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Silencing in Medical News

Scientists identify gene in breast cancer pathway

... cells, Dr. Singer and his team found that ZBP1 silencing occurs when a methyl group (CH3) attaches to ... silenced. The study also showed that the silencing of ZBP1 increases cancer cells' ability to ... According to the researchers, signs of ZBP1 silencing in breast cancer cells would indicate that a ...

Olivier Voinnet awarded 2009 EMBO Gold Medal

... work on the mechanisms and roles of gene silencing via RNA in plants. With this annual award, the ... contributions to our understanding of gene silencing via RNA have opened up new perspectives on how ... with significant implications for medicine. RNA silencing is a newly discovered and highly competitive ...

Researcher wins $1.2 million grant for gene regulation work

... recently discovered a direct link between RNA silencing and the genetic master switch controlling the sex ... process in gene regulation called the RNA-induced silencing complex (RISC) might interfere with or silence ... disease. "We want to know how RNA silencing affects fundamental gene expression," Horabin ...

Biologist finds plant polymerases IV and V are really variants of Polymerase II

... they have taken on specialized roles in gene silencing in plants. This is important to prevent the ... RNAs (abbreviated as siRNAs) that specify the silencing of matching DNA sequences, whereas Pol V makes ... a while and then unexpectedly goes silent. The silencing process may have parallels to the pathway in ...

Bread mold may hold secret to eliminating disease-causing genes

... the organism from genetic abnormalities by silencing unmatched genes during meiosis (sexual ... such as those from the HIV virus. Meiotic silencing also occurs in worms, mice and human beings, said ... but the principle of targeting unpaired DNA for silencing seems to be found in both simple and complex ...

Gene 'knockout' floors tobacco carcinogen

... North Carolina State University have shown that silencing a specific gene in burley tobacco plants ... But their findings show that targeted gene silencing can work as well in the field as it does on the ... has a number of other targets for their gene silencing method. ...

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Silencing in Medical Technology

Recent siRNA Research Publications Support Silence Therapeutics Combined Development Approach

... and IL-12) and induce RNAi-mediated gene silencing as demonstrated by the selective inhibition of ... and do act by selectively silencing the specifically targeted gene. We believe by ... Synthetic siRNA Mediating Potent Gene silencing in Vivo." Notes to Editors: About Silence ...

Thermo Fisher Scientific Advances Gene-Silencing Technology for Life Sciences Research

... faced when using RNAi, leading to permanent gene silencing in a wide range of cell types. "With the ... can now effectively deliver stably expressed gene silencing sequences into a broad range of cell ... algorithm uses criteria unique to shRNA- based silencing for the routine production of highly ...

Michael J. Fox Foundation Funds $1.1 Million for Cutting-Edge Approaches to Parkinson's Disease Under Rapid Response Innovation Awards 2008

... expected by year's end NEW YORK, July 29 /PRNewswire-USNewswire/ -- Gene silencing techniques and induced pluripotent stem cell technology are among the ... MD, PhD, of Columbia University is working to determine whether a gene silencing technique using microRNAs -- short, noncoding molecules of RNA -- can be ...

Thermo Fisher Scientific Introduces Breakthrough in RNA-Interference Technology

... Dharmacon Accell siRNA achieves highly efficient siRNA delivery for gene silencing without the need for optimization," explained Jardine. "In addition, the ... of RNAi experiments." Preliminary studies also suggest that long-term silencing of up to 30 days can now be achieved through repeated application of ...

Opko Health Doses First Patient in Phase 3 COBALT Trial of Bevasiranib for the Treatment of AMD

... because it is the first-ever Phase 3 trial of an agent based on RNAi gene silencing technology and because the growing population of older people at risk of ... healthcare company. Its lead investigational drug, the pioneering gene silencing agent bevasiranib, has entered a pivotal Phase 3 trial after successfully ...

Benitec MOU With CalbaTech, Inc.

... a license agreement with Benitec, an Australian corporation. Gene silencing Gene silencing is about controlling the flow of genetic information. Our genome operates ...

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Silencing in Biological News

To fight drug addiction, UB researchers target the brain with nanoparticles

... the brain that facilitates addictive behaviors. silencing of the DARPP-32 gene with certain kinds of ... to therapeutic concepts directed at silencing a gene in the brain, using RNA techniques," said ... The nanorods delivered 40 percent of the silencing RNA molecules across the blood-brain barrier ...

Malaria immunity trigger found for multiple mosquito species

... parasite that causes malaria in humans. By silencing the gene, caspar, the researchers were able to ... Rel 2 is activated. The researchers found that silencing of the caspar gene through the manipulation of ... of Plasmodium falciparum in the gut tissue. silencing the gene known as cactus, which is part of ...

A new gene silencing platform -- silence is golden

... Samuel Gunderson has developed a novel gene silencing platform with very significant improvements over ... of New Jersey, has created highly efficient gene silencing agents that function via a novel mechanism of ... gene function and to validate gene targets. Gene silencing molecules also have potential prophylactic and ...

In lung cancer, silencing one crucial gene disrupts normal functioning of genome

... of MTHFR, and consequent partial or complete silencing of the gene, may trigger global hypomethylation ... reveals the novel and surprising role that silencing of normal genes plays in development of lung ... in methylation levels of the other two genes. silencing of the RASSF1A and CDKN2A genes makes sense, said ...

Researchers solve piece of large-scale gene silencing mystery

... the phenomenon of nucleolar dominance, the silencing of an entire parental set of ribosomal RNA genes ... to Pikaard, if researchers could harness the silencing machinery involved in nucleolar dominance to ... that is the disease's trademark. Completely silencing all ribosomal genes would not be a viable ...

Plants display 'molecular amnesia'

... time the reversal of what is called epigenetic silencing in plants. The findings are important to ... Science Foundation at UC Berkeley, epigenetic silencing was triggered in maize. Once triggered, the maize ... thought, with the ability to remember epigenetic silencing varying depending on position. "This may ...

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Silencing in Biological Technology

Nobel Laureates to Speak at Keystone Symposia RNA Silencing Conference

... School will present on "Complexity of RNA silencing in C. elegans." Both scientists shared the 2006 ... the world working in different branches of RNA silencing to share their findings and facilitate a deeper ... complexity of small RNA-related phenomena. RNA silencing pathways control an ever-expanding range of ...

Lentigen Licenses Fundamental Lentiviral Vector Technology Patent From the University of Cambridge

... vehicles for stable delivery of genes or gene silencing sequences (e.g. RNAi) into cells. Gene delivery ... The LV genomic RNA comprising the gene or gene silencing sequence is then converted to DNA and permanently ... extraordinary high efficiency. The gene or gene silencing sequence is then expressed in the cells, ...

Pharmion and MethylGene Announce Collaboration to Develop Sirtuin Inhibitors as Anti-Cancer Agents

... of normal cell survival and aberrant gene silencing in cancer cells. Inhibition of sirtuins allows ... emerged as a key contributor to the epigenetic silencing of genes that drive tumorigenesis," said Stephen ... reversed by targeting the enzymes involved. The silencing of key cell cycle control genes and ...

Altogen Biosystems Launches New Nanoparticle-based In Vivo Transfection Reagent

... as generation of stably-transformed cell lines in 28-days, as well as gene silencing and RNAi services (http://www.altogen.com/support.htm ). About Altogen ... pharmaceutical services, including generation of stable cell lines, gene silencing and RNA Interference (RNAi) services, assay development, library ...

Paper in Cell Cycle Reports Alfacell's ONCONASE(R) Targets siRNA

... targets small interfering RNA (siRNA), likely within the RNA-induced silencing complex (RISC) of the RNA interference (RNAi) mechanism. The paper is ... at New York Medical College and Alfacell. The study demonstrated that silencing the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) gene (an abundant ...

Lentigen Corporation Announces Exclusive Licensing Agreement With Case Western Reserve University to Develop Novel Stem-Cell Therapy for Brain Cancer

... to the target cell membrane. The LV RNA containing the gene or gene silencing sequence is then incorporated into the cell via reverse transcription ... vectors are the most efficient vehicles for the delivery of genes or gene silencing sequences stably into cells. Lentigen is a highly collaborative company, ...

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Silencing in Biological Products

siPORT NeoFX Transfection Agent from Ambion

Description:... Gene silencing experiments often call for critical, but time-consuming optimization ... without increased cytotoxicity. From start to finish, successful gene silencing experiments can be completed in as early as 24 hours. This streamlined ...
Company:Ambion

siPORT NeoFX Transfection Agent 1 ml from Ambion

Description:... Gene silencing experiments often call for critical, but time-consuming optimization ... without increased cytotoxicity. From start to finish, successful gene silencing experiments can be completed in as early as 24 hours. This streamlined ...
Company:Ambion

INTERFERin from Polyplus Transfection

Description:... is a new-generation siRNA transfection reagent that achieves over 90 % silencing efficiency at 1 nM siRNA in a wide variety of adherent and primary cells ... siRNA at higher concentrations, thereby allowing accurate and reliable silencing results to be obtained. INTERFERin is ready-to-use, compatible with serum ...
Company:Polyplus Transfection

Magnetofection - SilenceMag from OZ Biosciences

Description:... Specifically designed for siRNA delivery, SilenceMag allows studying gene silencing at very low doses of siRNA. SilenceMag formulation gives reliable high gene silencing efficiencies in numerous cell types (primary cells, hard to transfect & ...
Company:OZ Biosciences

Magnetofection - SilenceMag from OZ Biosciences

Description:... Specifically designed for siRNA delivery, SilenceMag allows studying gene silencing at very low doses of siRNA. SilenceMag formulation gives reliable high gene silencing efficiencies in numerous cell types (primary cells, hard to transfect & ...
Company:OZ Biosciences

Magnetofection - SilenceMag from OZ Biosciences

Description:... Specifically designed for siRNA delivery, SilenceMag allows studying gene silencing at very low doses of siRNA. SilenceMag formulation gives reliable high gene silencing efficiencies in numerous cell types (primary cells, hard to transfect & ...
Company:OZ Biosciences

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Silencing in Biological Definition

Epigenetics

... involved in the unfolding development of an organism. This includes phenomena such as X chromosome inactivation in mammalian females, and gene silencing within an organism. The study of heritable changes in gene function that occur without a change in the sequence of nuclear DNA . This ...

Histone

... as merely packing material for nuclear DNA. During the early 1990s, the regulatory functions of histones were discovered. See also Gene silencing Genetics Histone deacetylase ...

Reverse genetics

... some organisms, such as yeast and mice ) -- and only afterwards look for the effect of such alterations in the whole organism. The discovery of gene silencing using double stranded RNA, also known as RNA interference (RNAi), and the development of gene knockdown using Morpholino oligos have made ...
Silencing in Biological Dictionary

SiRNA

... ), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA ... Each synthetic siRNA provides highly specific silencing for your gene of interest. ... narcotics ... service. Achieve highly effective gene silencing from the RNAi experts using genome-wide siRNA ...

RNAi

... ( RNAi ) or post-transcriptional gene silencing (PTGS) is a ... RNAi Is Discovered in Nematodes ... RNAi includes both initiation ... Gene silencing by RNA interference ( RNAi ) literature and ... presence ... RNAi is distinct from other gene silencing phenomena in ...

Gene silencing

... Gene silencing is a general term describing epigenetic processes of gene regulation. The term gene silencing is generally used to describe the ... RNA (siRNA) – are ... Today, gene silencing —or RNA interference (RNAi), as it is now ...

RNA interference

... genetic ... Zamore PD (2006) Essay: RNA interference : big applause for silencing in Stockholm. ... This chapter of the Promega Protocols and ... RNA interference provided a most unexpected ... RNA ... transposon silencing and RNA interference , is a homolog of ... RNA INTERFERENCE ... ...

Methylation

... is a mechanism used to regulate genes and protect DNA ... Gene silencing through methylation is a well conserved and important feature of ... Our ... in cancer ... When CpG island methylation and transcriptional silencing occurs at tumor ... ...

Heterochromatin

... DirectTextBook.com - Save up to 80%, buy or rent. New and used books like silencing Heterochromatin and DNA Double Strand Break Repair 7th ... Online Shopping at SpotCost.com - New and used books like silencing Heterochromatin and DNA Double Strand Break Repair 7th edition by Kevin ...

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(Date:9/15/2014)... from digestion to disease resistance. Despite the fact that ... the planet, more is known about belly-button bacteria than ... colleagues working on Panama,s Barro Colorado Island discovered that ... to more than 400 different kinds of bacteria. The ... 7,000 different kinds. , Bacteria in tropical forests may ...
(Date:9/15/2014)... CAMBRIDGE, Mass. (September 15, 2014) The so-called ... which makes proteinhas long provided a simplified explanation ... in living organisms. , In reality, of ... the schema first articulated nearly 60 years ago ... DNA,s double-helix structure. For one, there are multiple ...
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