Food additive may one day help control blood lipids and reduce disease risk

... a strain of mice that could not make fatty acid synthase in the liver. When humans or animals eat, we take in sugars. Fatty acid synthase converts those sugars to fatty acids in the ... "To our surprise, animals missing fatty acid synthase in the liver were just like animals that couldn't ...

Also in the March 24 JNCI

... , 301-496-6641 Overexpression of Fatty Acid synthase Promotes Prostate Cancer in Mouse Models Fatty acid synthase (FASN) can act as a prostate cancer oncogene in mouse models. FASN, a ...

E. coli engineered to produce important class of antibiotic, anti-cancer drugs

... graduate students Wenjun Zhang and Yanran Li first dissected a polyketide synthase enzyme from a rice plant fungus, then reassembled it and transferred it ... said Zhang, the paper's lead author. "Our work showed that polyketide synthase from the two kingdoms can indeed be functionally combined inside the E. ...

What are simple ways to judge the efficacy of 5-fluorouracil in colonic neoplasm?

... drug. It exerts its antitumor effect through competitive thymidylate synthase (TS) inhibition. Thymidylate synthase (TS) catalyses deoxyuridine-5-monophosphate (dUMP) to ...

Key Anthrax Virulence Factor Discovered

... they also suggest a new target, known as bacterial nitric oxide synthase (bNOS), for fighting the pathogen, said study leader Evgeny Nudler, a ... said Nudler, "to find small molecule inhibitors of bacterial nitric oxide synthase that would not touch its human counterpart. If we are lucky, we will find ...

FASgen Announces New Research Discoveries in Lung Cancer

... FASgen supported research into the selective inhibition of fatty acid synthase (FASi) at the Hopkins Oncology Center as a potential therapeutic agent ... results appear in the article, "Selective Inhibition of Fatty Acid synthase for Lung Cancer Treatment," Gabrielson et al, Clin Cancer Res 200l, 13(23) ...

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Synthase in Medical Technology

Trius Antibiotics to be Highlighted in 18 Presentations at ICAAC/IDSA

... a Novel Series of Pyrimidine Antibacterials Targeting Methionyl-tRNA synthase (MetRS) -- F1-335: In Vitro Activity of Rx100472 Against Clinically ... Guided Design of Pyrimidine Antibacterials Targeting Methionyl-tRNA synthase (MetRS) Copies of these posters will be available on the Trius ...

Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes

... data that suggested patients with a lower expression of thymidylate synthase (TS) enzyme show an increased efficacy when treated with ALIMTA.(3,4) ... in WiDr human colon cancer cells is associated with thymidylate synthase overexpression. Biochem Pharmacol 2003; 66:431-38. (4) Ceppi P, ...

In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy

... allow peak release of the vector when it can have the maximum benefit." The adenovirus vector carries genes that code for inducible nitric oxide synthase (iNOS), a protein that controls cell damage in blood vessels. In the current study, the iNOS reduced restenosis by 56 percent in the carotid arteries ...

ADVENTRX Announces Completion of Patient Enrollment in Phase 2 Clinical Trial of CoFactor(R) for the Treatment of Advanced Breast Cancer

... agent 5-FU. Compared to leucovorin, CoFactor creates more stable binding of the active form of 5-FU to the target enzyme, thymidylate synthase (TS). CoFactor bypasses the metabolic pathway required by leucovorin to deliver the active form of folate, potentially allowing 5-FU to work more ...

Synvista Therapeutics' Alagebrium Shows Potential for use in Treating Diabetes-Related Gastrointestinal Complications

... the ability of its compound, alagebrium, to reduce serum levels of advanced glycated end-products (AGEs) and restore neuronal nitric oxide synthase (nNOS) activity in rats with diabetes. Loss of gastrointestinal nNOS activity is one of the major putative mechanisms for the development of diabetic ...

ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer

... agent 5-FU. In comparison to leucovorin, CoFactor creates more stable binding of the active form of 5-FU to the target enzyme, thymidylate synthase (TS). CoFactor bypasses the metabolic pathway required by leucovorin to deliver the active form of folate, allowing 5-FU to work more effectively. ...

Synthase in Medical Products

Uroporphyrinogen I Synthase

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories

Hydroxymethylbilane Synthase

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories

Synthase in Biological News

Advance in understanding cellulose synthesis

... fluorescent molecules, and found that cellulose synthase moves along "tracks" defined by the microtubules. ... at how the association between the cellulose synthase complexes and microtubules begins. The scientists were able to watch individual cellulose synthase complexes as they were delivered to the plasma ...

Atomic structure of the mammalian 'fatty acid factory' determined

... Mammalian fatty acid synthase is one of the most complex molecular synthetic ... structure of a mammalian fatty acid synthase using data collected at the Swiss Light Source ... role in primary metabolism, mammalian fatty acid synthase is also considered a promising drug target. ...

American Chemical Society's Weekly PressPac -- March 26, 2008

... energy. Recent studies found high levels of ATP synthase on the surface of cancer cells, but until now the ... cancer cells to a substance that blocks ATP synthase killed the cancer cells but did not harm normal ... researchers say. The findings suggest that ATP synthase inhibitors may represent a new approach for ...

MSU discoveries upend traditional thinking about how plants make certain compounds

... unsuspected way." The two newly identified genes, neryl diphosphate synthase 1 (NDPS1) and phellandrene synthase 1 (PHS1), cause the tomato plant to make the new enzymes that produce the ...

Computational model examines the pathways of Alzheimer's that strikes at the young

... entitled A Computational Model of the Role of Presenilin-1 and Glycogen synthase Kinase-3 in Familial Alzheimer's Disease. They will present their findings ... presenilin-1 (PS1) (a mutated gene found in familial AD) and glycogen synthase kinase (GSK-3) (a protein) and amyloid beta (Aβ) plaque (amino acids ...

Computational model examines the pathways of Alzheimer's that strikes at the young

... entitled A Computational Model of the Role of Presenilin-1 and Glycogen synthase Kinase-3 in Familial Alzheimer's Disease. They will present their findings ... presenilin-1 (PS1) (a mutated gene found in familial AD) and glycogen synthase kinase (GSK-3) (a protein) and amyloid beta (Aβ) plaque (amino acids ...

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Synthase in Biological Technology

FASgen Diagnostics, LLC Announces Production and Investment Agreement With Tetracore, Inc.

... antibodies. The tests measure the over-expression of the enzyme fatty acid synthase (FAS), which is found in virtually all solid tumor cancers. FASgen's ... Hopkins who have been studying the role of over expression of fatty acid synthase in cancer. That work has been underway for more than 15 years. FASgen ...

Celadrin(R) Research Unveiled at Nutrigenomics 2008 Meeting in Paris, France

... organization for the pharmaceutical and biotechnology industries. In these in vitro studies, Celadrin(R) was shown to inhibit the thromboxane synthase enzyme using prostaglandin G2 (PGG2) and prostaglandin H2 (PGH2) as substrates. Thromboxane is a very strong facilitator of inflammation and local ...

New approach may render disease-causing staph harmless

... in Staph. He also knew that many compounds already had been developed to block the human enzyme. I thought there was a good chance that squalene synthase inhibitors developed early on as cholesterol lowering agents might also work on this other pathway, he said. Current cholesterol-lowering drugs like ...

ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer

... agent 5-FU. In comparison to leucovorin, CoFactor creates more stable binding of the active form of 5-FU to the target enzyme, thymidylate synthase (TS). CoFactor bypasses the metabolic pathway required by leucovorin to deliver the active form of folate, allowing 5-FU to work more effectively. ...

Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System

... of enolpyruval-shikimate-3-phosphate synthase (EPSPS), which is required for the production of ... target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic details. Proc Natl Acad Sci ... the 5-enolpyruvylshikimate-3-phosphate synthase active site. Journal of Biological Chemistry ...

Oragene and DNA sequencing with ABI PRISM

... Primer design PCR primers for the human Thymidylate synthase (TYMS) gene were designed based on the publicly available DNA ... 5 samples correctly aligned to the original human Thymidylate synthase gene sequence. Figure 1 shows a representative ABI PRISM ...

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Synthase in Biological Products

Mouse Anti-Bovine Complex V (F1F0 ATP Synthase) Heart Mitochondria Monoclonal Antibody, Unconjugated, Clone 12F4AD8AF8 from MitoScience LLC

Description:... Also included are 2 mg of bovine heart mitochondria for control immunocapture. The Complex V immunocapture kit allows isolation of the ATP synthase complex (E.C. 3.6.3.14) from small amounts of tissue. This facilitates subsequent analysis of assembly state and activity. Thus the enzyme retains ...
Company:MitoScience LLC

Mouse Anti-Thymidylate Synthase Monoclonal Antibody, Unconjugated, Clone 3A7.A11 from Abcam

Description:... Mouse monoclonal [3A7.A11] to Thymidylate synthase ( Abpromise for all tested applications). entrezGeneID: 7298 SwissProtID: ...
Company:Abcam

Mouse Anti-Human ALAS2 Monoclonal Antibody, Unconjugated, Clone 6C1 from Novus Biologicals

Description:... Mouse monoclonal antibody to ALAS2 - aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic ...
Company:Novus Biologicals

Nitric Oxide Synthase Radiometric Assay Kit from Cayman Chemical

Description: The NOS assay kit measures NOS activity by monitoring the conversion of radiolabeled arginine to citrulline. This assay is simple, sensitive, and specific for NOS activity and can be used with both crude and purified enzyme preparations. The kit includes sufficient materials and reagents for 50 ...
Company:Cayman Chemical

Synthase in Biological Definition

ATP synthase

... An ATP synthase ( EC 3.6.3.14) is a general term for an enzyme ... is: ADP + P i → ATP ATP synthase in E. coli These enzymes are of crucial ... of cells. In mitochondria , the F O F 1 ATP synthase has a long history of scientific study. The F 1 ...

Ion gradient

... used for driving the molecular motor enzyme ATP synthase to make the necessary conformational changes ... are also be made by bacteria by running ATP synthase in reverse, this is used to drive flagellas. The F 1 F O ATP synthase is a reversible enzyme. Large enough quantities ...

ATPase

... active transport . ATP synthetase The ATP synthetase (or ATP synthase ) of mitochondria and chloroplasts is an anabolic enzyme that ... protons against their thermodynamic gradient. External links "ATP synthase - a splendid molecular machine" ...

Electron transfer chain

... power membrane transporters and adenosine triphosphate synthesis by ATP synthase (aka the F 0 F 1 particle). They are used in photophosphorylation ... c reductase . Complex IV - Cytochrome c oxidase . Complex V - ATP synthase , also known as the F 0 F 1 particle. All of these are proteolipid ...

Mitochondrion

... is built up. The only exit for these protons is through the ATP synthase complex. By transporting protons from the intermembrane space back into the matrix, the ATP synthase complex can make ATP from ADP and inorganic phosphate (P i ). This ...

Mitochondrion

... is built up. The only exit for these protons is through the ATP synthase complex. By transporting protons from the intermembrane space back into the matrix, the ATP synthase complex can make ATP from ADP and inorganic phosphate (P i ). This ...

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Synthase in Biological Dictionary

Cristae

... membrane of a mitochondrion. They are studded with proteins, including ATP synthase and a variety of cytochromes. The maximum surface for chemical reactions ... folds inwards, forming the cristae . ... evidence that subunits of ATP synthase are involved in cristae formation. ... Plant glossary explains basic ...

Selfing

... as a trade-off ... If selfing also shortens the time between flower maturation and ovule ... ... plant rapd sativa scar selfing synthase tetrahydrocannabinol thc by xico ... posted to colonization evolution plant selfing by biomcgary on 2007-08-23 22:26: ... (more formally, I ...

Pseudogene

... a gene but cannot be transcribed. ... A pseudogene structure in 5S DNA of Xenopus laevis" ... The discovery of a functional nitric oxide synthase (NOS) pseudogene compels us to understand pseudogenes in a new light. It confirms earlier clues suggesting that ... Pseudogene ...

Gene product

... and ... Often, annotating a new gene product reveals relationships in an ontology that ... In addition, gene products such as chitin synthase can be annotated to nodes of ... This includes gene product information, with a link to the database providing ... The species from which ...

Electron transport chain

... ... The electron transport chain is the most complex and productive pathway of cellular respiration. ... Electron Transport Chain ATP synthase ... V. THE ELECTRON TRANSPORT CHAIN AND OXIDATIVE PHOSPHORYLATION. Introduction ... Some electron carriers of the transport chain ...

Chloroplast

... the evolution of mitochondria and chloroplasts in eukaryotes. ... The Chloroplast Genome ... 6 genes encoding parts of the chloroplast ATP synthase ... ... is directed at understanding how the genetic machineries in the chloroplast and nucleus communicate to produce a chloroplast that is ...

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