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Telomerase in Medical News

RevGenetics Releases Its New Science-Based Telomere Health Supplement Formulation for DNA and Chromosome Health

... What Astral Fruit does is activate the enzyme telomerase by using a natural herbal extract. telomerase is a naturally occurring activity that the immune ... when preparing to combat infection. However, telomerase also repairs cellular damage in the cells' ...

Also in the March 24 JNCI

... Human Cytomegalovirus Stimulates telomerase Activity in Tissue Culture Cells Infection ... cytomegalovirus (HCMV) triggers expression of the telomerase reverse transcriptase (hTERT) gene in both normal ... Several other cancer-related viruses stimulate telomerase activity, which promotes cell proliferation and ...

Immune cells from patients with rheumatoid arthritis have prematurely aged chromosomes

... information after repeated cell division. telomerase adds short repeated DNA sequences to the ends of ... of the very few cells in adults that can turn on telomerase when stimulated, probably because they have to ... with rheumatoid arthritis make 40 percent less telomerase enzyme when stimulated. The cells came from 69 ...

Secrets of Telomerase Revealed

... an enzyme involved in both cancer and aging. telomerase works by adding repeats of a short DNA sequence ... loss of genetic information during cell division. telomerase works in embryonic stem cells and other cells ... In cancer cells, the ability to activate telomerase is often ....

Stanford researchers unmask proteins in telomerase, a substance that enables cancer

... keeping stem cells healthy. With such a resume, telomerase has been the subject of avid interest by basic ... know is what other proteins make up the massive telomerase complex. Until now, that is. Researchers at ... have identified two new proteins that make up the telomerase complex and have a lead on several more. This is ...

JCI table of contents: Nov. 15, 2007

... pathologic accumulation of fibrous scar tissue. telomerase is a protein most notable for its connections to ... School, Ann Arbor, has identified a role for telomerase in the progression of this disease in mice. telomerase activity is dependent on the presence of a ...

Telomerase enzyme structure provides significant new target for anti-cancer therapies

... all of human cancers. Since the mid-1990s, when telomerase was first identified in human tumors, scientists ... structure of a domain, or region, of the telomerase molecule essential for the activity of the ... the first direct inhibitors of telomerase. telomerase also has been shown to play a central role in ...

New telomere discovery could help explain why cancer cells never stop dividing

... cells (and some stem cells), an enzyme called telomerase rebuilds the telomere so that the cells can keep dividing. Over time, this telomerase dwindles and eventually the telomere shortens and the cell becomes inactive. In cancer cells, the telomerase enzyme keeps rebuilding telomeres long past the ...

Chronic stress can steal years from caregivers' lifetimes

... shorten, losing genetic instructions. An enzyme telomerase normally works to repair that damage to the ... the telomeres shorten and the activity of the telomerase enzyme lessens, he said. It's part of the aging ... those of the controls, and that the level of the telomerase repair enzyme among caregivers was also lower. ...

AIDS Drug Slows Spread of Deadly Childhood Brain Cancer

... of Cancer reports that ABC (Abacavir) suppresses the enzyme telomerase. telomerase activity appears to be essential for certain tumor survival and growth, ... appeared better tolerated by patients than other drugs used to target telomerase in trials, and ABC's safety record in long-term AIDS treatment would make ...

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Telomerase in Medical Technology

A Milestone in Cancer Genetics: deCODE Discovers First Common Genetic Variants Affecting the Risk of Many Types of Cancer

... with increased risk of BCC and also with risk of cancer of the lung, bladder and prostate. Rs 2736089 is located in the gene encoding the human telomerase reverse transcriptase (TERT), which directs the addition of repeat DNA sequences to the ends of chromosomes. Importantly, the risk of these different ...

Vical Receives Milestone Payment from Merck & Co., Inc. Triggered by Planned Initiation of Investigational Cancer DNA Vaccine Trial

... of an investigational plasmid DNA (pDNA) cancer vaccine. The candidate vaccine is based on Vical's DNA gene delivery technology and encodes human telomerase reverse transcriptase (hTERT). hTERT is the subject of separate license agreement. "The breadth of applications for Vical's gene delivery ...

Telomerase Presentations at the AACR 2007 Annual Meeting

... referenced multiple presentations on the role of telomerase and telomeres in cancer at this year's American ... approximately 80 presentations on telomere and telomerase biology reflecting the growing body of evidence supporting the importance of telomerase as a universal cancer target for drug and vaccine ...

Geron's Telomerase Inhibitor Cancer Drug Demonstrates Good Pharmacokinetics and Tolerability in Phase I/II Trial

... 12, 2007 - Geron Corporation's (Nasdaq:GERN) telomerase inhibitor cancer drug, GRN163L, has demonstrated ... uncertain at this time given the lack of measured telomerase inhibition in this patient. "We are encouraged ... results," said Dr. Colowick. "The first and only telomerase inhibitor in clinical trials continues ...

Geron Corp. Licensee TA Sciences Announces Landmark 7/07/07 Teleconference to Answer Questions About TA-65, Their Telomerase Activator With Proven Age Management Benefits

... NEW YORK, June 15, 2007 /PRNewswire/ -- telomerase Activation Sciences, Inc. (T.A. Sciences) ... and positive anti-aging benefits from a telomerase Activator. Statistically significant results were ... of the vast, powerful, and tangible benefits of a telomerase Activator in human aging. This trial has been ...

Research Indicates Geron's Human Embryonic Stem Cell-Based Therapeutic for Spinal Cord Injury Evades Direct Attack by the Human Immune System

... cord injury, heart failure, diabetes and HIV/AIDS. The company is advancing an anti-cancer drug and a cancer vaccine that target the enzyme telomerase through multiple clinical trials. Geron is also the world leader in the development of human embryonic stem cell-based therapeutics, with its spinal ...

Research Documents Scalable Production, Survival Following Engraftment and Positive Impact on Cardiac Function in Infarcted Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for Heart Failure

... cord injury, heart failure, diabetes and HIV/AIDS. The company is advancing an anti-cancer drug and a cancer vaccine that target the enzyme telomerase through multiple clinical trials. Geron is also the world leader in the development of human embryonic stem cell-based therapeutics, with its spinal ...

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Telomerase in Medical Dictionary

Ferritin

... iron binding capacity by 7 per cent. All of these changes were statistically significant. The rise in serum ferritin was 12 ... tumor cell telomerase activity and RNA;[30] urinary vanillylmandelic acid , homovanillic acid , and their ratio; dopamine; CD44 expression; TrkA gene expression; ...
Telomerase in Biological News

Stowers Institute's Baumann Lab identifies key step in maturation pathway of telomerase

... enzyme is made and assembled from its components. telomerase uses part of an RNA subunit as a template to add ... must be processed into a shorter mature form for telomerase to function. "We discovered a new pathway of ... end. We now show that 3' end processing for telomerase RNA uses a fundamentally different and novel ...

Researchers use chemical from medicinal plants to fight HIV

... the T-cells fighting that virus can't keep their telomerase turned on forever," Effros said. "They turn off, ... Previous studies have shown that injecting the telomerase gene into T-cells can keep the telomeres from ... in traditional Chinese therapy and which enhances telomerase activity in other cell types. They tested ...

Novel anti-cancer mechanism found in long-lived rodents

... lived as long as we humans do needed to suppress telomerase activity to guard against cancer. telomerase helps cells reproduce, and cancer is essentially ... squirrel that live for 24 years or more? With telomerase fully active over such a long period, why isn't ...

Landmark study opens door to new cancer, aging treatments

... researchers in their efforts to design effective telomerase inhibitors, says Emmanuel Skordalakes, Ph.D., ... says. "That means a drug that deactivates telomerase would likely work against all cancers, with few ... The study elucidates the active region of telomerase and provides the first full-length view of ...

UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes

... have known for some time that an enzyme called telomerase is crucial to cancer's progress. Now, for the ... biology and genetics at UGA, "and the fact that telomerase keeps these telomeres growing when it should be ... for the proliferation of cancer. That makes telomerase a very promising target for a potential drug to ...

Researchers find way to make tumor cells easier to destroy

... also enhances the activity of an enzyme called telomerase in cancer cells," he says. "Telomerase helps ... them to survive. We used compounds that inhibit telomerase and showed that cancer cells then become easier ... and radiation used in combination." telomerase repairs the ends of chromosomes by maintaining ...

Baumann lab identifies elusive telomere RNA subunit in single cell model

... Baumann Lab has identified the long-sought telomerase RNA gene in a single-cell research model. Their ... the ends of chromosomes to replenish lost DNA. As telomerase is required for the continued growth of most ... has further intensified interest in understanding telomerase and its regulation. The RNA subunit ...

Columbia to award 2007 Horwitz Prize to three generations of teacher-student scientists

... did not set out to answer questions about aging, telomerase has provided answers. The sequencing of the telomeres and the discovery of telomerase has lead to an entirely new field of research ... telomerase, they have a limited lifespan. Adding telomerase to human cells in culture dishes makes cells ...

UT Southwestern researchers identify gene linked to inherited form of fatal lung disease

... TERT and TERC. These two genes are normally responsible for producing the telomerase enzyme, which elongates the lengths of DNA at the ends of chromosomes, ... familial IPF. Up to 40 percent have short telomere lengths and evidence of telomerase dysfunction. "But we were still left with a big question mark," Dr. ...

Telomeres resemble DNA fragile sites

... a considerable amount of time. The only other known replication problem posed by telomeres was solved in 1985 when it was shown that the enzyme telomerase elongates telomeres, which shorten during every cell division. The second problem posed by telomeres, the so-called end-protection problem, was ...

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Telomerase in Biological Technology

Lytix Biopharma and KAEL-GemVax Announce Joint Clinical Trial to Combine LTX-315 and GV1001 Cancer Immunotherapy

... that trigger activation of the immune system. On the other hand GV1001, a telomerase peptide vaccine in phase III trials, is one of the best documented ... a vaccine directed against the catalytic subunit of human telomerase. telomerase is a universal tumour antigen expressed in 85-90% of cancer tissues. ...

Former Telomolecular CEO Clarifies SEC Settlement

... Mr. Sarad said the company was the first to deliver active human telomerase and synthetic DNA nanocircles to human cells and observe significant signs of telomere regeneration that was not observed when delivering inactive telomerase or linear strands of the same DNA. Studies performed by UCLA suggest that ...

hNT BlueNeurons Express b-Galactosidase at High Levels

... neurons, hNT neurons* ( figure 1 ). In the course of RAinduced differentiation, NT2 cells lose neuroepithelial markers and telomerase activity, acquire many neuronal markers, begin to express glutamate receptor channels, change the metabolism of amyloid ...
Telomerase in Biological Products

TRAPEZE® RT Telomerase Detection Kit from CHEMICON

Description:... The TRAPeze RT telomerase Detection Kit is a highly sensitive in vitro ... detection and real time quantification of telomerase activity. It incorporates refinements to the ... TRAPeze assay and adds the ability to quantitate telomerase activity using fluorescence energy transfer (ET) ...
Company:CHEMICON
Telomerase in Biological Definition

Cancer

... are less likely to go into apoptosis (programmed cell death) when damaged by therapy. There are more mutations that make a tumor more malignant. telomerase mutations remove additional barriers, extending the number of times a cell can divide. Other mutations enable the tumor to grow new blood vessels ...

Cell division

... with each division and eventually can no longer protect the chromosome. Cancer cells, on the other hand, are "immortal." An enzyme called telomerase allows them to continue dividing indefinitely. See also Cell cycle Cell growth External link How Cells Divide: Mitosis ....
Telomerase in Biological Dictionary

Telomerase

... telomerase is an enzyme that adds specific DNA sequence ... contain condensed DNA material, ... telomerase ( ) n. An enzyme that is found in the ... most cancer cells and that preserves the telomerase is an enzymatic ribonucleoprotein complex that ...
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