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Spleen in Medical News

Spleen May Help Heart Recover From Disease

... doesn't rank down there with the appendix, the spleen isn't exactly known as a vital organ. In fact, ... fine without it. But new research suggests the spleen plays a bigger role in the immune system than previously thought. In mice, scientists found, the spleen serves as a home for a type of white blood cell ...

Embargoed Until Monday, July 21 at 5 p.m. EST; Scientists Figure Out How the Immune System and Brain Communicate to Control Disease

... anatomical path through which the brain and the spleen communicate. ... anatomical path through which the brain and the spleen communicate. The spleen, once thought to be ... ultimately lead to treatments that target the spleen to send the right message when fighting human ...

Preliminary Results from Phase 2 Genzyme Study Highlight Potential of Novel Oral Compound for Gaucher Disease

... one year of treatment: -- At six months, spleen volumes had decreased from baseline by a mean of ... the 21 patients for whom data were available. spleen volumes had decreased by 40 percent among 11 ... parts of the body, primarily the liver, spleen and bone marrow. Accumulation of Gaucher cells ...

Study identifies key player in the body's immune response to chronic stress

... rate and immune system organs like the thymus and spleen lose mass and begin to atrophy, said Dr. Shi. ... The normal OPN mice experienced weight loss, spleen and thymus atrophy, and a reduced number of white ... control group. White blood cell death in the spleen and thymus was evident only in the mice with ...

Research suggests new cellular targets for HIV drug development

... concentrations of macrophages, with lymphoid tissues such as from the spleen and lymph nodes that had a mix of HIV-infected macrophages and T cells. ... tissues generally associated with disease processes, such as the meninges, spleen and lymph nodes. The researchers concluded that HIV-infected ...

Medical Tourism - Choosing a Mexican Cancer Clinic

... for children because of this risk. When she asked about Tom's enlarged spleen and lymph nodes, the doctor told her not to worry, he did not need ... hospital. He was jaundiced, and needed a transfusion. An MRI showed his spleen was twice the normal size. Tom had one round of chemo and immediately ...

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Spleen in Medical Technology

VisEn Molecular Imaging Technology Enables Key Insights Into Newly Discovered Biologic Pathway Published in SCIENCE

... pathway relates to monocyte deployment from the spleen to inflammatory sites, including myocardial ... that monocytes were held in concentration in the spleen and released to injured tissue sites in the body ... "unambiguously the fate of monocytes from the spleen to the heart." "We see the integration of ...

Shire Reports Positive Results From First of Three Phase III Trials of velaglucerase alfa for Type 1 Gaucher Disease and Provides Important Updates on Interactions With FDA

... improvements compared with baselines were also observed in platelet and spleen sizes, and nominally significant improvements were observed in liver size ... statistically significant improvements in hemoglobin, platelet count, and spleen volume were also demonstrated. The magnitude of changes in the 45U/kg dose ...

S*BIO Advances JAK2 Inhibitor SB1518 into Phase 1/2 Clinical Trial in Australia for the Treatment of Chronic Idiopathic Myelofibrosis

... more blood cells are made in other organs, such as the liver and spleen which are not as efficient at blood cell production as the bone marrow. CIMF is characterized by an enlarged spleen and progressive anaemia. Current therapies for CIMF are mostly palliative ...

Exelixis Presents Encouraging Phase 1 Data For XL019, A Novel Selective Inhibitor of JAK2

... by the results from this ongoing trial that show rapid decrease in spleen size and relief of disease-related symptoms at low doses of XL019. XL019 ... activity observed in most subjects, including: - Reduction in spleen size of 33 to 100% in five of six patients evaluated - ...

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

... patients with leukemia cutis had complete or partial clearance of skin lesions. One patient had a 36% reduction in lymph node size, a 28% decrease in spleen size and a significant increase (44%) in hemoglobin. Mild grade 1 or 2 infusion toxicity was observed and there were three dose-limiting toxicities ...

Novel Therapeutic Approaches May Transform Treatment and Improve Patient Outcomes in Several Platelet Disorders

... low production of platelets in the bone marrow, increased breakdown of platelets in the bloodstream, or increased breakdown of platelets in the spleen or liver, which can be induced by certain anemias, cancers, infections, or medications. Symptoms can include bruising, nose bleeds, bleeding in the ...

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Spleen in Medical Products

Ferritin IRMA Test

Description:... iron oxide and phosphate [1]. Ferritin is synthesized in the liver, spleen and numerous other body tissues, with major concentrations found in the ... and intestinal mucosa [1,2]. Ferritin may comprise as much as 20% of spleen dry weight. In addition to serving as a major iron storage pool, ferritin ...
Company:Diagnostic Systems Laboratories, Inc.
Spleen in Medical Dictionary

Abdomen

... skin . Abdomen (e.g., liver , kidney s, spleen ) Chest (e.g., heart , lungs , major blood ... usually feels tender and painful when the spleen rupture s. Blood leaks out into the abdomen ... pain . Classically, a patient with a ruptured spleen describes feeling left shoulder -tip pain . ...

Bone pain

... hands to feel ( palpate ) for enlargement of the spleen and liver . Bone pain Difficulty walking ... in the bone marrow , liver , and spleen , resulting in anemia and other blood ... pathologic fractures , and enlarged liver and spleen . Bone pain Neurological symptoms if the ...

Hypersplenism

... Hypersplenism is increased activity of the spleen caused by tumor s, anemia , malaria , ... - In this condition, an overactive, enlarged spleen traps circulating red blood cells and destroys ... A syndrome marked by enlargement of the spleen , defects in one or more types of blood cells, ...

Left

... mass in the groin (inguinal)? Answer: The spleen is an organ that is located on the left side ... MUTATION or a block of DNA REPLICATION. The spleen is located in the upper left quadrant of the ... filter. There are two distinct components of the spleen , the red pulp and the white pulp. ...

Liver

... bleeding from the uterus ... Liver and spleen The most common symptoms are enlargement of ... hypertension , enlargement of the liver and spleen , jaundice , ... CYP 3A4: A liver enzyme ... and RNA. Abdomen (e.g., liver , kidney s, spleen ) Chest (e.g., heart , lungs , major blood ...

Liver function tests

... function tests kidney function tests liver - spleen scan lymph node biopsy routine blood studies ... ( Cholesterol Test ) Liver Scan ( Liver - spleen Scan) Liver Scintigraphy ( Liver - spleen Scan) Liver Biopsy Liver Function Tests ...

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Spleen in Biological News

Gene switch sites found mainly on 'shores,' not just 'islands' of the human genome

... comprehensive survey in human brain, liver and spleen tissues obtained from five autopsies, identifying ... they'd located in the normal brain, liver and spleen tissues they had examined. "This suggests that ... cancerous might start to act like brain, liver or spleen cells. They're losing the characteristics they ...

Weill Cornell science briefs June/July 2008

... to regain fine-motor control. Avoiding spleen Removal for Cooley's Anemia Sufferers Weill ... of malformed red blood cells within the body. The spleen works to filter out these unhealthy cells in ... harm, such as in a stroke, but eventually the spleen becomes over-stuffed and is commonly surgically ...

Avoiding Spleen Removal for Cooley's Anemia SufferersAvoiding spleen removal for Cooley's anemia suf

... of malformed red blood cells within the body. The spleen works to filter out these unhealthy cells in ... harm, such as in a stroke, but eventually the spleen becomes over-stuffed and is commonly surgically ... potentially fatal burst. Unfortunately, after the spleen is removed, patients are at a much greater risk ...

Mice stressed in simulated weightlessness show organ atrophy

... the Rutgers researchers should look at the spleen and thymus the organs responsible for most of the animals immune cells. If stress affects the spleen and thymus so that they atrophy, the immune ... said. We had no basis to expect this, but the spleen and thymus of the OPN-deficient animals remained ...

Penn researchers demonstrate a new model for drug discovery with a fluorescent anesthetic

... identified 1-AMA in a screen for compounds that bind to a cavity in horse spleen apoferritin, HSAF, that Eckenhoff and co-workers have shown to bind ... constant, Kd 0.1 mM, for binding to the general anesthetic site in horse spleen apoferritin, meaning the compound is behaving as traditional general ...

Scientists discover 21st century plague

... serious illness in humans worldwide from heart disease to infection of the spleen and nervous system. "A new species called Bartonella rochalimae was recently discovered in a patient with an enlarged spleen who had travelled to South America," said Professor Chao-Chin Chang from ...

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Spleen in Biological Technology

Oncolytics Biotech Inc. Collaborators to Present Reovirus Research at ASGT Meeting

... pre-loaded with reovirus localize to lymph nodes, spleen and liver and deliver the virus to sites of ... killing the tumour cells in the lymph nodes and spleen by reovirus generated potent anti-tumour immunity, preventing repopulation of the lymph nodes and spleen by further waves of cells spreading from the ...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

... against tuberculosis and have the potential to treat swine and other H1N1 influenzas. The TB investigators presented data that showed that blood and spleen cells from immunized mice produced gamma interferon in response to the vaccine, while the cells from mice in the various control groups did not. ...

Trubion Announces Acceptance of Three Presentations on Its TRU-016 Product Candidate at the 2009 ASCO Annual Meeting

... demonstrates the safety and early signs of efficacy of TRU-016 as shown by a reduction in tumor lymphocyte blood counts, reduction in lymph node and spleen size, and/or an improvement in hematopoiesis, or the production of red blood cells and platelets. Eight of the 10 patients had high-risk genomic ...

Safer nanoparticles spotlight tumors, deliver drugs

... more of a drug. Yet they self-destruct, and the remnants can be filtered away by the kidneys. Close examination of vulnerable organs like liver, spleen and kidney, which help to remove toxins, revealed no lasting changes in mice treated with the new nanoparticles. ...

Portola Data on Its Novel Syk Inhibitors and Novel Universal Factor Xa Inhibitor Antidote to be Presented at 2008 American Society of Hematology (ASH) Meeting

... in cardiovascular disease, inflammatory disease and cancer, today announced that data related to the Company's series of novel compounds that inhibit spleen tyrosine kinase (Syk) and its novel universal Factor Xa inhibitor antidote will be presented at the annual meeting of the American Society of ...

Proteolix's Carfilzomib Receives Orphan Drug Designation for Treatment of Multiple Myeloma

... cells multiply out of control, producing large amounts of a protein called monoclonal immunoglobulin M. WM can result in enlargement of the liver and spleen due to anemia and large amounts of immunoglobulin M can lead to hyperviscosity syndrome, in which the blood becomes abnormally thick. Symptoms of ...

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Spleen in Biological Products

Rat Tissue Array: Brain, heart, kidney, liver, lung, muscle, spleen and stomach, each tissue from 10 female and 10 male, respectively from BioChain

Description:... rapidly screening genes or proteins of interest in extensive panels of different types of tissues. Rat brain, heart, kidney, liver, lung, muscle, spleen and stomach tissues are arrayed on positively charged glass slide. Each tissue is from 10 female and 10 male, ...
Company:BioChain

Mouse Hematopoietic Stem Cell Expansion Cytokine Panel from R&D Systems

Description:... cells that reside in adult bone marrow where hematopoiesis is continuously taking place. They can also be found in cord blood, fetal liver, adult spleen and peripheral blood. Many HSC studies rely on ex vivo expansion of HSC in culture. The combined use of multiple cytokines, Flt-3 ligand, SCF and ...
Company:R&D Systems

Dynabeads Mouse Pan B (B220) from Dynal Biotech

Description:... pan B (B220), 4.5 m, coated with anti-B220 monoclonal antibody. For the efficient positive isolation or depletion of mouse B cells directly from spleen or lymph node cell suspensions. B220 antigen is expressed on mouse B cells and lytically active subsets of lymphokine activated killer cells from all ...
Company:Dynal Biotech

Rabbit Anti-Asb-2 Polyclonal Antibody, Unconjugated from IMGENEX

Description:... protein) This polyclonal antibody was raised against synthetic peptides containing amino acids 75-93 and 348-368 of human Asb-2 protein. Human spleen lysate (Imgenex Catalog No. 40149) can be used as a positive control. It should cross react with mouse and rat Asb-2, based on amino acid sequences ...
Company:IMGENEX

StemSep Rat T Cells, 2 mL from StemCell Technologies, Inc.

Description:... This depletion cocktail is tailored to highly enrich T cells from suspensions of rat spleen cells. Cells are separated using the StemSep (or compatible 0.5 Tesla) immunomagnetic negative selection system. The T cell content of the enriched ...
Company:StemCell Technologies, Inc.

StemSep Rat CD4+ T Cells, 10 mL from StemCell Technologies, Inc.

Description:... This depletion cocktail is tailored to highly enrich CD4+ T cells from suspensions of rat spleen cells. Cells are separated using the StemSep (or compatible 0.5 Tesla) immunomagnetic negative cell selection system. The CD4+ T cell content of the ...
Company:StemCell Technologies, Inc.

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Spleen in Biological Definition

Anatomy

... Labia Larynx Liver Lung Nose Ovary Pharynx Pancreas Penis Placenta Rectum Skin Small intestine spleen Stomach Tongue Uterus Bones in the human skeleton : Collar bone (clavicle) Thigh bone (femur) Humerus Mandible ...

Blood

... hormones are produced by the endocrine glands and the watery fraction maintained by the gut and the kidney . Blood cells are degraded by the spleen and the Kuppfer cells in the liver. The liver also clears proteins and amino acids (the kidney secretes many small proteins into the urine ). ...

Immune system

... It may be broken down into the adaptive immune system (only found in vertebrates [1] ), composed of four lymphoid organs ( thymus , lymph nodes , spleen and submucosal lymphoid nodules) and the group motile cells that are involved in the body's defense against foreign bodies. The term may also be ...

Immunology

... early physicians characterised organs that would later prove to be part of the immune system. The key organs of the immune system are thymus , spleen , bone marrow , lymph vessels , lymph nodes and secondary lymphatic tissues such as tonsils and adenoids ) and skin . The major organs, the ...

Kidney

... the kidneys are two organs located in the posterior part of the abdomen . There is one on each side of the spine just below the liver and spleen . Superior to each kidney is an adrenal gland (also called the suprarenal gland ). The kidneys are retroperitoneal, which means they lie ...

Malaria

... attack by the body's immune system because it stays inside liver and blood cells. However, circulating infected blood cells are killed in the spleen . To avoid this fate, the parasite produces certain surface proteins which infected blood cells express on their cell surface, causing the blood ...

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Spleen in Biological Dictionary

Spleen

... The spleen is an organ found in all vertebrate animals ... holds a reserve in case of ... The spleen , an organ found in all vertebrate animals, is a major part of the immune system. In humans, the spleen is located in the abdomen of the body, where ...

Serosa

... serosa negative/positive cancers) with a well-known ... into the spleen or tumor invasion through serosa to the spleen was detected. ... Outside the abdominopelvic cavity the serosa is ...

Monoclonal antibodies

... importantly, we can utilize monoclonal antibodies directly as therapy. ... To produce monoclonal antibodies , one removes B-cells from the spleen of an ... The process of producing monoclonal antibodies described above was invented by ... ... Methods of Producing Monoclonal ...

Dendritic cell

... —the preeminent component of the immune system that initiates and regulates the body's response ... Two dendritic cells (arrows) from the spleen of a mouse. ... Dendritic cells have a set of transmembrane receptors that recognize ... Dendritic cell subsets ... These dendritic ...

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