Basic work on E. coli identifies two new keys to regulation of bacterial gene expression
...ved but previously underappreciated segment of the sigma subunit of RNA polymerase. While the contact with sigma is very strong at promoters for most genes, it is particularly weak at promoters that make ribosomal...Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C
...tin 7, the component of the Ras-Raf pathway 14-3-3 sigma (also known as stratifin), and keratins 5, 10, and 14 (Celis et al. 1996b, stergaard et al. 1997 and references therein). Other markers useful in assessing the grade of differentiation and origin of the tumors correspond ...Part 6 Project Performance Get on the path to continuous improvement
...n the number of defects and then translated into a sigma number. A sigma of 6 translates to 3.4 defects per million opportunities. Its common to find 3σ to 4σ leve......to occur in all bacteria, the transcription factor sigma must bind to the core RNA polymerase. This U.S. patent 6,613,531 is for a method of screening small-molecule compounds (drugs) that interfere with this binding. This target and screening method could lead to a new class of broad spectrum antibiotic...