revolutionary technology that is based on telomere biology. Telomeres are part of your DNA. They are ... an opportunity to slow or potentially reverse telomere shortening-hence technically making ... 64, recipient of TA-65. The emerging science of telomere biology is changing the way science and society ...

Sedentary Lifestyle Accelerates Aging

... Overall, the study participants had an average telomere loss of 21 nucleotides (structural units) per ... active. "Such a relationship between leukocyte telomere length and physical activity remained significant ... wrote. "The mean difference in leukocyte telomere length between the most active [who performed an ...

Mayo Clinic study points to a possible biomarker for colon cancer in people 50 and under

... telomeres raises the possibility of one day using telomere length as a biomarker of cancer or an early ... between colon cancer patients and increased telomere shortening is exciting because, if validated, it ... treatment strategies. For example, we know that telomere length can be repaired, so we want to look ...

Advances in drug screening: building a better haystack for the needles of tomorrow

... of molecular compounds for the ability to disrupt telomere maintenance. Through their screening process, the ... that keep the DNA from fraying at the ends. The telomere consists of a short repeated segment of six DNA ... below a critical threshold. In cancers, the telomere structures are maintained but they require ...

New telomere discovery could help explain why cancer cells never stop dividing

... may provide a new avenue of attack for stopping telomere renewal in cancer cells. Inside the cell ... from getting scrambled when cells divide. The telomere is like a cellular clock, because every time a cell divides, the telomere shortens. After a cell has grown and divided a ...

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Telomere in Medical Technology

Telomerase Presentations at the AACR 2007 Annual Meeting

... genes in mouse models of cancer showed how telomere loss is a tumor suppressive mechanism when growth control genes are generally intact. telomere shortening in this setting triggers arrest of ... latter setting, telomerase upregulation quells telomere dysfunction and genomic instability, and confers ...

Geron's Telomerase Inhibitor Cancer Drug Demonstrates Good Pharmacokinetics and Tolerability in Phase I/II Trial

... properties that are linear with respect to the doses tested so far. Up to the current dose levels, no significant changes in telomerase activity or telomere length in the bulk circulating CLL cells of treated patients have been observed. These pharmacodynamic results are consistent with expectations ...

Geron Corp. Licensee TA Sciences Announces Landmark 7/07/07 Teleconference to Answer Questions About TA-65, Their Telomerase Activator With Proven Age Management Benefits

... of the exclusive 12 month "PATTON PROTOCOL." TA-65 is sold under exclusive license from the Geron Corporation, the recognized worldwide leader in telomere Biology. CONTACT: TA Sciences, +1-212-588-8805 Web site: http://www.tasciences.com/ ...

Autosomal recessive

... including genomic instability, cell cycle checkpoint defects and predisposition to cancer and aging , which are believed to be related to telomere dysfunction. ...
Telomere in Biological News

Researchers use chemical from medicinal plants to fight HIV

... because a part of their chromosomes known as a telomere becomes progressively shorter with cell division. ... therapy, can prevent or slow this progressive telomere shortening, which could make it a key weapon in ... . A telomere is a region at the end of every cell chromosome ...

When cells go bad

... the first to show in animals that losing just one telomere the end of a chromosome can lead to many ... "The essential point is that loss of a single telomere may be a primary event that puts a cell on the ... biology, found how fruit fly cells with a missing telomere sometimes avoid suicide and instead continue to ...

Baumann lab identifies elusive telomere RNA subunit in single cell model

... for new anti-cancer drugs. A correlation between telomere length and a variety of diseases has further ... on the sometimes surprising correlations between telomere shortening and stress, smoking, obesity, and a ... in a variety of simple model organisms, but telomere maintenance turned out to be quite different in ...

Could vitamin D, a key milk nutrient, affect how you age?

... stress. Using a genetic marker called leukocyte telomere length (LTL), they found those with the highest ... lower levels of inflammation and body stress. The telomere difference between those with the highest and ... there are several lifestyle factors that affect telomere length (obesity, smoking and lack of physical ...

Peter Baumann named Howard Hughes Medical Institute Early Career Scientist

... degenerative diseases. On the other hand, telomerase, a protein central to telomere elongation, is activated in most cancer cells and is considered a promising target for anticancer drugs. By understanding how telomere lengthening is regulated and how telomeres are prevented from becoming too ...

UT Southwestern researchers identify gene linked to inherited form of fatal lung disease

... almost 15 percent of those with familial IPF. Up to 40 percent have short telomere lengths and evidence of telomerase dysfunction. "But we were still left ... Dr. Garcia said. "What about the rest of the families that have normal telomere lengths? What was causing their lung disease?" In the current study, ....

Landmark study opens door to new cancer, aging treatments

... "It's extremely exciting," Skordalakes says. "For the first time, we can see how telomerase assembles at the end of chromosomes to initiate telomere replication." Looking ahead Skordalakes plans to further study TERT and search for new telomerase inhibitors that could become cancer ...

UCLA study identifies mechanism behind mind-body connection

... heart disease and aging. Previous studies show that an enzyme within the cell, called telomerase, keeps immune cells young by preserving their telomere length and ability to continue dividing. FINDINGS: UCLA scientists found that the stress hormone cortisol suppresses immune cells' ability to ...

Osteoarthritis may be sign of faster 'biological ageing'

... the findings showed that white cell telomere lengths were associated with chronological age. ... the 160 people with hand osteoarthritis, the telomere length was significantly shorter than among those ... osteoarthritis were over 50, and the amount of telomere shortening was equivalent to that accrued over 11 ...

A little telomerase isn't enough

... animals turns out to be the animal's inherited telomere length, not the status of the telomerase gene, ... "We know it only takes one critically short telomere to make a cell die, so it's clear that the more ... lab reported the role of the critically short telomere in 2001. The usual treatment for people with ...

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Telomere in Biological Technology

Former Telomolecular CEO Clarifies SEC Settlement

... particularly diseases related to chromosomal telomere shortening. The Company worked with a number of ... to human cells and observe significant signs of telomere regeneration that was not observed when ... diseases of aging might respond positively to telomere elongation. The company had also made advances in ...

Ten Top Latin American Scientists Named 2009 Pew Fellows in the Biomedical Sciences

... Luis Francisco Zirnberger Batista, Ph.D. Laboratory of Steven Artandi, M.D., Ph.D. Stanford University telomere complex and genetic disease Chile Veronica Eisner, Ph.D. Laboratory of Gyorgy ...

Gemin X Pharmaceuticals Selects and Deploys Clinical Force CTMS

... candidates obatoclax (GX15-070), an innovative pan Bcl-2 inhibitor, and GMX1777, a novel inhibitor of NAD+ synthesis, and preclinical studies for its telomere Capping and SMAC Mimetic programs. Potential treatment indications for the full scope of pipeline programs span a broad range of hematological and ...
Telomere in Biological Dictionary

Telomere

... A telomere is a region of repetitive DNA at the ends of ... themselves genes, but neither are they ... The telomere theory ... Thus, telomere erosion and Hayflick limits could account for ...

Telomerase

... specific DNA sequence repeats to the 3' end of DNA strands in the telomere regions, which are found at the ends of eukaryotic chromosomes. The ... of the cellular aging ... Though telomerase is required to maintain telomere length, it is inactive in ... Since such cells still lack telomerase , ...

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