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Reticulum in Medical News

Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells

... and distribution of cytoplasmic and endoplasmic reticulum chaperones, possibly by activating certain ... calcium homeostasisXin the endoplasmic reticulum appears to be a relatively safe and selective ... Altering calcium homeostasis in the endoplasmic reticulum does not appear to affect the folding efficiency ...

St. Jude finds mechanism for faulty protein disposal

... proteins are ejected from the endoplasmic reticulum through channels called retrotranslocons and put ... proteins do not accumulate in the endoplasmic reticulum and kill the cell by disrupting the vital process ... identified a channel out of the endoplasmic reticulum for glycosylated proteins, or proteins tagged ...

Researchers aim to over-stress already taxed mantle cell lymphoma cells

... in response to stress. They also found that the usually busy endoplasmic reticulum of these cells, which is supposed to be making normal antibodies, is ... and proteasome inhibitors to study protective versus lethal endoplasmic reticulum stress as a way to get rid of mantel cell lymphoma cells. The laboratory ...

Key protein may explain the anti-aging and anti-cancer benefits of dietary restriction

... stems from the effects of misfolded proteins and opens up a rich area of investigation to examine the mechanisms by which stress in the endoplasmic reticulum affects lifespan. ...

Retinal Gene Is Linked to Childhood Blindness

... but SPATA7 is the first gene with a mutation that disrupts the protein transport between two important compartments of the cell -- the endoplasmic reticulum and the Golgi apparatus. Because all proteins in every cell have to pass through this transport system, a mutation in SPATA7 might affect many ...

Slices of living brain tissue are helping scientists identify new stroke therapies

... they need for normal function. MCG Retinal Biologist Sylvia Smith and others have shown that sigma receptors are located within the endoplasmic reticulum of cells, which controls protein synthesis and regulates calcium levels. When needed, the receptors appear to chaperone these proteins to the cell ...

Researchers identify toehold for HIV's assault on brain

... team also showed, in mice, that a single exposure to Tat has long-lasting effects on the brain, causing problems with mitochondria and endoplasmic reticulum weeks later. Perhaps most striking, Gelbard says, is the observation that the exact same types of damage were seen in brain tissue of patients with ...

Fat Cells in Obese People Are 'Sick'

... Medicine and chief of endocrinology, said in Temple press release. Boden said that the obese people's fat cells showed stress on the endoplasmic reticulum (ER), which helps cells synthesize proteins and monitor how they are folded. When the ER is stressed, Boden explained, it produces several proteins ...

Calcium may be the key to understanding Alzheimer's disease

... Professor of Physiology. "Mutated PS1 and PS2 caused exaggerated cellular calcium signaling in cells through a calcium channel in the endoplasmic reticulum called the inositol trisphosphate receptor [InsP3R], suggesting that it or other proteins in this calcium signaling pathway could be targets for new ...

Discovery of gene mechanism could bring about new ways to treat metastatic cancer

... carcinomas and melanomas. Further, the team determined that mda-7/IL-24 induces tumor-specific killing through a process known as endoplasmic reticulum stress. The endoplasmic reticulum, or ER, is a subcellular structure that plays a key role in cellular protein disposition. ER stress results from ...

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Reticulum in Medical Technology

FDA Accepts Arno Therapeutics' IND for AR-12 a PDK1 Inhibitor That Blocks the PI3K/Akt Pathway

... the PI3K/Akt pathway and induces the endoplasmic reticulum stress pathway. Acceptance of the IND permits ... the PI3K/Akt pathway and induces the endoplasmic reticulum stress pathway. About Arno Therapeutics ... the PI3K/Akt pathway and induces the endoplasmic reticulum stress pathway, that received FDA acceptance of ...

Amicus Therapeutics Announces Successful Completion of End of Phase 2 Meeting With FDA for Amigal in Fabry Disease

... disease, alpha-GAL. After binding to the enzyme, Amigal promotes the proper folding, processing, and trafficking of the enzyme from the endoplasmic reticulum to its final destination, the lysosome, the area of the cell where the enzyme does its work. Once it reaches the lysosome, the pharmacological ...

Arno Therapeutics, Inc. Completes $18 Million Financing and Reverse Merger with Laurier International, Inc.

... a highly aggressive form of brain cancer. AR-12 is a PDK-1 inhibitor that targets the Akt pathway while also possessing activity in the endoplasmic reticulum (ER) stress and other pathways targeting apoptosis. Preclinical data have demonstrated that AR-12 has activity in a wide range of tumor types and ...

Clinical Update - Debio 0614 (Istaroxime) in Acute Heart Failure

... low output stage. It inhibits the Na+K+ ATPase pump, also known as the sodium-potassium pump and restores the SERCA2 ATPase activity (Sarcoplasmic reticulum Calcium ATPase 2 activity). The combined mechanism of action allows for cytosolic calcium accumulation during systole (inotropic response), as well ...
Reticulum in Biological News

Little-known protein found to be key player

... showed that cells with extra atlastin had an overdeveloped endoplasmic reticulum (ER), a system of interconnected membrane tubes and chambers that's ... with defective atlastin were sterile and short-lived. "The endoplasmic reticulum is an ever-changing environment," McNew said. "It grows. It retracts. It ...

Visualizing virus replication in three dimensions

... "We now know that viral RNA is replicated in vesicles in the endoplasmic reticulum and is secreted through tiny pores. We were also able to show that ... incorporated into pre-stages of viruses and then penetrate the endoplasmic reticulum a second time. There they are enveloped in a membrane that disguises them ...

Story ideas from the Journal of Lipid Research

... in obese fat cells is a maze-like compartment called the endoplasmic reticulum (ER) that makes proteins and lipid droplets and senses the amount of ... the scientists conclude. Article: Adipocyte stress: the endoplasmic reticulum and metabolic disease , by Margaret F. Gregor and Gokhan S. Hotamisligil ...

'Deranged calcium signaling' contributes to neurological disorder, UT Southwestern researchers find

... targets with fewer side effects," Dr. Bezprozvanny said. The researchers now are studying whether blocking calcium release from the endoplasmic reticulum also can improve function in mouse models of Huntington's and other neurodegenerative diseases such as spinocerebellar ataxia type 2 and Alzheimer's ...

Hot peppers really do bring the heat

... called SERCA. Normally, muscle contraction initiates following the release of a wave of calcium ions from a compartment called the sarcoplasmic reticulum (SR); SERCA then actively pumps the calcium back into the SR (using ATP energy), causing muscle relaxation and renewing the cycle. Capsaicin, ...

Researchers discover cell's 'quality control' mechanism

... Dr. Gregor Jansen at McGill University in Montreal, have discovered the important role played by an enzyme called ERdj5 inside the cell's endoplasmic reticulum (ER). The ER acts as a sort of packaging plant that folds and prepares proteins for distribution inside or outside the cell. But when proteins are ...

Genetics of ALS progression

... The researchers characterized a molecular pathway by which mutated SOD1 contributes to the accumulation of malformed proteins inside the endoplasmic reticulum (ER) compartment of motor neuron cells. Beyond a certain threshold, this ER stress induces cell death. Interestingly, Dr. Ichijos team found that ...

RING finger protein 5 may guide treatment for muscle disease in older adults

... future diagnostic and therapeutic opportunities for this disease. In muscles, proteins are continuously made and broken down by the endoplasmic reticulum (ER), a protein factory in the cell. To assure that proteins produced pass quality control, a set of ER-based inspectors identify and remove those ...

Legionnaire's bacterial proteins work together to survive

... found that one protein, DrrA, that turns on a molecular switch, Rab1, and subverts its function. This allows the Legionella to fuse the endoplasmic reticulum and the vacuole, creating a compartment that ensures bacterial survival. They also found a second bacterial protein, LepB, that turns off the Rab1 ...

Botched production of insulin molecule may lead to diabetes

... belt to make insulin. Simultaneously, this blocked the traffic of the normal proinsulin in the same cells. This protein mess in the endoplasmic reticulum directly inhibits insulin production in the beta cells, even including insulin production that comes from the otherwise normal rat proinsulin. The ...

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Reticulum in Biological Technology

Discovery of a new retinal gene involved in childhood blindness

... LCA, but SPATA7 is the first gene with a mutation that disrupts the protein transport between two important compartments of the cell: the endoplasmic reticulum and the Golgi apparatus. All proteins in every cell have to pass through this transport pathway; thus SPATA7 plays a major role and its mutation may ...

Cystic Fibrosis - Axentis Pharma Takes Over Patents and Continues Development of Innovative Platform Technology

... mutations. Although the mutated proteins still offer sufficient functionality, they are eliminated by quality control functions in the endoplasmic reticulum of the cells. The therapeutic approach now under development at Axentis Pharma enables these proteins - which are still functional despite their ...

Syndexa Pharmaceuticals Corporation and ChemDiv, Inc. Announce Discovery Collaboration

... obesity, type 2 diabetes and atherosclerosis. Syndexa's current programs include the development of inhibitors of obesity-induced Endoplasmic reticulum (ER) stress and c-jun N-terminal kinase (JNK). Founded by leading scientists from Harvard and University of California, San Diego, the company ...

Glossary for The BioPharm Guide to Fermentation and Cell Culture

... foreign nucleic acids. endoplasmic reticulum A highly specialized and complex network of ... animal and plant cells. The rough endoplasmic reticulum is where ribosomes make proteins. It ... with ribosomes. The smooth endoplasmic reticulum is the site for synthesis and ...

High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation

... the medium which facilitates recovery of the protein. However, E. coli is a prokaryote and lacks intracellular organelles, such as the endoplasmic reticulum and the golgi apparatus that are present in eukaryotes, which are responsible for modifications of the proteins being produced. Many eukaryotic ...

Gq-coupled receptor assays using FLEXstation: M1 muscarinic receptor

... the M1 muscarinic G q coupled receptor 1 . This receptor is stimulated with carbachol, which leads to the release of calcium from the endoplasmic reticulum into the cytosol. Activation of the M1 G q -coupled receptor can be monitored using FLEXstation in conjunction with either the calcium-sensitive ...
Reticulum in Biological Products

NADPH-cytochrome c reductase Colorimetric Assay Kit from Sigma-Aldrich

Description:... extracts and in purified microsomes [endoplastic reticulum (ER)]. It has been tested on samples prepared ... c reductase is widely used as an endoplasmic reticulum marker and as one of the biomarkers for ... kit is suitable for: Detection of endoplasmic reticulum (ER) during isolation and subcellular ...
Company:Sigma-Aldrich

Rabbit Anti-Human S100 A6 Ab-9 Polyclonal Antibody, Unconjugated from Lab Vision

Description:... composed of two beta chains. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes. Epitope: Not determined Immunogen: Purified recombinant human S100A6 monomer expressed in E coli. ...
Company:Lab Vision

Mouse Anti-PRKAR2 Monoclonal Antibody, Unconjugated, Clone RS17 from GeneTex

Description:... localization of AMPK. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). Immunogen: Purified regulatory subunit of cAMP-dependent protein kinase type II from bovine brain. Specificity: Does not influence cAMP ...
Company:GeneTex

Endoplasmic Reticulum Isolation Kit from Sigma-Aldrich

Description:... Application: For the efficient enrichment of functional endoplasmic reticulum (ER) from mammalian tissue or cell culture. The isolated ER are useful for protein synthesis, degradation and metabolic pathway analysis. Metabolic ...
Company:Sigma-Aldrich

A - 20 cell line slides ( mouse: B lymphocyte; reticulum cell sarcoma ) from GeneTex

Description: Mouse A-20 cells were cultured in RPMI 1640 with 2 mM L-glutamine and harvested at the log phase of growth. In order to keep the antigens in their native forms, cells were fixed in acetone-methanol. The cells are arrayed on a 12-well (5 mm) adhesive coated slide, with each wells surface ...
Company:GeneTex
Reticulum in Biological Definition

Endoplasmic reticulum

... The endoplasmic reticulum or ER (endoplasmic means "within the cytoplasm ", reticulum means "little net") is an organelle found in ... Figure 1 : Image of nucleus , endoplasmic reticulum and Golgi apparatus. (1) Nucleus. (2) Nuclear ...

Golgi apparatus

... transport vesicles that leave the endoplasmic reticulum (ER), specifically rough ER, are transported ... Figure 1: Image of nucleus , endoplasmic reticulum and Golgi apparatus: (1) Nucleus, (2) Nuclear pore, (3) Rough endoplasmic reticulum (RER), (4) Smooth ...

Endoplasmic reticulum

... The endoplasmic reticulum or ER (endoplasmic means "within the cytoplasm ", reticulum means "little net") is an organelle found in ... Figure 1 : Image of nucleus , endoplasmic reticulum and Golgi apparatus. (1) Nucleus. (2) Nuclear ...

Endoplasmic reticulum

... The endoplasmic reticulum or ER (endoplasmic means "within the cytoplasm ", reticulum means "little net") is an organelle found in ... Figure 1 : Image of nucleus , endoplasmic reticulum and Golgi apparatus. (1) Nucleus. (2) Nuclear ...

Signal transduction

... within organelles , usually the endoplasmic reticulum ( sarcoplasmic reticulum in muscle cells), where it is bound to molecules ... Ca 2+ has to be released from the endoplasmic reticulum into the cytosol . There are two combined ...

Endoplasmic reticulum

... The endoplasmic reticulum or ER (endoplasmic means "within the cytoplasm ", reticulum means "little net") is an organelle found in ... Figure 1 : Image of nucleus , endoplasmic reticulum and Golgi apparatus. (1) Nucleus. (2) Nuclear ...

Cell nucleus

... the nucleus. The outer membrane is continuous with the rough endoplasmic reticulum (RER) and may be studded with ribosomes . The space between the two ... with the lumen of the RER. Drawing of nucleus and the endoplasmic reticulum . (1) Nuclear envelope . (2) Ribosomes . (3) Nuclear pore complexes. ...

Endomembrane system

... is the membrane around the nucleus of the cell. The endoplasmic reticulum is a synthesis and transport organelle [the endoplasmic reticulum is an extension of the nuclear envelope]. The Golgi apparatus acts as ...

Ribosome

... fluid of the cell) or bind to another organelle called the endoplasmic reticulum . Since ribosomes are ribozymes , it is thought that they might be ... associated with the membrane of the nucleus and the rough endoplasmic reticulum (in eukaryotes only) for the time of synthesis. They insert the freshly ...

Vesicle

... vesicles are made in the Golgi apparatus , but also in the endoplasmic reticulum , or are made from parts of the plasma membrane . Lysosomes ... between locations inside the cell, e.g., proteins from the endoplasmic reticulum to the Golgi apparatus, and from there to the outer cell membrane, where ...

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Reticulum in Biological Dictionary

Sarcoplasmic reticulum

... The endoplasmic reticulum (ER) is a eukaryotic organelle that forms an ... cells. The lacey membranes of the endoplasmic reticulum were first seen by Keith ... Aspects of the topic sarcoplasmic - reticulum are discussed in the following places at ...

Rough ER

... Micrograph of rough endoplasmic reticulum network around the nucleus (shown in ... Only ... ER to the Golgi complex. ... endoplasmic reticulum n. A membrane network within the cytoplasm of ... the synthesis, ... The term rough endoplasmic reticulum is based on the ... Biology4Kids.com! The web ...

Endoplasmic reticulum

... The endoplasmic reticulum (ER) is a eukaryotic organelle that forms an ... cells. The lacey membranes of the endoplasmic reticulum were first seen by Keith ... endoplasmic reticulum n. A membrane network within the cytoplasm of ...

Trans face

... of the trans -Golgi network is the face from which vesicles leave ... reticulum or Golgi apparatus are moved towards the trans face , to a complex ... ... apparatus is the distribution and shipping department for the cell's ... reticulum for processing, while the trans face is where they exit in the form of ...

Eukaryotes

... and ... The cells of eukaryotes also contain an endoplasmic reticulum and numerous ... Eukaryotes comprise animals, plants, and ... dictionary ... The cells of eukaryotes also contain an endoplasmic reticulum and numerous ... However, all eukaryotes confine the bulk of their ...

Vesicle

... Vesicle - Definition of Vesicle at Dictionary.com a free online dictionary with ... Vesicles bulge out and break off from the endoplasmic reticulum and the ... MySpace Music profile for Vesicle . Download Vesicle music singles, watch music videos, listen to free streaming mp3s, & read ...

Sarcoplasm

... striated muscle fiber (hypernym) cytoplasm ... Histology Learning System [ Muscle Tissue (EM), sarcoplasm of skeletal muscle, sarcoplasmic reticulum and mitochondria] ... © 2002 Oxford University Press ... BACKGROUND: Sonic muscle fibers intrinsic to the swim bladder of the oyster toadfish ...

Ribosome

...... The ribosome moves to the next triplet code from 5' to the 3' direction (note arrow on mRNA) ... Introduction to the Ribosome -Endoplasmic reticulum Unit ... In cell biology, a ribosome is an organelle composed of RNA and ribosomal ... A triennial conference is held to discuss the ...

Plasmalemma

... Try Windows Live QnA ... plasmalemma /plas·ma·lem·ma/ (-lem'ah) 1. plasma membrane. ... The nature of the phagosomal membrane: endoplasmic reticulum versus plasmalemma ... ER OR PLASMALEMMA ? CONCLUDING REMARKS. REFERENCES ... ... penetrate through the plasmalemma of intestinal ... of ...

Peroxisome

... Contribution of the endoplasmic reticulum to peroxisome formation" ... origin of peroxisomes: an ER- peroxisome connection" ... PeroxisomeDB: Peroxisome -Database ... ...

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