New universal breast cancer marker predicts recurrence and clinical outcome
The absence of caveolin-1 in the stroma
also appeared to be a marker for drug resistance ... Center, caveolin-1 is expressed by cells in the stroma
called fibroblasts, which are present in the ... that a prognostic biomarker is present in the stroma
rather than the epithelial cancer cell is ...
Mayo researchers find potential links between breast density and breast cancer risk
... composed of milk glands and ductal cells, and stroma
is the connective tissue that supports epithelial ... contained much more epithelium (6 percent) and stroma
(64 percent) and much less fat (30 percent), ... fat. "This shows us that both the epithelium and stroma
contribute to density, and suggests that the ...
New target for cancer therapy may improve treatment for solid tumors
We already knew that targeting the stroma
is essential for eradicating established large tumors, because the stroma
is like the 'root of the tumor," said study ... effects of current treatments that target stroma
are usually transient and not cancer-specific." ...
Area Around Breast Tumor May Predict Cancer's Spread
... in the tumor-suppressing p53 gene in the stroma
-- the region surrounding the tumor -- have future implications, the researchers said.
looks innocent under the microscope, but there's ... to patients.
Even further down the line, the stroma
might provide a new target for drug therapies.
Lab Study Finds Protein That May Inhibit Cancer Spread
... p53 in connective tissue (stroma) surrounding the tumor, which then stimulated production of an inhibitor of blood vessel growth in the tumor stroma
and in distant cells, according to the study.
"Prosaposin, or derivatives that stimulate p53 activity in a similar manner in the tumor stroma, ...
Potent metastasis inhibitor identified
... the tumor. This in turn stimulated production of thrombospondin-1, a natural inhibitor of blood vessel growth (angiogenesis), both in the tumor stroma
and in cells at the distant location.
"Prosaposin, or derivatives that stimulate p53 activity in a similar manner in the tumor stroma, might be ...
Genetic disease treatments and pharmacogenetics: From scientific discovery to medical delivery
... features and pathophysiology of inherited metabolic genetic disorders.
COMMON AND CANCER TYPE-SPECIFIC LOSS-OF-HETEROZYGOSITY (LOH) IN THE TUMOR stroma
AND EPITHELIUM OF 3 CARCINOMA TYPES ASSOCIATED WITH CLINICAL OUTCOME
A team of researchers led by Charis Eng, M.D., Ph.D., Chair and Director of ...
JCI online early table of contents: March 3, 2008
... bone marrow and stromal cells had to express IFN-gamma and TNF receptors. These data led the authors to suggest that IFN-gamma and TNF acted on tumor stroma
to effect bystander killing of ALVs, and they hope that this insight will aid in the development of effective strategies to eliminate established ...
Scientists discover who is likely to get dry eye syndrome after LASIK surgery
... The PRK has the same goal as LASIK, but the procedures differ. In LASIK a flap of corneal epithelium is cut and lifted to allow the underlying stroma
to be shaped by the laser. Then the flap is placed down on the eye. In PRK the corneal epithelium is mechanically removed to allow laser shaping of ...
Stroma in Medical Technology
Improved Cornea Surgery Technique Provides Enhanced Transplant Success
... keratoplasy). Today, DSAEK
(descemet-stripping automated endothelial keratoplasy)---where only
endothelial tissue attached to a thin layer of deep stroma
and the normal structure of the recipient cornea is not disrupted--is
increasingly preferred by corneal surgeons. Most patients ...
Stroma in Medical Products
Description:... epithelium from the
Bowmans membrane leaving a pristine
optical zone for laser ablation.
Epi-Lasik preserves the structural integrity
of the stroma
and is expected to minimize
discomfort, shorten the length of visual
recovery, and reduce the incidence of haze
associated with other surface ...
MEL 80 Excimer Laser
Features:... The exceptionally fast MEL 80's short ablation time reduces procedure time for greater patient comfort
exposure time means faster visual recovery
Very small 0.7 mm spot permits the finest corrections without losing the benefits of smooth ablation ...
Company:Carl Zeiss Meditec, Inc.
Stroma in Medical Dictionary
... antibiotic used to treat and prevent PCP. Sputum Material produced within the alveoli in response to an infectious or inflammatory process. stroma
... cough ing sputum production difficulty breathing , in advanced stages wheezing shortness of breath. GENERAL"Destroy sputum ...
... s and mycoplasma pneumonia s do not result in consolidation. These types of pneumonia primarily infect the walls of the alveoli and the stroma
of the lung. Symptoms of viral pneumonia are often less obvious, less severe, and come on gradually. Viral pneumonia often goes unrecognized ...
Stroma in Biological News
Gene activity reveals dynamic stroma microenvironment in prostate cancer
... HOUSTON -- (June 9, 2009) As stroma
the supportive framework of the prostate gland ... gene changes may explain why men with reactive stroma
face a more aggressive disease, said Ittmann and ... in this subgroup of patients (in which the stroma
become visibly reactive), you see a ...
Stroma genomic signature predicts resistance to anthracyclin-based chemotherapy in breast cancer
... colleagues showed the potential of the reactive stroma
to modulate tumor phenotype and the clinical ... found that it is precisely the magnitude of this stroma
reaction that was predictive of a response to ... Dr Farmer continued. "Patients who had a strong stroma
reaction characterized by an increased quantity ...
Cancer-causing protein can also help fight the tumors it causes
... be less active," says Rechavi. "It's also possible that a tumor could transfer the Ras protein into cells that normally support tumor growth, like stroma
cells that grow blood vessels for the tumor. This is why we have to work to understand what is happening."
Protein linked to change in tissue that surround and support breast tumors
... which seems to increase growth factor responses, is required for cancer to develop, or whether cancer would regress if development of this abnormal stroma
was interrupted," she says.
Tips from the American Journal of Pathology
... of human breast cancer. Stromal expression of caveolin-1 correlated with reduced levels of metastasis, and caveolin-1 was not expressed in stroma
of patients with poor clinical outcome. In addition, tumor onset in mice was accelerated in the absence of stromal caveolin-1. Caveolin-1 may ...
Newly discovered behavior in cancer cells signals dangerous metastasis
... this co-factor could be activated by contact with stroma
--the supporting structural cells of a tumor -- because the stroma
is where the majority of epithelial-type cancer ... observed. Their heavy presence implies that the stroma
may have induced the cancer cells to revert to ...
Study shows how herpes infects cornea, evades immune cells
... coworkers determined that the HSV-1 virus enters stroma
cells in a process similar to the way bacteria, ... electron microscope pictures, it looks like the stroma
cells form long arms that reach out and collect ... acidic. But even though the sacs formed by the stroma
cells were similar to the phagocyte's sacs, ...
An artificial cornea is in sight, thanks to biomimetic hydrogels
... contact lenses.
Inlays are also possible. The cornea contains layers--a top layer of protective epithelial cells, a middle layer called stroma
that provides the collagen matrix that gives the cornea its shape, and an innermost endothelial layer. With inlays, some of the epithelial layer can ...
Links between DNA damage and breast cancer studied
... can change or disrupt gene expression.
The team identified a unique oxidation-induced lesion in the DNA of breast epithelium, myoepithelium and stroma
and found that the highest concentrations of this lesion tended to occur in women in the 33- to 46-years age group, a bracket that corresponds to a ...
New human retrovirus originated in mice
Nevertheless, said Ganem, an indirect link to cancer cannot be ruled out, since "in cancer research these days, there is a lot of interest in the stroma
as the soil in which cancer arises." He added that the chronic inflammation from infection of stromal tissues may play a role in triggering such ...
Stroma in Biological Technology
Stroma in Biological Definition
... four membrane layers.
The fluid within the chloroplast is called the stroma
, corresponding to the cytoplasm of the bacterium, and contains tiny ... most of their proteins are synthesized by the cell nucleus.
Within the stroma
are stacks of thylakoids , the sub-organelle where photosynthesis ...
... This article is about stroma
in biology. For the island, see Stroma, Scotland .
can refer to:
1) The connective supportive framework of a biological ...
... synthase is also present in chloroplasts (CF O F 1 -ATP synthase). The enzyme is integrated into thylakoid membrane; the CF 1 -part sticks into stroma
, were dark reactions of photosynthesis ( Calvin cycle ) and ATP synthesis take place. The overall structure and the catalytic mechanism of the ...
... by Melvin Calvin and Andy Benson at the University of California, Berkeley . It is one of the light-independent reactions and occurs in the stroma
During photosynthesis, light energy has been converted into chemical energy stored in ATP and NADPH . The light-independent Calvin cycle ...
... and metabolites , but the inner membrane is highly specialised with transport proteins .
Within the inner membrane, in the region called the stroma
, there is a system of interconecting flattened membrane compartments, called the lamellae , or thylakoid membrane . These are sites of light ...
... the cytosol in terms of solutes relevent for the functioning of these organelles . Enzymes destined for the mitochondrial matrix or the stroma
can bypass the intermembrane space via transport through translocases . These are known as TOM and TIM in mitochondria and TOC and TIC in ...
Stroma in Biological Dictionary
(animal tissue), the connective, functionally supportive framework of a ... stroma
, the thick fluid found in between grana, which are stacks of ... stroma
is an island on the northern coast of the ...
... out in specialized organelles called chloroplasts . ... ( DNA ), the stroma
contains chloroplast DNA and special ribosomes and RNAs as well. ...... is enclosed in a double membrane and the area ... ( DNA ), the stroma
contains chloroplast DNA and special ribosomes and RNAs as well. ......
... ... ... of Rubisco, and RCA in thylakoids compensates for the reduction of RCA in the ... was subtracted from the average density within the stroma
and thylakoids . ... Figure 3 Western analysis of thylakoids from PS1 mutants. ... the 1500 to 1800 cm-1 frequency range for the thylakoids ...
... JJ, Thuneberg L. Interstitial cells of Cajal in human small intestine. ... interstitial or Leydig cells are found in the fibrovascular stroma
of the ... interstitial cell tumors are benign but functional tumors and associated with ... Interstitial cells : Wikipedia, the Free ...
... The graphic shows the steps in the fixation of carbon dioxide during photosynthesis. ... All the reactions of carbon fixation occur in the stroma
of the chloroplast. ... Britannica online encyclopedia article on carbon fixation (biochemistry), The assimilation of carbon into organic ...