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Renin in Medical News

New Survey Finds Majority of Adults Don't Understand a Key Source of High Blood Pressure

... are not at all familiar with the role of the renin system(1) -- a key regulator of blood pressure in ... materials about an important enzyme called renin. renin plays a role in blood pressure rising and falling ... that narrows blood vessels. In some people, the renin system is too active and that can lead to high ...

JCI online early table of contents: June 5, 2008

... glucose triggered cells in the kidney to release renin and this was associated with accumulation of a ... GPR91, which recognizes succinate, had less renin in their kidney that did diabetic mice expressing ... a direct link between high glucose levels and renin release in murine and rabbit kidney AUTHOR ...

JCI online early table of contents: Feb. 7, 2008

... NEPHROLOGY: The CNRE region of the renin gene cant handle the blood pressure The kidney protein renin has a crucial role in maintaining blood pressure. Transcription of the renin gene involves the decoding of its gene sequence ...

Lungs' mast cells could provide new treatment target for asthma, other respiratory disease

... response, mast cells release the enzyme -- called renin -- which in turn produces angiotensin, a potent ... to discover that mast cells in the heart released renin locally, which elicited heart arrhythmias by ... trigger constriction in the airway," he says. renin is no stranger to medical research -- for ...

Two-Drug Combo Reduces Diabetic Kidney Damage

... in diabetes, he said. "What this study seems to indicate is that using a renin inhibitor is another way of blocking the pathway that is associated with ... "Based on the results of this study, I am much more likely to use a direct renin inhibitor in addition to an angiotensin blocker in patients with Type 2 ...

SAGE acquires 2 new medical journals

... of the Renin-Angiotensin-Aldosterone System is the official journal of the renin Academy, dedicated to highlighting the importance of the renin Angiotensin Aldosterone System (RAAS) in circulatory control and ...

Blood pressure drug may have added benefit

... by inhibiting renin, an enzyme that is primarily produced in the kidneys. renin is the first step in the synthesis of one of the most important molecules in blood pressure regulation. "Our data shows that renin inhibition is an effective approach to both lowering blood pressure and ...

Blood Pressure Vaccine Shows Promise

... experts noted. The vaccine also produced only a slight increase in renin levels. renin is an enzyme that is thought to cause inflammation and may play a role in ...

Why African-Americans are at greater risk of hypertension and kidney disease

... mechanisms of TGF-B1 require further study, the authors believe that in black patients, higher levels of the growth factor are correlated with lower renin activity -- an enzyme that constricts blood vessels and raises blood pressure. High blood pressure is the leading risk factor for end-stage kidney ...

Center receives grant renewal for hypertension and vascular disease studies

... those that lower it. Specifically, researchers at the School of Medicine plan to use the money to continue studying the mechanisms by which the renin angiotensin system, which regulates blood pressure, contributes to hypertension, cardiac hypertrophy (a thickening of the heart muscle that results ...
Renin in Medical Technology

FDA Approves Tekturna HCT(R) as Initial Treatment in Patients Unlikely to Achieve Their Blood Pressure Goals With a Single Agent

... (aliskiren), the first and only approved direct renin inhibitor, and the diuretic hydrochlorothiazide ... drug, Tekturna, that works by directly targeting renin and decreasing the activity of the renin angiotensin aldosterone system (RAAS) and, HCTZ, ...

Pharmacopeia Announces Upcoming Late-Breaker Presentation of Phase 2a Results for Its First-in-Class Investigational DARA Compound, PS433540

... Acadia Ballroom, 3rd Floor Poster presentation: -- "PS433540 a Novel Dual Acting Receptor Antagonist Dose Dependently Increases Plasma renin Activity in Healthy Volunteers" -- Abstract # P-14 -- Wednesday, May 14, 2008, Posters on Display: 3:00 - 7:00 p.m. CDT (4:00 - 8:00 ....

New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard Therapy in Treatment of Hypertension

... of this first-in-class once daily direct renin inhibitor for the treatment of hypertension. ... which lowers blood pressure and plasma renin activity, irrespective of the amount of renin circulating in the bloodstream." Speedel also ...

Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur

... in plasma renin concentration (PRC) from a mean renin concentration of 5.1 pg/ml at baseline to 6.3 ... is known to induce a reactive rise of the plasma renin concentration, which is a counter-reaction of ... for the minor reactive rise observed in plasma renin concentration, and to the potent effect of the ...

Speedel Reports Successful SPP635 Phase IIa Trial in Hypertension

... Next Generation renin Inhibitor to Continue Phase II Profiling in ... in the development of its family of renin inhibitors with the successful completion of a ... compound is the first of a next generation of renin inhibitors following Speedel's lead ...
Renin in Medical Products

Aldosterone RIA Test

Description:... sodium chloride concentrations lead to increased renin secretion and activation of angiotensin, with ... observed in primary hyperaldosteronism, in which renin levels are low, blood pressure is elevated and ... hyperaldosteronism as a result of elevated renin secretion [3,6]. Abnormally low aldosterone ...
Company:Diagnostic Systems Laboratories, Inc.

Renin IRMA Test

Description:... water and electrolyte retention by the kidney. renin is secreted in response to several factors ... plasma sodium and chloride concentration. renin acts by converting the renin-substrate ... secretion of potassium and hydrogen [1]. renin plasma levels are useful in the diagnosis of ...
Company:Diagnostic Systems Laboratories, Inc.

Lyphochek Hypertension Markers Control

Description:... Lyphochek Hypertension Markers Control is a trilevel control designed to monitor the performance of testing procedures for renin and other analytes associated with hypertension ....
Company:Bio-Rad Laboratories

Plasma Renin Activity

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories
Renin in Medical Dictionary

Erythropoietin

... the bone marrow to produce red blood cells renin - Regulates blood volume and blood pressure ... the bone marrow to make red blood cells renin (REE-nin), which regulates blood pressure ... ... the bone marrow to make red blood cells renin , which helps to regulate blood pressure the ...

Renin

... renin Alternative Names: Plasma renin activity; Random plasma renin ; PRA What the risks are: ... ...

Aldosteronism

... aldosteronism , your doctor may measure the levels of aldosterone and renin in your blood . renin is an enzyme released by your kidney s that helps regulate blood ...

Aldosterone

... disease , cause the adrenals to release an excessive amount of the hormone aldosterone (al-DOS-tuhr-ohn). ACE plays an important role in the renin / aldosterone mechanism which controls blood pressure by converting angiotensin I to angiotensin II, two protein s involved in regulating blood ...

Blood clots

... disease ... Blood clots in the vessel that carries blood away from the kidney . This can occur in people with the nephrotic syndrome . renin (REE-nin): A hormone made by the kidney s that helps regulate the volume of fluid in the body and blood pressure . Blood clots (call your ...

Bone marrow

... outlines the mechanisms of o edema and possible causes. Erythropoietin (EPO) - Stimulates the bone marrow to produce red blood cells renin - Regulates blood volume and blood pressure What is the difference between kidney failure and kidney disease ? Cancer of the tissue s ...

Essential hypertension

... type that has no clear cause and produces no symptoms until it is advanced—is detected mainly in the adult years. Patients may also have renin and aldosterone levels checked in essential hypertension to evaluate if patients are salt sensitive. Verelan PM (verapamil hydro chloride ) ...

Growth hormone

... Overall, some hormone s are decreased, some unchanged, and some increased with age. Hormone s that are usually decreased include aldosterone , renin , estrogen (in women), calcitonin , prolactin (in women), and growth hormone . Other conditions that can cause high blood glucose levels ...

Marrow

... outlines the mechanisms of o edema and possible causes. Erythropoietin (EPO) - Stimulates the bone marrow to produce red blood cells renin - Regulates blood volume and blood pressure What is the difference between kidney failure and kidney disease ? Cancer of the tissue s ...

PPD skin test

... (Atopic Dermatitis ) more>> ... Potpourri (Sachets) Potter Syndrome Power of Attorney ( Advanced Care Directives ) PPD Skin Test PRA ( renin ) ... ...

More>>

Renin in Biological Technology

Video and Photo: Tekturna HCT(R), a Single-tablet Combination of Tekturna(R)* and a Diuretic, Receives US Approval for Treatment of High Blood Pressure

... - Tekturna HCT combines first approved direct renin inhibitor with the diuretic ... and convenience, by combining the first direct renin inhibitor and a diuretic in one tablet." High ... Tekturna is the only drug that works by targeting renin and decreasing the activity of ...

Recombinant Human Renin - Crystallographic Grade

... of crystallographic grade recombinant human renin and native human renin from human kidney. Human renin is an important enzyme in the regulation of blood ...

Bystolic(TM), a Novel Beta Blocker, is Now Approved by the FDA for the Treatment of Hypertension

... of traditional beta blocker side effects. Like other beta blockers, Bystolic decreases heart rate and myocardial contractility, and suppresses renin activity. Bystolic is a selective beta 1 blocker at doses less than or equal to 10 mg per day and has the added pharmacological properties of ...

Presentation of Phase IIa Results for Cytos Biotechnology's Hypertension Vaccine at the American Heart Association Scientific Sessions 2007

... drugs on the market: inhibitors of the angiotensin-converting enzyme (ACEI), blockers of the angiotensin II subtype I receptor (ARB) and direct renin inhibitors (DRI). Like other antihypertensive drugs these also come with the need for daily dosing and often fail to provide a good solution for ...

Medical College receives $11 million grant to study high blood pressure

... rats. In the third and final project, the research team will attempt to identify and characterize the mutation that regulates the "renin gene." renin is an enzyme released by special cells in the kidney in response to salt, and its release can lead to an increase in blood pressure. Eight ...

Gq-coupled Receptor Assays Using FLEXstation

... Immunol. Cell. Biol. 78: 369374. 7. van der Weyden, L., D. J. Adams, and B. J. Morris. 2000. Capacity for purinergic control of renin promoter via P2Y(11) receptor and cAMP pathways. Hypertension 36: 10931098. 8. Communi, D., R. Janssens, B. Robaye, N. Zeelis, and J. ...
Renin in Biological Definition

Kidney

... densa and juxtaglomerular cells . Juxtaglomerular cells are the site of renin synthesis and secretion. Fluids become more concentrated along the ... bloodstream, secretion of hormones - particularly erythropoietin and renin and maintaining serum electrolyte, acid-base levels and osmolality. For ...

Hormone

... (LH) melanocyte stimulating hormone (MSH or α-MSH) neuropeptide Y oxytocin parathyroid hormone (PTH) prolactin (PRL) renin secretin somatostatin thrombopoietin thyroid-stimulating hormone (TSH) thyrotropin-releasing hormone (TRH) Steroid ...
Renin in Biological Dictionary

Osmoregulation

... n. Maintenance of an optimal, constant osmotic pressure in the body of a living organism ... Blood sugar · Osmoregulation · Pressure: renin ... Osmoregulation is usually achieved by excretory organs that serve also for the ... Thus, urination is a mechanism of both waste excretion ...

Kidney

... treatment for kidney cancer? ... Offers emergency financial assistance to transplant or dialysis patients. The kidney makes hormones. ... renin is made by the kidney if there is low blood ... Kidney stones – this is when a solid substance forms in the urine. ... The kidneys perform ...

Glomerulus

... the glomerulus passes into a second capillary network (not shown ... only 50% of the urea filtered at the glomerulus is reclaimed ... renin Release by Kidney Glomerulus ,Afferent arteries from the glomerulus release renin, an enzyme that acts on circulating angiotensinogen to form ...
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