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Targeting in Medical News

Raptor Pharmaceuticals Corp. and TorreyPines Therapeutics, Inc. Announce Merger Agreement

... Company Focusing on Improved Drug targeting and Reformulation of Existing Therapeutic ... development candidates and preclinical drug targeting platforms designed to improve drug delivery of ... existing treatments, through enhanced drug targeting or reformulation of existing therapeutic ...

A Phase III Alzheimer's Drug Increases Levels of Beta Amyloid in the Brain - But Still Provides Benefits

... were among the advances in potential therapies targeting two abnormal brain proteins - beta amyloid and ... enhancing, or suppressing an immune response) targeting beta amyloid is being researched widely by ... Aging) Moran Boimel, et al -- Immunotherapy targeting Pathologically Phosphorylated Tau In A Tauopathy ...

Purdue researchers create prostate cancer 'homing device' for drug delivery

... tumors, and, if they could be linked to this new targeting molecule, we could have a two-pronged attack for ... the tumors." There also is potential for the targeting molecule to be used to attack the vasculature of ... and first author of both papers, compared the targeting molecule to a homing device. "The molecule ...

Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells

... vector was produced on 293T cells. Specific targeting of this novel adenoviral vector to pancreatic ... specific in vitro targeting, in vivo targeting to subcutaneous growing human pancreatic cancer ... ) mouse model however, no increased adenoviral targeting to subcutaneously growing human pancreas cancer ...

UNC study suggests new approach to common cause of blindness

... that leads to macular degeneration. Furthermore, targeting this new protein may prove to be safer and more ... the generation of abnormal blood vessels. Drugs targeting CCR3 were significantly more effective than those targeting VEGF, meaning this could represent a new therapy ...

New antibiotics could come from a DNA binding compound that kills bacteria in 2 minutes

... drugs. As this antibiotic compound operates by targeting DNA, it should avoid all current resistance ... on the application of this useful property for targeting the DNA of cancer cells as it could bind to, coil ... that it might also be a very clever way of targeting drug-resistant bacteria. New research at the ...

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Targeting in Medical Technology

Raptor Pharmaceuticals Receives Notices of Allowance for Two NeuroTrans(TM) Patent Applications

... effect. The development of effective brain targeting and delivery technologies, such as ... to protect the use of our NeuroTrans(TM) CNS targeting peptides and the extensive range of potential ... the application of highly specialized drug targeting platforms and formulation expertise. Raptor ...

Cequent tkRNAi Technology to be Presented at the Centennial Meeting of the American Association for Cancer Research

... Safety and Efficacy of a tk RNAi Therapeutic targeting Beta-Catenin (CTNNB1) , received special ... tkRNAi therapeutic Presentation targeting the primary oncogene (beta-catenin, CTNNB1) ... present data describing the targeting of chemotherapy resistance with tkRNAi. Here, ...

Pharmacyclics, Inc. Announces Closing of a Private Financing With the Principals of Pacific Biopharma Group, Ltd.

... cancers; an inhibitor of Factor VIIa (PCI-27483) targeting pancreatic, gastric, colon and breast cancers; a ... currently in a Phase I clinical trial and targeting B-cell related oncology applications; a Btk inhibitor in advanced preclinical testing (PCI-45261) targeting autoimmune and allergic indications; and an ...

Cequent to Present First Proof of Activity of an Oral RNAi Drug in Non-Human Primates at February Keystone Conference

... an orally administered tk RNAi therapeutic targeting the primary oncogene (beta-catenin, CTNNB1) in ... affected." The study showed that tk RNAi targeting beta-catenin was well tolerated at high dosing ... in pre-clinical development, are drug candidates targeting colon-cancer prevention and inflammatory bowel ...

Raptor Pharmaceuticals Provides Update on Targeting Platforms

... that could increase the utility of RAP-based targeting platforms and potential therapeutics. RAP-based ... and will complement our growing in-house set of targeting peptides." Raptor also announced that the ... company focused on improving drug targeting to expand the reach and benefit of existing ...

Novel Photoconductive Life Science Research Innovation Enables Rapid, Reproducible, and Non-Invasive Cellular Excitation

... electrode arrays). The non-invasive, optical targeting used by the PSD allows for an extended ... without causing damage to the cells while optical targeting enables highly controlled depolarization of only ... which does not allow for specific cell targeting and/or rapid repetitive depolarization, ...

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Targeting in Medical Products

Autolet Impression

Description:... Zone Technology and Force Adjustment that allows ultimate control and comfort when lancing. Comfort Zone Technology increases comfort when lancing by targeting the sensation and perception of pain. This approach masks the pain of lancing to maximize comfort when ....
Company:Owen Mumford, Inc.

Photosilk

Description:... operating time. Photosilk is an effective and reliable pulsed light system for faster and extensive treatments suitable for any phototype, especially targeting fairer skins. These characteristics make it a real help for the operator who will be now able to satisfy all customers with successful results in a ...
Company:DEKA Research & Development Corp.

Parvovirus (Erythrovirus) B-19 ASR

Description:... The Parvo B19 ASR contains primers and a FAM-labeled probe targeting the VP1 gene of Parvovirus B19. In addition, the Parvo B19 ASR contains primers and a Texas Red-labeled probe for an internal control sequence. This ...
Company:Cepheid

BioPlex® 2200

Description:... bead-based multiplexing immunoassay platform that can deliver up to 2200 results per hour. The system will initially include a panel of assays targeting autoimmune diagnostics. Future assays in development are in the areas of serology, infectious disease, cardiac and ....
Company:Bio-Rad Laboratories

HSV Typing ASR

Description:... The HSV Typing ASR contains primers and a FAM-labeled probe targeting the glycoprotein D gene of HSV Type 1 as well as primers and an Alexa 532-labeled probe designed to detect the glycoprotein G gene of HSV Type 2. ...
Company:Cepheid

Code Reader 2 Scanner

Description:... Supports both PC and Microsoft Windows CE platforms Reads most of the common matrix and linear bar codes Highly accurate, customizable laser targeting system Features omni-directional reading capabilities Features 1 year full replacement warranty ...
Company:Brady Corporation

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Targeting in Medical Dictionary

Dependence

... are currently focusing on the molecular mechanisms underlying Subcellular targeting of Glutamate Receptors, including the independent targeting of nmda versus ampa receptors, the activity dependence of ndma receptor ...

Colon

... complication. This risk increases in those who have bleeding disorder or those who take aspirin or other medicines that increase bleeding . targeting Liver Extends Metastatic Colon Cancer Survival THURSDAY, March 2 (HealthDay News) -- Delivering chemotherapy directly to the liver improves ...

Colon Cancer

... Merck & Co., Inc. is not responsible for this content. Please discuss any and all treatment options with your healthcare professional. targeting Liver Extends Metastatic Colon Cancer Survival THURSDAY, March 2 (HealthDay News) -- Delivering chemotherapy directly to the liver improves ...

Necrosis

... cancer in combination with radiation therapy . tumor necrosis therapy (TNT) Investigational protocol for treatment of solid tumor s by targeting and delivering cancer -fighting therapies to the nucleus of necrotic cells without affecting healthy tissue s. See Cotara; also see TNT for solid ...

Trichomoniasis

... infections , such as amebiasis , giardiasis , and trichomoniasis . It belongs to a family of drugs called antiprotozoal agents. Note: Tests targeting candidiasis and trichomoniasis are in development. Mfg: Litmus Concepts, Inc. search help: Gardnerella vagina lis ... Bacterial vaginosis, ...

Tumor

... cancer in combination with radiation therapy . tumor necrosis therapy (TNT) Investigational protocol for treatment of solid tumor s by targeting and delivering cancer -fighting therapies to the nucleus of necrotic cells without affecting healthy tissue s. See Cotara; also see TNT for solid ...
Targeting in Biological News

New cancer drug delivery system is effective and reversible

... such folate, a vitamin, also work as cancer cell targeting agents, but those now in use are not as good as ... Cheng, who helped pioneer the use of aptamers as targeting molecules for drug delivery. "This is the first ... Another advantage of using aptamers as targeting agents is that they are easily disabled. They ...

Gene-targeting pioneer Mario Capecchi shares 2007 Nobel Prize in Medicine

... in a concentration camp. His achievements in gene targeting were recognized with the 2001 Albert Lasker Award ... Mario Capecchis groundbreaking work in gene targeting will have an incalculable impact on generations ... is one of ours. Capecchis development of gene targeting in mouse embryo-derived stem cells allows ...

Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols

... de Lyon ( http://hvd.ens-lyon.fr/human_virology_dpt ) present a method for targeting hematopoietic stem cells using engineered viral vectors. The article, "Hematopoietic Stem Cell targeting with Surface-Engineered Lentiviral Vectors," is freely available on the ...

Targeting children effective use of limited supplies of flu vaccine and could help control flu spread

... targeting children may be an effective use of limited supplies of flu vaccine, ... might help control a potential pandemic." The researchers argue that targeting children for vaccination would not only help protect those at greatest ...

La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery

... and inflammatory diseases, and currently has multiple programs underway targeting asthma treatment. The company will use its expertise within this arena for the development of a potential drug candidate targeting OX40 ligand. Dr. Croft began studying OX40 in the 1990s because of ...

LSTM and UoL secure £1.4m ($2m) to develop new 'magic bullet' antimalarial drug

... Trust, aims to develop new antimalarial drug candidates which work by targeting a novel enzyme in the respiratory chain of Plasmodium falciparum the ... prerequisite of a target for a 'magic bullet' - a drug capable of targeting an organism without affecting its host. Having identified this enzyme, ...

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Targeting in Biological Technology

Data Published in Cell Stem Cell Demonstrates Potent Anti-Cancer Activity for OncoMed Pharmaceuticals' Lead Antibody

... underlining the therapeutic potential of targeting cancer stem cells to treat solid tumors. ... are made up of different types of cells and targeting cancer stem cells has a profound effect on tumor ... that discovers and develops novel therapeutics targeting cancer stem cells, the cells believed to be ...

Debiopharm and MSM Protein Technologies Sign Agreement for Research and Development of Debio 0929, a Novel Oncology Biologic

... and commercialisation of Debio 0929, an antibody targeting a G protein-coupled receptor (GPCR), to be ... MSM is the leader in the discovery of antibodies targeting multispanning membrane proteins. The company ... weight drugs currently on the market are targeting this kind of receptors. Debiopharm S.A. ...

Morphotek(R), Inc. and Cancer Innovations, Inc. Announce Evaluation and Option Agreement for Therapeutic Monoclonal Antibodies

... Morphotek will evaluate monoclonal antibodies targeting certain tumor-associated proteins. The ... that these antibodies provide a novel approach to targeting tumor-associated proteins. Antibody targeting of tumor-associated proteins has demonstrated ...

Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009

... (23,6m EUR). - In Q2 the SPC3649 compound targeting hepatitis C finalized a single dose ... for preclinical trials. - Lead candidates targeting PCSK9, which is known to play a critical ... report the results of its phase I clinical trials targeting solid tumors with EZN2968 in the 2nd half of ....

YM BIOSCIENCES REPORTS DAIICHI-SANKYO ENROLLS FIRST PATIENTS IN PHASE II, FIRST-LINE LUNG CANCER TRIAL WITH NIMOTUZUMAB

... mechanistic attributes result in it selectively targeting tissues over-expressing EGFR while avoiding ... drugs result from their indiscriminant targeting of normal healthy tissues in addition to their ... monoclonal antibody in development worldwide, targeting multiple tumor types primarily in combination ...

Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on GenSpera, Inc.

... target cancer cells in one of two ways: (1) by targeting tumor-associated blood vessels; or (2) by targeting tumors directly. The Company's lead prodrug ... also be used to attack cancer cells directly by targeting the prodrug to enzymes believed to be found ...

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Targeting in Biological Products

HEEBO Human Genome Set 200 pmol from Invitrogen

Description:... probes in 128 384-well plates. The set includes 44,308 probes targeting human genes, 864 positive control probes, 410 negative control probes, and ... probes in 101 384-well plates. The set includes 35,302 probes targeting mouse genes, 1,152 positive control probes, 97 negative control probes, ...
Company:Invitrogen

pHyPer-dMito from Evrogen JSC

Description:... (mammalian) expression vector designed to express mitochondria-targeted HyPer. pHyPer-dMito carries HyPer fused to duplicated mitochondrial targeting sequence ....
Company:Evrogen JSC

* Quick & Easy Conditional Knock Out Kit - FRT from Gene Bridges GmbH

Description:... for E.coli ) and 40C (mouse body temperature). This kit can also be used to work on bacterial artificial chromosomes (BACs). The generation of targeting constructs is achieved utilizing the high Red/ET efficiency plus the convenient removal of the Red/ET Recombineering protein expression plasmid ...
Company:Gene Bridges GmbH

* Quick & Easy Conditional Knock Out Kit - loxP from Gene Bridges GmbH

Description:... plasmid allows Cre recombination in E.coli . This kit can also be used to work on bacterial artificial chromosomes (BACs). The generation of targeting constructs is achieved utilizing the high Red/ET efficiency plus the convenient removal of the Red/ET Recombineering protein expression plasmid ...
Company:Gene Bridges GmbH

FRT flanked, Pro and Euk. Neomycin Selection Cassette plus loxP site(FRT-PGK-gb2-neo-FRT-loxP) from Gene Bridges GmbH

Description:... choice. The restriction sites can be introduced by adding the corresponding sequence in the PCR primer. The template can easily be used to generate targeting constructs mediated by Red/ET Recombination. The FRT-PGK-gb2-neo-FRT-loxP template is not linear but plasmid based (3485 bp in size). Due to its R6K ...
Company:Gene Bridges GmbH

loxP flanked, Pro and Euk. Neomycin Selection Cassette (loxP-PGK-gb2-neo-loxP) from Gene Bridges GmbH

Description:... choice. The restriction sites can be introduced by adding the corresponding sequence in the PCR primer. The template can easily be used to generate targeting constructs mediated by a single Red/ET Recombination step. The loxP-PGK-gb2-neo-loxP template is not linear but plasmid based (3446bp in size). Due ...
Company:Gene Bridges GmbH

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Targeting in Biological Definition

Malaria

... Reserve University in Ohio in 2002 (See Jacobs-Lorena et al, 2002) [4] . A major public health effort to eradicate malaria by selectively targeting mosquitos in areas where malaria was rampant was embarked upon in the 1950s and 1960s. ( The Mosquito Killer — PDF of the same article ) ...

Peroxisome

... imported from the cytosol . Each enzyme transferred to a peroxisome has a special sequence at one end of the protein, called a PTS or peroxisomal targeting signal , that allows the protein to be taken into that organelle, where they then function to rid the cell of toxic substances. Peroxisomes also ...

Protein

... Crystallography Denatured protein Intein Peptide Prion Proteinoid Protein structure prediction Protein targeting Proteome Proteomics Ribosome Structural genomics External links Proteins: Biogenesis to Degradation - The Virtual ...
Targeting in Biological Dictionary

Gene targeting

... Gene targeting is a genetic technique that uses homologous ... a gene , and introduce point mutations. Gene targeting can be permanent or conditional. Conditions can ... commercial researchers. ITL provides gene targeting services to create genetically altered mice for ...

Gene knockout

... every gene in the zebrafish genome a ... Vega Biolab is a gene targeting service company providing custom services for gene knockout and ... combination of BAC library screening, ... Vega Biolab is a gene targeting service company providing custom services for gene knockout and ...

Vesicle

... gene products] ... Definition and other additional information on Vesicle from Biology-Online.org dictionary. ... regulated, about vesicle targeting with clathrin coat proteins ... The synaptic vesicle cycle. Synapses can fire at very rapid rates. ... Synaptic vesicle components are ...

Untranslated region

... of beta-globin transcripts linked to the c-myc 3' untranslated region . ... Distinct regions in the 3' untranslated region are responsible for targeting and ... An electronic protocol book with 500 protocols ... Untranslated region (UTR) Untranslated region (UTR) ... Untranscribed Region . ...

Transport vesicle

... specifically, transport vesicles are usually refered to those ... Transport vesicles - Glossary Entry - Genetics Home Reference ... The targeting of transport vesicles to the correct membrane destination involves ... the steps involved in delivering a newly formed transport vesicle to ...

Site-specific recombination

... recombination is a special type of site - specific recombination developed by Dr. Brian Sauer (DuPont) . Cre-Lox recombination involves the targeting of a specific sequence of DNA and splicing it with the help of ... Aspects of the topic site - specific - recombination are discussed in ...

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