JCI table of contents: Sept. 4, 2007
... built of many repeating units known as sarcomeres. As the proteins of the sarcomere
are therefore crucial for muscle contraction, their synthesis, assembly, ... myopathy and hypertrophic cardiomyopathy because degradation of their sarcomere
proteins by the ubiquitin proteasome system was reduced. Inhibitors of ...
Gene Mutations for Rare Heart Disease Also Found in Kids
... which can lead to sudden death. About 3 percent to 4 percent of adults have the condition. Most of the genes implicated in cardiac hypertrophy encode sarcomere
proteins, which help the heart tighten and relax to pump blood.
"Cardiac hypertrophy increases your risk of all types of negative cardiovascular ...
The structural basis of familial hypertrophic cardiomyopathy is revealed
... a structural basis for the change in function of the mutant myosin. Dr. Hanein illustrates how the conformational instability within the sarcomere
affects ability of the heart to function properly and may lead to compensatory hypertrophy in cardiac muscle tissue, which is a trademark phenotype ...
Sarcomere in Biological News
Media highlights in the Dec. 15 issue of Biophysical Journal
... Shin'ichi Ishiwata, Waseda University
Keywords: ADP-bound cross-bridges; cooperativity; dextran; lattice spacing; length-dependent activation; sarcomere
Muscle is one of the most important organs in biological system, yet its regulatory mechanism is still not fully revealed because of its complex ...
The giant protein titin helps build muscles
... detailed image of the connections between the proteins they discovered that telethonin links the tails in a unique way that may give some clues to sarcomere
The Gautel lab used advanced microscope techniques to watch the molecules link to each other in live cells. "We knew that telethonin ...
Sarcomere in Biological Technology
Sarcomere in Biological Definition
... cells (sometimes known as "muscle fibers"). Within the cells are myofibrils ; the basic unit of a the contractile apparatus of a myofibril is the sarcomere
, which is composed of three different filament systems, the thin filaments assembled by actin proteins, the thick filament system consisting ...
Sarcomere in Biological Dictionary
... A sarcomere
(Greek sárx = "flesh", méros = ... and titin give stability and structure to the sarcomere
. ... sarcomere
( ) n. One of the segments into which a fibril ...
... in transversely cut cells. ... Spontaneous oscillation of tension and sarcomere
length in skeletal myofibrils . ... Single myofibrils were isolated ... ... 3. myofibril - cylindrical bundle of myofilaments (proteins) ... sarcomere
- segment of myofibril ... an array of myofibrils that are ...
... Muscle ... Skeletal muscle fibers are also multinucleated, with the cell's nuclei located ... section of skeletal muscle is called a sarcomere
... Muscle , tissue or organ of the animal body characterized by the ability to ... Muscle - Wikipedia, the free encyclopedia ... ...