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reuptake in Medical News

Forest Laboratories, Inc. and Cypress Bioscience, Inc. Announce Commercial Availability of Savella(TM)

... a selective serotonin and norepinephrine dual reuptake inhibitor approved for the management of ... that, in-vitro, preferentially blocks the reuptake of norepinephrine with higher potency than ... is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), similar to some drugs used ...

Forest and Cypress Announce FDA Approval of Savella(TM) for the Management of Fibromyalgia

... a selective serotonin and norepinephrine dual reuptake inhibitor, was approved by the U.S. Food and Drug ... be central to fibromyalgia. Savella blocks the reuptake of both norepinephrine and serotonin, with greater selectivity for the inhibition of norepinephrine reuptake in vitro. This may be the mechanism by which ...

Zogenix and Astellas Enter Exclusive Co-Promotion Agreement in the US for Newly Approved Sumavel(TM) DosePro(TM)

... and is not generally recommended for use with selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors SNRIs or MAO inhibitors. Sumavel DosePro should be used ...

Surveyed Psychiatrists and PCPs Expect to Increase Their First-Line Use of SNRIs Over the Next Two Years for the Treatment of Generalized Anxiety Disorder

... physicians (PCPs) expect to increase their use of serotonin-norepinephrine reuptake inhibitors (SNRIs) over the next two years for the treatment of ... claims data show that benzodiazepines and selective serotonin reuptake inhibitors (SSRIs) dominate early lines of treatment. However, the ...

Results of phase III study on Labopharm's novel antidepressant published in Psychiatry (Edgemont) Journal

... treated with two different types of drug therapy: selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs)). However, some 40 to 50% of patients being treated for ...

New Once-Daily RYZOLT(TM) (tramadol HCl extended-release tablets) Now Available in the U.S.

... analgesic that binds to the mu -opioid receptor and also inhibits the reuptake of both serotonin and norepinephrine. Taken once every 24 hours, RYZOLT ... increases the seizure risk in patients taking selective serotonin reuptake inhibitors (SSRI antidepressants or anorectics), tricyclic antidepressants ...

FDA Approves Symbyax(R) as First Medication for Treatment-Resistant Depression

... or NMS-like reactions have been reported with serotonin-norepinephrine reuptake inhibitors (SNRIs) and selective serotonin reuptake inhibitors (SSRIs) alone, including Symbyax treatment, but particularly ...

AstraZeneca Licenses Novel Antidepressant Compounds Discovered by Mayo Clinic and Virginia Tech Collaboration

... announced that AstraZeneca has licensed a portfolio of preclinical Triple reuptake Inhibitor (TRI) compounds for depression. Researchers at Virginia Tech ... as selective serotonin (SSRI) and dual serotonin/norepinephrine (SNRI) reuptake inhibitors are proven treatments for depression and anxiety. However, they ...

SSRI Antidepressants May Lower Adult Suicide Risk

... say TUESDAY, Feb. 3 (HealthDay News) -- Selective serotonin reuptake inhibitors (SSRIs) may significantly reduce the risk of attempted or ... observational studies should reassure doctors that prescribing serotonin reuptake inhibitors in patients with major depression is safe," but children and ...

Certain Antidepressants Ease Fibromyalgia Symptoms

... Journal of the American Medical Association . Serotonin and noradrenaline reuptake inhibitors helped with those three symptoms but to a much lesser extent, while selective serotonin reuptake inhibitors and monoamine oxidase inhibitors helped lessen pain some. ...

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reuptake in Medical Technology

XTL Biopharmaceuticals Announces Completion of Patient Randomization Into the Bicifadine Phase 2b Clinical Trial for the Treatment of Diabetic Neuropathic Pain

... of Bicifadine -- a serotonin and norepinephrine reuptake inhibitor (SNRI) -- for the treatment of diabetic ... Importantly, Bicifadine has a unique ratio of reuptake inhibition of serotonin versus norepinephrine, ... Bicifadine, a serotonin and norepinephrine reuptake inhibitor, for the treatment of diabetic ...

Genaera Corporation Announces MSI-1436 Data Presented at Society of Neuroscience Meeting

... and body weight affect the rate of dopamine reuptake by inhibiting the dopamine transporter (DAT), ... designed. The effects of MSI-1436 on dopamine reuptake were investigated using in vivo fast-scan cyclic ... minutes and the resultant dopamine and rate of reuptake were measured. Peak concentrations of dopamine ...

DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947

... Phase Ib results for DOV 21,947, its lead triple reuptake inhibitor ("TRIP") for the treatment of ... underscore the therapeutic versatility of triple reuptake inhibitors such as DOV 21,947," said Dr. Phil ... of 2008. DOV 21,947 is a TRIP that inhibits the reuptake of the neurotransmitters serotonin, ...

FDA Approves Tapentadol Immediate-Release Tablets for Relief of Moderate to Severe Acute Pain

... of action, combining mu-opioid receptor agonism and norepinephrine reuptake inhibition. Tapentadol tablets have been approved in 50 mg, 75 ... at parts of the brain that control how pain is perceived. Norepinephrine reuptake inhibitors are a type of central nervous system medication that increases ...

Results of Phase 3 Study Show Tapentadol IR Relieves Acute Pain and Offers Favorable Gastrointestinal Tolerability Profile

... of action, combining mu-opioid receptor agonism and norepinephrine reuptake inhibition in a single molecule. It is being developed in ... at parts of the brain that control how pain is perceived. Norepinephrine reuptake inhibitors are a type of central nervous system medication that increases ...

AstraZeneca Submits sNDA for SEROQUEL XR(TM) for the Treatment of Generalized Anxiety Disorder - a First for the Atypical Antipsychotic Class of Medicines

... in the treatment of GAD. Treatment typically includes selective- serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs); however, approximately 30 percent of patients do not ...

FDA Approves Cymbalta(R) for Maintenance Treatment of Major Depressive Disorder

... of a class of drugs commonly referred to as serotonin and norepinephrine reuptake inhibitors (SNRI), has been studied in more than 27,000 patients ... pain. Based on pre-clinical studies, duloxetine is a balanced and potent reuptake inhibitor of serotonin and norepinephrine that is believed to potentiate ...

Popular Breast Cancer Drug Used with Certain Antidepressants Puts New Jersey Women at Risk

... of Medicine released a study revealing that women using tamoxifen to prevent a recurrence of breast cancer who also use certain selective serotonin reuptake inhibitors (SSRI), for example Prozac(R) (fluoxetine), Paxil(R) (paroxetine) and Zoloft(R) (sertraline), have up to twice the chance of having a ...

New Study: Antidepressants Commonly Prescribed with Tamoxifen Put Women at Much Higher Risk for Recurrent Breast Cancer

... drugs impact breast cancer recurrence rates when taken with tamoxifen. The antidepressants at issue are three widely used selective serotonin reuptake inhibitors (SSRIs), Prozac(R) (fluoxetine), Paxil(R) (paroxetine) and Zoloft(R) (sertraline), and are among a group of drugs known as CYP2D6 ...

March 2009 Mayo Clinic Health Letter Highlights Knee Repair Surgery, Anxiety Disorder and Preventing Blood Clots

... Medications, both antidepressants and anti-anxiety drugs, also can help. Among antidepressants, the first choice often is a selective serotonin reuptake inhibitor (SSRI). This category includes fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft) and citalopram (Celexa). Other antidepressants ...

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reuptake in Medical Dictionary

Serotonin

... Serotonin and norepinephrine reuptake inhibitors (SNRIs) are a type of antidepressant ... amount of serotonin . Selective serotonin reuptake inhibitors (SSRIs) balance brain chemicals ... and pineal gland . Selective serotonin reuptake inhibitors maintain levels of the excitatory ...

Norepinephrine

... Norepinephrine and dopamine reuptake inhibitors (NDRIs) are a type of antidepressant medication that increases ... Vestra (reboxetine mesylate) tablets A selective norepinephrine reuptake inhibitor (SNRI) for the acute treatment of depressive illness/ major ...

Obsessive

... , a type of drugs used to treat depression , selective serotonin reuptake inhibitors (SSRIs; such as Prozac and Paxil), are the treatment of ... \ ',CAPTION, ... Zoloft (sertraline HCl) A selective serotonin reuptake inhibitor (SSRI) for the treatment of panic disorder , depression in ...

Obsessive-compulsive disorder

... , a type of drugs used to treat depression , selective serotonin reuptake inhibitors (SSRIs; such as Prozac and Paxil), are the treatment of choice. Zoloft (sertraline HCl) A selective serotonin reuptake inhibitor (SSRI) for the treatment of panic disorder , depression in ...

Obsessive-compulsive

... , a type of drugs used to treat depression , selective serotonin reuptake inhibitors (SSRIs; such as Prozac and Paxil), are the treatment of choice. Zoloft (sertraline HCl) A selective serotonin reuptake inhibitor (SSRI) for the treatment of panic disorder , depression in ...

Panic disorder

... , panic disorder This is one of the new SSRI (selective serotonin reuptake inhibitors) drugs. Care should be taken if you have: - epilepsy - ... \ ',CAPTION, ... Zoloft (sertraline HCl) A selective serotonin reuptake inhibitor (SSRI) for the treatment of panic disorder , depression in ...

Bulimia

... vitamin B12 for up to five years, so it's rare for diet to cause this anemia . Prozac (fluoxetine hydro chloride ) A selective serotonin reuptake inhibitor (SSRI) initially approved by the FDA for the treatment of clinical depression ; subsequently approved for the treatment of ...

Bulimia nervosa

... ( Bulimia ) Bulk ( Fiber ) Bullae Bullous Myringitis (Infectious Myringitis) ... Prozac (fluoxetine hydro chloride ) A selective serotonin reuptake inhibitor (SSRI) initially approved by the FDA for the treatment of clinical depression ; subsequently approved for the treatment of ...

D Depression

... A small anatomical sac , cavity , or deep narrow-mouthed depression (eg, a hair follicle). hydro chloride ) A selective serotonin reuptake inhibitor (SSRI) initially approved by the FDA for the treatment of clinical depression ; subsequently approved for the treatment of ...

Epinephrine

... Nor epinephrine and dopamine reuptake inhibitors (NDRIs) are a type of antidepressant medication that increases the levels of both nor epinephrine and dopamine by inhibiting their re ...

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reuptake in Biological News

Chinese slimming capsules

... examination of the formulation has shown that it also contains the active substance sibutramine, which resembles amphetamine and which inhibits the reuptake of serotonin and noradrenaline in the brain. The sibutramine dose in each capsule corresponded to twice the daily maximum dose of the prescription ...

The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders

... the enzyme COMT. Serotonin is a brain chemical involved in mood regulation. The serotonin transporter, which is the target of selective serotonin reuptake inhibitors (SSRI) used to treat anxiety and depression, harbors a common polymorphism in its gene. This polymorphism can come in two different ...

Researchers iron out new role for serotonin

... including alcoholism, depression, autism and obsessive-compulsive disorder. SERT is also a major target for medications like the selective serotonin reuptake inhibitors (SSRI) used for treating depression. Thanks to a serendipitous mix-up in an animal order, Blakely and first author Ana Carnerio, Ph.D., ...

Likely cause of postpartum blues and depression identified

... interleukin-1 beta. If our hypothesis holds true, lowering interleukin-1 beta levels may be a better treatment option." He notes that while serotonin reuptake inhibitors, commonly used for depression, work well in these women, transferring the drug to the baby during nursing can be problematic. But ...

New treatment mechanisms for schizophrenia

... in the discovery of a completely novel means of adjunct therapy for schizophrenia that is analogous to the use of SSRIs [selective serotonin reuptake inhibitors] for the treatment of depression." In the second article, Hashimoto and colleagues demonstrated that repeated administration of the ...

Insulin's brain impact links drugs and diabetes

... Library of Science Biology (PLoS Biology). The psychostimulant drugs amphetamine and cocaine, as well as related medications for ADHD, block the reuptake of the neurotransmitter dopamine by dopamine transporters (DATs) and increase the level of dopamine signaling. Some of these compounds, including ...

High dopamine transporter levels not correlated with ADHD

... attempt to compensate for lower dopamine levels by reducing the number of reuptake proteins. This would explain the positive correlation between transporter levels and inattention: as the number of reuptake proteins rises, the amount of dopamine would decline, leading to a higher ...

Commonly used antidepressants may also affect human immune system

... They do not know yet, however, whether these SSRI (selective serotonin reuptake inhibitors) drugs "including the brands Prozac, Zoloft, Paxil and others" ... way of stimulating a T cell response." Drugs that block serotonin reuptake "likely change some of the parameters of T-cell activation, but we don't ...

Adolescent but not adult hamsters are more aggressive on low dose of fluoxetine

... are different. Thus, she says, "It is unwise to expect a drug to work the same in juveniles as in adults." Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), is the only medication approved to treat depression in children and adolescents. However, it has carried an FDA "black box" ...

Nobelist discovers antidepressant protein in mouse brain

... with each other by secreting messengers, such as serotonin, which bind to receptors located on the surface of receiving cells. Serotonin selective reuptake inhibitors (SSRIs), medications commonly prescribed for anxiety and depression, compensate for reduction in serotonin signaling by boosting levels ...

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reuptake in Biological Technology

US Neuropathic Pain Market Value Doubles to $5 Billion by 2018

... two serotonin/norepinephrine reuptake inhibitors desvenlafaxine (Wyeth), and paroxetine ... receptor antagonist/norepinehrine reuptake inhibitor reboxetine (Pfizer); an opioid receptor agonist/norepinephrine reuptake inhibitor tapentadol (Ortho-McNeil); a dopamine ...

XTL Biopharmaceuticals Initiates Phase IIb Clinical Trial of Bicifadine for the Treatment of Diabetic Neuropathic Pain

... of Bicifadine - a serotonin and norepinephrine reuptake inhibitor (SNRI) - for the treatment of diabetic ... Importantly, Bicifadine has a unique ratio of reuptake inhibition of serotonin versus norepinephrine, ... having another SNRI with a unique ratio of reuptake inhibition of serotonin versus norepinephrine to ...

Sumavel(TM) DosePro(TM) (sumatriptan injection) Approved by FDA for Acute Migraine and Cluster Headache: First Product Featuring Novel DosePro Needle-Free Delivery System

... and is not generally recommended for use with selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors SNRIs or MAO inhibitors. Sumavel DosePro should be used ...

REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients

... a mechanism of action that is different from that of selective serotonin reuptake inhibitors (SSRI) and serotonin-noradrenaline reuptake inhibitors (SNRI). Important Safety Information About REMERON in ...

Northern Antibiotics Presents New Data on Novel Polymyxin Compounds at the Joint ICAAC/IDSA 2008

... are excreted into urine to a significant extent. This indicates that the reuptake of the NAB compounds in the proximal tubuli of the kidneys is less intense than that of colistin and polymyxin B. The extensive reuptake is regarded to be the mechanism of the nephrotoxicity of polymyxins. Thus ...

New Phase 3 Data Showed PRISTIQ Significantly Reduced Symptoms of Major Depressive Disorder Versus Placebo

... PRISTIQ(TM) (desvenlafaxine), an investigational serotonin-norepinephrine reuptake inhibitor (SNRI), showed that adult patients who received a 50 mg/day dose ... About Antidepressants Antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and SNRIs, increased the risk compared to placebo of ...

Forest Laboratories' Lexapro and Generics-Dominated Fluoxetine Lead First-Line Therapy in the Treatment for Major Depression

... entitled Treatment Algorithms in Major Depression, selective serotonin reuptake inhibitors (SSRIs), which include Lexapro and Prozac, account for 63.6 ... of surveyed psychiatrists chose SSRIs over serotonin/norepinephrine reuptake inhibitors (SNRIs) is cost, while 49 percent of PCPs say they chose SSRIs ...

Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia

... The highest dose tested (10 mg) is thought to fully occupy 5HT2A receptors while adding incremental amounts of dopamine receptor and serotonin reuptake transporter (SERT) occupancy. Together, these data suggest that ITI-007 induces a novel pattern of sleep improvement. Doses of ITI-007 were ...

Valdoxan(R) Granted Marketing Authorisation for the Treatment of Major Depressive Episodes in Europe

... almost 6,000 adult patients with depression. The results demonstrate the superior efficacy of Valdoxan as compared with placebo, selective serotonin reuptake inhibitors (SSRIs) and serotonin noradrenaline reuptake inhibitor (SNRI) treatments and also show that: - Valdoxan has proven efficacy ...

European CHMP Adopts Negative Opinion on Cymbalta for the Treatment of Fibromyalgia

... serotonin and norepinephrine/noradrenaline mediated nerve signaling in the brain and the spinal cord. Based on pre-clinical studies, duloxetine is a reuptake inhibitor of serotonin and norepinephrine/noradrenaline. Scientists believe its effect on pain perception is due to increasing the activity of ...
reuptake in Biological Definition

Neurotransmitter

... from the synaptic cleft by a process is called reuptake (or often simply uptake ). Without reuptake, ... by drugs. Cocaine , for example, blocks the reuptake of dopamine , leaving these neurotransmitters in ... synaptic gap longer. Prozac is a serotonin reuptake inhibitor, hence potentiating its effect. AMPT ...

Selective serotonin reuptake inhibitor

... Selective serotonin reuptake inhibitors ( SSRIs ) are a class of ... 5-HT), in the synaptic gap by inhibiting its reuptake . One notable characteristic of SSRIs is that, ... transporters in the sending cell (thus reuptake ). Depression has been linked to a lack of ...
reuptake in Biological Dictionary

Norepinephrine

... and Pulmonary ... Norepinephrine . Epinephrine. A norepinephrine reuptake inhibitor (NRI, NERI) or ... Norepinephrine reuptake Inhibitors: Atomoxetine (Tomoxetine) • Ciclazindol ... NB ...
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