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Ribosomal in Medical News

Orlando Regional Medical Center (ORMC) Implements PNA FISH(R) Tests to Help Provide Better Care for Patients with Bloodstream Infections

... highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. PNA FISH tests enable microbiology labs to provide rapid and accurate identification of bloodstream pathogens, ...

Memorial University Medical Center (MUMC) Implements PNA FISH(R) Tests to Help Provide Best Care for Patients with Bloodstream Infections

... highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. PNA FISH tests enable microbiology labs to provide rapid and accurate identification of bloodstream pathogens ...

ChemGenex's omacetaxine may provide first viable treatment option for highly resistant form of CML

... activity as a single agent in a range of hematological malignancies. Omacetaxine has a novel mechanism of action, specifically binding to the ribosomal A-site cleft and inhibiting protein translation of short-lived oncoproteins that are upregulated in leukemic cells (particularly Cyclin-D1, Mcl-1 and ...

AdvanDx Receives FDA 510(k) Clearance for GBS PNA FISH(R) for Rapid Detection of Group B Strep from Lim Broths

... highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. The unique properties of the non-charged, peptide backbone of PNA probes enable the use of FISH assays in ...

AdvanDx Receives FDA 510(k) Clearance for EK/P. aeruginosa PNA FISH(R)

... highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. The unique properties of the non-charged, peptide backbone of PNA probes enable the use of FISH assays in ...

Mercy Integrated Labs Implements PNA FISH(R) Tests to Help Clinicians Provide Best Care for Patients With Bloodstream Infections

... highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. PNA FISH tests enable microbiology labs to provide rapid and accurate identification of bloodstream pathogens ...

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Ribosomal in Medical Technology

Rib-X Pharmaceuticals, Inc. Announces Recent and Upcoming Presentations at Scientific Conferences

... studies of known and new antibiotics bound to the bacterial 50S ribosomal subunit with data-driven computational chemistry tools allows for a fresh ... Structure-Based Discovery to Define Novel Antibiotics Targeting the 50S ribosomal Subunit." RX-04 is Rib-X's de novo design of three completely new series ...

PTC Therapeutics Completes Enrollment of Pivotal Trial in Muscular Dystrophy

... deemed ataluren's mechanism of action to be significantly novel, warranting creation of a new stem, -luren, for pharmaceuticals that are inducers of ribosomal readthrough of nonsense mutation mRNA stop codons. "We are pleased to have completed enrollment of our first pivotal study of ataluren in boys ...

Study Shows Use of AdvanDx's PNA FISH(TM) Test was Associated with an 82% Reduction in Intensive Care Unit Mortality Rates from Staphylococcus aureus Bloodstream Infections

... highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. The unique properties of the non-charged, peptide backbone of PNA probes enable the use of FISH assays in ...

AdvanDx Submits Yeast Traffic Light PNA FISH(TM) for FDA 510(k) Clearance for Detection of Candida species in Positive Blood Cultures

... highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in bacteria and yeast. PNA FISH tests enable microbiology labs to provide rapid and accurate identification of bloodstream pathogens ...

PTC Therapeutics Announces Data Supporting Cough Frequency as a New Outcome Measure in Evaluating Treatments for Cystic Fibrosis

... was generally well tolerated, achieved target plasma concentrations that have been associated with activity in preclinical models and did not induce ribosomal read through of normal stop codons. PTC124 has demonstrated pharmacodynamic proof of concept in Phase 2a clinical trials in ...

PTC Therapeutics Announces Initiation of Phase 2b Registration-Directed Clinical Trial of PTC124 in Duchenne/Becker Muscular Dystrophy

... was generally well tolerated, achieved target plasma concentrations that have been associated with activity in preclinical models and did not induce ribosomal read through of normal stop codons. PTC124 has demonstrated pharmacodynamic proof of concept in Phase 2a clinical trials in ...
Ribosomal in Medical Products

GC OIA

Description:... for the diagnosis of gonorrhea. Thermo solved the challenge of developing a specific rapid assay for Neisseria gonorrhea by using the proprietary ribosomal protein, L7/L12, to bring about a first in GC ....
Company:Biostar

MESACUP ANA Test Kit

Features:... Detects autoantibodies to specific nuclear antigens, including RNP, Sm, SSA, SSB, Scl-70, Jo-1, CENP-B, ribosomal P, DNA and Histones Excellent correlation with specific autoantibody ELISA test kits Improved specificity compared immunofluorescent assays (IFA) ...
Company:Corgenix, Inc.
Ribosomal in Biological News

Researchers solve piece of large-scale gene silencing mystery

... the silencing of an entire parental set of ribosomal RNA genes in a hybrid plant or animal. Since ... inherited from the other parent. Expression of ribosomal RNA genes drives the formation of these nucleoli. ... species, always "chooses" to express the ribosomal RNA genes of one particular parental species, ...

Researchers observe spontaneous 'ratcheting' of single ribosome molecules

... the dynamic, ratchet-like movements of single ribosomal molecules in the act of building proteins from ... N.Y., using cryo-electron microscopy, showed the ribosomal subunits in two distinct positions relative to ... to observe in real time the movement of the ribosomal subunits that is essential for protein synthesis. ...

Symposium marks 30th anniversary of discovery of third domain of life

... discovery which was based on an analysis of ribosomal RNA, an ancient molecule essential to the ... contains sets of genetic sequences in their ribosomal RNA that are distinctive. These genetic ... discovery came when the researchers looked at the ribosomal RNA (rRNA) of a group of methane-generating ...

Einstein researchers devise a fast and sensitive way to detect ricin

... proteins─a basic cellular function. Ricin does this by disrupting ribosomal RNA (the key component of ribosomes, the cell's protein manufacturing "machines"). The ricin attack causes ribosomal RNA to release a molecule of adenine. Dr. Schramm's assay detects and ...

Rhythmic genomics -- the yeast metronome and the walk of life

... clock. In a paper published in Genome Research scientists show how ribosomal RNA genes that are essential to all Earth's organisms provide insight into how genomes maintain their integrity on their evolutionary journey. ribosomal RNA sequence changes have been ticking away like clockwork for over 3 ...

Cellular discovery may lead to targeted treatment for rare form of anemia

... even stopred blood cell death. DBA has recently been attributed to a ribosomal protein defect that the UC team hypothesizes leads to abnormal activation ... research has attributed p53 activation to the passive diffusion of ribosomal protein L11 from the nucleolus, the part of the nucleus where ribosomes ...

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Ribosomal in Biological Technology

Molecular sleuths track evolution through the ribosome

... tree of life and suggests that differences in ribosomal structure between the three main branches of that ... looked at the three-dimensional structures of the ribosomal RNA and proteins and their proximity to each ... study, developed computer programs to analyze the ribosomal sequences of different organisms. Whenever he ...

Cylene Pharmaceuticals Initiates Phase II Clinical Trial of Quarfloxin (CX-3543) in Patients With Carcinoid/Neuroendocrine Tumors

... fluoroquinolone class of drugs. Rationally designed to selectively inhibit ribosomal RNA (rRNA) biogenesis in cancer cells, quarfloxin disrupts the interaction between the Nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis and one ...

Cylene Pharmaceuticals Appoints Kenna Anderes, Ph.D. as Vice President of Cancer Biology

... drugs to treat life-threatening cancers. Using its proprietary ribosomal RNA Biogenesis Inhibition Technology (RABIT(TM)) to design molecules that ... Cylene's most advanced cancer agent, quarfloxin (CX-3543), is a ribosomal RNA Biogenesis Inhibitor (RBI) in Phase II clinical development in ...

Celsis Introduces ReACT(TM) RNA-Based Microbial Detection Assays

... assay to obtain a fast, 2-hour result on samples that test positive for microbial contamination. Celsis ReACT assays use proprietary selections of ribosomal RNA sequences to confirm or to rule out the presence of Gram-negative organisms, Staph. aureus, yeast and mold, and can be customized for ...

AdvanDx's PNA FISH(TM) Test Shown to Reduce Mortality by 42% for Patients With Hospital-Acquired Enterococcus faecium Bloodstream Infections

... highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. The unique properties of the non-charged, peptide backbone of PNA probes enable the use of FISH assays in ...

Norgen Biotek Corp. Launches Four New Kits for the Purification of RNA and DNA from Plants and Fungi

... from a wide range of plant and filamentous fungal species. The Plant/Fungi RNA Purification Kit isolates all sizes of RNA, from large mRNA and ribosomal RNA down to microRNA. The purified RNA is of the highest integrity, and can be used in a number of downstream applications including Real-Time PCR, ...

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Ribosomal in Biological Products

GIBCO Streptomycin Sulfate from Invitrogen

Description:... Streptomycin sulfate an aminoglycoside used for bacterial selection binds to the small ribosomal subunit and interferes with protein biosynthesis.21H39N7O12)2x3H2SO4Formula ...
Company:Invitrogen

Anisomycin from Sigma-Aldrich

Description:... (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.• Inhibits formation of the 80S ribosomal complex from 60S subunits• From Streptomyces griseolus Assay: ≥ 96.0 % (TLC)• Synonyms ...
Company:Sigma-Aldrich

AmpliTaq DNA Polymerase, LD with Buffer I from Applied Biosystems

Description:... effecitvely minimized when amplifying bacterial sequences. The enzyme is quality control tested to verify that less than 10 copies of bactieral 16S ribosomal RNA gene sequences are present in a standard 2.5 Unit ....
Company:Applied Biosystems
Ribosomal in Biological Definition

Ribosome

... of rRNA (synthesized in the nucleolus ) and ribosomal proteins. It translates mRNA into a ... of one or two very large RNA molecules (known as ribosomal RNA or rRNA ) and multiple smaller protein ... expelled from the cell via exocytosis . The ribosomal subunits of prokaryotes and eukaryotes are quite ...

Antibiotic

... with bacterial protein synthesis Antibiotics which bind to the 50S ribosomal unit Lincosamides/lincosides including clindamycin and lincomycin; chloramphenicol, macrolides Antibiotics which interfere the 30S ribosomal unit Tetracyclines; aminoglycosides including gentamicin ...

Nucleolus

... of the cell nucleus , which is an organelle . It is a consequence of ribosomal RNA ( rRNA ) synthesis: nucleolar organizers , special regions on some ... synthesis, rRNA molecules are attached to proteins, forming ribosomal subunits, which leave for the cytosol through nuclear pores . ...

RNA

... The best-known examples of RNA genes are transfer RNA ( tRNA ) and ribosomal RNA ( rRNA ). Both forms participate in the process of translation , but ... The most prominent examples of RNA genes are transfer RNA (tRNA) and ribosomal RNA (rRNA), both of which are involved in the process of translation. ...

Biodiversity

... from Sean Nee "the contribution of visible life to biodiversity is very small indeed". "On the tree of life, based on analyses of small-subunit ribosomal RNA , visible life consists of barely noticeable twigs. This should not be surprising — invisible life had at least three billion years to ...

Chromosome

... even if they are far apart on the chromosome. The short arm of a chromosome can be extended by a satellite chromosome that contains codes for ribosomal RNA . Chromosomes in different species Table 1: Examples of chromosome numbers (diploid). Species # of chromosomes ...

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Ribosomal in Biological Dictionary

Ribosomal RNA

... ribosomal RNA (rRNA) is the central component of the ... to ... The 16S rRNA is a part of the ribosomal RNA −-- a 1542 nt long component of the small prokaryotic ribosomal subunit (30S). ...

Ribosomal DNA genes

... ribosomal DNA (rDNA) are sequences encoding ribosomal RNA. These sequences regulate amplification ... loops that carry ... ribosomal RNA (rRNA) Transfer RNA (tRNA) Small Nuclear RNA ...

Peptidyl transferase

... , which is part of the larger of the two ribosomal subunits, catalyzes the transfer of ... ... The photochemical oxidation of the 50-S ribosomal subunit results in a rapid irreversible loss of peptidyl transferase activity. ribosomal binding sites were investigated for the diverse ...

Messenger RNA

... This will later be translated into a polypeptide. ribosomal RNA (rRNA) ... Only messenger RNA encodes ... Genetics, defines messenger RNA (mRNA) ... ribosomal RNA (rRNA) 1. messenger rna ... Hence the ... This will later be translated into a polypeptide. ribosomal RNA (rRNA) ... EcoSal is comprised of ...

Tet resistance

... ) ... Resistance to tetracyclines can arise through drug efflux, ribosomal protection ... ... moderate resistance to macrolides (10), and tet genes coding for ribosomal ... resistance genes have been found in anaerobes (3, 18), only the tet ...

Stop codon

... of the ribosome is ... Class 1 RFs recognize stop codons within the ribosomal A site and trigger the ... Stop codons : the Good, the Bad, and ... the sequence surrounding ... In response to a stop codon in the ribosomal A-site, ... This may result from an altered stop codon recognition ...

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