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Substrate in Medical News

Expert consensus on catheter ablation of ventricular arrhythmias

... or identifying abnormal areas that contain the substrate for VA based on findings during sinus rhythm. ... no longer be triggered by catheters or no further substrate can be identified. Recent innovations in ... and facilitate identification of the arrhythmia substrate during stable sinus rhythm. Percutaneous ...

Catalyst mystery unlocked

... a perfect physical fit between catalyst and substrate is not necessary. "What really fits is the ... interaction between the enzyme active site to the substrate charges at the so-called transition state, where ... said. If Warshel is correct, catalyst and substrate would be less like lock and key, and more like ...

New ADDHERE(TM) Adhesive Tie Layer Bonds Acrylic Cap Layers to Substrates of Thermoplastic Polyolefin (TPO) in Production of Sheet for Use in Thermoforming

... to bond an acrylic layer onto a substrate of thermoplastic polyolefin (TPO) for use in ... same time, the absence of pigment from the TPO substrate means its performance properties can be easily ... thermoforming can be recycled back into the TPO substrate - both the line-trim from the sheet extrusion, ...

Making nanoparticles in artificial cells

... from the production chamber. Instead, the bubbles remain attached to their substrate via small membrane channels, like balloons tied to strings, and stand in a ... vesicles at first. The second ingredient only creeps gradually between the substrate and membrane into the channel and to the vesicle. In the vesicle, where ...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

... renal excretion and involves active tubular secretion. Sitagliptin is a substrate for human organic anion transporter-3 (hOAT-3), which may be involved in ... in sitagliptin transport has not been established. Sitagliptin is also a substrate of p-glycoprotein, which may also be involved in mediating the renal ...

Genetic difference predicts antidepressant response

... drug administered to treat CNS diseases should be analyzed for its P-gp substrate status, which can be determined by using knockout mice. From a clinical ... view, the findings warrant that patients receiving a drug that is a P-gp substrate for the treatment of brain diseases are genotyped to exclude the ...

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Substrate in Medical Technology

Amicus Therapeutics Commences Phase 3 Trial Evaluating Amigal(TM) for the Treatment of Fabry Disease

... of the change in the amount of kidney interstitial capillary GL-3, the substrate that accumulates in the cells of Fabry patients. In addition, the FDA is ... in white blood cells and in the kidney, and reduced levels of the target substrate (GL-3), as measured in renal interstitial capillary cells from kidney ...

Oxygen Biotherapeutics, Inc. Receives Letter From FDA Outlining Path Forward to Resume Oxycyte Clinical Trials in TBI in U.S.A.

... Inc. is dedicated to commercializing innovative pharmaceuticals and medical devices in the field of oxygen therapeutics and continuous substrate monitoring. The company has under development a perfluorocarbon therapeutic oxygen carrier and liquid ventilation product (Oxycyte(R)) and an ...

Amicus Therapeutics Announces Positive Progress of Three Lead Clinical Programs and General Outlook for 2009

... supports a Phase 3 clinical trial comparing Amigal to placebo based on a surrogate primary endpoint of the change in the amount of kidney GL-3, the substrate that accumulates in the cells of Fabry patients. Amicus plans to continue discussions with the FDA through a Special Protocol Assessment (SPA) ...

Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia

... if possible. Tasigna inhibits human P-glycoprotein. If Tasigna is administered with drugs that are substrates of Pgp, increased concentrations of the substrate are likely and caution should be exercised. Tasigna may also induce CYP2B6, CYP2C8, and CYP2C9. Therefore, Tasigna may alter serum concentration of ...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

... if possible. Tasigna inhibits human P-glycoprotein. If Tasigna is administered with drugs that are substrates of Pgp, increased concentrations of the substrate are likely and caution should be exercised. Tasigna may also induce CYP2B6, CYP2C8 and CYP2C9. Therefore, Tasigna may alter serum concentration of ...

SuperGen's PIM Kinase Inhibitor, SGI-1776, Causes Tumor Regression in AML Xenograft Models

... cell cycle arrest, dose dependent apoptosis and a reduction in phospho-BAD levels in leukemia and lymphoma cell lines. Phospho-BAD is a direct substrate for PIM, and may serve as a useful in vivo biomarker for future clinical trials. Most notably, SGI-1776 induced significant tumor regression in ...

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Substrate in Medical Products

ZstatFlu

Description:... quickly diagnose all strains of influenza A and B. The test uses a unique substrate for influenza neuraminidase, an enzyme that assists viral replication by promoting the release of the virus from infected cells. The ZstatFlu substrate is labeled with a chromagen. When influenza virus is present, the viral ...
Company:ZymeTx, Inc.

Anti-Thyroid Antibody (TA) Test Kit - Monkey Thyroid Substrate

Description:... conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate slides, controls, conjugate, mounting medium, phosphate-buffered saline (PBS) and ZORBA-NS serum diluents to reduce the nonspecific fluorescence ...
Company:Inverness Medical Innovations

Autoantibody Screen (AAS) Test Kit - Rat Kidney/Stomach Substrate

Description:... conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate slides, controls, conjugate, mounting medium, phosphate-buffered saline (PBS) and ZORBA-NS serum diluents to reduce the nonspecific fluorescence ...
Company:Inverness Medical Innovations

Anti-Nuclear Antibodies (ANA) Hep-2 Substrate

Description:... conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate slides, controls, conjugate, mounting medium, phosphate-buffered saline (PBS) and ZORBA-NS serum diluents to reduce the nonspecific fluorescence ...
Company:Inverness Medical Innovations

Anti-Smooth Muscle Antibody (ASMA) Test Kit

Description:... conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate slides, controls, conjugate, mounting medium, phosphate-buffered saline (PBS) and ZORBA-NS serum diluents to reduce the nonspecific fluorescence ...
Company:Inverness Medical Innovations

Anti-Mitochondrial Antibody (AMA) Test Kit

Description:... conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate slides, controls, conjugate, mounting medium, phosphate-buffered saline (PBS) and ZORBA-NS serum diluents to reduce the nonspecific fluorescence ...
Company:Inverness Medical Innovations

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Substrate in Medical Definition

Muscle atrophy

... of at least four copies of a small peptide called ubiquitin onto a substrate protein. When a substrate is thus "poly-ubiquitinated", it is targeted for destruction by the ...
Substrate in Medical Dictionary

Enzyme

... product, an enzyme is missing or defective. Enzyme Protein or RNA chain that catalyzes a particular biochemical reaction involving specific substrate (reactant) molecules. Virtually all intracellular chemical reactions are catalyzed by enzyme s. An example of an enzyme is Lactase . Home ... ...

Pathogen

... is abnormal. ^ Top ... Prevention : Routine aquarium maintenance including large, frequent water changes as well as regular vacuuming of substrate keeping pathogen ic bacteria to an absolute minimum. Post -mortem Examination - or autopsy , systematic examination of a cadaver for study or ...

Protein

... sample for screening of glycated protein . Enzyme Protein or RNA chain that catalyzes a particular biochemical reaction involving specific substrate (reactant) molecules. Virtually all intracellular chemical reactions are catalyzed by enzyme s. An example of an enzyme is Lactase . Home ... ...
Substrate in Biological News

New high-throughput screening technique makes probing puzzling proteins possible

... progression. Most studies of enzymes rely on substrate assays, which allow researchers to visibly track ... research, though, is that developing conventional substrate assays and related tools demands knowledge of the ... says Cravatt, "And if you don't know what the substrate is, you're basically out of luck." At least ...

Killer pulses help characterize special surfaces

... Dana Dlott, have devised a method to evaluate substrate surfaces by using a series of killer laser ... and report measurements for a commonly used substrate in the July 18 issue of the journal Science . ... and create an average value across the entire substrate surface. "Looking at a spectrum, you can't tell ...

New electrostatic-based DNA microarray technique could revolutionize medical diagnostics

... assays using a DNA microarray a thumbnail-sized substrate containing thousands of microscopic spots of ... process which takes about 20 minutes. Because the substrate or background surface of the microassay is ... DNA, the microspheres will levitate above the substrate surface, stacking up in "equilibrium heights" ...

A molecular switch turns on the flame in 'nature's blowtorch'

... that is, it is not in a state to react with the substrate (or anything else, for that matter). In the other orientation, however, the substrate is held tightly in the correct orientation for ... bond, and moves the P450 from the form in which substrate binds to the active form. After the reaction is ...

Unlocking the function of enzymes

... lot more difficult since both the enzyme and the substrate are conformationally flexible. After the ... use to try to determine an enzymes function or substrate specificity include physically testing thousands ... targets for new drugs. Understanding the substrate specificity of certain enzymes could allow ...

UMass Medical School researchers receive $8.5M grant award to fight AIDS

... fit within a similar space, which they dubbed the substrate envelope. Significantly, the investigators found ... the currently used inhibitors protrude beyond the substrate envelope, and many mutations that cause drug ... synthesizing novel inhibitors to fit within the substrate envelope. This strategy should greatly retard the ...

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Substrate in Biological Technology

New 'near-field' radiation therapy promises relief for overheating laptops

... new cooling method requires that the nanotubes' substrate be composed of a polar material such as ... channels excess heat from the nanotubes into the substrate which, being much larger, can be more effectively ... in the past year. Because the nanotubes and substrate are made of heterogeneous materials, says Rotkin, ...

Nanogenerators produce electricity from running rodents and tapping fingers

... and the tapping of the finger flexed the substrate in which the nanowires were encapsulated, ... Li and Guang Zhu solved that problem by using a substrate that was flexible in only one direction, forcing ... to stay on and to wrinkle the nanogenerator substrate but not so tight as to make the hamster ...

A supercharged metal-ion generator

... ions reaches the substrate, insuring that the substrate is coated with a uniform, voidless film with ... (the cathode) and a grounded anode nearby. The substrate to be coated, which carries a small to moderate ... of self-sputtering, the ion current to the substrate greatly exceeded the discharge current a result ...

Engineering nanoparticles for maximum strength

... (MSE). "We put the nanospheres on a flat silicon substrate inside NCEM's In Situ Microscope sample chamber ... nanosphere squirts out from between the substrate and the punch like a watermelon seed. "If you ... and bottom of the sphere where it contacted the substrate and the diamond anvil. This is where the spheres ...

Killer pulses help characterize special surfaces

... Dana Dlott, have devised a method to evaluate substrate surfaces by using a series of killer laser ... and report measurements for a commonly used substrate in the July 18 issue of the journal Science . ... and create an average value across the entire substrate surface. "Looking at a spectrum, you can't tell ...

A first in integrated nanowire sensor circuitry

... nanowire arrays that we can produce on any substrate even paper! and to reproduce them uniformly on ... the nanowires are detached by sliding the growth substrate away, leaving them attached to the application ... and the electronics were now positioned on the substrate as such elements might be mapped onto a much ...

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Substrate in Biological Products

CaspSCREEN from CHEMICON

Description:... cytometry in intact cells. The assay utilizes a substrate that contains two aspartate residues linked to rhodamine 110 (D2R), a reported substrate for members of capase family proteases. The rhodamine 110 conjugated substrate is non-fluorescent, however, upon cleavage of ...
Company:CHEMICON

Dithio-bis(2-nitrobenzoic acid) BioChemica from AppliChem GmbH

Description:... product no. A3754) is used as a synthetic substrate, replacing the natural substrate acetylcholine. This enzyme hydrolyses the substrate to yield acetate and thiocholine. The free thiol group of thiocholine ...
Company:AppliChem GmbH

Amphetamine ELISA Kit, Ultra from Neogen Corporation

Description:... microplate. After the incubation, the microplate is washed and K-Blue substrate (TMB) is added. After a 30 minute substrate incubation the test can be read visually or with a microplate reader. The ...
Company:Neogen Corporation

PPase-2A from Promega

Description:... kinase. With its 3638kDa catalytic subunit, PPase-2A has broad substrate specificity and may play a regulatory role in DNA replication, ... in the Ser/Thr Phosphatase Assay System, Cat.# V2460), is an excellent substrate for ....
Company:Promega

Amylase Fluorometric (Green) Assay Kit, EnzChek® from Molecular Probes (Invitrogen)

Description:... FL dye to such a degree that the fluorescence is quenched. The DQ starch substrate is efficiently degraded by a-amylase to yield highly fluorescent ... Assay Kit to serve as a control enzyme. Using 12.5 g/mL of the DQ starch substrate and a 60 minute incubation period at room temperature, the assay can ...
Company:Molecular Probes (Invitrogen)

20S Proteasome Fluorometric (AMC) Assay Kit from CHEMICON

Description:... and convenient means for assaying proteasome activity that recognize the substrate LLVY (Meng et al. 1999). The assay is based on detection of the fluorophore 7-Amino-4-methylcoumarin (AMC) after cleavage from the labeled substrate LLVY-AMC. The free AMC fluorescence can be quantified using a 380/460 nm ...
Company:CHEMICON

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Substrate in Biological Definition

Active site

... site allow the recognition and binding of the substrate . The active site in many enzymes can be ... blocked when a molecule chemically similar to the substrate binds to the active site but cannot be processed ... whereby the active site binds and encloses the substrate molecule. Often enzymes bond to ...

Allostery

... or relaxed (R), and that relaxed subunits bind substrate more readily than those in the tense state. The ... the T state over the R state The binding of substrate to one subunit causes all other subunits to ... the sequential model dictates that molecules of substrate bind via an induced fit protocol. Namely, when a ...

Allostery

... or relaxed (R), and that relaxed subunits bind substrate more readily than those in the tense state. The ... the T state over the R state The binding of substrate to one subunit causes all other subunits to ... the sequential model dictates that molecules of substrate bind via an induced fit protocol. Namely, when a ...

Competitive inhibitor

... on the same active site as the normal enzyme substrate . The substrate molecules cannot enter the active site while the ... and inhibitors cannot enter the site when the substrate is there. Characteristic for this mode of ...

Enzyme

... of one or more binding sites where the substrate (s) attach, and active site (s), where the amino ... structural properties of the enzyme and substrate are responsible for this specificity (Fig. 2). ... the maximum speed of an enzymatic reaction, the substrate concentration is increased until a constant rate ...

Fungus

... typically form a microscopic network within the substrate (food source) called the mycelium , through ... They develop into new mycelia, which invade some substrate and repeat the life cycle. These may become very ... by secreting exoenzymes into the surrounding substrate . Exoenzymes act like the digestive enzymes of ...

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Substrate in Biological Dictionary

Substrate

... substrate (building), Natural stone,masonry surface, ceramic & porcelain tiles. substrate (aquarium), the material used in the bottom of an aquarium ... In biochemistry, a substrate is a molecule upon which an enzyme acts. ...

Competitive inhibition

... to the enzyme prevents binding of the substrate and vice versa. Non- competitive inhibition ... binding affinity of the catalyst for the substrate . What is competitive inhibition ? Meaning ... the inhibitor is similar in structure to the substrate ... Competitive inhibition usually involves ...

Ribozyme

... ... More details on the Ligase Ribozyme . ... ... correspond to substrate and ribozyme as in reference 1. ... Hammerhead Ribozyme - Main ... consensus structure for the hammerhead ribozyme is shown above. ... substrate is the green strand and much of the ribozyme is magenta. ... The ...

Active site

... active site n. The part of an enzyme at which catalysis of the substrate occurs. ... The active site is usually a big pocket or cleft ... site . The part of an enzyme where the catalytic activity on the substrate takes place. ... Find and register online for sports and recreational ...

UvrA

... a high preference of binding the end of a ... The UvrA protein on its own binds preferentially to damaged DNA (Seeberg and ... Incubation of substrate G1 with UvrA and wild-type UvrB results in two retarded ... The UvrA protein forms a dimer that interacts with UvrB to form a ...

Saturation mutagenesis

... Based on Combinatorial Saturation Mutagenesis and. Logical Redesign of the Castor ... saturation mutagenesis at positions known to affect substrate ... ...

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