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Retrovirus in Medical News

Scientists Show Stem Cells Don't Cause Cancer

... treat disease has been the possibility that the retrovirus used to implant the cells might cause cancer, but ... that these stem cells can be implanted using a retrovirus without fear of causing cancer. "This is a ... In addition, there has been a fear that using a retrovirus to implant stem cells results in an increased ...

Viruses for a healthy pregnancy

... in the February issue of Microbiology Today. retrovirus infections represent the most intimate ... in the germ line. As a result, an endogenous retrovirus (ERV) can exist for millions of years. Over ... there are some related viruses in animals. For a retrovirus to become part of the host genome it is usually ...

Coming Soon: Lung-Cancer Spray?

... disorders and offers numerous advantages over more invasive modes of delivery." In the study, researchers used a lentiviral vector derived from a retrovirus able to infect non-dividing cells, causing lasting genetic changes. The lentiviral vector included a carboxyl-terminal modulator protein (CTMP), ...

Vaporized viral vector shows promise in anti-cancer gene therapy

... of non-small cell lung carcinomas were associated with the activation of the Akt signaling pathway. They chose a lentiviral vector, derived from a retrovirus and known for its ability to infect nondividing cells and effect persistent genetic changes. They transfected the lentiviral vector with a negative ...

A Global Call to Action From HIV Co-Discoverers Robert Gallo and Luc Montagnier

... Cancer Institute (NCI). These reports followed the publication by Dr. Montagnier and his co-workers who showed the first existence of this new retrovirus and subsequently contributed to demonstrate its causative role in AIDS." Drs. Gallo and Montagnier are participating in a symposium, "25 Years ...

Exploring the frontiers of retrovirology

... BioMed Central recently announced the launch of "Frontiers of Retrovirology", an international conference that will bring together leading human retrovirus researchers to review current progress and to chart future challenges. HIV affects 33 million individuals worldwide. To date, 25 million have died ...

New Roche Dual Target HIV-1 Test Approved for Use in European Union

... million people became newly infected, and 2.1 million died of AIDS, including 330,000 children. The human immunodeficiency virus (HIV) is a retrovirus that infects cells of the human immune system, destroying or impairing their function. In the early stages of infection, the person has no symptoms. ...

Hopes for AIDS Vaccine Still Alive Despite Setbacks

... for when you get exposed to HIV." But there's yet one more hurdle unique to HIV. Unlike standard flu or cold viruses, HIV -- a more primitive retrovirus -- actually inserts a piece of its DNA into the genome of the human host cell. This "integration" begins within hours or days of infection, mainly ...

Recipe for cell reprogramming adds protein

... the reprogramming process time-consuming and highly inefficient. To bypass these obstacles, the Whitehead researchers replaced c-Myc and its retrovirus with a naturally occurring signaling molecule called Wnt3a. When added to the fluid surrounding the cells being reprogrammed, Wnt3a promotes the ...

Dr. Anthony Fauci reflects on 25 years of HIV

... On the 25th anniversary of the first scientific article linking a retrovirus to AIDS, Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, ...

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Retrovirus in Medical Technology

Dr. Harriet Robinson Joins GeoVax Team as V.P. of R & D to Accelerate AIDS Vaccine Trials Program

... & Development. Dr. Robinson is known worldwide for her outstanding work on retrovirus biology and development of DNA vaccines with special emphasis on ... of Science) where she was recognized for her outstanding work on retrovirus biology and development of DNA vaccines with special emphasis on HIV/AIDS ...

Indevus Pharmaceuticals Announces PRO 2000 Found to Show Promise in Large HIV Prevention Study

... Results of NIH-sponsored Clinical Trial to be Presented at retrovirus Conference LEXINGTON, Mass., Feb. 9 /PRNewswire-FirstCall/ -- Indevus Pharmaceuticals, Inc. (Nasdaq: IDEV ) announced today that a National ...

GeoVax Labs, Inc. Reports Fourth Quarter and Year-End 2007 Financial Results

... Dr. Harriet Robinson to its staff as Vice President of Research & Development. Dr. Robinson is known worldwide for her outstanding work on retrovirus biology and development of DNA vaccines with special emphasis on HIV/AIDS. Significant advances by GeoVax's HIV/AIDS vaccine development ...

Preclinical Study Finds Protease Inhibitor-Resistant HIV May Have Reduced Potential to Develop Resistance to Panacos' Bevirimat

... Program at the National Cancer Institute, Frederick, MD, in collaboration with Panacos, was presented at the Cold Spring Harbor Laboratory's (CSHL) retrovirus Conference held May 22-27, 2007 in Cold Spring Harbor, NY. While resistance to bevirimat has not yet been reported in clinical studies, ...

Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics

... which can produce toxic side effects in normal cells. They expanded the number of mesenchymal stem cells in the laboratory and then used a retrovirus vector to insert the gene cytosine deaminase into the cell. This gene can convert a less toxic drug, 5-fluorocytosine (5-FC), to 5-FU inside the ...
Retrovirus in Medical Products

Commander

Features:... Can initiate up to 800 tests per hour Screens blood for hepatitis, retrovirus and other ...
Company:Abbott Diagnostics
Retrovirus in Medical Dictionary

Retrovirus

... retrovirus : A type of virus that, when not infecting a ... double-stranded DNA. HIV is an example of a retrovirus . retrovirus A virus that produces DNA from RNA (the ...

Mutation

... humans and many other organ isms, mutation s occur in DNA. However, in retrovirus es like HIV , mutation s occur in RNA which is the genetic material of retrovirus es. Mutation , germline: A heritable change in the DNA that occurred ...

Acquired Immunodeficiency Syndrome

... The passage by which air enters and exits the lungs . or acquired immunodeficiency syndrome , fatal disease caused by a rapidly mutating retrovirus that attacks the immune system and leaves the victim vulnerable to infections , malignancies, and neurological disorders. The acquired ...

AIDS

... AIDS . More on Acquired Immunodeficiency Syndrome Aids - or acquired immunodeficiency syndrome , fatal disease caused by a rapidly mutating retrovirus that attacks the immune system and leaves the victim vulnerable to infections , malignancies, ... HIV and AIDS continues to spread. This ...

Epidemic

... or bisexual men was first reported as part of an epidemic now known as AIDS .[14] The etiology of AIDS is a T- cell lymph otropic retrovirus known as HIV . Epidemic s, when they occur, usually reach their peak during the warmest months (July and August). TREATMENT " ... During an ...

Hemochromatosis

... Tremor ( Essential Tremor ) Idiopathic Thrombocytopenic Purpura ... DNA screening test for hemochromatosis - Source:MedicineNet retrovirus es and Opportunistic Infections Conf. 2/2006 - Source:MedicineNet Rabid Bat Rabies Warning - Source:Government ... Hemochromatosis ( Iron ...

Host

... nations. A tick passes through three stages of development-larva, nymph, and adult-each of which is dependent on a live host for food . A retrovirus is a virus that contains a unique enzyme called reverse transcriptase that allows it to replicate within new host cells. coli is produced ...

Intoxication

... 2003;3(2):5-17. Bent, S. cycle; endogenous depression ; endogenous fibres; endogenous infection ; endogenous pyrogen; endogenous retrovirus ; endogenous virus ; endogeny; endoglobular; endoglycoceramidase; endognath; endognathal; endognathion; endoherniotomy; endo intoxication ; ... ...

Leukemia

... , debilitating neurological illnesses and a drastic weakening of a child's immune system . VIRUS TYPE I (HTLV-I): HTLV-I and HTLV-II, like all retrovirus es, are single-stranded RNA virus es that replicate through a DNA intermediate. HTLV-I has an affinity for T lymphocyte s; it appears to be the ...

Lymphadenopathy

... lymph otropic virus type III, the lymphadenopathy -associated virus and the lymphadenopathy virus . No matter what name is applied, it is a retrovirus . Dandy fever : An acute mosquito- borne viral illness of sudden onset that usually follows a benign course with headache , fever , ...

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Retrovirus in Biological News

Two Hutchinson Center researchers named HHMI Early Career Scientists

... are critical for proper cell division. For example, to explore why humans are susceptible to HIV, Malik and his colleagues resurrected an extinct retrovirus that infected chimps and gorillas, but not humans, 4 million years ago. Malik's research suggests that we may be vulnerable to HIV infection because ...

Evolutionary biologist will study HIV with grant from AIDS research foundation

... cells, the virus hijacks its host's genetic machinery to produce proteins and ultimately replicate itself. It has been recently found that the retrovirus hijacks about 1,000 human genes. "The big challenge now is to find which of these 1,000 genes and the proteins they encode are critical for HIV ...

Gene therapy demonstrates benefit in patients with rheumatoid arthritis

... females under the age of 75 with a diagnosis of advanced rheumatoid arthritis. After tissue was removed from the subjects' knuckle joints, a harmless retrovirus was inserted into the tissue cells, in order to serve as a "vector" to transport the gene into the patients' joints. After being placed in culture to ...

Body's anti-HIV drug explained

... for drug development. APOBEC-3G is present in every human cell. It is capable of stopping HIV at the first step of replication, when the retrovirus transcribes its RNA into viral DNA. The study's authors, led by Xiaojiang Chen of the University of Southern California, were able to show the ...

Yamanaka eliminates viral vector in stem cell reprogramming

... as Shinya has shown, each step forward reveals a new set of challenges." Dr. Yamanka's team began this series of experiments by replacing the retrovirus with an adenoviral vector. While transfections with the genes on separate vectors didn't work, they did work when the genes were arranged in a ...

UT pathologists believe they have pinpointed Achilles heel of HIV

... the abzymes after decades of the infection. The immune system in some people can cope with HIV after all." Carl Hanson, Ph.D., who heads the retrovirus Diagnostic Section of the Viral and Rickettsial Disease Laboratory of the California Department of Public Health, has shown that the abzymes ...

UC Davis stem researchers demonstrate safety of gene therapy using adult stem cells

... and can give rise to bone, cartilage, fat, and muscle. Genes were inserted into the hematopoietic stem cells using one of two viral vectors either a retrovirus or a lentivirus before they were transplanted into the mice, along with genetically modified mesenchymal stem cells. Of the mice used in the ...

Ireland Cancer Center researchers advance stem cell gene therapy

... In the Phase I trial for patients with advanced malignancies, researchers collected peripheral blood stem cells from patients and exposed them to a retrovirus containing the G156A-MGMT gene. In addition to this promising research, Ireland Cancer Center scientists presented 24 oral and poster ...

New class of drug offers hope to treatment-resistant AIDS patients

... medicines, a discovery by a University of Georgia researcher may offer a new treatment option by targeting a previously elusive enzyme in the complex retrovirus responsible for the devastating disease. Approximately 40 million people worldwide have the infectious viral disease known as HIV-AIDS. Although ...

Ancient retrovirus sheds light on modern pandemic

... Human resistance to a retrovirus that infected chimpanzees and other nonhuman ... Evidence of human immunity to this ancient retrovirus first emerged with the sequencing of the ... story of TRIM5a's role in battling one ancient retrovirus while increasing human susceptibility to ...

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Retrovirus in Biological Technology

New Test from Quest Diagnostics Helps Physicians Choose HIV Antiretroviral Therapy in Patients with History of Drug Resistance

... reaction to abacavir (Ziagen(R)), an antiretroviral therapy. About HIV and AIDS HIV, or the human immunodeficiency virus, is a retrovirus that infects cells of the human immune system, destroying or impairing their function. The two major viruses that cause AIDS are HIV-1 and HIV-2. The ...

GeoVax Labs, Inc. Reports Fourth Quarter and Year-End 2008 Financial Results

... and in June 2008 Dr. Robinson joined the Company's Board of Directors. Dr. Robinson is known worldwide for her outstanding work on retrovirus biology and a pioneer of DNA vaccines with special emphasis on HIV/AIDS. Dr. Robinson has published extensively on HIV/AIDS vaccine ...

GeoVax Labs, Inc. Announces Six Month Financial Results and Provides Operational Update

... Dr. Harriet Robinson to its staff as Vice President of Research & Development. Dr. Robinson is known worldwide for her outstanding work on retrovirus biology and a pioneer of DNA vaccines with special emphasis on HIV/AIDS. Dr. Robinson has published extensively on HIV/AIDS vaccine research, ...

Safe Production of High-Titer Retrovirus

... for the production of high-titer recombinant retrovirus that are capable of infecting a virtually ... of production of replication-competent retrovirus (RCR) due to homologous recombination ... of generating replication-competent retrovirus (RCR) by homologous recombination is ...

Enhanced siRNA Delivery and Long-term Gene Silencing

... from either the H1 or U6 promoter were transfected into a retrovirus packaging cell line in 6 well plates. Three days following ... Retroviral Delivery Used to Elicit RNAi in Primary Cells. retrovirus expressing cyclophilin A siRNA or a negative control siRNA (nc) ...

The Genesis of Gendicine: The Story Behind the First Gene Therapy

... FDA,CBER.Guidance for industry: supplemental guidance on testing for replication competent retrovirus in retroviral vector based gene therapy products and during follow-up of patients in clinical trials using retroviral vectors. ...

Development of a Multiplex Bead-Based Assay for Antibody Screening of a Nonhuman Primate Colony on the Bio-Plex System

... separate enzyme-linked immunosorbent assays (ELISAs) to screen our primate colony for the viruses of greatest concern: simian retrovirus (SRV), simian T-cell leukemia virus (STLV), herpes B, and simian immunodeficiency virus (SIV). To minimize the labor involved, testing ...

New Mammalian Expression Vectors Employ Stable, High-Level Fluorescence Humanized Renilla GFP Reporter

... Biol. 5: 635-642. 5. Gould, SG., et.al.. (1997) J. Cell Biol., 105(6Pt2): 2923-2931. 6. Miller, A. D. (1990) retrovirus Packaging Cells. In Human Gene Therapy, pp. 514. Mary Ann Liebert, Inc.,Publishers. 7. Felts, K, Bauer, J., and Vaillancourt, ...
Retrovirus in Biological Definition

Retrovirus

... Lentivirus Spumavirus A retrovirus is a virus which has a genome consisting of ... transcribes RNA into DNA. The term "retro" in retrovirus refers to this reversal of the Central dogma of ... HIV has not been developed yet. Among others, retrovirus genomes commonly contain three genes , that ...

Gene therapy

... while the genetic material of their hosts is in the form of DNA. When a retrovirus infects a host cell, it will introduce its RNA together with some enzymes into the cell. This RNA molecule from the retrovirus must produce a DNA copy from its RNA molecule before it can be considered ...
Retrovirus in Biological Dictionary

Retrovirus

... A retrovirus is an RNA virus that is replicated in a host ... genome by an integrase enzyme. The ... retrovirus n. , pl. -ruses . Any of a group of viruses, ... RNA and reverse transcriptase, including the retrovirus , any virus belonging to the family ...

Transient transfection

... 6 Vector Titration. 6.1 Packaging cells ... While transient transfection is advantageous for fast ... Production of Replication-Defective retrovirus by Transient Transfection of 293T cells ... transient transfection protocol using 293T cells, a human renal ... Article : Optimizing ...

Tobacco mosaic virus

... are very closely related. ... How to Identify Tobacco Mosaic Virus and Tomato Mosaic Virus ... virus of tobacco and nightshades: a retrovirus that causes mosaic disease in ... Tobacco mosaic virus - Wikipedia, the free encyclopedia ... Disintegration of tobacco mosaic virus ...

Reverse transcription

... DNA is carried out ... Two species are incompetent for reverse transcription in vivo, while a third ... A full understanding of any single retrovirus depends on an appreciation of the common properties of retroviruses as a ... of reverse transcription generates, ... II. Protocol for ...

DNA virus

... double-stranded DNA (dsDNA) but may also be single-stranded DNA (ssDNA). DNA viruses belong to either Group I or Group II of ... A retrovirus is an RNA virus that is replicated in a host cell via the enzyme reverse transcriptase to produce DNA from its RNA genome. The DNA is ...

Composite transposon

... is flanked by two separate IS elements which may or may not be exact replicas. Instead ... A DNA composite transposon . ... the retrovirus bears a marked similarity to a transposon . ... The most common form of transposon in humans is the Alu sequence. ... File: Composite ...

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