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Repeats in Medical News

Researchers estimate risk of transmission of Huntington's disease to offspring among male carriers

... 4. Individuals with a variant of at least 36 CAG repeats will likely develop HD in their lifetime. Most individuals have a variant below 27 CAG repeats and are not at risk for the disease nor are they ... individuals with a variant between 27 and 35 CAG repeats (called high normal) are not at risk of ...

What are simple ways to judge the efficacy of 5-fluorouracil in colonic neoplasm?

... genotypes of TS: (1) Homozygous with two tandem repeats (2R/2R); (2) homozygous with three tandem repeats (3R/3R); (3) heterozygous with both alleles (2R/3R). It was reported that TS genes with the triple repeats have higher expression activity than those with ...

Abnormal glutamine repeats interfere with key transcription factor, leading to neurodegeneration

... composition, abnormal expansion of trinucleotide repeats is the known cause of multiple inherited ... caused by an abnormal number of glutamine repeats (generally, more than 37) are known as ... glutamine sequence and some symptoms, the repeats for the different PolyQ diseases occur in genes ...

Scientists explore factors contributing to DNA mutations

... decreases with repeat length, possibly because, for a fixed length, longer repeats indicate a lower repeat number and mutability is lower for microsatellites ... mutability. AG (adenine and guanine) had higher mutability than AC for repeats greater than 15. The team attributed these differences to the strength of ...

Telomerase enzyme structure provides significant new target for anti-cancer therapies

... and cancer. In humans, the usual role of telomerase is to add multiple repeats of a short length of DNA to the ends of chromosomes, known as telomeres, ... and a stretch of RNA that is used as a template to create the short DNA repeats that are added to the ends of chromosomes. In order for telomerase to ...

Scientists Reverse Muscular Dystrophy in Mice

... messenger RNA (mRNA) in cells, which affects muscle control and other cellular functions. The original defects in the DNA translate into expanded repeats in the RNA which then bind up various cellular proteins. These include one called "muscleblind," thought to be a key factor in myotonic dystrophy. ...

Your Chemist Shop Responds to Online Shopping Trends

... service online pharmacy providing patients with complete professional service, allowing them to easily fill their prescriptions online and file their repeats for quick and fast delivery too. Patients are asked to fill in a simple form to register their details at Your Chemist Shop when they first visit ...

Sleep Apnea Seems to Wear Down the Brain

... even ceases. This causes blood oxygen levels to drop and blood pressure to rise, but order is restored when the person momentarily awakens. The cycle repeats itself throughout the night. The study found that those with sleep apnea had lower cerebral blood flow velocity and notably lower blood oxygen ...

Doctors Urged to Screen Diabetics for Sleep Apnea

... of soft tissue in the back of the throat during sleep. Between snores, breathing stops for a period of 10 seconds or longer, and this pattern repeats itself multiples times over the course of a night. Not only does it deprive the person of a good night's sleep, but it may increase the risk for ...

Science Fiction Has Become Reality with Remarkable Anti-Aging Treatment Breakthrough - Turning Back the Biological Clock in Aging

... "younger" as they grow older. TA-65 doesn't just stop cell aging, but it reverses it. "It has been scientifically proven that telomeres, which are repeats of certain base pairs of DNA, are the actual "biological clock of aging cells," said Eva Hodgens, Wellness Research Chief Marketing Officer. ...

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Repeats in Medical Technology

Vion Pharmaceuticals Announces Initiation of a Phase I/II Trial of Cloretazine(R) (VNP40101M) in Combination with Temodar(R) in Adult Brain Tumors

... on days 1-7 and intravenous Cloretazine(R) (VNP40101M) over 15-30 minutes 2 hours after the last dose of temozolomide on day 7. Treatment repeats every 7 weeks in the absence of disease progression or unacceptable toxicity. Correlative studies conducted as part of the trial will measure: ...
Repeats in Medical Products

Digistim 2 Plus Nerve Stimulator

Description:... position) Double Burst : 2 60-ms bursts of 50 Hz separated by .75 s; repeats every 10 s Twitch: 1 s (1 pulse/s); single or repeat Tetanus: 50 Hz ... pulses/s) Train-Of-Four: Single (4 pulses/2 s); repeat (4 pulses/2 s; repeats every 10 s) Output Current: Adjustable from 0-70 mA (HI range) 0-6.0 mA ...
Company:CCR Medical

Digistim 3 Plus Nerve Stimulator

Description:... pulses. Double Burst : 2 60-ms bursts of 50 Hz separated by .75 s; repeats every 10 s Twitch: 1 s (1 pulse/s); 2 Hz (2 pulses/s) Tetanus: 50 Hz (50 pulses/s) or 100 Hz (100 pulses/s) Train-Of-Four: 4 pulses/2 s; repeats every 10 s Output Current: Adjustable from 0-70 mA (HI range) 0-6.0mA ...
Company:CCR Medical

NanoChip Molecular Biology Workstation

Description:... instrument that facilitates detection of known sequences, such as in the analysis of Single Nucleotide Polymorphisms (SNPs) and Short Tandem repeats (STRs) using the NanoChip Electronic Microarray. The unique, open-architecture design permits researchers to define, select and build their own test ...
Company:Nanogen, Inc.

Digistim II Nerve Stimulator

Description:... pulse/s); 10 s (1 pulses/10 s) Tetanus: 50 Hz (50 pulses/s) or 100 Hz (100 pulses/s) Train-Of-Four: Single (4 pulses/2 s); repeat (4 pulses/2 s; repeats every 10 s) Output Current: Adjustable from 0-70 mA(HI range) 0-6.0mA (LO range) Stimulus Pulse: Square Wave Monophasic pulses (200-us duration) ...
Company:CCR Medical

DigiStim III Nerve Stimulator

Description:... 1 s (1 pulse/s); 2 Hz (2 pulses/s); 10 s (1 pulse/10 s) Tetanus: 50 Hz (50 pulses/s) or 100 Hz (100 pulses/s) Train-Of-Four: 4 pulses/2 s; repeats every 10 s Output Current: Adjustable from 0-70 mA Stimulus Pulse: Square Wave Monophasic pulses (200-us duration) Indicators: Digital LCD ...
Company:CCR Medical

BenchMark® XT

Features:... or your own Eliminate over 80% of the labor required by other slide staining systems Deliver up to 60 slides in a single 8 hour shift Reduce repeats with standardized slide processing Automate any or all slide preparation stepsbaking, cell conditioning deparaffinization, staining ...
Company:Ventana Medical Systems Inc.
Repeats in Medical Dictionary

Drug

... prevention Raloxifene works as well as tamoxifen in protecting older, high-risk women from breast cancer . April 13, 2006 Abortion pill: FDA repeats warnings of risks ... DRUG ABUSE - Use of a drug for a reason other than which it was intended, or in a manner or in quantities other than ...

Pregnancy Loss

... The researchers from the study concluded that heavy smoking by the father increased the risk of early pregnancy loss . Abortion pill: FDA repeats warnings of risks Coping with pregnancy loss Ask a Specialist Abortion : Does it increase the risk of breast cancer ? APLS (antiphospho lipid ...
Repeats in Biological News

Saved by junk DNA

... foster such a wasteful system'. Unstable repeats The international team of scientists found that stretches of tandem repeats influence the activity of neighboring genes. The repeats determine how tightly the local DNA is wrapped ...

Biologists discover link between CGG repeats in DNA and neurological disorders

... M. Krasilnikova, explored the link between CGG repeats and replication delays. Mirkin's research was ... Mirkin and his team analyzed different cloned CGG repeats in a mammalian cell culture line called COS-1 ... triplets do not cause any problems. When the repeats got longer, however, the replication machinery ...

NIST guides genetic genealogy labs toward improved accuracy

... on the Y chromosome known as short tandem repeats (STRs). Each STR is considered a separate marker ... example, a person may have one STR sequence that repeats 12 times, another 11 times, a third 17 times and ... ancestor. Accurately counting the number of repeats is a tricky task and the source of much of the ...

'Junk' DNA proves functional

... identical sequences. A major source of these repeats is internal viruses that have inserted themselves ... families. Over evolutionary time, these repeats were dispersed within different species, creating ... This research also shows that these repeats are anything but "junk DNA," since they provide a ...

Genome communication

... the paramutagenic allele. Seven of these tandem repeats are required for b1 paramutation. If only three tandem repeats are present, there is only partial paramutagenic activity. One possibility is that these tandem repeats are involved in direct interactions of chromatin ...

Deep into the machinery of adult fragile X

... that is to have abnormally long strings of repeats of the same sequence of three genetic units, ... between 55 and 200 repeats, versus fewer than 55 repeats for most unaffected people. These repeats in the mutant DNA gene are copied onto the ...

Researchers identify proteins involved in new neurodegenerative syndrome

... differ. In both, the gene FMR1 contains too many repeats of the tri-nucleotide CGG. Those with fragile X ... syndrome later in life have a premutation set of repeats of CGG totaling between 60 and 200. These ... syndrome. Previously, it was thought that 60-200 repeats had no effect on premutation carrier individuals. ...

Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA

... X syndrome occurs when a region of the FMR1 gene repeats a particular sequence of three DNA ... Called a trinucleotide repeat, this CGG sequence repeats only about 6 to 55 times in normal individuals, ... those with the premutation of the FMR1 gene, CGG repeats between 60 and 100 times. Scientists estimate ...

Researchers gain insight into mechanism underlying Huntington's

... other neurodegenerative or neuromuscular disorders caused by trinucleotide repeats (or TNRs) in DNA. The research, performed in the laboratory of Dr. ... and/or DNA repair must be involved. Two key TNRs, CAG and CTG repeats associated with Huntington's disease and myotonic dystrophy, respectively ...

Small molecules might block mutant protein production in Huntington's disease

... and Machado-Joseph are fatal inherited diseases caused by abnormal repeats of a small segment in a person's DNA, or genetic code, represented by the ... ataxin-3. A person with Huntington's can have up to 100 CAG repeats. CAG repeats are involved in several other neurodegenerative diseases, including ...

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Repeats in Biological Technology

TripleMaster PCR System

... (non-random) nucleotide base composition, repeats or high GC-content is longer than for ... (GC-content >70 %; homopolymeric stretches), repeats and inverted repeats can be amplified. General ...

TripleMaster PCR System

... (non-random) nucleotide base composition, repeats or high GC-content is longer than for ... (GC-content >70 %; homopolymeric stretches), repeats and inverted repeats can be amplified. General ...

New Reporter Plasmids for Studying Interferon-Stimulated Signal Transduction Pathways

... pISRE-Luc cis-reporter plasmid contains direct repeats of the interferon-stimulated response element ... pGAS-Luc cis-reporter plasmid contains direct repeats of the gamma-activating sequence from the ... promoter element (TATA box), and the direct repeats of ISRE or GAS, control expression of ...

Signal Transduction Reporting Systems Using Cis-Acting Enhancer Elements

... promoter element (TATA box) joined to tandem repeats of AP-1, CRE, SRE, NF- k B or SRF binding ... PathDetect cis-reporting systems contain tandem repeats of one of the following enhancer ... promoter element (TATA box) joined to tandem repeats of CRE, SRE, AP-1, NF- k B or SRF binding ...

SNPs Powerful Tools for Association Studies

... length polymorphisms (RFLPs), short tandem repeats (STRs), and SNPs have played significant roles in ... sequences of interest. Short tandem repeats The mid- to late-80s brought the ... as (CA)n and (CAG)n, where n is the number of repeats all of which are flanked by unique sequences. ...

Real-Time PCR: General Considerations, Rev A

... template secondary structures Avoid templates with long (>4) repeats of single bases Maintain a GC content of 5060% ... 50 and 65C Eliminate secondary structure Avoid repeats of Gs or Cs longer than 3 bases Place Gs and Cs on ends of ...

Real-Time PCR/Melt-Curve Analysis: SNP Detection With FRET, Rev A

... an initial denaturation step of 95C for 3 min, followed by 45 repeats of 95C for 10 sec and 50C for 40 sec. A melt-curve protocol ... with 95C for 1 min and 50C for 1 min, followed by 70 repeats of heating for 10 sec, starting at 50C with 0.5C increments. ...

siRNA Design Guidelines

... the expressed siRNA. Most of the designs had two inverted repeats separated by a short spacer sequence and ended with a string ... of siRNA target sequence, the length of the inverted repeats that encode the stem of a putative hairpin, the order of the ...

QIAGEN Multiplex PCR Handbook

... to as a short tandem repeat (STR). In some cases, slightly longer repeats are used for analysis. These are referred to as variant number of tandem repeats (VNTRs) and can vary in both repeat length and number of repeats. ...

Optimizing Transfection Conditions for Studying Signal Transduction Pathways

... gene driven by a basic promoter element (TATA box) joined to tandem repeats of either AP-1, CRE, SRE, NF- k B, p53, or SRF binding elements. When a ... from a basic promoter element (TATA box) joined to five tandem repeats of the 17-bp GAL4 binding element, was used in the experiment to ...

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Repeats in Biological Products

Mouse Anti-Mucin 3 (MUC3) Ab-2 Monoclonal Antibody, Unconjugated, Clone 1143/B7 from Lab Vision

Description:... and to a lesser extent in breast, lung and salivary gland tissues. Comments: Ab-2 shows no cross-reaction with MUC1 and MUC2. Epitope: Tandem repeats of the human MUC3 Immunogen: MUC3 tandem repeat peptide Positive Control: Colon carcinoma. Cellular Localization: Cell ...
Company:Lab Vision

GeneChoice TEMPase II DNA Polymerase from GeneChoice, Inc.

Description:... nonspecific products due to inactivity at room temperature • Excellent specificity allows extension through DNA regions which contain repeats and secondary structures • Leaves an 'A' overhang TEMPase II is a chemically modified form of GeneChoice DNA Polymerase that remains ...
Company:GeneChoice, Inc.
Repeats in Biological Definition

Microsatellite

... times within the genome of an organism. Many repeats tend to be concentrated at the same locus. In a ... of ... The number of repeats at a particular locus is hypervariable (highly ... high frequency of loss or insertion of additional repeats by confusing the DNA replication machinery. ...

Repeated sequence (DNA)

... one can distinguish two main types of repeated sequence : Tandem repeats : Satellite DNA , Minisatellite , Microsatellite ; Interspersed repeats : SINE ( S hort IN terspersed E lements), LINE ( L ong IN ...

Centromere

... within individual repeat elements is similar but not identical. In humans, the centromeric repeat unit is called α-satellite. However, repeats of α-satellite are not sufficient to cause the assembly of a kinetochore, and there are functioning centromeres with no α-satellite DNA. ...

DNA

... process called DNA profiling or genetic fingerprinting. In DNA profiling the relative lengths of sections of repetitive DNA, such as short tandom repeats and minisatellites are compared. DNA profiling was developed in 1984 English geneticist Alec Jeffries , and was first used in 1986 in the ...

Genetic fingerprinting

... . Two unrelated humans will be likely to have different numbers of microsatellites at a given locus . By using PCR to detect the number of repeats at several loci, it is possible to establish a match that is extremely unlikely to have arisen by coincidence. Genetic fingerprinting is used in ...

Genetic recombination

... between any two double helices of DNA which are very close in sequence and come into contact with one another. Thus, crossover may occur between Alu repeats on the same chromatid, or between similar sequences on two completely different chromosomes. These processes are called unbalanced recombination. ...

Prion

... from detailed biochemical analysis of yeast prion proteins. A typical yeast prion proteins contain a region ( protein domain ) with many repeats of the amino acids glutamine (Q) and asparagine (N); these Q/N-rich domains form the core of the prion's structure. Ordinarily, prion domains are ...

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Repeats in Biological Dictionary

Tandem repeat sequence

... ... tandem repeats in strings (e.g. DNA sequences ) can ... ... , we systematically cataloged all tandem repeats with periods ... of the consensus sequence ... from ALL TRs ... Polymorphism of tandem repeats within protein-coding sequences is known to ......

Tandem repeat sequences

... ... Computer Science, tandem repeats in strings (e.g. DNA sequences ) can be ... ... on ... ... Computer Science, tandem repeats in strings (e.g. DNA sequences ) can be ... A ... Poly-A Sequences and Heteroplasmic Tandem repeats . David A. Ray. 1. and ... 7.—Aligned sequences ...

Simple Sequence Repeat

... ... how many repeats of the STR sequence in question there ... ... Microsatellites, or Simple Sequence repeats (SSRs), are polymorphic loci present ... ISSR ... ... Microsatellites, or Simple Sequence repeats (SSRs), are polymorphic loci present ... ISSR ...

Repeats

... The repeats are tandem - they are clustered together and oriented in the same direction. Individual repeats can be removed from (or added to) the VNTR via ... Tandem repeats occur in DNA when a pattern of two or more ...

Inverted Repeats

... palindromic repeat . mirror and everted repeats [edit] See also ... Tandem repeats ... Interspersed repeats ... Inverted ...

Direct Repeats

... Direct repeats are a type of genetic sequence that consists of two or more repeats of a specific sequence. local direct repeats with spacer. inverted ...

VNTR

... range of copy numbers, even among highly ... Variable-Number Tandem repeats ( VNTR's ) are well known for their high mutation ... Some VNTR's , ... with ... One type of minisatellites is called variable number of tandem repeats ( VNTR ) ... VNTR . Reference Laboratories. Reference Materials. ...

Triplet repeat expansion

... a dynamic or unstable mutation ... Disease. 1.2 Expansion of Triplet repeats ... Lesson 1: Triplet Repeat Expansion (1 of 3) ... The triplet ... (2009) ... driving triplet repeat contraction ... ... Triplet repeats in Noncoding Regions Fragile X syndrome (CGG repeat ) Fragile ... is ...

Intergenic DNA

... have greater regulatory ... Plant viral intergenic DNA sequence repeats with transcription enhancing activity ... DNA sequences from the ... intergenic DNA in ... Plant viral intergenic DNA sequence repeats with transcription enhancing activity ... DNA sequences from the ...

Alu sequence

... Alu sequences in the database of human genome is ... Alu repeats digestion at recognition sequence AGCT produces 3 DNA fragment: 60 ...... Alu sequences in the database of human genome is ... Alu repeats digestion at recognition sequence AGCT produces 3 DNA fragment: 60 ......

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