Spindle

Molecule tracking reveals mechanism of chromosome separation in dividing cells

... before cell division. The apparatus is called a spindle because it looks like a tiny wool-spinner with thin strands of microtubules or spindle fibers sticking out. The lengthening and ... on each chromosome that mechanically couples to spindle fibers. "Kineochores are also regulatory ...

Lack of CHFR gene expression sets stage for breast cancer

... for two new daughter cells. If the spindle doesn't form correctly, genetic material becomes ... too many chromosomes. The fact that the spindle is affected is important, because some cancer drugs interact with the mitotic spindle as a way to curb cell division. Research ...

Cell division studies hint at future cancer therapy

... to one side of the mother cell and directs spindle orientation. In work published in Nature Cell ... he detailed a group of proteins critical for spindle organization and positioning in mammalian cells. ... cooperate with other proteins to organize the spindle and direct its orientation. These details may ...

NYP/Columbia physician-scientists present at ASCO 44th annual meeting

... or following reduced-intensity AlloSCT in standard-risk AML. Kinesin spindle Protein (KSP) for Hodgkin's Lymphoma Dr. Owen O'Connor Director of ... of Physicians and Surgeons A Phase 1 dose-escalation trial of Kinesin spindle Protein (KSP), a drug that targets a unique aspect of cancer cell ...

Key factor in brain development revealed, offers insight into disorder

... of cell division. Specifically, Lis 1 makes sure that the mitotic spindle is oriented perpendicular to the top and base components of the ... in reduced and weakened microtubules and an inability of the mitotic spindle to rotate the microtubules properly in the apical-basal axis. Of note, ...

From mother to daughters: A central mystery in cell division solved

... muscle. During cell division, the genome is replicated and the two copies are separated to opposite sides of the cell by the mitotic spindle. The spindle then directs the assembly of a contractile ring, which forms a belt around the cell middle. As happens during muscle contraction, the myosin ...

Spindle in Medical Technology

CRi Oosight(TM) Instrument Crucial in IVF Breakthrough Demonstrating a Correlation Between Non-Invasive Egg Metrics and Pregnancy

... are the first to show a direct link between egg spindle characteristics and pregnancy. ... of these results would suggest that when a normal spindle is found, the chances of a pregnancy, if a high ... non-invasive, high-contrast images of the meiotic spindle and zona pellucida without the need for ...

Phase I/II Study of Targeted Gene Delivery In Vivo - Intravenous Infusions of REXIN-G - Demonstrates Dose-Dependent Anti-Tumor Activity Without Toxicity in Patients With Progressive Chemo-Resistant Bone and Soft Tissue Sarcoma (ASCO 2008)

... including osteosarcoma, Ewing's sarcoma, leiomyosarcoma, malignant fibrous histiocytoma, chondrosarcoma, fibrosarcoma, liposarcoma, angiosarcoma, spindle cell sarcoma, and malignant mixed Mullerian tumor of ovary, were treated with 1 x 10e11 cfu Rexin-G, administered i.v. over 5 minutes, 2 times a week ...

EntreMed Commences Phase 2 Study With MKC-1 in Ovarian/Endometrial Cancers

... growth inhibition or regression in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. Furthermore, MKC-1 inhibits the Akt-mTOR ...

EntreMed Commences Phase 2 Study with MKC-1 in Pancreatic Cancer

... antitumor effects, including tumor growth inhibition or regression, in multiple preclinical models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. Carolyn F. Sidor, M.D., M.B.A., ...

EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer

... intracellular target important in cellular trafficking that has been shown to be involved in cell division. MKC- 1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase of the cell cycle, and induce apoptosis in multiple cell lines, consistent with a mechanism ...

Cytokinetics Announces Non-clinical Data to be Presented at the 2007 AACR Annual Meeting

... and will present data evaluating ispinesib, a novel inhibitor of Kinesin spindle Protein (KSP), in models of multiple myeloma, data evaluating GSK-923295, ... 2007 AACR Annual Meeting Ispinesib: Abstract #1435: Kinesin spindle Protein Inhibition for the Treatment of Multiple Myeloma. (Poster ...

Spindle in Medical Products

ANA SCREEN IgG

Description:... DNA (dsDNA), Jo-1, Sm, Sm/RNP, SSA, SSB, and Scl-70. The test is also capable of detecting ANA demonstrating centromere, nucleolar, peripheral, and spindle indirect immunofluorescence antibody (IFA) patterns. This device is for in vitro diagnostic ....
Company:Zeus Scientific, Inc.

Spindle in Medical Definition

Anterior mediastinal mass

... Most common primary anterior mediastinal tumor (20%) in adults but rarely seen in children. It can be classified as lymphocytic, epithelial, or spindle cell histologies, but this is not very significant clinically (2). Tonofibrils seen under electron microscopy can differentiate thymoma from other ...

Spindle in Medical Dictionary

Behavior

... s of dividing mammalian cells- Using a dominant-negative chimeric tropomyosin, we have studied roles of actin filaments in cytokinesis, mitotic spindle orientation, and blebbing of dividing cells. Studies of behavior therapy for OCD have found it to be a successful treatment for the majority ...

In situ

... University of Colorado - Boulder (J. Richard McIntosh, P.I.), we have begun to use dual-axis electron tomography to create 3-dimensional tomograms of spindle pole bodies in situ. The earliest form of squamous cell carcinoma is known as carcinoma in situ, or Bowen's disease . Cloacogenic ...

Organ

... economics, hospital ; economics, medical; economics, nursing ; economics, pharmaceutical; economic value of life; economy; eco- organ ; ... The spindle pole body is the microtubule- organ izing center in this cell , organ izing all of the microtubules of the mitotic and meiotic spindles, and is ...

Polyp

... c oated with sugar s. Chial, H. J., Giddings Jr., T. H., Siewert, E. A., Hoyt, M. A. and Winey, M. (1999) Altered dosage of the S. cerevisiae spindle pole body duplication gene , NDC1, leads to aneuploidy and polyp loidy. Proc. Natl. Acad. Sci. 96:10200-10205. include malfunction of the tiny, ...

Yeast

... itching , and swelling . It is not serious and, with treatment , usually goes away in about 2 weeks. The labor atory continues to study the spindle pole body of the budding yeast , Saccharomyces cerevisiae. A general term used to describe a group of eukaryotic protists, which include ...

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Spindle in Biological News

Scientists deconstruct cell division

... have tried for years to unravel the process of spindle assembly. Now, researchers at Carnegie's ... are essential to regulate assembly of the spindle matrix. "The mechanisms that cells use during ... adult tissues, such as skin and bones. Forming a spindle requires the assembly of a 'skeleton' from ...

Oosight microscope enables embryonic stem cell breakthrough

... team to clearly see and remove the meiotic spindle (and the attached genetic material) from 304 ... the problem was always that you could not see the spindle in the egg, Mitalipov says. The only way to see ... polarized light technology to image the spindle noninvasively, with high contrast and quality. ...

A unique arrangement for egg cell division

... the correct number of chromosomes is a bipolar spindle consisting of protein filaments, called microtubules that are part of the cells skeleton. spindle microtubules attach themselves to the ... They predetermine the bipolar structure of the spindle that is essential to extrude exactly half of the ...

Slicing chromosomes leads to new insights into cell division

... through mitosis, during which the DNA-containing chromosomes separate between the resulting daughter cells. Forces in a structure called the mitotic spindle guide the replicated chromosomes to opposing sides as one cell eventually becomes two. "Each cell needs the right number of chromosomes. It's ...

Dartmouth researchers find new protein function

... own, it hitches a ride on the ends of microtubules which results in a dynamic cross-linking between the arms of chromosomes and the cell's growing spindle of microtubules. If NOD doesn't function properly, then the two cells end up with either both or none of that particular chromosome, which is lethal ...

How chemo kills tumors: research to reduce side effects

... published in the journal Cancer Cell (August 2008), have shown how different tumours respond to the anti-mitotic drugs which target the mitotic spindle (the structure that separates the chromosomes during cell division) and revealed that the variation in cell behaviour was far greater than ...

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Spindle in Biological Technology

JCI online early table of contents: March 6, 2008

... components of a cell. Consistent with a role for SBDS in mitotic spindle stability, BMSCs from individuals with SDS exhibited increased abnormal ... a new approach to the treatment of individuals with SDS. TITLE: Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome ...

Oncolytics Biotech Inc.'s REOLYSIN(R) Exceeds Primary Statistical Endpoint in U.S. Phase 2 Sarcoma Study

... Chordoma 6* SD ------------------------------------------------------------------------- Unspecified spindle Cell 6* SD ------------------------------------------------------------------------- * patients still on study ...

EntreMed's MKC-1 Meets Primary Efficacy Endpoint in Non-Small Cell Lung Cancer Clinical Trial

... growth inhibition or regression in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. Furthermore, MKC-1 inhibits the Akt-mTOR ...

Oncolytics Biotech Inc. Investigators Present Interim U.S. REOLYSIN(R) Phase II Sarcoma Trial Data

... Chordoma 5* SD ------------------------------------------------------------------------- Unspecified spindle Cell 5* SD ------------------------------------------------------------------------- * patients still on study An oral ...

Mouse Brain or Impressionist Painting?

... Research at UCSD for his photos of rat tongue and cerebellum; Pat Wadsworth of the University of Massachusetts for her depiction of the mitotic spindle in a diving cell; Earl Nishiguchi of the University of Hawaii for his fruit fly testis image; Jan Schmoranzer of Columbia University for his photo of ...

Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27)

... Dissolution. 1 Each individual apparatus (i.e. spindle or basket) must be tested with disintegrating ... deaeration, verification of temperature and spindle speed). Prepare the samples and standards ... easily for different calibrators, lot numbers or spindle speeds. The Calculation ...

Spindle in Biological Definition

Anaphase

... poles of the cell (opposite ends of the nuclear spindle ). Anaphase is preceded by metaphase , by the ... along a surface known as the metaphase plate. spindle fibres (microtubules containing γ-tubulin) extend from the spindle poles to the centromeres . The point of contact ...

Meiosis

... and nuclear envelope and the formation of the spindle fibres (including their attachment to ... envelope has already dispersed into vesicles. spindle fibres ( microtubules ) attach only to one ... I includes the disappearance of spindles and spindle fibres as well as the uncoiling of the chromatids ...

Mitosis

... spindles . By increasing the length of the spindle (growing the microtubules), the centrioles push ... chromosome - one for each chromatid. When the spindle grows to sufficient length, the microtubules ... process by generating a signal - the mitotic spindle checkpoint - that tells the cell to wait before ...

Mitotic spindle

... The mitotic spindle is a structure of the eukaryotic cytoskeleton ... resembling an American football in shape. The spindle is aligned perpendicularly to the plane along which the cell is to divide. In most cells, the spindle is formed by the centrosomes as they move ....

Mitosis

... spindles . By increasing the length of the spindle (growing the microtubules), the centrioles push ... chromosome - one for each chromatid. When the spindle grows to sufficient length, the microtubules ... process by generating a signal - the mitotic spindle checkpoint - that tells the cell to wait before ...

Centromere

... where the kinetochore is assembled. Thus, it is the site where spindle fibers of the mitotic spindle attach to the chromosome during mitosis . It is also the site of the ...

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Spindle in Biological Dictionary

Spindle Fibers

... In cell biology, the spindle apparatus is the structure that separates the ... cell ... Encyclopedia article about spindle fibers . Information about spindle fibers in the Columbia Encyclopedia, Computer ...

Prometaphase

... from the centrosomes at the poles (ends) of the spindle reach the ... ... stages are ... into five phases. In prophase the mitotic spindle forms and the chromosomes condense. In ... enters prometaphase , during which the mitotic spindle ... Prometaphase I embryos contained ...

Mitotic spindle

... In cell biology, the spindle apparatus is the structure that separates the ... which divides the ... mitotic spindle n. The fusiform figure characteristic of a ... Bub3 is a conserved component of the mitotic spindle assembly complex. ... attachment of chromosomes ...

Microtubules

... with their plus ... These clusters of microtubules are called spindle fibers. ... The Cell - A Molecular Approach is a basic text that ... to determine cell shape, and provide a ... Microtubules also form the spindle fibers for separating chromosomes during mitosis. ... ...

Kinetochore

... The kinetochore is the protein structure on chromosomes where the spindle fibers attach during division to pull the chromosomes apart. ... Microtubules emerging from the centrosomes at the poles (ends) of the spindle reach the ... Keywords - chromatin component, assembles ...

Anaphase

... begin to move towards the poles. ... ... and migrate to the opposite spindle poles in a process known as anaphase . ... View a second, third, and ... article on anaphase (biology), ... chromosome attach to the spindle at a specialized chromosomal region called the kinetochore. ... ...

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