Scientists Show Stem Cells Don't Cause Cancer
... treat disease has been the possibility that the retrovirus used to implant the cells might cause cancer, but ... that these stem cells can be implanted using a retrovirus without fear of causing cancer. "This is a ... In addition, there has been a fear that using a retrovirus to implant stem cells results in an increased ...Viruses for a healthy pregnancy
... in the February issue of Microbiology Today. retrovirus infections represent the most intimate ... in the germ line. As a result, an endogenous retrovirus (ERV) can exist for millions of years. Over ... there are some related viruses in animals. For a retrovirus to become part of the host genome it is usually ...Coming Soon: Lung-Cancer Spray?
... disorders and offers numerous advantages over more invasive modes of delivery." In the study, researchers used a lentiviral vector derived from a retrovirus able to infect non-dividing cells, causing lasting genetic changes. The lentiviral vector included a carboxyl-terminal modulator protein (CTMP), ...Vaporized viral vector shows promise in anti-cancer gene therapy
... of non-small cell lung carcinomas were associated with the activation of the Akt signaling pathway. They chose a lentiviral vector, derived from a retrovirus and known for its ability to infect nondividing cells and effect persistent genetic changes. They transfected the lentiviral vector with a negative ...A Global Call to Action From HIV Co-Discoverers Robert Gallo and Luc Montagnier
... Cancer Institute (NCI). These reports followed the publication by Dr. Montagnier and his co-workers who showed the first existence of this new retrovirus and subsequently contributed to demonstrate its causative role in AIDS." Drs. Gallo and Montagnier are participating in a symposium, "25 Years ...Exploring the frontiers of retrovirology
... BioMed Central recently announced the launch of "Frontiers of Retrovirology", an international conference that will bring together leading human retrovirus researchers to review current progress and to chart future challenges. HIV affects 33 million individuals worldwide. To date, 25 million have died ...New Roche Dual Target HIV-1 Test Approved for Use in European Union
... million people became newly infected, and 2.1 million died of AIDS, including 330,000 children. The human immunodeficiency virus (HIV) is a retrovirus that infects cells of the human immune system, destroying or impairing their function. In the early stages of infection, the person has no symptoms. ...Hopes for AIDS Vaccine Still Alive Despite Setbacks
... for when you get exposed to HIV." But there's yet one more hurdle unique to HIV. Unlike standard flu or cold viruses, HIV -- a more primitive retrovirus -- actually inserts a piece of its DNA into the genome of the human host cell. This "integration" begins within hours or days of infection, mainly ...Recipe for cell reprogramming adds protein
... the reprogramming process time-consuming and highly inefficient. To bypass these obstacles, the Whitehead researchers replaced c-Myc and its retrovirus with a naturally occurring signaling molecule called Wnt3a. When added to the fluid surrounding the cells being reprogrammed, Wnt3a promotes the ...Dr. Anthony Fauci reflects on 25 years of HIV
... On the 25th anniversary of the first scientific article linking a retrovirus to AIDS, Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, ...Dr. Harriet Robinson Joins GeoVax Team as V.P. of R & D to Accelerate AIDS Vaccine Trials Program
... & Development. Dr. Robinson is known worldwide for her outstanding work on retrovirus biology and development of DNA vaccines with special emphasis on ... of Science) where she was recognized for her outstanding work on retrovirus biology and development of DNA vaccines with special emphasis on HIV/AIDS ...Indevus Pharmaceuticals Announces PRO 2000 Found to Show Promise in Large HIV Prevention Study
... Results of NIH-sponsored Clinical Trial to be Presented at retrovirus Conference LEXINGTON, Mass., Feb. 9 /PRNewswire-FirstCall/ -- Indevus Pharmaceuticals, Inc. (Nasdaq: IDEV ) announced today that a National ...GeoVax Labs, Inc. Reports Fourth Quarter and Year-End 2007 Financial Results
... Dr. Harriet Robinson to its staff as Vice President of Research & Development. Dr. Robinson is known worldwide for her outstanding work on retrovirus biology and development of DNA vaccines with special emphasis on HIV/AIDS. Significant advances by GeoVax's HIV/AIDS vaccine development ...Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
... which can produce toxic side effects in normal cells. They expanded the number of mesenchymal stem cells in the laboratory and then used a retrovirus vector to insert the gene cytosine deaminase into the cell. This gene can convert a less toxic drug, 5-fluorocytosine (5-FC), to 5-FU inside the ...Acquired Immunodeficiency Syndrome
... The passage by which air enters and exits the lungs . or acquired immunodeficiency syndrome , fatal disease caused by a rapidly mutating retrovirus that attacks the immune system and leaves the victim vulnerable to infections , malignancies, and neurological disorders. The acquired ...Two Hutchinson Center researchers named HHMI Early Career Scientists
... are critical for proper cell division. For example, to explore why humans are susceptible to HIV, Malik and his colleagues resurrected an extinct retrovirus that infected chimps and gorillas, but not humans, 4 million years ago. Malik's research suggests that we may be vulnerable to HIV infection because ...Evolutionary biologist will study HIV with grant from AIDS research foundation
... cells, the virus hijacks its host's genetic machinery to produce proteins and ultimately replicate itself. It has been recently found that the retrovirus hijacks about 1,000 human genes. "The big challenge now is to find which of these 1,000 genes and the proteins they encode are critical for HIV ...Gene therapy demonstrates benefit in patients with rheumatoid arthritis
... females under the age of 75 with a diagnosis of advanced rheumatoid arthritis. After tissue was removed from the subjects' knuckle joints, a harmless retrovirus was inserted into the tissue cells, in order to serve as a "vector" to transport the gene into the patients' joints. After being placed in culture to ...Body's anti-HIV drug explained
... for drug development. APOBEC-3G is present in every human cell. It is capable of stopping HIV at the first step of replication, when the retrovirus transcribes its RNA into viral DNA. The study's authors, led by Xiaojiang Chen of the University of Southern California, were able to show the ...Yamanaka eliminates viral vector in stem cell reprogramming
... as Shinya has shown, each step forward reveals a new set of challenges." Dr. Yamanka's team began this series of experiments by replacing the retrovirus with an adenoviral vector. While transfections with the genes on separate vectors didn't work, they did work when the genes were arranged in a ...UT pathologists believe they have pinpointed Achilles heel of HIV
... the abzymes after decades of the infection. The immune system in some people can cope with HIV after all." Carl Hanson, Ph.D., who heads the retrovirus Diagnostic Section of the Viral and Rickettsial Disease Laboratory of the California Department of Public Health, has shown that the abzymes ...UC Davis stem researchers demonstrate safety of gene therapy using adult stem cells
... and can give rise to bone, cartilage, fat, and muscle. Genes were inserted into the hematopoietic stem cells using one of two viral vectors either a retrovirus or a lentivirus before they were transplanted into the mice, along with genetically modified mesenchymal stem cells. Of the mice used in the ...Ireland Cancer Center researchers advance stem cell gene therapy
... In the Phase I trial for patients with advanced malignancies, researchers collected peripheral blood stem cells from patients and exposed them to a retrovirus containing the G156A-MGMT gene. In addition to this promising research, Ireland Cancer Center scientists presented 24 oral and poster ...New class of drug offers hope to treatment-resistant AIDS patients
... medicines, a discovery by a University of Georgia researcher may offer a new treatment option by targeting a previously elusive enzyme in the complex retrovirus responsible for the devastating disease. Approximately 40 million people worldwide have the infectious viral disease known as HIV-AIDS. Although ...Ancient retrovirus sheds light on modern pandemic
... Human resistance to a retrovirus that infected chimpanzees and other nonhuman ... Evidence of human immunity to this ancient retrovirus first emerged with the sequencing of the ... story of TRIM5a's role in battling one ancient retrovirus while increasing human susceptibility to ...GeoVax Labs, Inc. Reports Fourth Quarter and Year-End 2008 Financial Results
... and in June 2008 Dr. Robinson joined the Company's Board of Directors. Dr. Robinson is known worldwide for her outstanding work on retrovirus biology and a pioneer of DNA vaccines with special emphasis on HIV/AIDS. Dr. Robinson has published extensively on HIV/AIDS vaccine ...GeoVax Labs, Inc. Announces Six Month Financial Results and Provides Operational Update
... Dr. Harriet Robinson to its staff as Vice President of Research & Development. Dr. Robinson is known worldwide for her outstanding work on retrovirus biology and a pioneer of DNA vaccines with special emphasis on HIV/AIDS. Dr. Robinson has published extensively on HIV/AIDS vaccine research, ...Safe Production of High-Titer Retrovirus
... for the production of high-titer recombinant retrovirus that are capable of infecting a virtually ... of production of replication-competent retrovirus (RCR) due to homologous recombination ... of generating replication-competent retrovirus (RCR) by homologous recombination is ...Enhanced siRNA Delivery and Long-term Gene Silencing
... from either the H1 or U6 promoter were transfected into a retrovirus packaging cell line in 6 well plates. Three days following ... Retroviral Delivery Used to Elicit RNAi in Primary Cells. retrovirus expressing cyclophilin A siRNA or a negative control siRNA (nc) ...The Genesis of Gendicine: The Story Behind the First Gene Therapy
... FDA,CBER.Guidance for industry: supplemental guidance on testing for replication competent retrovirus in retroviral vector based gene therapy products and during follow-up of patients in clinical trials using retroviral vectors. ...